SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4mzd'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1G60_B_SAMB501_0
(ADENINE-SPECIFIC
METHYLTRANSFERASE
MBOIIA)		 4mzd NISIN LEADER
PEPTIDE-PROCESSING
SERINE PROTEASE NISP
(Lactococcus
lactis) 		5 / 12 ASN A 555
ASP A 451
ILE A 456
GLY A 449
TYR A 468
 None
 1.11A 1g60B-4mzdA:
undetectable		 1g60B-4mzdA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MAA_D_DMED999_1
(ACETYLCHOLINESTERASE)		 4mzd NISIN LEADER
PEPTIDE-PROCESSING
SERINE PROTEASE NISP
(Lactococcus
lactis) 		4 / 8 GLY A 510
TYR A 509
SER A 512
HIS A 306
 None
 1.07A 1maaD-4mzdA:
undetectable		 1maaD-4mzdA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OLT_A_SAMA502_0
(OXYGEN-INDEPENDENT
COPROPORPHYRINOGEN
III OXIDASE)		 4mzd NISIN LEADER
PEPTIDE-PROCESSING
SERINE PROTEASE NISP
(Lactococcus
lactis) 		5 / 9 TYR A 387
GLU A 383
PHE A 286
GLN A 366
ILE A 362
 None
 1.37A 1oltA-4mzdA:
undetectable		 1oltA-4mzdA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDT_A_VIAA1000_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 4mzd NISIN LEADER
PEPTIDE-PROCESSING
SERINE PROTEASE NISP
(Lactococcus
lactis) 		5 / 12 ALA A 471
ILE A 450
VAL A 447
ALA A 446
LEU A 541
 None
 1.23A 1udtA-4mzdA:
undetectable		 1udtA-4mzdA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_2
(CES1 PROTEIN)		 4mzd NISIN LEADER
PEPTIDE-PROCESSING
SERINE PROTEASE NISP
(Lactococcus
lactis) 		4 / 4 LEU A 541
PRO A 249
ILE A 556
LEU A 559
 None
 1.04A 1ya4B-4mzdA:
1.8		 1ya4B-4mzdA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOU_A_CQAA403_0
(HISTAMINE
N-METHYLTRANSFERASE)		 4mzd NISIN LEADER
PEPTIDE-PROCESSING
SERINE PROTEASE NISP
(Lactococcus
lactis) 		4 / 8 GLY A 510
PHE A 513
ASP A 233
THR A 498
 None
 0.67A 2aouA-4mzdA:
2.0		 2aouA-4mzdA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOU_B_CQAB401_0
(HISTAMINE
N-METHYLTRANSFERASE)		 4mzd NISIN LEADER
PEPTIDE-PROCESSING
SERINE PROTEASE NISP
(Lactococcus
lactis) 		4 / 7 GLY A 510
PHE A 513
ASP A 233
THR A 498
 None
 0.69A 2aouB-4mzdA:
undetectable		 2aouB-4mzdA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G72_B_SAMB2002_1
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 4mzd NISIN LEADER
PEPTIDE-PROCESSING
SERINE PROTEASE NISP
(Lactococcus
lactis) 		4 / 7 GLY A 305
ASP A 302
ASN A 501
ASP A 299
 None
 1.06A 2g72B-4mzdA:
undetectable		 2g72B-4mzdA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		 4mzd NISIN LEADER
PEPTIDE-PROCESSING
SERINE PROTEASE NISP
(Lactococcus
lactis) 		5 / 12 LEU A 269
ALA A 311
ILE A 314
ASP A 268
LEU A 496
 None
 1.16A 2jn3A-4mzdA:
undetectable		 2jn3A-4mzdA:
13.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNJ_A_225A501_1
(CYTOCHROME P450 2C8)		 4mzd NISIN LEADER
PEPTIDE-PROCESSING
SERINE PROTEASE NISP
(Lactococcus
lactis) 		6 / 10 ILE A 314
VAL A 323
ALA A 324
VAL A 526
VAL A 359
VAL A 525
 None
 1.44A 2nnjA-4mzdA:
undetectable		 2nnjA-4mzdA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R5P_B_MK1B902_1
(PROTEASE)		 4mzd NISIN LEADER
PEPTIDE-PROCESSING
SERINE PROTEASE NISP
(Lactococcus
lactis) 		5 / 12 LEU A 559
VAL A 237
GLY A 322
ILE A 327
ILE A 556
