SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4mzy'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BX4_A_ADNA355_1
(PROTEIN (ADENOSINE
KINASE))		 4mzy NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE
(Enterococcus
faecalis) 		5 / 12 GLY A  55
ILE A 436
ALA A 177
ALA A 142
ILE A 180
 None
GOL  A 504 ( 4.3A)
None
None
None
 0.89A 1bx4A-4mzyA:
undetectable		 1bx4A-4mzyA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_N_TRPN81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 4mzy NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE
(Enterococcus
faecalis) 		5 / 10 GLY A 174
THR A 186
THR A 175
ILE A 320
GLY A 192
 None
 1.05A 1c9sN-4mzyA:
undetectable
1c9sO-4mzyA:
undetectable		 1c9sN-4mzyA:
13.27
1c9sO-4mzyA:
13.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_P_TRPP81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 4mzy NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE
(Enterococcus
faecalis) 		5 / 11 GLY A 174
THR A 186
THR A 175
ILE A 320
GLY A 192
 None
 1.05A 1c9sP-4mzyA:
undetectable
1c9sQ-4mzyA:
undetectable		 1c9sP-4mzyA:
13.27
1c9sQ-4mzyA:
13.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_Q_TRPQ81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 4mzy NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE
(Enterococcus
faecalis) 		5 / 9 GLY A 174
THR A 186
THR A 175
ILE A 320
GLY A 192
 None
 1.05A 1c9sQ-4mzyA:
undetectable
1c9sR-4mzyA:
undetectable		 1c9sQ-4mzyA:
13.27
1c9sR-4mzyA:
13.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_V_TRPV81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 4mzy NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE
(Enterococcus
faecalis) 		5 / 10 GLY A 192
GLY A 174
THR A 186
THR A 175
ILE A 320
 None
 1.03A 1c9sL-4mzyA:
undetectable
1c9sV-4mzyA:
undetectable		 1c9sL-4mzyA:
13.27
1c9sV-4mzyA:
13.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_Q_TRPQ81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 4mzy NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE
(Enterococcus
faecalis) 		5 / 11 GLY A 174
THR A 186
THR A 175
ILE A 320
GLY A 192
 None
 1.02A 1gtfQ-4mzyA:
undetectable
1gtfR-4mzyA:
undetectable		 1gtfQ-4mzyA:
13.27
1gtfR-4mzyA:
13.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_R_TRPR81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 4mzy NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE
(Enterococcus
faecalis) 		5 / 9 GLY A 174
THR A 186
THR A 175
ILE A 320
GLY A 192
 None
 1.04A 1gtfR-4mzyA:
undetectable
1gtfS-4mzyA:
undetectable		 1gtfR-4mzyA:
13.27
1gtfS-4mzyA:
13.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_S_TRPS81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 4mzy NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE
(Enterococcus
faecalis) 		5 / 11 GLY A 174
THR A 186
THR A 175
ILE A 320
GLY A 192
 None
 1.03A 1gtfS-4mzyA:
undetectable
1gtfT-4mzyA:
undetectable		 1gtfS-4mzyA:
13.27
1gtfT-4mzyA:
13.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_T_TRPT81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 4mzy NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE
(Enterococcus
faecalis) 		5 / 11 GLY A 174
THR A 186
THR A 175
ILE A 320
GLY A 192
 None
 1.06A 1gtnT-4mzyA:
undetectable
1gtnU-4mzyA:
undetectable		 1gtnT-4mzyA:
13.27
1gtnU-4mzyA:
13.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_F_DVAF2_0
(7-AMINO-ACTINOMYCIN
D)		 4mzy NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE
(Enterococcus
faecalis) 		3 / 3 THR A 358
PRO A 360
THR A 359
 None
None
MLA  A 517 (-3.9A)
 0.83A 1unjF-4mzyA:
undetectable		 1unjF-4mzyA:
6.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_E_TRPE81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4mzy NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE
(Enterococcus
faecalis) 		5 / 10 GLY A 174
THR A 186
THR A 175
ILE A 320
GLY A 192
 None
 1.02A 1utdE-4mzyA:
undetectable
1utdF-4mzyA:
undetectable		 1utdE-4mzyA:
13.27
1utdF-4mzyA:
13.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_H_TRPH81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4mzy NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE
