SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4n01'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJT_A_SAMA501_1
(N(2),N(2)-DIMETHYLGU
ANOSINE TRNA
METHYLTRANSFERASE)		 4n01 PERIPLASMIC BINDING
PROTEIN
(Veillonella
parvula) 		3 / 3 ARG A 305
ASP A 212
ASP A 215
 None
GOL  A 404 ( 4.5A)
None
 0.67A 2ejtA-4n01A:
3.1		 2ejtA-4n01A:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD3_B_CHDB504_0
(FERROCHELATASE)		 4n01 PERIPLASMIC BINDING
PROTEIN
(Veillonella
parvula) 		4 / 6 ILE A  93
PRO A 152
SER A 154
MET A 169
 None
 1.20A 2qd3B-4n01A:
3.5		 2qd3B-4n01A:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CYX_A_ROCA201_4
(HIV-1 PROTEASE)		 4n01 PERIPLASMIC BINDING
PROTEIN
(Veillonella
parvula) 		4 / 4 LEU A  97
ASP A  81
VAL A 104
THR A  86
 None
 1.22A 3cyxB-4n01A:
undetectable		 3cyxB-4n01A:
14.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MG0_K_BO2K1402_1
(PROTEASOME COMPONENT
PRE2
PROTEASOME COMPONENT
C5)		 4n01 PERIPLASMIC BINDING
PROTEIN
(Veillonella
parvula) 		5 / 11 ALA A 125
THR A 126
VAL A 147
ALA A  84
GLY A  85
 None
 0.92A 3mg0K-4n01A:
undetectable
3mg0L-4n01A:
undetectable		 3mg0K-4n01A:
20.64
3mg0L-4n01A:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R6I_A_JMSA332_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 4n01 PERIPLASMIC BINDING
PROTEIN
(Veillonella
parvula) 		5 / 12 LEU A 172
TRP A 150
SER A 154
MET A 155
ASN A 165
 None
 1.50A 3r6iA-4n01A:
undetectable		 3r6iA-4n01A:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9S_C_BEZC264_0
(CARNITINYL-COA
DEHYDRATASE)		 4n01 PERIPLASMIC BINDING
PROTEIN
(Veillonella
parvula) 		4 / 6 ALA A 325
ILE A 196
LEU A 200
ALA A 235
 None
 0.87A 3r9sC-4n01A:
undetectable		 3r9sC-4n01A:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HS6_A_J3ZA302_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE 14)		 4n01 PERIPLASMIC BINDING
PROTEIN
(Veillonella
parvula) 		4 / 8 GLN A 217
LEU A 292
MET A 239
THR A 220
 None
 1.17A 5hs6A-4n01A:
2.9		 5hs6A-4n01A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KGP_B_GCSB405_1
(PREDICTED
ACETYLTRANSFERASE)		 4n01 PERIPLASMIC BINDING
PROTEIN
(Veillonella
parvula) 		4 / 8 TRP A 150
GLU A  45
PRO A 129
GLY A 127
 None
 0.99A 5kgpB-4n01A:
undetectable		 5kgpB-4n01A:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODI_G_ACTG702_0
(HETERODISULFIDE
REDUCTASE, SUBUNIT A)		 4n01 PERIPLASMIC BINDING
PROTEIN
(Veillonella
parvula) 		3 / 3 GLY A 314
THR A 317
ASN A 165
 None
 0.61A 5odiG-4n01A:
3.9		 5odiG-4n01A:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OSR_A_ACTA402_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 4n01 PERIPLASMIC BINDING
PROTEIN
(Veillonella
parvula) 		4 / 7 VAL A 147
ILE A 149
VAL A  64
ALA A 125
 None
 0.78A 5osrA-4n01A:
undetectable		 5osrA-4n01A:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWT_D_BEZD202_0
(PR 10 PROTEIN)		 4n01 PERIPLASMIC BINDING
PROTEIN
(Veillonella
parvula) 		3 / 3 PHE A 279
ASP A 278
LYS A 282
 None
 0.79A 6awtD-4n01A:
undetectable		 6awtD-4n01A:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EF6_A_BEZA401_0
(AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		 4n01 PERIPLASMIC BINDING
PROTEIN
(Veillonella
parvula) 		5 / 9 LEU A 230
THR A 226
ILE A 311
VAL A 306
ILE A 265
 None
 1.22A 6ef6A-4n01A:
undetectable		 6ef6A-4n01A:
20.00