 None
 1.06A 2r5pA-4mzdA:
undetectable		 2r5pA-4mzdA:
10.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R5P_D_MK1D902_1
(PROTEASE)		 4mzd NISIN LEADER
PEPTIDE-PROCESSING
SERINE PROTEASE NISP
(Lactococcus
lactis) 		5 / 12 LEU A 559
VAL A 237
GLY A 322
ILE A 327
ILE A 556
 None
 1.06A 2r5pC-4mzdA:
undetectable		 2r5pC-4mzdA:
10.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EIG_A_MTXA200_2
(DIHYDROFOLATE
REDUCTASE)		 4mzd NISIN LEADER
PEPTIDE-PROCESSING
SERINE PROTEASE NISP
(Lactococcus
lactis) 		4 / 5 ASP A 465
ILE A 467
VAL A 402
THR A 395
 None
 1.15A 3eigA-4mzdA:
undetectable		 3eigA-4mzdA:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM3_B_478B200_1
(PROTEASE)		 4mzd NISIN LEADER
PEPTIDE-PROCESSING
SERINE PROTEASE NISP
(Lactococcus
lactis) 		6 / 10 GLY A 365
ALA A 364
ASP A 259
LEU A 405
VAL A 401
ILE A 362
 None
 1.27A 3em3A-4mzdA:
undetectable		 3em3A-4mzdA:
13.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRQ_A_ERYA195_0
(REPRESSOR PROTEIN
MPHR(A))		 4mzd NISIN LEADER
PEPTIDE-PROCESSING
SERINE PROTEASE NISP
(Lactococcus
lactis) 		5 / 12 LEU A 541
SER A 545
SER A 460
VAL A 518
ILE A 445
 None
 1.29A 3frqA-4mzdA:
undetectable		 3frqA-4mzdA:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HRD_E_NIOE5660_1
(NICOTINATE
DEHYDROGENASE LARGE
MOLYBDOPTERIN
SUBUNIT
NICOTINATE
DEHYDROGENASE MEDIUM
MOLYBDOPTERIN
SUBUNIT)		 4mzd NISIN LEADER
PEPTIDE-PROCESSING
SERINE PROTEASE NISP
(Lactococcus
lactis) 		3 / 3 GLU A 293
GLU A 290
TRP A 344
 None
 0.96A 3hrdA-4mzdA:
undetectable
3hrdE-4mzdA:
undetectable
3hrdF-4mzdA:
undetectable		 3hrdA-4mzdA:
22.93
3hrdE-4mzdA:
22.93
3hrdF-4mzdA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IW1_A_ASDA1223_1
(CYTOCHROME P450
CYP125)		 4mzd NISIN LEADER
PEPTIDE-PROCESSING
SERINE PROTEASE NISP
(Lactococcus
lactis) 		5 / 12 ILE A 450
MET A 234
ILE A 314
VAL A 323
VAL A 237
 None
 1.23A 3iw1A-4mzdA:
undetectable		 3iw1A-4mzdA:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JAY_A_SAMA1102_0
(STRUCTURAL PROTEIN
VP3)		 4mzd NISIN LEADER
PEPTIDE-PROCESSING
SERINE PROTEASE NISP
(Lactococcus
lactis) 		5 / 12 GLY A 449
GLY A 448
ALA A 466
PRO A 470
ILE A 462
 None
 1.10A 3jayA-4mzdA:
undetectable		 3jayA-4mzdA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_A_30BA500_1
(GENOME POLYPROTEIN)		 4mzd NISIN LEADER
PEPTIDE-PROCESSING
SERINE PROTEASE NISP
(Lactococcus
lactis) 		5 / 12 HIS A 306
ASP A 259
GLY A 510
SER A 512
ALA A 364
 None
 0.70A 3keeA-4mzdA:
undetectable		 3keeA-4mzdA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_A_30BA500_2
(GENOME POLYPROTEIN)		 4mzd NISIN LEADER
PEPTIDE-PROCESSING
SERINE PROTEASE NISP
(Lactococcus
lactis) 		4 / 4 GLN A 313
PHE A 513
TYR A 507
VAL A 553
 None
 1.07A 3keeA-4mzdA:
0.0		 3keeA-4mzdA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_B_30BB500_1
(GENOME POLYPROTEIN)		 4mzd NISIN LEADER
PEPTIDE-PROCESSING
SERINE PROTEASE NISP
(Lactococcus
lactis) 		5 / 12 HIS A 306
ASP A 259
GLY A 510
SER A 512
ALA A 364
 None
 0.77A 3keeB-4mzdA:
undetectable		 3keeB-4mzdA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_C_30BC500_1
(GENOME POLYPROTEIN)		 4mzd NISIN LEADER