(Enterococcus
faecalis) 		5 / 10 GLY A 174
THR A 186
THR A 175
ILE A 320
GLY A 192
 None
 1.04A 1utdH-4mzyA:
undetectable
1utdI-4mzyA:
undetectable		 1utdH-4mzyA:
13.27
1utdI-4mzyA:
13.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_O_TRPO81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4mzy NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE
(Enterococcus
faecalis) 		5 / 12 GLY A 174
THR A 186
THR A 175
ILE A 320
GLY A 192
 None
 1.04A 1utdO-4mzyA:
undetectable
1utdP-4mzyA:
undetectable		 1utdO-4mzyA:
13.27
1utdP-4mzyA:
13.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_S_TRPS81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4mzy NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE
(Enterococcus
faecalis) 		5 / 11 GLY A 174
THR A 186
THR A 175
ILE A 320
GLY A 192
 None
 1.03A 1utdS-4mzyA:
undetectable
1utdT-4mzyA:
undetectable		 1utdS-4mzyA:
13.27
1utdT-4mzyA:
13.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_U_TRPU81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4mzy NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE
(Enterococcus
faecalis) 		5 / 10 GLY A 174
THR A 186
THR A 175
ILE A 320
GLY A 192
 None
 1.04A 1utdU-4mzyA:
undetectable
1utdV-4mzyA:
undetectable		 1utdU-4mzyA:
13.27
1utdV-4mzyA:
13.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_V_TRPV81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4mzy NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE
(Enterococcus
faecalis) 		5 / 11 GLY A 192
GLY A 174
THR A 186
THR A 175
ILE A 320
 None
 1.03A 1utdL-4mzyA:
undetectable
1utdV-4mzyA:
undetectable		 1utdL-4mzyA:
13.27
1utdV-4mzyA:
13.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2F7F_A_NIOA601_1
(NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE, PUTATIVE)		 4mzy NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE
(Enterococcus
faecalis) 		4 / 6 ARG A 163
SER A 187
GLY A 201
ARG A 262
 CL  A 518 (-4.1A)
None
CL  A 521 (-3.8A)
FMT  A 520 (-3.1A)
 0.65A 2f7fA-4mzyA:
59.0		 2f7fA-4mzyA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2F7F_A_NIOA602_1
(NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE, PUTATIVE)		 4mzy NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE
(Enterococcus
faecalis) 		5 / 5 HIS A 398
ILE A 404
LYS A 406
PRO A 461
ASP A 463
 GOL  A 513 ( 4.1A)
None
GOL  A 505 (-4.3A)
GOL  A 505 ( 4.2A)
GOL  A 505 ( 2.8A)
 0.18A 2f7fA-4mzyA:
59.0		 2f7fA-4mzyA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_A_ASDA1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 4mzy NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE
(Enterococcus
faecalis) 		4 / 7 PHE A  86
ALA A 122
LEU A 126
PHE A  68
 None
 1.14A 2vcvA-4mzyA:
undetectable		 2vcvA-4mzyA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QXV_D_MTXD2000_2
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)		 4mzy NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE
(Enterococcus
faecalis) 		3 / 3 LEU A 447
ARG A 147
ASN A 110
 None
None
GOL  A 513 ( 4.0A)
 0.68A 3qxvD-4mzyA:
undetectable		 3qxvD-4mzyA:
13.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VRM_A_VD3A502_1
(VITAMIN D(3)
25-HYDROXYLASE)		 4mzy NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE
(Enterococcus
faecalis) 		5 / 12 ILE A 148
LEU A 140
LEU A 319
ILE A 141
ALA A 178
 None
 1.04A 3vrmA-4mzyA:
undetectable		 3vrmA-4mzyA:
23.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FIA_A_0U9A601_1
(CHOLESTEROL
24-HYDROXYLASE)		 4mzy NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE
(Enterococcus
faecalis) 		5 / 12 PHE A 258
VAL A 261
ALA A 245
GLU A 281
ALA A 282
 None
 1.17A 4fiaA-4mzyA:
undetectable		 4fiaA-4mzyA:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FIA_A_198A602_1
(CHOLESTEROL
24-HYDROXYLASE)		 4mzy NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE
(Enterococcus
faecalis) 		5 / 12 PHE A 258
VAL A 261
ALA A 245
GLU A 281
ALA A 282
 None
 1.17A 4fiaA-4mzyA:
