SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4mzw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK1_A_T44A3004_1
(SERUM ALBUMIN)		 4mzw GLUTATHIONE
S-TRANSFERASE
(Streptococcus
sanguinis) 		4 / 6 GLU A 124
LEU A 122
VAL A  55
MET A  58
 None
 1.05A 1hk1A-4mzwA:
2.6		 1hk1A-4mzwA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RK3_A_VDXA500_2
(VITAMIN D3 RECEPTOR)		 4mzw GLUTATHIONE
S-TRANSFERASE
(Streptococcus
sanguinis) 		4 / 4 LEU A 221
ILE A 244
ARG A 247
TYR A 213
 None
 1.36A 1rk3A-4mzwA:
undetectable		 1rk3A-4mzwA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SBR_A_VIBA502_1
(YKOF)		 4mzw GLUTATHIONE
S-TRANSFERASE
(Streptococcus
sanguinis) 		4 / 6 ALA A 100
LEU A 101
ILE A 118
SER A  46
 None
 0.95A 1sbrA-4mzwA:
undetectable
1sbrB-4mzwA:
undetectable		 1sbrA-4mzwA:
21.58
1sbrB-4mzwA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZLC_A_VDXA500_2
(VITAMIN D3 RECEPTOR)		 4mzw GLUTATHIONE
S-TRANSFERASE
(Streptococcus
sanguinis) 		4 / 5 LEU A 221
ILE A 244
ARG A 247
TYR A 213
 None
 1.38A 2zlcA-4mzwA:
undetectable		 2zlcA-4mzwA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRE_X_TOPX300_1
(DIHYDROFOLATE
REDUCTASE)		 4mzw GLUTATHIONE
S-TRANSFERASE
(Streptococcus
sanguinis) 		5 / 9 ALA A 123
LEU A 119
LEU A 144
VAL A 140
SER A 211
 None
 1.21A 3freX-4mzwA:
undetectable		 3freX-4mzwA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P7N_A_GCSA702_1
(POLY-BETA-1,6-N-ACET
YL-D-GLUCOSAMINE
N-DEACETYLASE)		 4mzw GLUTATHIONE
S-TRANSFERASE
(Streptococcus
sanguinis) 		3 / 3 ASP A 206
TYR A 202
TRP A 240
 None
 1.39A 4p7nA-4mzwA:
undetectable		 4p7nA-4mzwA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WH5_A_3QBA204_1
(LINCOSAMIDE
RESISTANCE PROTEIN)		 4mzw GLUTATHIONE
S-TRANSFERASE
(Streptococcus
sanguinis) 		5 / 12 GLY A  82
ASP A  81
ILE A  79
GLN A  84
PHE A  19
 None
None
GDS  A 301 ( 3.8A)
GDS  A 301 (-4.0A)
GDS  A 301 (-3.6A)
 1.29A 4wh5A-4mzwA:
undetectable		 4wh5A-4mzwA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZDZ_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4mzw GLUTATHIONE
S-TRANSFERASE
(Streptococcus
sanguinis) 		4 / 7 ILE A  79
GLY A  52
THR A  56
LEU A  74
 GDS  A 301 ( 3.8A)
None
None
None
 0.81A 4zdzA-4mzwA:
undetectable		 4zdzA-4mzwA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KMD_C_6UBC1304_1
(ION TRANSPORT
PROTEIN)		 4mzw GLUTATHIONE
S-TRANSFERASE
(Streptococcus
sanguinis) 		4 / 5 TYR A 164
LEU A 154
GLY A 155
PHE A 158
 None
None
GDS  A 301 (-3.3A)
None
 0.93A 5kmdC-4mzwA:
2.3
5kmdD-4mzwA:
2.6		 5kmdC-4mzwA:
22.91
5kmdD-4mzwA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZY_A_CE3A1103_1
(DNA CROSS-LINK
REPAIR 1A PROTEIN)		 4mzw GLUTATHIONE
S-TRANSFERASE
(Streptococcus
sanguinis) 		4 / 8 TYR A  45
GLN A 259
VAL A -12
GLY A -13
 None
 0.82A 5nzyA-4mzwA:
undetectable		 5nzyA-4mzwA:
22.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5UUN_B_ACTB308_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 4mzw GLUTATHIONE
S-TRANSFERASE
(Streptococcus
sanguinis) 		3 / 3 LEU A  47
ILE A  79
TYR A 164
 None
GDS  A 301 ( 3.8A)
None
 0.30A 5uunB-4mzwA:
36.0		 5uunB-4mzwA:
48.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5UUN_B_ACTB311_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 4mzw GLUTATHIONE
S-TRANSFERASE
(Streptococcus
sanguinis) 		4 / 4 PHE A  19
PRO A  50
TYR A 164
TYR A 222
 GDS  A 301 (-3.6A)
None
None
None
 0.28A 5uunB-4mzwA:
36.0		 5uunB-4mzwA:
48.04