SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4n03'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DMA_A_NCAA700_0
(EXOTOXIN A)		 4n03 ABC-TYPE
BRANCHED-CHAIN AMINO
ACID TRANSPORT
SYSTEMS PERIPLASMIC
COMPONENT-LIKE
PROTEIN
(Thermomonospora
curvata) 		4 / 7 GLY A 332
LEU A  77
ALA A  74
TYR A 333
 None
 0.83A 1dmaA-4n03A:
undetectable		 1dmaA-4n03A:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQW_A_RTLA135_0
(CELLULAR
RETINOL-BINDING
PROTEIN)		 4n03 ABC-TYPE
BRANCHED-CHAIN AMINO
ACID TRANSPORT
SYSTEMS PERIPLASMIC
COMPONENT-LIKE
PROTEIN
(Thermomonospora
curvata) 		5 / 12 ILE A 269
THR A 206
LEU A 270
LEU A 215
ILE A 183
 None
 1.26A 1kqwA-4n03A:
0.8		 1kqwA-4n03A:
15.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CC8_A_RBFA1067_1
(VNG1446H)		 4n03 ABC-TYPE
BRANCHED-CHAIN AMINO
ACID TRANSPORT
SYSTEMS PERIPLASMIC
COMPONENT-LIKE
PROTEIN
(Thermomonospora
curvata) 		3 / 3 PHE A 294
VAL A 404
TRP A 176
 EDO  A 602 ( 4.5A)
None
None
 0.41A 2cc8A-4n03A:
undetectable		 2cc8A-4n03A:
11.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CCB_A_RBFA1067_1
(VNG1446H)		 4n03 ABC-TYPE
BRANCHED-CHAIN AMINO
ACID TRANSPORT
SYSTEMS PERIPLASMIC
COMPONENT-LIKE
PROTEIN
(Thermomonospora
curvata) 		3 / 3 PHE A 294
VAL A 404
TRP A 176
 EDO  A 602 ( 4.5A)
None
None
 0.38A 2ccbA-4n03A:
undetectable		 2ccbA-4n03A:
11.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H42_B_VIAB902_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 4n03 ABC-TYPE
BRANCHED-CHAIN AMINO
ACID TRANSPORT
SYSTEMS PERIPLASMIC
COMPONENT-LIKE
PROTEIN
(Thermomonospora
curvata) 		5 / 12 ALA A 296
ILE A 390
LEU A 213
ILE A 183
MET A 178
 None
 1.12A 2h42B-4n03A:
undetectable		 2h42B-4n03A:
23.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHF_A_ACTA504_0
(CHORISMATE SYNTHASE)		 4n03 ABC-TYPE
BRANCHED-CHAIN AMINO
ACID TRANSPORT
SYSTEMS PERIPLASMIC
COMPONENT-LIKE
PROTEIN
(Thermomonospora
curvata) 		4 / 5 SER A 247
HIS A 191
LEU A 270
SER A 272
 None
 1.16A 2qhfA-4n03A:
undetectable		 2qhfA-4n03A:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QXS_B_RALB600_1
(ESTROGEN RECEPTOR)		 4n03 ABC-TYPE
BRANCHED-CHAIN AMINO
ACID TRANSPORT
SYSTEMS PERIPLASMIC
COMPONENT-LIKE
PROTEIN
(Thermomonospora
curvata) 		5 / 12 LEU A 177
LEU A 245
LEU A 203
LEU A 236
PRO A 268
 None
 1.16A 2qxsB-4n03A:
undetectable		 2qxsB-4n03A:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VX9_A_RBFA1064_1
(DODECIN)		 4n03 ABC-TYPE
BRANCHED-CHAIN AMINO
ACID TRANSPORT
SYSTEMS PERIPLASMIC
