SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4n06'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZB7_A_NCAA901_0
(PROSTAGLANDIN
REDUCTASE 2)		 4n06 CRISPR-ASSOCIATED
ENDONUCLEASE CAS1 1
(Archaeoglobus
fulgidus) 		4 / 5 TYR A 175
ILE A 179
LEU A 135
LEU A 120
 None
 1.14A 2zb7A-4n06A:
undetectable		 2zb7A-4n06A:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_C_SVRC505_2
(PHOSPHOLIPASE A2)		 4n06 CRISPR-ASSOCIATED
ENDONUCLEASE CAS1 1
(Archaeoglobus
fulgidus) 		4 / 5 VAL A 226
VAL A 223
GLN A  38
ARG A   2
 None
 1.39A 3bjwH-4n06A:
undetectable		 3bjwH-4n06A:
13.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_G_SVRG506_2
(PHOSPHOLIPASE A2)		 4n06 CRISPR-ASSOCIATED
ENDONUCLEASE CAS1 1
(Archaeoglobus
fulgidus) 		4 / 5 VAL A 226
VAL A 223
GLN A  38
ARG A   2
 None
 1.32A 3bjwB-4n06A:
undetectable		 3bjwB-4n06A:
13.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BRF_A_SORA1_0
(LIN-12 AND GLP-1
PHENOTYPE PROTEIN 1,
ISOFORM A)		 4n06 CRISPR-ASSOCIATED
ENDONUCLEASE CAS1 1
(Archaeoglobus
fulgidus) 		3 / 3 GLY A 198
ASP A 241
SER A 243
 None
 0.55A 3brfA-4n06A:
undetectable		 3brfA-4n06A:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM4_V_DR7V100_1
(PROTEASE)		 4n06 CRISPR-ASSOCIATED
ENDONUCLEASE CAS1 1
(Archaeoglobus
fulgidus) 		6 / 11 GLY A  13
ALA A  51
ASP A  50
GLY A  17
LEU A  18
VAL A  60
 None
 1.41A 3em4U-4n06A:
undetectable		 3em4U-4n06A:
14.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EAH_F_ACTF402_0
(ACTIN, ALPHA
SKELETAL MUSCLE)		 4n06 CRISPR-ASSOCIATED
ENDONUCLEASE CAS1 1
(Archaeoglobus
fulgidus) 		3 / 3 PHE A 341
ASP A 327
ARG A 311
 None
 0.90A 4eahF-4n06A:
undetectable		 4eahF-4n06A:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTF_F_GFNF101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 4n06 CRISPR-ASSOCIATED
ENDONUCLEASE CAS1 1
(Archaeoglobus
fulgidus) 		4 / 7 SER A  49
ASP A  61
ARG A  74
GLY A  73
 None
 0.98A 5btfA-4n06A:
undetectable
5btfB-4n06A:
undetectable
5btfC-4n06A:
undetectable		 5btfA-4n06A:
22.86
5btfB-4n06A:
25.07
5btfC-4n06A:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QH8_A_ACTA302_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 4n06 CRISPR-ASSOCIATED
ENDONUCLEASE CAS1 1
(Archaeoglobus
fulgidus) 		3 / 3 CYH A 222
MET A 253
ASN A 255
 None
 1.04A 5qh8A-4n06A:
undetectable		 5qh8A-4n06A:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T7B_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 4n06 CRISPR-ASSOCIATED
ENDONUCLEASE CAS1 1
(Archaeoglobus
fulgidus) 		4 / 7 LEU A  12
TYR A  11
LYS A  22
GLU A  15
 None
 1.01A 5t7bA-4n06A:
undetectable		 5t7bA-4n06A:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XOO_A_ADNA506_1
(GLYCOSAMINOGLYCAN
XYLOSYLKINASE)		 4n06 CRISPR-ASSOCIATED
ENDONUCLEASE CAS1 1
(Archaeoglobus
fulgidus) 		4 / 6 LEU A 164
LYS A 109
GLU A 254
LEU A 238
 None
 1.20A 5xooA-4n06A:
undetectable		 5xooA-4n06A:
14.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_B_CHDB401_0
(BILE SALT HYDROLASE)		 4n06 CRISPR-ASSOCIATED
ENDONUCLEASE CAS1 1
(Archaeoglobus
fulgidus) 		5 / 10 LEU A 288
ILE A  42
LEU A  65
ASN A 212
LEU A 219
 None
 1.25A 5y7pB-4n06A:
undetectable		 5y7pB-4n06A:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BM5_A_SAMA1301_0
(METHIONINE SYNTHASE)		 4n06 CRISPR-ASSOCIATED
ENDONUCLEASE CAS1 1
(Archaeoglobus
fulgidus) 		5 / 11 PRO A 200
PRO A 233
ALA A 249
ALA A 235
TYR A 234
 None
 1.44A 6bm5A-4n06A:
undetectable		 6bm5A-4n06A:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GSD_A_STRA401_0
(PROGESTERONE
5-BETA-REDUCTASE)		 4n06 CRISPR-ASSOCIATED
ENDONUCLEASE CAS1 1
(Archaeoglobus
fulgidus) 		5 / 12 VAL A 182
PHE A 189
ILE A 183
VAL A 265
ILE A 269
 None
 1.10A 6gsdA-4n06A:
undetectable		 6gsdA-4n06A:
13.47