PEPTIDE-PROCESSING
SERINE PROTEASE NISP
(Lactococcus
lactis) 		5 / 12 HIS A 306
ASP A 259
GLY A 510
SER A 512
ALA A 364
 None
 0.76A 3keeC-4mzdA:
undetectable		 3keeC-4mzdA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_D_30BD500_1
(GENOME POLYPROTEIN)		 4mzd NISIN LEADER
PEPTIDE-PROCESSING
SERINE PROTEASE NISP
(Lactococcus
lactis) 		5 / 12 HIS A 306
ASP A 259
GLY A 510
SER A 512
ALA A 364
 None
 0.72A 3keeD-4mzdA:
undetectable		 3keeD-4mzdA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LP9_D_SPMD230_1
(LS-24)		 4mzd NISIN LEADER
PEPTIDE-PROCESSING
SERINE PROTEASE NISP
(Lactococcus
lactis) 		3 / 3 GLU A 289
GLU A 337
ASN A 338
 None
 0.79A 3lp9B-4mzdA:
undetectable
3lp9D-4mzdA:
undetectable		 3lp9B-4mzdA:
17.24
3lp9D-4mzdA:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QT0_A_486A4_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4mzd NISIN LEADER
PEPTIDE-PROCESSING
SERINE PROTEASE NISP
(Lactococcus
lactis) 		4 / 4 LYS A 341
GLN A 382
ILE A 370
LEU A 422
 None
 1.20A 3qt0A-4mzdA:
undetectable		 3qt0A-4mzdA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_A_SUEA1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 4mzd NISIN LEADER
PEPTIDE-PROCESSING
SERINE PROTEASE NISP
(Lactococcus
lactis) 		5 / 12 HIS A 306
ASP A 259
GLY A 510
SER A 512
ALA A 364
 None
 0.72A 3sueA-4mzdA:
undetectable		 3sueA-4mzdA:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_B_SUEB1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 4mzd NISIN LEADER
PEPTIDE-PROCESSING
SERINE PROTEASE NISP
(Lactococcus
lactis) 		5 / 12 HIS A 306
ASP A 259
GLY A 510
SER A 512
ALA A 364
 None
 0.68A 3sueB-4mzdA:
undetectable		 3sueB-4mzdA:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_C_SUEC1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 4mzd NISIN LEADER
PEPTIDE-PROCESSING
SERINE PROTEASE NISP
(Lactococcus
lactis) 		5 / 12 HIS A 306
ASP A 259
GLY A 510
SER A 512
ALA A 364
 None
 0.74A 3sueC-4mzdA:
undetectable		 3sueC-4mzdA:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_D_SUED1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 4mzd NISIN LEADER
PEPTIDE-PROCESSING
SERINE PROTEASE NISP
(Lactococcus
lactis) 		5 / 12 HIS A 306
ASP A 259
GLY A 510
SER A 512
ALA A 364
 None
 0.72A 3sueD-4mzdA:
undetectable		 3sueD-4mzdA:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_A_SUEA1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 4mzd NISIN LEADER
PEPTIDE-PROCESSING
SERINE PROTEASE NISP
(Lactococcus
lactis) 		5 / 12 HIS A 306
ASP A 259
GLY A 510
SER A 512
ALA A 364
 None
 0.66A 3sufA-4mzdA:
undetectable		 3sufA-4mzdA:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_B_SUEB1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 4mzd NISIN LEADER
PEPTIDE-PROCESSING
SERINE PROTEASE NISP
(Lactococcus
lactis) 		6 / 12 VAL A 310
HIS A 306
ASP A 259
GLY A 510
SER A 512
ALA A 364
 None
 0.83A 3sufB-4mzdA:
undetectable		 3sufB-4mzdA:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_C_SUEC1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 4mzd NISIN LEADER
PEPTIDE-PROCESSING
SERINE PROTEASE NISP
(Lactococcus
lactis) 		5 / 11 HIS A 306
ASP A 259
GLY A 510