COMPONENT-LIKE
PROTEIN
(Thermomonospora
curvata) 		3 / 3 PHE A 294
VAL A 404
TRP A 176
 EDO  A 602 ( 4.5A)
None
None
 0.39A 2vx9A-4n03A:
undetectable		 2vx9A-4n03A:
10.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X1L_C_ADNC601_1
(METHIONYL-TRNA
SYNTHETASE)		 4n03 ABC-TYPE
BRANCHED-CHAIN AMINO
ACID TRANSPORT
SYSTEMS PERIPLASMIC
COMPONENT-LIKE
PROTEIN
(Thermomonospora
curvata) 		5 / 11 ALA A  57
GLY A 101
HIS A 100
GLY A  68
ILE A  71
 None
 1.12A 2x1lC-4n03A:
undetectable		 2x1lC-4n03A:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZZA_A_FOLA164_0
(DIHYDROFOLATE
REDUCTASE)		 4n03 ABC-TYPE
BRANCHED-CHAIN AMINO
ACID TRANSPORT
SYSTEMS PERIPLASMIC
COMPONENT-LIKE
PROTEIN
(Thermomonospora
curvata) 		5 / 12 ILE A 171
LEU A 270
ILE A 183
LEU A 189
THR A 388
 None
 1.25A 2zzaA-4n03A:
undetectable		 2zzaA-4n03A:
15.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZZA_B_FOLB164_0
(DIHYDROFOLATE
REDUCTASE)		 4n03 ABC-TYPE
BRANCHED-CHAIN AMINO
ACID TRANSPORT
SYSTEMS PERIPLASMIC
COMPONENT-LIKE
PROTEIN
(Thermomonospora
curvata) 		5 / 11 ILE A 171
LEU A 270
ILE A 183
LEU A 189
THR A 388
 None
 1.27A 2zzaB-4n03A:
undetectable		 2zzaB-4n03A:
15.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BWM_A_SAMA301_0
(CATECHOL
O-METHYLTRANSFERASE)		 4n03 ABC-TYPE
BRANCHED-CHAIN AMINO
ACID TRANSPORT
SYSTEMS PERIPLASMIC
COMPONENT-LIKE
PROTEIN
(Thermomonospora
curvata) 		5 / 12 GLY A 332
TYR A  78
ILE A 145
SER A 147
HIS A 123
 None
 1.34A 3bwmA-4n03A:
5.3		 3bwmA-4n03A:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BWY_A_SAMA301_0
(COMT PROTEIN)		 4n03 ABC-TYPE
BRANCHED-CHAIN AMINO
ACID TRANSPORT
SYSTEMS PERIPLASMIC
COMPONENT-LIKE
PROTEIN
(Thermomonospora
curvata) 		5 / 12 GLY A 332
TYR A  78
ILE A 145
SER A 147
HIS A 123
 None
 1.35A 3bwyA-4n03A:
2.2		 3bwyA-4n03A:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BXO_A_SAMA238_0
(N,N-DIMETHYLTRANSFER
ASE)		 4n03 ABC-TYPE
BRANCHED-CHAIN AMINO
ACID TRANSPORT
SYSTEMS PERIPLASMIC
COMPONENT-LIKE
PROTEIN
(Thermomonospora
curvata) 		5 / 12 ALA A 202
GLY A 200
PHE A 194
SER A 247
LEU A 270
 None
 1.12A 3bxoA-4n03A:
4.9		 3bxoA-4n03A:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BXO_A_SAMA238_0
(N,N-DIMETHYLTRANSFER
ASE)		 4n03 ABC-TYPE
BRANCHED-CHAIN AMINO
ACID TRANSPORT
SYSTEMS PERIPLASMIC
COMPONENT-LIKE
PROTEIN
(Thermomonospora
curvata) 		5 / 12 ALA A 202
MET A 170
PHE A 194
SER A 247
LEU A 270
 None
 1.23A 3bxoA-4n03A:
4.9		 3bxoA-4n03A:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BXO_B_SAMB238_0
