SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4myn'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WG8_A_SAMA3142_0
(PREDICTED
S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 4myn FORMIMINOGLUTAMASE
(Trypanosoma
cruzi) 		5 / 12 PRO A 276
GLY A 111
GLY A 112
ASP A 270
MET A 269
 None
 0.94A 1wg8A-4mynA:
5.8		 1wg8A-4mynA:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WG8_B_SAMB3141_0
(PREDICTED
S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 4myn FORMIMINOGLUTAMASE
(Trypanosoma
cruzi) 		5 / 12 PRO A 276
GLY A 111
GLY A 112
ASP A 270
MET A 269
 None
 0.96A 1wg8B-4mynA:
5.5		 1wg8B-4mynA:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WG8_B_SAMB3141_0
(PREDICTED
S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 4myn FORMIMINOGLUTAMASE
(Trypanosoma
cruzi) 		5 / 12 PRO A 276
GLY A 111
GLY A 112
ASP A 270
SER A 272
 None
 1.18A 1wg8B-4mynA:
5.5		 1wg8B-4mynA:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OUZ_A_C3DA999_1
(ESTROGEN RECEPTOR)		 4myn FORMIMINOGLUTAMASE
(Trypanosoma
cruzi) 		4 / 6 ALA A  78
ASP A  77
GLU A  19
ARG A 103
 None
 1.11A 2ouzA-4mynA:
undetectable		 2ouzA-4mynA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AF0_A_PAUA314_0
(PANTOTHENATE KINASE)		 4myn FORMIMINOGLUTAMASE
(Trypanosoma
cruzi) 		4 / 8 VAL A 134
ASP A 270
GLY A 121
HIS A 114
 None
None
None
MN  A 400 (-3.3A)
 1.05A 3af0A-4mynA:
undetectable		 3af0A-4mynA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I5U_B_SAMB401_0
(O-METHYLTRANSFERASE)		 4myn FORMIMINOGLUTAMASE
(Trypanosoma
cruzi) 		5 / 12 HIS A  90
LEU A  86
GLY A 113
GLY A 112
PRO A  48
 None
 1.17A 3i5uB-4mynA:
undetectable		 3i5uB-4mynA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_A_THHA642_0
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		 4myn FORMIMINOGLUTAMASE
(Trypanosoma
cruzi) 		5 / 12 GLU A 273
GLY A 112
ASP A 270
VAL A 134
SER A 154
 None
 1.03A 3k13A-4mynA:
undetectable		 3k13A-4mynA:
24.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_B_THHB643_0
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		 4myn FORMIMINOGLUTAMASE
(Trypanosoma
cruzi) 		5 / 12 GLU A 273
GLY A 112
ASP A 270
VAL A 134
SER A 154
 None
 1.02A 3k13B-4mynA:
undetectable		 3k13B-4mynA:
24.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_C_THHC643_0
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		 4myn FORMIMINOGLUTAMASE
(Trypanosoma
cruzi) 		5 / 12 GLU A 273
GLY A 112
ASP A 270
VAL A 134
SER A 154
 None
 1.01A 3k13C-4mynA:
undetectable		 3k13C-4mynA:
24.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_E_TFPE201_1
(PROTEIN S100-A4)		 4myn FORMIMINOGLUTAMASE
(Trypanosoma
cruzi) 		4 / 7 PHE A 298
GLY A 297
MET A 269
PHE A 291
 None
 1.10A 3ko0D-4mynA:
undetectable
3ko0E-4mynA:
undetectable		 3ko0D-4mynA:
14.87
3ko0E-4mynA:
14.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRK_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 4myn FORMIMINOGLUTAMASE
(Trypanosoma
cruzi) 		4 / 5 PHE A 298
GLY A 104
ILE A  24
VAL A  25
 None
 0.88A 3wrkA-4mynA:
undetectable		 3wrkA-4mynA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HOJ_A_ACTA303_0
(REGF PROTEIN)		 4myn FORMIMINOGLUTAMASE
(Trypanosoma
cruzi) 		4 / 5 VAL A 286
MET A 237
GLU A 279
LEU A 274
 None
 1.41A 4hojA-4mynA:
undetectable		 4hojA-4mynA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LA0_A_198A601_1
(SERUM ALBUMIN)		 4myn FORMIMINOGLUTAMASE
(Trypanosoma
cruzi) 		5 / 10 MET A 256
ALA A 260
PHE A 225
PHE A 227
LEU A 248
 None
 1.39A 4la0A-4mynA:
undetectable		 4la0A-4mynA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LA0_B_198B601_1
(SERUM ALBUMIN)		 4myn FORMIMINOGLUTAMASE
(Trypanosoma
cruzi) 		5 / 9 MET A 256
ALA A 260
PHE A 225
PHE A 227
LEU A 248
 None
 1.41A 4la0B-4mynA:
undetectable		 4la0B-4mynA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O33_A_TZNA501_1
(PHOSPHOGLYCERATE
KINASE 1)		 4myn FORMIMINOGLUTAMASE
(Trypanosoma
cruzi) 		5 / 12 GLY A 113
GLY A 112
PHE A  29
THR A  82
GLY A  34
 None
 0.92A 4o33A-4mynA:
4.2		 4o33A-4mynA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZ8_A_GCSA208_1
(GLUCANASE/CHITOSANAS
E)		 4myn FORMIMINOGLUTAMASE
(Trypanosoma
cruzi) 		4 / 7 ARG A 103
ASP A  21
ALA A  22
TYR A  76
 None
 0.81A 4zz8A-4mynA:
undetectable		 4zz8A-4mynA:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_D_SORD1343_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 4myn FORMIMINOGLUTAMASE
(Trypanosoma
cruzi) 		4 / 5 ALA A 176
ARG A 204
ALA A 211
GLU A 252
 None
 1.33A 5a06C-4mynA:
undetectable
5a06D-4mynA:
undetectable		 5a06C-4mynA:
22.38
5a06D-4mynA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HES_A_032A401_2
(MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLT)		 4myn FORMIMINOGLUTAMASE
(Trypanosoma
cruzi) 		4 / 6 LYS A 233
PHE A 254
SER A 201
VAL A 203
 None
 1.24A 5hesA-4mynA:
undetectable		 5hesA-4mynA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_D_C2FD3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 4myn FORMIMINOGLUTAMASE
(Trypanosoma
cruzi) 		5 / 12 GLU A 273
GLY A 112
LYS A  46
VAL A 134
LEU A 161
 None
 1.18A 5vooD-4mynA:
2.4		 5vooD-4mynA:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_D_C2FD3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 4myn FORMIMINOGLUTAMASE
(Trypanosoma
cruzi) 		5 / 12 GLU A 273
GLY A 112
LYS A  46
VAL A 134
SER A 154
 None
 0.99A 5vooD-4mynA:
2.4		 5vooD-4mynA:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_B_NOVB403_2
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		 4myn FORMIMINOGLUTAMASE
(Trypanosoma
cruzi) 		5 / 10 ALA A  44
TYR A  31
GLU A  88
VAL A  36
ARG A  37
 None
 1.43A 6b89B-4mynA:
undetectable		 6b89B-4mynA:
14.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GH9_A_MIXA1003_0
(UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 15)		 4myn FORMIMINOGLUTAMASE
(Trypanosoma
cruzi) 		4 / 5 ASN A 136
GLY A  34
HIS A 114
ASP A 270
 MN  A 400 ( 4.9A)
None
MN  A 400 (-3.3A)
None
 0.90A 6gh9A-4mynA:
undetectable		 6gh9A-4mynA:
11.37