SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4myd'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J7K_A_ACTA701_0
(HOLLIDAY JUNCTION
DNA HELICASE RUVB)		 4myd 2-SUCCINYL-6-HYDROXY
-2,4-CYCLOHEXADIENE-
1-CARBOXYLATE
SYNTHASE
(Escherichia
coli) 		4 / 4 GLY A  89
LEU A  87
GLY A 111
ARG A  90
 None
164  A 301 (-4.0A)
None
164  A 301 (-3.6A)
 1.15A 1j7kA-4mydA:
undetectable		 1j7kA-4mydA:
24.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_I_BEZI517_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 4myd 2-SUCCINYL-6-HYDROXY
-2,4-CYCLOHEXADIENE-
1-CARBOXYLATE
SYNTHASE
(Escherichia
coli) 		4 / 7 ILE A 107
PHE A  37
ARG A 251
ALA A 247
 None
 1.10A 1oniG-4mydA:
undetectable
1oniI-4mydA:
undetectable		 1oniG-4mydA:
20.92
1oniI-4mydA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SA1_B_PODB700_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 4myd 2-SUCCINYL-6-HYDROXY
-2,4-CYCLOHEXADIENE-
1-CARBOXYLATE
SYNTHASE
(Escherichia
coli) 		5 / 12 LEU A 180
ALA A 177
LEU A 176
ASN A 172
VAL A 143
 None
 1.18A 1sa1A-4mydA:
4.4
1sa1B-4mydA:
3.9		 1sa1A-4mydA:
20.26
1sa1B-4mydA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SA1_D_PODD701_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 4myd 2-SUCCINYL-6-HYDROXY
-2,4-CYCLOHEXADIENE-
1-CARBOXYLATE
SYNTHASE
(Escherichia
coli) 		5 / 12 LEU A 180
ALA A 177
LEU A 176
ASN A 172
VAL A 143
 None
 1.16A 1sa1C-4mydA:
undetectable
1sa1D-4mydA:
3.5		 1sa1C-4mydA:
20.26
1sa1D-4mydA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SBR_A_VIBA502_1
(YKOF)		 4myd 2-SUCCINYL-6-HYDROXY
-2,4-CYCLOHEXADIENE-
1-CARBOXYLATE
SYNTHASE
(Escherichia
coli) 		4 / 6 LEU A  43
ILE A  77
SER A  41
CYH A 104
 None
 0.95A 1sbrA-4mydA:
undetectable
1sbrB-4mydA:
undetectable		 1sbrA-4mydA:
19.71
1sbrB-4mydA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRK_A_TFPA204_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 4myd 2-SUCCINYL-6-HYDROXY
-2,4-CYCLOHEXADIENE-
1-CARBOXYLATE
SYNTHASE
(Escherichia
coli) 		5 / 9 PHE A 200
PHE A  80
LEU A  68
PHE A  61
LEU A 100
 None
 1.26A 1wrkA-4mydA:
undetectable
1wrkB-4mydA:
undetectable		 1wrkA-4mydA:
16.44
1wrkB-4mydA:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD2_B_CHDB1_0
(FERROCHELATASE)		 4myd 2-SUCCINYL-6-HYDROXY
-2,4-CYCLOHEXADIENE-
1-CARBOXYLATE
SYNTHASE
(Escherichia
coli) 		5 / 10 LEU A  72
PRO A  48
SER A  53
VAL A  91
GLY A  88
 None
 1.38A 2qd2B-4mydA:
2.9		 2qd2B-4mydA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B9M_A_SALA1100_1
(SERUM ALBUMIN)		 4myd 2-SUCCINYL-6-HYDROXY
-2,4-CYCLOHEXADIENE-
1-CARBOXYLATE
SYNTHASE
(Escherichia
coli) 		4 / 4 LEU A  20
ARG A  69
LEU A  72
ALA A  95
 None
 1.08A 3b9mA-4mydA:
undetectable		 3b9mA-4mydA:
17.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCN_A_CHDA3_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4myd 2-SUCCINYL-6-HYDROXY
-2,4-CYCLOHEXADIENE-
1-CARBOXYLATE
SYNTHASE
(Escherichia
coli) 		4 / 7 LEU A  72
PRO A  48
SER A  53
GLY A  88
 None
 1.04A 3hcnA-4mydA:
2.8		 3hcnA-4mydA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCO_A_CHDA4_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4myd 2-SUCCINYL-6-HYDROXY