undetectable		 4fiaA-4mzyA:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4mzy NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE
(Enterococcus
faecalis) 		5 / 10 GLY A 192
GLY A 174
THR A 186
THR A 175
ILE A 320
 None
 1.01A 5eevA-4mzyA:
undetectable
5eevB-4mzyA:
undetectable		 5eevA-4mzyA:
13.27
5eevB-4mzyA:
13.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4mzy NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE
(Enterococcus
faecalis) 		5 / 10 GLY A 192
GLY A 174
THR A 186
THR A 175
ILE A 320
 None
 1.01A 5eewA-4mzyA:
undetectable
5eewB-4mzyA:
undetectable		 5eewA-4mzyA:
13.27
5eewB-4mzyA:
13.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4mzy NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE
(Enterococcus
faecalis) 		5 / 10 GLY A 192
GLY A 174
THR A 186
THR A 175
ILE A 320
 None
 1.01A 5eexA-4mzyA:
undetectable
5eexB-4mzyA:
undetectable		 5eexA-4mzyA:
13.27
5eexB-4mzyA:
13.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4mzy NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE
(Enterococcus
faecalis) 		5 / 10 GLY A 192
GLY A 174
THR A 186
THR A 175
ILE A 320
 None
 1.01A 5eeyA-4mzyA:
undetectable
5eeyB-4mzyA:
undetectable		 5eeyA-4mzyA:
13.27
5eeyB-4mzyA:
13.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4mzy NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE
(Enterococcus
faecalis) 		5 / 10 GLY A 192
GLY A 174
THR A 186
THR A 175
ILE A 320
 None
 1.01A 5eezA-4mzyA:
undetectable
5eezB-4mzyA:
undetectable		 5eezA-4mzyA:
13.27
5eezB-4mzyA:
13.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4mzy NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE
(Enterococcus
faecalis) 		5 / 10 GLY A 192
GLY A 174
THR A 186
THR A 175
ILE A 320
 None
 1.01A 5ef0A-4mzyA:
undetectable
5ef0B-4mzyA:
undetectable		 5ef0A-4mzyA:
13.27
5ef0B-4mzyA:
13.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4mzy NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE
(Enterococcus
faecalis) 		5 / 10 GLY A 192
GLY A 174
THR A 186
THR A 175
ILE A 320
 None
 1.01A 5ef1A-4mzyA:
undetectable
5ef1B-4mzyA:
undetectable		 5ef1A-4mzyA:
13.27
5ef1B-4mzyA:
13.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4mzy NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE
(Enterococcus
faecalis) 		5 / 10 GLY A 192
GLY A 174
THR A 186
THR A 175
ILE A 320
 None
 1.01A 5ef2A-4mzyA:
undetectable
5ef2B-4mzyA:
undetectable		 5ef2A-4mzyA:
13.27
5ef2B-4mzyA:
13.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4mzy NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE
(Enterococcus
faecalis) 		5 / 10 GLY A 192
GLY A 174
THR A 186
THR A 175
ILE A 320
 None
 1.01A 5ef3A-4mzyA:
undetectable
5ef3B-4mzyA:
undetectable		 5ef3A-4mzyA:
13.27
5ef3B-4mzyA:
13.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KB6_A_ADNA401_1
(ADENOSINE KINASE)		 4mzy NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE
(Enterococcus
faecalis) 		5 / 12 GLY A  55
ILE A 436
ALA A 177
ALA A 142
ILE A 180
 None
GOL  A 504 ( 4.3A)
None
None
None
 0.81A 5kb6A-4mzyA:
2.9		 5kb6A-4mzyA:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KB6_B_ADNB401_1
(ADENOSINE KINASE)		 4mzy NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE
(Enterococcus
faecalis) 		5 / 12 GLY A  55
ILE A 436
ALA A 177
ALA A 142
ILE A 180
 None
GOL  A 504 ( 4.3A)
None
None
None
 0.82A 5kb6B-4mzyA:
undetectable		 5kb6B-4mzyA:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZHM_B_SAMB301_0
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 4mzy NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE
(Enterococcus
faecalis) 		4 / 4 ARG A 164
SER A 292
ASP A 264
HIS A 205
 CL  A 518 (-3.9A)
None
FMT  A 520 ( 4.5A)
MLA  A 515 (-3.9A)
 1.27A 5zhmA-4mzyA:
0.3		 5zhmA-4mzyA:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BXM_A_SAMA402_0
(DIPHTHAMIDE
BIOSYNTHESIS ENZYME
DPH2)		 4mzy NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE
(Enterococcus
faecalis) 		5 / 12 LEU A 158
GLY A 314
VAL A 275
ILE A 263
ASP A 264
 None
None
None
None
FMT  A 520 ( 4.5A)
 1.11A 6bxmA-4mzyA:
undetectable		 6bxmA-4mzyA:
23.40