SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4myo'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_F_ACTF3008_0
(BETA-CARBONIC
ANHYDRASE)		 4myo VIRGINIAMYCIN A
ACETYLTRANSFERASE
(Staphylococcus
aureus) 		4 / 8 PHE A  25
TYR A  40
ASP A  10
GLY A   8
 None
 0.89A 1ekjE-4myoA:
undetectable
1ekjF-4myoA:
undetectable		 1ekjE-4myoA:
21.99
1ekjF-4myoA:
21.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1MRL_A_DOLA300_1
(STREPTOGRAMIN A
ACETYLTRANSFERASE)		 4myo VIRGINIAMYCIN A
ACETYLTRANSFERASE
(Staphylococcus
aureus) 		6 / 11 TYR A  59
HIS A  87
LEU A  98
MET A 107
PRO A 108
LEU A 113
 None
 0.54A 1mrlA-4myoA:
29.0
1mrlB-4myoA:
29.0		 1mrlA-4myoA:
59.52
1mrlB-4myoA:
59.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1MRL_B_DOLB301_1
(STREPTOGRAMIN A
ACETYLTRANSFERASE)		 4myo VIRGINIAMYCIN A
ACETYLTRANSFERASE
(Staphylococcus
aureus) 		6 / 12 TYR A  59
HIS A  87
LEU A  98
MET A 107
PRO A 108
LEU A 113
 None
 0.64A 1mrlB-4myoA:
29.0
1mrlC-4myoA:
29.1		 1mrlB-4myoA:
59.52
1mrlC-4myoA:
59.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1MRL_C_DOLC302_1
(STREPTOGRAMIN A
ACETYLTRANSFERASE)		 4myo VIRGINIAMYCIN A
ACETYLTRANSFERASE
(Staphylococcus
aureus) 		5 / 10 TYR A  59
HIS A  87
LEU A  98
MET A 107
LEU A 113
 None
 0.64A 1mrlA-4myoA:
29.0
1mrlC-4myoA:
29.1		 1mrlA-4myoA:
59.52
1mrlC-4myoA:
59.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLC_A_CHDA332_0
(CHOLOYLGLYCINE
HYDROLASE)		 4myo VIRGINIAMYCIN A
ACETYLTRANSFERASE
(Staphylococcus
aureus) 		5 / 12 PHE A  51
THR A  29
ILE A  26
ILE A  74
LEU A  15
 None
 1.10A 2rlcA-4myoA:
undetectable		 2rlcA-4myoA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2TSR_A_D16A309_1
(THYMIDYLATE SYNTHASE)		 4myo VIRGINIAMYCIN A
ACETYLTRANSFERASE
(Staphylococcus
aureus) 		4 / 7 ARG A 170
ILE A 178
ASP A 124
GLY A 142
 None
 0.78A 2tsrA-4myoA:
undetectable		 2tsrA-4myoA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HGX_A_SALA102_1
(SALICYLATE
BIOSYNTHESIS PROTEIN
PCHB)		 4myo VIRGINIAMYCIN A
ACETYLTRANSFERASE
(Staphylococcus
aureus) 		4 / 7 ILE A  74
TYR A  42
ILE A  26
GLN A  24
 None
 1.04A 3hgxA-4myoA:
undetectable		 3hgxA-4myoA:
17.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4POO_B_SAMB301_0
(PUTATIVE RNA
METHYLASE)		 4myo VIRGINIAMYCIN A
ACETYLTRANSFERASE
(Staphylococcus
aureus) 		5 / 12 GLY A  63
ASN A  34
HIS A  58
SER A 109
ASN A  83
 None
 1.40A 4pooB-4myoA:
undetectable		 4pooB-4myoA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RVD_A_SAMA502_0
(D-MYCAROSE
3-C-METHYLTRANSFERAS
E)		 4myo VIRGINIAMYCIN A
ACETYLTRANSFERASE
(Staphylococcus
aureus) 		5 / 12 TYR A 158
ILE A 121
GLY A 122
VAL A 125
ILE A 145
 None
 1.08A 4rvdA-4myoA:
undetectable		 4rvdA-4myoA:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_E_CHDE104_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 4myo VIRGINIAMYCIN A
ACETYLTRANSFERASE
(Staphylococcus
aureus) 		5 / 11 GLU A 180
ALA A 183
LEU A 184
GLU A 207
LEU A 209
 None
 0.92A 4wg0C-4myoA:
undetectable
4wg0D-4myoA:
undetectable
4wg0E-4myoA:
undetectable		 4wg0C-4myoA:
5.12
4wg0D-4myoA:
5.12
4wg0E-4myoA:
5.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_G_CHDG103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 4myo VIRGINIAMYCIN A
ACETYLTRANSFERASE
(Staphylococcus
aureus) 		5 / 11 GLU A 180
ALA A 183
LEU A 184
GLU A 207
LEU A 209
 None
 0.92A 4wg0E-4myoA:
undetectable
4wg0F-4myoA:
undetectable
4wg0G-4myoA:
undetectable		 4wg0E-4myoA:
5.12
4wg0F-4myoA:
5.12
4wg0G-4myoA:
5.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0P_A_TE4A201_1
(BETA-LACTOGLOBULIN)		 4myo VIRGINIAMYCIN A
ACETYLTRANSFERASE
(Staphylococcus
aureus) 		5 / 12 ILE A 127
ILE A  74
ILE A  68
VAL A 155
LEU A 166
 None
 1.12A 4y0pA-4myoA:
undetectable		 4y0pA-4myoA:
17.78