-2,4-CYCLOHEXADIENE-
1-CARBOXYLATE
SYNTHASE
(Escherichia
coli) 		5 / 9 LEU A  72
PRO A  48
SER A  53
VAL A  91
GLY A  88
 None
 1.30A 3hcoA-4mydA:
2.7		 3hcoA-4mydA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCO_B_CHDB924_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4myd 2-SUCCINYL-6-HYDROXY
-2,4-CYCLOHEXADIENE-
1-CARBOXYLATE
SYNTHASE
(Escherichia
coli) 		5 / 10 LEU A  72
PRO A  48
SER A  53
VAL A  91
GLY A  88
 None
 1.33A 3hcoB-4mydA:
2.7		 3hcoB-4mydA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCR_B_CHDB924_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4myd 2-SUCCINYL-6-HYDROXY
-2,4-CYCLOHEXADIENE-
1-CARBOXYLATE
SYNTHASE
(Escherichia
coli) 		4 / 7 LEU A  72
PRO A  48
SER A  53
GLY A  88
 None
 1.00A 3hcrB-4mydA:
3.6		 3hcrB-4mydA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HZN_G_ACTG225_0
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 4myd 2-SUCCINYL-6-HYDROXY
-2,4-CYCLOHEXADIENE-
1-CARBOXYLATE
SYNTHASE
(Escherichia
coli) 		3 / 3 PRO A 113
LEU A 191
GLN A 188
 None
 0.72A 3hznG-4mydA:
undetectable
3hznH-4mydA:
undetectable		 3hznG-4mydA:
22.30
3hznH-4mydA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OGQ_A_AB1A200_1
(FIV PROTEASE)		 4myd 2-SUCCINYL-6-HYDROXY
-2,4-CYCLOHEXADIENE-
1-CARBOXYLATE
SYNTHASE
(Escherichia
coli) 		5 / 10 LEU A  72
ALA A  95
VAL A  64
GLY A  88
LEU A  68
 None
 1.01A 3ogqA-4mydA:
undetectable		 3ogqA-4mydA:
17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OGQ_A_AB1A200_1
(FIV PROTEASE)		 4myd 2-SUCCINYL-6-HYDROXY
-2,4-CYCLOHEXADIENE-
1-CARBOXYLATE
SYNTHASE
(Escherichia
coli) 		5 / 10 LEU A  72
ALA A  95
VAL A  64
GLY A  89
LEU A  68
 None
 0.85A 3ogqA-4mydA:
undetectable		 3ogqA-4mydA:
17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IG5_A_MMZA616_1
(LACTOPEROXIDASE)		 4myd 2-SUCCINYL-6-HYDROXY
-2,4-CYCLOHEXADIENE-
1-CARBOXYLATE
SYNTHASE
(Escherichia
coli) 		4 / 5 GLN A 160
ARG A 236
GLU A 237
LEU A 156
 None
 0.97A 4ig5A-4mydA:
undetectable		 4ig5A-4mydA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IG5_B_MMZB617_1
(LACTOPEROXIDASE)		 4myd 2-SUCCINYL-6-HYDROXY
-2,4-CYCLOHEXADIENE-
1-CARBOXYLATE
SYNTHASE
(Escherichia
coli) 		4 / 5 GLN A 160
ARG A 236
GLU A 237
LEU A 156
 None
 0.91A 4ig5B-4mydA:
0.0		 4ig5B-4mydA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KLR_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4myd 2-SUCCINYL-6-HYDROXY
-2,4-CYCLOHEXADIENE-
1-CARBOXYLATE
SYNTHASE
(Escherichia
coli) 		4 / 8 LEU A  72
PRO A  48
SER A  53
GLY A  88
 None
 0.88A 4klrB-4mydA:
3.5		 4klrB-4mydA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LA0_A_198A601_1
(SERUM ALBUMIN)		 4myd 2-SUCCINYL-6-HYDROXY
-2,4-CYCLOHEXADIENE-
1-CARBOXYLATE
SYNTHASE
(Escherichia
coli) 		5 / 10 MET A  93
ALA A  92
GLU A 109
PHE A 202
LEU A 220
 None
 1.30A 4la0A-4mydA:
undetectable		 4la0A-4mydA:
17.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LA0_B_198B601_1
(SERUM ALBUMIN)		 4myd 2-SUCCINYL-6-HYDROXY
-2,4-CYCLOHEXADIENE-
1-CARBOXYLATE
SYNTHASE
(Escherichia
coli) 		5 / 9 MET A  93
ALA A  92
GLU A 109
PHE A 202
LEU A 220
 None
 1.30A 4la0B-4mydA:
