SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4n02'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_C_NCAC339_0
(ADP-RIBOSYL CYCLASE)		 4n02 ISOPENTENYL-DIPHOSPH
ATE DELTA-ISOMERASE
(Streptococcus
pneumoniae) 		3 / 3 GLU A 148
ASN A 144
TRP A 161
 None
SO4  A 403 (-4.4A)
None
 1.26A 1r15C-4n02A:
1.2		 1r15C-4n02A:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_F_NCAF369_0
(ADP-RIBOSYL CYCLASE)		 4n02 ISOPENTENYL-DIPHOSPH
ATE DELTA-ISOMERASE
(Streptococcus
pneumoniae) 		3 / 3 GLU A 148
ASN A 144
TRP A 161
 None
SO4  A 403 (-4.4A)
None
 1.18A 1r15F-4n02A:
1.1		 1r15F-4n02A:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GL0_D_ADND904_1
(CONSERVED
HYPOTHETICAL PROTEIN)		 4n02 ISOPENTENYL-DIPHOSPH
ATE DELTA-ISOMERASE
(Streptococcus
pneumoniae) 		5 / 12 SER A 251
ASN A 117
ALA A  60
ASN A  59
VAL A 198
 FNR  A 404 ( 4.4A)
FNR  A 404 (-3.0A)
FNR  A 404 (-3.7A)
FNR  A 404 ( 4.0A)
None
 1.46A 2gl0D-4n02A:
undetectable
2gl0E-4n02A:
undetectable		 2gl0D-4n02A:
19.78
2gl0E-4n02A:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UVN_A_ECNA1409_1
(CYTOCHROME P450 130)		 4n02 ISOPENTENYL-DIPHOSPH
ATE DELTA-ISOMERASE
(Streptococcus
pneumoniae) 		5 / 12 LEU A  95
ASP A 100
THR A 116
THR A  88
GLY A  89
 None
None
None
None
FNR  A 404 (-3.5A)
 0.98A 2uvnA-4n02A:
undetectable		 2uvnA-4n02A:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_A_HSMA1160_1
(ALLERGEN ARG R 1)		 4n02 ISOPENTENYL-DIPHOSPH
ATE DELTA-ISOMERASE
(Streptococcus
pneumoniae) 		4 / 6 SER A 251
TYR A  57
VAL A  87
ASP A 202
 FNR  A 404 ( 4.4A)
None
None
None
 1.40A 2x45A-4n02A:
undetectable		 2x45A-4n02A:
15.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADS_A_IMNA2_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4n02 ISOPENTENYL-DIPHOSPH
ATE DELTA-ISOMERASE
(Streptococcus
pneumoniae) 		5 / 12 PHE A  54
LEU A 249
LEU A 264
PHE A  56
LEU A 113
 SO4  A 401 (-4.6A)
None
None
None
None
 1.35A 3adsA-4n02A:
undetectable		 3adsA-4n02A:
23.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADX_A_IMNA2_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4n02 ISOPENTENYL-DIPHOSPH
ATE DELTA-ISOMERASE
(Streptococcus
pneumoniae) 		5 / 12 PHE A  54
LEU A 249
LEU A 264
PHE A  56
LEU A 113
 SO4  A 401 (-4.6A)
None
None
None
None
 1.34A 3adxA-4n02A:
undetectable		 3adxA-4n02A:
23.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KM6_A_EAAA222_1
(GLUTATHIONE
S-TRANSFERASE P)		 4n02 ISOPENTENYL-DIPHOSPH
ATE DELTA-ISOMERASE
(Streptococcus
pneumoniae) 		5 / 10 TYR A 168
VAL A 141
GLY A 119
VAL A 174
ASN A 117
 None
None
None
None
FNR  A 404 (-3.0A)
 1.30A 3km6A-4n02A:
undetectable		 3km6A-4n02A:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KMO_A_EAAA214_1
(GLUTATHIONE
S-TRANSFERASE P)		 4n02 ISOPENTENYL-DIPHOSPH
ATE DELTA-ISOMERASE
(Streptococcus
pneumoniae) 		5 / 9 TYR A 168
VAL A 141
GLY A 119
VAL A 174
ASN A 117
 None
None
None
None
FNR  A 404 (-3.0A)
 1.30A 3kmoA-4n02A:
undetectable		 3kmoA-4n02A:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RFM_A_CFFA330_1
(ADENOSINE RECEPTOR
A2A)		 4n02 ISOPENTENYL-DIPHOSPH
ATE DELTA-ISOMERASE
(Streptococcus
pneumoniae) 		4 / 7 VAL A 271
LEU A 300
MET A 304
ILE A 261
 None
 1.02A 3rfmA-4n02A:
undetectable		 3rfmA-4n02A:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FR0_A_SAMA401_0
(ARSENIC
METHYLTRANSFERASE)		 4n02 ISOPENTENYL-DIPHOSPH
ATE DELTA-ISOMERASE
(Streptococcus
pneumoniae) 		5 / 12 GLY A  68
GLY A  64
ASP A 101
ILE A  71
GLU A 282
 None
 1.15A 4fr0A-4n02A:
undetectable		 4fr0A-4n02A:
23.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TRQ_B_ACTB307_0
(WELO5)		 4n02 ISOPENTENYL-DIPHOSPH
ATE DELTA-ISOMERASE
(Streptococcus
pneumoniae) 		3 / 3 GLU A 180
HIS A 142
VAL A 143
 None
SO4  A 403 ( 3.8A)
None
 0.86A 5trqB-4n02A:
undetectable		 5trqB-4n02A:
22.31