SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4mzq'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICU_A_NIOA221_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 4mzq BETA-ALANYL-COA:AMMO
NIA LYASE
(Anaerotignum
propionicum) 		4 / 6 SER A  49
PHE A  51
PHE A  87
GLY A  34
 None
 0.99A 1icuA-4mzqA:
undetectable
1icuB-4mzqA:
undetectable		 1icuA-4mzqA:
20.74
1icuB-4mzqA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICU_B_NIOB219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 4mzq BETA-ALANYL-COA:AMMO
NIA LYASE
(Anaerotignum
propionicum) 		4 / 6 PHE A  87
GLY A  34
SER A  49
PHE A  51
 None
 1.03A 1icuA-4mzqA:
undetectable
1icuB-4mzqA:
undetectable		 1icuA-4mzqA:
20.74
1icuB-4mzqA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICU_C_NIOC225_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 4mzq BETA-ALANYL-COA:AMMO
NIA LYASE
(Anaerotignum
propionicum) 		4 / 6 SER A  49
PHE A  51
PHE A  87
GLY A  34
 None
 1.03A 1icuC-4mzqA:
undetectable
1icuD-4mzqA:
undetectable		 1icuC-4mzqA:
20.74
1icuD-4mzqA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICU_D_NIOD223_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 4mzq BETA-ALANYL-COA:AMMO
NIA LYASE
(Anaerotignum
propionicum) 		4 / 5 PHE A  87
GLY A  34
SER A  49
PHE A  51
 None
 0.97A 1icuC-4mzqA:
undetectable
1icuD-4mzqA:
undetectable		 1icuC-4mzqA:
20.74
1icuD-4mzqA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICV_B_NIOB702_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 4mzq BETA-ALANYL-COA:AMMO
NIA LYASE
(Anaerotignum
propionicum) 		4 / 5 PHE A  87
GLY A  34
SER A  49
PHE A  51
 None
 1.04A 1icvA-4mzqA:
undetectable
1icvB-4mzqA:
undetectable		 1icvA-4mzqA:
20.74
1icvB-4mzqA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQB_A_BEZA524_0
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 4mzq BETA-ALANYL-COA:AMMO
NIA LYASE
(Anaerotignum
propionicum) 		4 / 6 SER A  49
PHE A  51
PHE A  87
GLY A  34
 None
 1.10A 1kqbA-4mzqA:
undetectable
1kqbB-4mzqA:
undetectable		 1kqbA-4mzqA:
21.26
1kqbB-4mzqA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQB_C_BEZC522_0
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 4mzq BETA-ALANYL-COA:AMMO
NIA LYASE
(Anaerotignum
propionicum) 		4 / 6 SER A  49
PHE A  51
PHE A  87
GLY A  34
 None
 1.06A 1kqbC-4mzqA:
undetectable
1kqbD-4mzqA:
undetectable		 1kqbC-4mzqA:
21.26
1kqbD-4mzqA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQB_D_BEZD523_0
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 4mzq BETA-ALANYL-COA:AMMO
NIA LYASE
(Anaerotignum
propionicum) 		4 / 6 PHE A  87
GLY A  34
SER A  49
PHE A  51
 None
 1.06A 1kqbC-4mzqA:
undetectable
1kqbD-4mzqA:
undetectable		 1kqbC-4mzqA:
21.26
1kqbD-4mzqA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TKQ_B_DVAB8_0
(GRAMICIDIN A)		 4mzq BETA-ALANYL-COA:AMMO
NIA LYASE
(Anaerotignum
propionicum) 		4 / 5 VAL A   6
GLY A  73
VAL A   7
TRP A  33
 None
 1.16A 1tkqB-4mzqA:
undetectable		 1tkqB-4mzqA:
13.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OKC_A_SAMA500_1
(TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN)		 4mzq BETA-ALANYL-COA:AMMO
NIA LYASE
(Anaerotignum
propionicum) 		4 / 6 THR A  38
ASP A  47
ASN A 128
ASP A 127
 None
 1.27A 2okcA-4mzqA:
undetectable		 2okcA-4mzqA:
15.52