undetectable		 4la0B-4mydA:
17.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TVT_A_ASCA302_0
(THAUMATIN-1)		 4myd 2-SUCCINYL-6-HYDROXY
-2,4-CYCLOHEXADIENE-
1-CARBOXYLATE
SYNTHASE
(Escherichia
coli) 		3 / 3 ARG A 236
GLN A 160
GLU A 163
 None
 0.82A 4tvtA-4mydA:
undetectable		 4tvtA-4mydA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_R_BEZR801_1
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 4myd 2-SUCCINYL-6-HYDROXY
-2,4-CYCLOHEXADIENE-
1-CARBOXYLATE
SYNTHASE
(Escherichia
coli) 		4 / 8 PRO A  48
MET A 179
LEU A  68
LEU A  67
 None
 1.15A 5dzkd-4mydA:
undetectable
5dzkr-4mydA:
undetectable		 5dzkd-4mydA:
21.32
5dzkr-4mydA:
2.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FF1_A_MMZA601_1
(LACTOPEROXIDASE)		 4myd 2-SUCCINYL-6-HYDROXY
-2,4-CYCLOHEXADIENE-
1-CARBOXYLATE
SYNTHASE
(Escherichia
coli) 		4 / 5 GLN A 160
ARG A 236
GLU A 237
LEU A 156
 None
 0.94A 5ff1A-4mydA:
undetectable		 5ff1A-4mydA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FF1_A_MMZA602_1
(LACTOPEROXIDASE)		 4myd 2-SUCCINYL-6-HYDROXY
-2,4-CYCLOHEXADIENE-
1-CARBOXYLATE
SYNTHASE
(Escherichia
coli) 		4 / 5 GLN A 160
ARG A 236
GLU A 237
LEU A 156
 None
 0.94A 5ff1A-4mydA:
undetectable		 5ff1A-4mydA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FF1_B_MMZB601_1
(LACTOPEROXIDASE)		 4myd 2-SUCCINYL-6-HYDROXY
-2,4-CYCLOHEXADIENE-
1-CARBOXYLATE
SYNTHASE
(Escherichia
coli) 		4 / 5 GLN A 160
ARG A 236
GLU A 237
LEU A 156
 None
 0.93A 5ff1B-4mydA:
undetectable		 5ff1B-4mydA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FF1_B_MMZB613_1
(LACTOPEROXIDASE)		 4myd 2-SUCCINYL-6-HYDROXY
-2,4-CYCLOHEXADIENE-
1-CARBOXYLATE
SYNTHASE
(Escherichia
coli) 		4 / 5 GLN A 160
ARG A 236
GLU A 237
LEU A 156
 None
 0.93A 5ff1B-4mydA:
undetectable		 5ff1B-4mydA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E43_A_BEZA502_0
(INDOLEAMINE
2,3-DIOXYGENASE 1)		 4myd 2-SUCCINYL-6-HYDROXY
-2,4-CYCLOHEXADIENE-
1-CARBOXYLATE
SYNTHASE
(Escherichia
coli) 		4 / 6 PHE A 213
LEU A  87
ARG A  90
HIS A 112
 None
164  A 301 (-4.0A)
164  A 301 (-3.6A)
None
 0.94A 6e43A-4mydA:
undetectable		 6e43A-4mydA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E43_B_BEZB502_0
(INDOLEAMINE
2,3-DIOXYGENASE 1)		 4myd 2-SUCCINYL-6-HYDROXY
-2,4-CYCLOHEXADIENE-
1-CARBOXYLATE
SYNTHASE
(Escherichia
coli) 		4 / 6 PHE A 213
LEU A  87
ARG A  90
HIS A 112
 None
164  A 301 (-4.0A)
164  A 301 (-3.6A)
None
 0.95A 6e43B-4mydA:
undetectable		 6e43B-4mydA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E43_C_BEZC502_0
(INDOLEAMINE
2,3-DIOXYGENASE 1)		 4myd 2-SUCCINYL-6-HYDROXY
-2,4-CYCLOHEXADIENE-
1-CARBOXYLATE
SYNTHASE
(Escherichia
coli) 		4 / 6 PHE A 213
LEU A  87
ARG A  90
HIS A 112
 None
164  A 301 (-4.0A)
164  A 301 (-3.6A)
None
 0.94A 6e43C-4mydA:
undetectable		 6e43C-4mydA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E43_D_BEZD502_0
(INDOLEAMINE
2,3-DIOXYGENASE 1)		 4myd 2-SUCCINYL-6-HYDROXY
-2,4-CYCLOHEXADIENE-
1-CARBOXYLATE
SYNTHASE
(Escherichia
coli) 		4 / 6 PHE A 213
LEU A  87
ARG A  90
HIS A 112
 None
164  A 301 (-4.0A)
164  A 301 (-3.6A)
None
 0.95A 6e43D-4mydA:
undetectable		 6e43D-4mydA:
19.70