(N,N-DIMETHYLTRANSFER
ASE)		 4n03 ABC-TYPE
BRANCHED-CHAIN AMINO
ACID TRANSPORT
SYSTEMS PERIPLASMIC
COMPONENT-LIKE
PROTEIN
(Thermomonospora
curvata) 		5 / 12 ALA A 202
GLY A 200
MET A 170
PHE A 194
SER A 247
 None
 1.20A 3bxoB-4n03A:
5.2		 3bxoB-4n03A:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_A_REMA350_1
(RENIN)		 4n03 ABC-TYPE
BRANCHED-CHAIN AMINO
ACID TRANSPORT
SYSTEMS PERIPLASMIC
COMPONENT-LIKE
PROTEIN
(Thermomonospora
curvata) 		5 / 12 GLY A 372
LEU A 306
SER A 327
SER A 303
ALA A 304
 None
None
PLM  A 601 (-3.6A)
None
None
 1.25A 3d91A-4n03A:
undetectable		 3d91A-4n03A:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_A_REMA350_1
(RENIN)		 4n03 ABC-TYPE
BRANCHED-CHAIN AMINO
ACID TRANSPORT
SYSTEMS PERIPLASMIC
COMPONENT-LIKE
PROTEIN
(Thermomonospora
curvata) 		5 / 12 GLY A 372
THR A 297
LEU A 306
SER A 327
ALA A 304
 None
PLM  A 601 ( 4.8A)
None
PLM  A 601 (-3.6A)
None
 1.17A 3d91A-4n03A:
undetectable		 3d91A-4n03A:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OGP_B_017B200_1
(FIV PROTEASE)		 4n03 ABC-TYPE
BRANCHED-CHAIN AMINO
ACID TRANSPORT
SYSTEMS PERIPLASMIC
COMPONENT-LIKE
PROTEIN
(Thermomonospora
curvata) 		5 / 10 LEU A 119
ILE A  56
GLY A 335
ILE A 338
LEU A  54
 None
 0.90A 3ogpA-4n03A:
undetectable		 3ogpA-4n03A:
13.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PFG_A_SAMA264_0
(N-METHYLTRANSFERASE)		 4n03 ABC-TYPE
BRANCHED-CHAIN AMINO
ACID TRANSPORT
SYSTEMS PERIPLASMIC
COMPONENT-LIKE
PROTEIN
(Thermomonospora
curvata) 		5 / 12 ALA A 202
GLY A 200
MET A 170
PHE A 194
SER A 247
 None
 1.20A 3pfgA-4n03A:
4.5		 3pfgA-4n03A:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q87_B_SAMB300_0
(N6 ADENINE SPECIFIC
DNA METHYLASE)		 4n03 ABC-TYPE
BRANCHED-CHAIN AMINO
ACID TRANSPORT
SYSTEMS PERIPLASMIC
COMPONENT-LIKE
PROTEIN
(Thermomonospora
curvata) 		5 / 12 THR A  58
GLY A 328
ASP A 326
LEU A 325
LEU A 312
 None
PLM  A 601 ( 4.0A)
None
None
None
 1.16A 3q87B-4n03A:
2.8		 3q87B-4n03A:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q95_A_ESLA700_1
(ESTROGEN RECEPTOR)		 4n03 ABC-TYPE
BRANCHED-CHAIN AMINO
ACID TRANSPORT
SYSTEMS PERIPLASMIC
COMPONENT-LIKE
PROTEIN
(Thermomonospora
curvata) 		5 / 12 LEU A 182
ALA A 243
ARG A 261
ILE A 390
GLY A 173
 EDO  A 602 ( 4.8A)
None
None
None
None
 1.11A 3q95A-4n03A:
undetectable		 3q95A-4n03A:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q95_B_ESLB700_1
(ESTROGEN RECEPTOR)		 4n03 ABC-TYPE
BRANCHED-CHAIN AMINO
ACID TRANSPORT
