SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4mzv'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KLM_A_SPPA999_1
(HIV-1 REVERSE
TRANSCRIPTASE)		 4mzv EPITHELIAL CELL
ADHESION MOLECULE
(Homo
sapiens) 		5 / 11 LEU A 166
LYS A 168
TYR A 186
TYR A 157
LEU A 233
 None
None
None
None
DMU  A 301 ( 4.6A)
 1.48A 1klmA-4mzvA:
2.7		 1klmA-4mzvA:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3B_B_CFFB2434_1
(CHITINASE)		 4mzv EPITHELIAL CELL
ADHESION MOLECULE
(Homo
sapiens) 		4 / 6 GLU A 223
ASP A 219
PHE A 226
ARG A 173
 None
None
None
DMU  A 301 (-4.0A)
 1.46A 2a3bB-4mzvA:
undetectable		 2a3bB-4mzvA:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G72_A_SAMA2001_1
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 4mzv EPITHELIAL CELL
ADHESION MOLECULE
(Homo
sapiens) 		4 / 6 TYR A 251
GLY A 123
TYR A 214
ASN A 120
 None
 1.14A 2g72A-4mzvA:
undetectable		 2g72A-4mzvA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHF_A_ACTA507_0
(CHORISMATE SYNTHASE)		 4mzv EPITHELIAL CELL
ADHESION MOLECULE
(Homo
sapiens) 		3 / 3 LEU A 264
ASN A  91
ARG A 125
 None
 0.92A 2qhfA-4mzvA:
undetectable		 2qhfA-4mzvA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QM9_A_TDZA201_1
(FATTY ACID-BINDING
PROTEIN, ADIPOCYTE)		 4mzv EPITHELIAL CELL
ADHESION MOLECULE
(Homo
sapiens) 		5 / 12 ALA A  64
ALA A 210
ASP A 208
ARG A 140
TYR A  95
 None
 1.41A 2qm9A-4mzvA:
undetectable		 2qm9A-4mzvA:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R24_A_SAMA302_1
(2'-O-METHYL
TRANSFERASE)		 4mzv EPITHELIAL CELL
ADHESION MOLECULE
(Homo
sapiens) 		3 / 3 TYR A 174
ASP A 232
ASP A 219
 DMU  A 301 (-4.7A)
DMU  A 301 (-3.5A)
None
 0.67A 3r24A-4mzvA:
undetectable		 3r24A-4mzvA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_A_STRA601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4mzv EPITHELIAL CELL
ADHESION MOLECULE
(Homo
sapiens) 		4 / 6 LEU A 242
GLU A 169
VAL A 212
ALA A 213
 DMU  A 301 ( 4.6A)
None
None
None
 0.87A 4nkxA-4mzvA:
undetectable		 4nkxA-4mzvA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XE0_A_40LA1101_0
(PHOSPHATIDYLINOSITOL
4,5-BISPHOSPHATE
3-KINASE CATALYTIC
SUBUNIT DELTA
ISOFORM)		 4mzv EPITHELIAL CELL
ADHESION MOLECULE
(Homo
sapiens) 		5 / 12 ILE A 146
ASP A 253
THR A 141
ASN A 120
ILE A 209
 DMU  A 301 (-4.6A)
None
None
None
None
 0.96A 4xe0A-4mzvA:
undetectable		 4xe0A-4mzvA:
14.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_B_GMJB301_1
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 4mzv EPITHELIAL CELL
ADHESION MOLECULE
(Homo
sapiens) 		4 / 6 ASP A 211
GLN A 175
VAL A 207
ALA A  71
 None
 1.17A 6djzB-4mzvA:
undetectable		 6djzB-4mzvA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD6_A_STIA603_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4mzv EPITHELIAL CELL
ADHESION MOLECULE
(Homo
sapiens) 		4 / 5 LEU A  34
TYR A  32
ILE A 146
MET A  69
 None
None
DMU  A 301 (-4.6A)
None
 1.00A 6hd6A-4mzvA:
undetectable		 6hd6A-4mzvA:
16.29