SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4mzu'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HXB_A_ROCA100_1
(HIV-1 PROTEASE)		 4mzu WXCM-LIKE PROTEIN
(Shewanella
denitrificans) 		5 / 12 ALA A 103
ILE A  73
GLY A  74
GLY A 106
ILE A 117
 None
 0.79A 1hxbA-4mzuA:
undetectable		 1hxbA-4mzuA:
15.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HXB_A_ROCA100_1
(HIV-1 PROTEASE)		 4mzu WXCM-LIKE PROTEIN
(Shewanella
denitrificans) 		5 / 12 ALA A 121
ILE A 105
GLY A 106
GLY A 124
ILE A 140
 None
 0.88A 1hxbA-4mzuA:
undetectable		 1hxbA-4mzuA:
15.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SDU_B_MK1B902_1
(PROTEASE RETROPEPSIN)		 4mzu WXCM-LIKE PROTEIN
(Shewanella
denitrificans) 		5 / 11 ALA A 121
ILE A 105
GLY A 106
GLY A 124
ILE A 140
 None
 0.92A 1sduA-4mzuA:
undetectable		 1sduA-4mzuA:
14.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SDV_B_MK1B902_1
(PROTEASE RETROPEPSIN)		 4mzu WXCM-LIKE PROTEIN
(Shewanella
denitrificans) 		5 / 10 ALA A 103
ILE A  73
GLY A  74
GLY A 106
ILE A 117
 None
 0.86A 1sdvA-4mzuA:
undetectable		 1sdvA-4mzuA:
14.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SDV_B_MK1B902_1
(PROTEASE RETROPEPSIN)		 4mzu WXCM-LIKE PROTEIN
(Shewanella
denitrificans) 		5 / 10 ALA A 121
ILE A 105
GLY A 106
GLY A 124
ILE A 140
 None
 0.92A 1sdvA-4mzuA:
undetectable		 1sdvA-4mzuA:
14.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VQ1_A_SAMA301_1
(N5-GLUTAMINE
METHYLTRANSFERASE,
HEMK)		 4mzu WXCM-LIKE PROTEIN
(Shewanella
denitrificans) 		3 / 3 GLY A  14
ASP A  15
ASN A  12
 None
 0.67A 1vq1A-4mzuA:
undetectable		 1vq1A-4mzuA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VQ1_B_SAMB301_0
(N5-GLUTAMINE
METHYLTRANSFERASE,
HEMK)		 4mzu WXCM-LIKE PROTEIN
(Shewanella
denitrificans) 		5 / 12 THR A  17
ILE A  61
GLY A  50
ILE A  31
VAL A  99
 None
 1.00A 1vq1B-4mzuA:
undetectable		 1vq1B-4mzuA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4K_A_DR7A301_1
(PROTEASE)		 4mzu WXCM-LIKE PROTEIN
(Shewanella
denitrificans) 		5 / 12 ALA A 121
GLY A 106
GLY A 124
ILE A 140
ILE A 117
 None
 1.12A 2o4kA-4mzuA:
undetectable		 2o4kA-4mzuA:
14.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4K_A_DR7A301_1
(PROTEASE)		 4mzu WXCM-LIKE PROTEIN
(Shewanella
denitrificans) 		5 / 12 ALA A 121
ILE A 105
GLY A 106
GLY A 124
ILE A 140
 None
 0.79A 2o4kA-4mzuA:
undetectable		 2o4kA-4mzuA:
14.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V7B_A_BEZA1529_0
(BENZOATE-COENZYME A
LIGASE)		 4mzu WXCM-LIKE PROTEIN
(Shewanella
denitrificans) 		5 / 9 ALA A 137
ALA A 103
GLY A 102
GLY A 118
ILE A 117
 None
 1.18A 2v7bA-4mzuA:
undetectable		 2v7bA-4mzuA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V7B_B_BEZB1529_0
(BENZOATE-COENZYME A
LIGASE)		 4mzu WXCM-LIKE PROTEIN
(Shewanella
denitrificans) 		5 / 9 ALA A 137
ALA A 103
GLY A 102
GLY A 118
ILE A 117
 None
 1.19A 2v7bB-4mzuA:
undetectable		 2v7bB-4mzuA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZV_A_AZMA263_1
(CARBONIC ANHYDRASE
13)		 4mzu WXCM-LIKE PROTEIN
(Shewanella
denitrificans) 		5 / 12 VAL A  59
PHE A  79
THR A  54
VAL A  53
VAL A  99
 None
 1.24A 3czvA-4mzuA:
undetectable
3czvB-4mzuA:
undetectable		 3czvA-4mzuA:
18.96
3czvB-4mzuA:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXV_C_478C200_2
(HIV-1 PROTEASE)		 4mzu WXCM-LIKE PROTEIN
(Shewanella
denitrificans) 		5 / 11 ALA A 103
VAL A  99
ILE A  73
GLY A 106
ILE A 117
 None
 1.07A 3oxvD-4mzuA:
undetectable		 3oxvD-4mzuA:
14.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_C_DXCC1478_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 4mzu WXCM-LIKE PROTEIN
(Shewanella
denitrificans) 		4 / 7 ASP A 198
GLY A 258
ILE A 231
PHE A 195
 None
 0.96A 4acaC-4mzuA:
undetectable		 4acaC-4mzuA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K36_A_SAMA504_0
(ANAEROBIC
SULFATASE-MATURATING
ENZYME)		 4mzu WXCM-LIKE PROTEIN
(Shewanella
denitrificans) 		5 / 12 ASN A 189
VAL A 233
ILE A 231
CYH A 232
LEU A 252
 None
 1.28A 4k36A-4mzuA:
undetectable		 4k36A-4mzuA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4mzu WXCM-LIKE PROTEIN
(Shewanella
denitrificans) 		5 / 12 ARG A 205
TYR A 291
TYR A 260
ALA A 282
SER A 283
 TYD  A 402 (-3.6A)
None
None
None
None
 1.11A 5ikrA-4mzuA:
undetectable		 5ikrA-4mzuA:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_F_Z80F401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 4mzu WXCM-LIKE PROTEIN
(Shewanella
denitrificans) 		5 / 10 ILE A  67
ILE A  61
VAL A  99
THR A  97
ILE A 111
 None
 1.21A 5lg3F-4mzuA:
undetectable		 5lg3F-4mzuA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_G_Z80G401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 4mzu WXCM-LIKE PROTEIN
(Shewanella
denitrificans) 		5 / 10 ILE A  67
ILE A  61
VAL A  99
THR A  97
ILE A 111
 None
 1.23A 5lg3G-4mzuA:
undetectable		 5lg3G-4mzuA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_H_Z80H401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 4mzu WXCM-LIKE PROTEIN
(Shewanella
denitrificans) 		5 / 10 ILE A  67
ILE A  61
VAL A  99
THR A  97
ILE A 111
 None
 1.22A 5lg3H-4mzuA:
undetectable		 5lg3H-4mzuA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EMU_B_SAMB301_0
(TRNA
(GUANINE(9)-/ADENINE
(9)-N1)-METHYLTRANSF
ERASE)		 4mzu WXCM-LIKE PROTEIN
(Shewanella
denitrificans) 		5 / 12 ILE A 115
GLY A 114
ILE A 105
VAL A  77
ILE A 111
 None
 0.82A 6emuB-4mzuA:
undetectable		 6emuB-4mzuA:
20.45