SYSTEMS PERIPLASMIC
COMPONENT-LIKE
PROTEIN
(Thermomonospora
curvata) 		5 / 12 LEU A 182
ALA A 243
ARG A 261
ILE A 390
GLY A 173
 EDO  A 602 ( 4.8A)
None
None
None
None
 1.06A 3q95B-4n03A:
undetectable		 3q95B-4n03A:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9S_C_BEZC264_0
(CARNITINYL-COA
DEHYDRATASE)		 4n03 ABC-TYPE
BRANCHED-CHAIN AMINO
ACID TRANSPORT
SYSTEMS PERIPLASMIC
COMPONENT-LIKE
PROTEIN
(Thermomonospora
curvata) 		4 / 6 ALA A 260
ILE A 244
LEU A 256
ALA A 288
 None
 0.88A 3r9sC-4n03A:
undetectable		 3r9sC-4n03A:
26.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJW_A_SRYA2001_2
(TRANSCRIPTIONAL
REGULATOR TCAR)		 4n03 ABC-TYPE
BRANCHED-CHAIN AMINO
ACID TRANSPORT
SYSTEMS PERIPLASMIC
COMPONENT-LIKE
PROTEIN
(Thermomonospora
curvata) 		4 / 6 GLU A  94
ILE A  93
ASN A  83
VAL A  41
 None
 1.03A 4ejwB-4n03A:
undetectable		 4ejwB-4n03A:
15.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JQ4_B_IMNB401_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 4n03 ABC-TYPE
BRANCHED-CHAIN AMINO
ACID TRANSPORT
SYSTEMS PERIPLASMIC
COMPONENT-LIKE
PROTEIN
(Thermomonospora
curvata) 		5 / 10 TYR A 198
TYR A 166
ASN A 331
LEU A 125
LEU A  67
 PLM  A 601 (-3.9A)
PLM  A 601 (-4.5A)
PLM  A 601 ( 4.6A)
PLM  A 601 ( 4.3A)
PLM  A 601 ( 3.8A)
 1.32A 4jq4B-4n03A:
undetectable		 4jq4B-4n03A:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M6T_A_SAMA201_0
(RNA POLYMERASE
II-ASSOCIATED FACTOR
1 HOMOLOG, LINKER,
RNA
POLYMERASE-ASSOCIATE
D PROTEIN LEO1)		 4n03 ABC-TYPE
BRANCHED-CHAIN AMINO
ACID TRANSPORT
SYSTEMS PERIPLASMIC
COMPONENT-LIKE
PROTEIN
(Thermomonospora
curvata) 		4 / 4 ILE A  52
VAL A 118
VAL A  47
ARG A  91
 None
 1.36A 4m6tA-4n03A:
undetectable		 4m6tA-4n03A:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_A_GCSA302_1
(CHITOSANASE)		 4n03 ABC-TYPE
BRANCHED-CHAIN AMINO
ACID TRANSPORT
SYSTEMS PERIPLASMIC
COMPONENT-LIKE
PROTEIN
(Thermomonospora
curvata) 		4 / 5 THR A 165
THR A 151
ASP A 167
TYR A 416
 None
 1.13A 4oltA-4n03A:
1.0		 4oltA-4n03A:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_B_GCSB302_1
(CHITOSANASE)		 4n03 ABC-TYPE
BRANCHED-CHAIN AMINO
ACID TRANSPORT
SYSTEMS PERIPLASMIC
COMPONENT-LIKE
PROTEIN
(Thermomonospora
curvata) 		4 / 5 THR A 165
THR A 151
ASP A 167
TYR A 416
 None
 1.08A 4oltB-4n03A:
0.6		 4oltB-4n03A:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_A_GCSA302_1
(CHITOSANASE)		 4n03 ABC-TYPE
BRANCHED-CHAIN AMINO
ACID TRANSPORT
SYSTEMS PERIPLASMIC
COMPONENT-LIKE
PROTEIN
(Thermomonospora
