SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4myc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DLS_A_MTXA188_1
(DIHYDROFOLATE
REDUCTASE)		 4myc IRON-SULFUR CLUSTERS
TRANSPORTER ATM1,
MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 274
SER A 240
ILE A 239
PRO A 238
LEU A 389
 None
 1.20A 1dlsA-4mycA:
undetectable		 1dlsA-4mycA:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ETA_2_T442129_1
(TRANSTHYRETIN)		 4myc IRON-SULFUR CLUSTERS
TRANSPORTER ATM1,
MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		4 / 5 LYS A 122
LEU A 118
GLU A 242
ALA A 121
 None
 0.99A 1eta2-4mycA:
undetectable		 1eta2-4mycA:
13.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SN5_C_T3C601_2
(TRANSTHYRETIN)		 4myc IRON-SULFUR CLUSTERS
TRANSPORTER ATM1,
MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		4 / 8 LEU A 645
GLU A 653
THR A 465
VAL A 627
 None
 0.59A 1sn5C-4mycA:
undetectable		 1sn5C-4mycA:
14.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2LH8_A_VIBA1_1
(MAJOR PRION PROTEIN)		 4myc IRON-SULFUR CLUSTERS
TRANSPORTER ATM1,
MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		4 / 6 PRO A 429
ASP A 506
ASP A 504
TYR A 503
 None
 1.41A 2lh8A-4mycA:
1.9		 2lh8A-4mycA:
10.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNH_A_9CRA502_1
(CYTOCHROME P450 2C8)		 4myc IRON-SULFUR CLUSTERS
TRANSPORTER ATM1,
MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		6 / 12 SER A 574
ILE A 573
ASN A 529
LEU A 581
VAL A 566
ILE A 583
 None
 1.49A 2nnhA-4mycA:
0.0		 2nnhA-4mycA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZZN_B_SAMB402_0
(UNCHARACTERIZED
PROTEIN MJ0883)		 4myc IRON-SULFUR CLUSTERS
TRANSPORTER ATM1,
MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 339
ARG A 280
PHE A 391
GLY A 393
ILE A 239
 None
 1.38A 2zznB-4mycA:
undetectable		 2zznB-4mycA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_A_THHA642_1
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		 4myc IRON-SULFUR CLUSTERS
TRANSPORTER ATM1,
MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		3 / 3 ASN A 421
ASP A 506
ARG A 413
 None
 0.80A 3k13A-4mycA:
undetectable		 3k13A-4mycA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O1C_A_ADNA127_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 1)		 4myc IRON-SULFUR CLUSTERS
TRANSPORTER ATM1,
MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		5 / 10 ILE A 643
PHE A 457
ILE A 459
ILE A 629
SER A 476
 None
 1.13A 3o1cA-4mycA:
undetectable		 3o1cA-4mycA:
11.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O94_A_NCAA192_0
(NICOTINAMIDASE)		 4myc IRON-SULFUR CLUSTERS
TRANSPORTER ATM1,
MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		5 / 11 PHE A 254
LEU A 377
PHE A 130
LEU A 250
ILE A 249
 None
 1.36A 3o94A-4mycA:
undetectable		 3o94A-4mycA:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O94_B_NCAB192_0
(NICOTINAMIDASE)		 4myc IRON-SULFUR CLUSTERS
TRANSPORTER ATM1,
MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		5 / 11 PHE A 254
LEU A 377
PHE A 130
LEU A 250
ILE A 249
 None
 1.36A 3o94B-4mycA:
undetectable		 3o94B-4mycA:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O94_C_NCAC192_0
(NICOTINAMIDASE)		 4myc IRON-SULFUR CLUSTERS
TRANSPORTER ATM1,
MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		5 / 11 PHE A 254
LEU A 377
PHE A 130
LEU A 250
ILE A 249
 None
 1.36A 3o94C-4mycA:
undetectable		 3o94C-4mycA:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O94_D_NCAD192_0
(NICOTINAMIDASE)		 4myc IRON-SULFUR CLUSTERS
TRANSPORTER ATM1,
MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		5 / 11 PHE A 254
LEU A 377
PHE A 130
LEU A 250
ILE A 249
 None
 1.36A 3o94D-4mycA:
undetectable		 3o94D-4mycA:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IK6_B_LURB201_1
(TRANSTHYRETIN)		 4myc IRON-SULFUR CLUSTERS
TRANSPORTER ATM1,
MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		4 / 8 LEU A 645
GLU A 653
THR A 465
VAL A 627
 None
 0.84A 4ik6B-4mycA:
undetectable		 4ik6B-4mycA:
11.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_B_SORB1341_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 4myc IRON-SULFUR CLUSTERS
TRANSPORTER ATM1,
MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		4 / 7 ARG A 492
ASP A 499
ILE A 500
TYR A 503
 None
 1.22A 5a06B-4mycA:
undetectable		 5a06B-4mycA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_J_ZOLJ401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 4myc IRON-SULFUR CLUSTERS
TRANSPORTER ATM1,
MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		4 / 6 LEU A 381
ASP A 374
GLN A 253
GLN A 134
 None
 1.36A 6g31J-4mycA:
undetectable		 6g31J-4mycA:
7.76