SER A 512
ALA A 364
 None
 0.85A 3sufC-4mzdA:
undetectable		 3sufC-4mzdA:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_D_SUED1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 4mzd NISIN LEADER
PEPTIDE-PROCESSING
SERINE PROTEASE NISP
(Lactococcus
lactis) 		5 / 12 VAL A 310
HIS A 306
ASP A 259
GLY A 510
ALA A 364
 None
 0.83A 3sufD-4mzdA:
undetectable		 3sufD-4mzdA:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ7_B_SAMB302_1
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 4mzd NISIN LEADER
PEPTIDE-PROCESSING
SERINE PROTEASE NISP
(Lactococcus
lactis) 		4 / 5 SER A 363
ASP A 302
ASP A 299
ILE A 300
 None
 1.35A 3uj7B-4mzdA:
undetectable		 3uj7B-4mzdA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A3U_B_ACTB1358_0
(NADH:FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE)		 4mzd NISIN LEADER
PEPTIDE-PROCESSING
SERINE PROTEASE NISP
(Lactococcus
lactis) 		4 / 7 ILE A 314
GLY A 256
VAL A 359
SER A 519
 None
 1.00A 4a3uB-4mzdA:
undetectable		 4a3uB-4mzdA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJ8_A_SPMA201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 4mzd NISIN LEADER
PEPTIDE-PROCESSING
SERINE PROTEASE NISP
(Lactococcus
lactis) 		4 / 8 ASN A 338
GLU A 290
GLU A 293
TYR A 332
 None
 1.21A 4mj8A-4mzdA:
undetectable
4mj8C-4mzdA:
undetectable		 4mj8A-4mzdA:
17.01
4mj8C-4mzdA:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QTU_D_SAMD301_1
(PUTATIVE
METHYLTRANSFERASE
BUD23)		 4mzd NISIN LEADER
PEPTIDE-PROCESSING
SERINE PROTEASE NISP
(Lactococcus
lactis) 		4 / 5 LEU A 273
SER A 272
ASP A 268
ASP A 226
 None
 1.17A 4qtuD-4mzdA:
2.6		 4qtuD-4mzdA:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW8_C_FK5C201_1
(FK506-BINDING
PROTEIN 1)		 4mzd NISIN LEADER
PEPTIDE-PROCESSING
SERINE PROTEASE NISP
(Lactococcus
lactis) 		5 / 10 ASP A 380
ARG A 426
VAL A 440
LEU A 385
ILE A 419
 None
 1.18A 5hw8C-4mzdA:
undetectable
5hw8H-4mzdA:
undetectable		 5hw8C-4mzdA:
19.23
5hw8H-4mzdA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JH7_B_6K9B503_1
(TUBULIN ALPHA-1B
CHAIN
TUBULIN BETA-2B
CHAIN)		 4mzd NISIN LEADER
PEPTIDE-PROCESSING
SERINE PROTEASE NISP
(Lactococcus
lactis) 		4 / 7 LEU A 410
ILE A 428
LYS A 433
VAL A 434
 None
 1.08A 5jh7C-4mzdA:
2.0		 5jh7C-4mzdA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_A_RCXA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4mzd NISIN LEADER
PEPTIDE-PROCESSING
SERINE PROTEASE NISP
(Lactococcus
lactis) 		5 / 12 VAL A 255
ALA A 404
VAL A 310
GLY A 312
ALA A 311
 None
 1.09A 5kirA-4mzdA:
undetectable		 5kirA-4mzdA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YK2_A_ERYA501_0
(PROBABLE CONSERVED
ATP-BINDING PROTEIN
ABC TRANSPORTER)		 4mzd NISIN LEADER
PEPTIDE-PROCESSING
SERINE PROTEASE NISP
(Lactococcus
lactis) 		5 / 11 GLY A 520
ALA A 521
ALA A 324
PRO A 325
VAL A 255
 None
 1.01A 5yk2A-4mzdA:
0.2		 5yk2A-4mzdA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_C_SUEC1203_0
(NS3 PROTEASE)		 4mzd NISIN LEADER
PEPTIDE-PROCESSING
SERINE PROTEASE NISP
(Lactococcus
lactis) 		5 / 12 HIS A 306
ASP A 259
GLY A 510
SER A 512
ALA A 364
 None
 0.70A 6c2mC-4mzdA:
undetectable		 6c2mC-4mzdA:
10.52