curvata) 		4 / 5 THR A 165
THR A 151
ASP A 167
TYR A 416
 None
 1.11A 4qwpA-4n03A:
undetectable		 4qwpA-4n03A:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_B_GCSB306_1
(CHITOSANASE)		 4n03 ABC-TYPE
BRANCHED-CHAIN AMINO
ACID TRANSPORT
SYSTEMS PERIPLASMIC
COMPONENT-LIKE
PROTEIN
(Thermomonospora
curvata) 		4 / 5 THR A 165
THR A 151
ASP A 167
TYR A 416
 None
 1.13A 4qwpB-4n03A:
undetectable		 4qwpB-4n03A:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_D_29SD601_1
(ESTROGEN RECEPTOR)		 4n03 ABC-TYPE
BRANCHED-CHAIN AMINO
ACID TRANSPORT
SYSTEMS PERIPLASMIC
COMPONENT-LIKE
PROTEIN
(Thermomonospora
curvata) 		5 / 12 LEU A 177
LEU A 245
LEU A 203
LEU A 236
PRO A 268
 None
 1.22A 4xi3D-4n03A:
undetectable		 4xi3D-4n03A:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUE_B_SAMB303_0
(CATECHOL
O-METHYLTRANSFERASE)		 4n03 ABC-TYPE
BRANCHED-CHAIN AMINO
ACID TRANSPORT
SYSTEMS PERIPLASMIC
COMPONENT-LIKE
PROTEIN
(Thermomonospora
curvata) 		5 / 12 GLY A 332
TYR A  78
ILE A 145
SER A 147
HIS A 123
 None
 1.32A 4xueB-4n03A:
4.7		 4xueB-4n03A:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EB3_A_UEGA202_1
(YFIR)		 4n03 ABC-TYPE
BRANCHED-CHAIN AMINO
ACID TRANSPORT
SYSTEMS PERIPLASMIC
COMPONENT-LIKE
PROTEIN
(Thermomonospora
curvata) 		4 / 4 LEU A 125
ILE A  71
PRO A  66
LEU A  60
 PLM  A 601 ( 4.3A)
None
None
None
 1.23A 5eb3A-4n03A:
7.7		 5eb3A-4n03A:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H5F_A_SAMA301_1
(PROTEIN ARGININE
N-METHYLTRANSFERASE
SFM1)		 4n03 ABC-TYPE
BRANCHED-CHAIN AMINO
ACID TRANSPORT
SYSTEMS PERIPLASMIC
COMPONENT-LIKE
PROTEIN
(Thermomonospora
curvata) 		4 / 5 GLY A  68
PRO A 122
THR A  58
GLN A  75
 None
 0.63A 5h5fA-4n03A:
undetectable		 5h5fA-4n03A:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW8_H_FK5H201_1
(FK506-BINDING
PROTEIN 1)		 4n03 ABC-TYPE
BRANCHED-CHAIN AMINO
ACID TRANSPORT
SYSTEMS PERIPLASMIC
COMPONENT-LIKE
PROTEIN
(Thermomonospora
curvata) 		4 / 8 TYR A 198
PHE A 194
VAL A  63
ILE A 295
 PLM  A 601 (-3.9A)
None
None
None
 0.85A 5hw8H-4n03A:
undetectable		 5hw8H-4n03A:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LSA_A_SAMA303_0
(CATECHOL
O-METHYLTRANSFERASE)		 4n03 ABC-TYPE
BRANCHED-CHAIN AMINO
ACID TRANSPORT
SYSTEMS PERIPLASMIC
COMPONENT-LIKE
PROTEIN
(Thermomonospora
curvata) 		5 / 12 GLY A 332
TYR A  78
ILE A 145
SER A 147
HIS A 123
 None
 1.35A 5lsaA-4n03A:
5.1		 5lsaA-4n03A:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0O_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 4n03 ABC-TYPE
BRANCHED-CHAIN AMINO
ACID TRANSPORT
SYSTEMS PERIPLASMIC
COMPONENT-LIKE
PROTEIN
(Thermomonospora
curvata) 		3 / 3 ALA A 254
GLN A 279
THR A 283
 None
 0.73A 5n0oA-4n03A:
undetectable		 5n0oA-4n03A:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_C_CVIC301_1
(REGULATORY PROTEIN
TETR)		 4n03 ABC-TYPE
BRANCHED-CHAIN AMINO
ACID TRANSPORT
SYSTEMS PERIPLASMIC
COMPONENT-LIKE
PROTEIN
(Thermomonospora
curvata) 		4 / 7 GLN A 175
GLY A 173
ILE A 183
TRP A 176
 None
 1.02A 5vlmC-4n03A:
undetectable		 5vlmC-4n03A:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7P_A_ACRA1431_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 4n03 ABC-TYPE
BRANCHED-CHAIN AMINO
ACID TRANSPORT
SYSTEMS PERIPLASMIC
COMPONENT-LIKE
PROTEIN
(Thermomonospora
curvata) 		4 / 7 ASN A 273
ASP A 169
ASP A 167
GLY A 205
 PLM  A 601 ( 3.8A)
None
None
None
 1.01A 5x7pA-4n03A:
undetectable		 5x7pA-4n03A:
16.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XV7_A_EMHA705_1
(SERINE-ARGININE (SR)
PROTEIN KINASE 1)		 4n03 ABC-TYPE
BRANCHED-CHAIN AMINO
ACID TRANSPORT
SYSTEMS PERIPLASMIC
COMPONENT-LIKE
PROTEIN
(Thermomonospora
curvata) 		5 / 12 LEU A 189
GLY A 190
VAL A 217
ALA A 210
LEU A 177
 None
 0.84A 5xv7A-4n03A:
undetectable		 5xv7A-4n03A:
12.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YOD_H_BEZH201_0
(NS3 PROTEASE)		 4n03 ABC-TYPE
BRANCHED-CHAIN AMINO
ACID TRANSPORT
SYSTEMS PERIPLASMIC
COMPONENT-LIKE
PROTEIN
(Thermomonospora
curvata) 		4 / 5 HIS A 191
SER A 247
TYR A 198
GLY A 199
 None
None
PLM  A 601 (-3.9A)
None
 1.31A 5yodH-4n03A:
undetectable		 5yodH-4n03A:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_A_ACRA608_0
(ALPHA-AMYLASE)		 4n03 ABC-TYPE
BRANCHED-CHAIN AMINO
ACID TRANSPORT
SYSTEMS PERIPLASMIC
COMPONENT-LIKE
PROTEIN
(Thermomonospora
curvata) 		4 / 6 GLY A  68
THR A  72
GLN A  73
TYR A 316
 None
 1.06A 6ag0A-4n03A:
undetectable		 6ag0A-4n03A:
14.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_C_ACRC606_0
(ALPHA-AMYLASE)		 4n03 ABC-TYPE
BRANCHED-CHAIN AMINO
ACID TRANSPORT
SYSTEMS PERIPLASMIC
COMPONENT-LIKE
PROTEIN
(Thermomonospora
curvata) 		4 / 6 GLY A  68
THR A  72
GLN A  73
TYR A 316
 None
 1.05A 6ag0C-4n03A:
undetectable		 6ag0C-4n03A:
14.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		 4n03 ABC-TYPE
BRANCHED-CHAIN AMINO
ACID TRANSPORT
SYSTEMS PERIPLASMIC
COMPONENT-LIKE
PROTEIN
(Thermomonospora
curvata) 		5 / 12 THR A 353
GLY A 356
LEU A 357
THR A  36
GLY A  37
 None
 1.16A 6gngA-4n03A:
2.2		 6gngA-4n03A:
23.13