SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4n0f'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBI_C_SAMC2293_0
(GLYCINE
N-METHYLTRANSFERASE)		 4n0f IGG RECEPTOR FCRN
LARGE SUBUNIT P51
(Homo
sapiens) 		5 / 12 GLY A  95
THR A 107
SER A   6
GLY A  92
HIS A  10
 None
 1.30A 1nbiC-4n0fA:
undetectable		 1nbiC-4n0fA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBI_D_SAMD3293_0
(GLYCINE
N-METHYLTRANSFERASE)		 4n0f IGG RECEPTOR FCRN
LARGE SUBUNIT P51
(Homo
sapiens) 		5 / 12 GLY A  95
THR A 107
SER A   6
GLY A  92
HIS A  10
 None
 1.29A 1nbiD-4n0fA:
undetectable		 1nbiD-4n0fA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OAF_A_ASCA1253_0
(ASCORBATE PEROXIDASE)		 4n0f IGG RECEPTOR FCRN
LARGE SUBUNIT P51
(Homo
sapiens) 		4 / 6 CYH A  48
PRO A  47
LEU A  36
HIS A 166
 None
 1.24A 1oafA-4n0fA:
undetectable		 1oafA-4n0fA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXM_A_IMNA2001_1
(SERUM ALBUMIN)		 4n0f IGG RECEPTOR FCRN
LARGE SUBUNIT P51
(Homo
sapiens) 		4 / 8 ALA A  23
PHE A  24
TRP A  25
LEU A  68
 None
 0.92A 2bxmA-4n0fA:
2.4		 2bxmA-4n0fA:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2LH6_A_NIOA155_1
(LEGHEMOGLOBIN A
(NICOTINATE MET))		 4n0f IGG RECEPTOR FCRN
LARGE SUBUNIT P51
(Homo
sapiens) 		4 / 5 PHE A  24
PHE A  75
PHE A 110
VAL A  26
 None
 1.07A 2lh6A-4n0fA:
undetectable		 2lh6A-4n0fA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHF_A_ACTA507_0
(CHORISMATE SYNTHASE)		 4n0f IGG RECEPTOR FCRN
LARGE SUBUNIT P51
(Homo
sapiens) 		3 / 3 LEU A  98
ASN A 102
ARG A 164
 None
 0.64A 2qhfA-4n0fA:
undetectable		 2qhfA-4n0fA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PP1_A_ACTA590_0
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		 4n0f IGG RECEPTOR FCRN
LARGE SUBUNIT P51
(Homo
sapiens) 		4 / 5 GLU A 151
LEU A 152
GLN A 142
GLY A 125
 None
 1.25A 3pp1A-4n0fA:
undetectable		 3pp1A-4n0fA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RQW_C_ACHC323_0
(ELIC PENTAMERIC
LIGAND GATED ION
CHANNEL FROM ERWINIA
CHRYSANTHEMI)		 4n0f IGG RECEPTOR FCRN
LARGE SUBUNIT P51
(Homo
sapiens) 		4 / 8 PHE A  24
GLU A 151
LEU A  68
PHE A 154
 None
 1.11A 3rqwC-4n0fA:
3.0
3rqwD-4n0fA:
3.0		 3rqwC-4n0fA:
19.58
3rqwD-4n0fA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RQW_J_ACHJ323_0
(ELIC PENTAMERIC
LIGAND GATED ION
CHANNEL FROM ERWINIA
CHRYSANTHEMI)		 4n0f IGG RECEPTOR FCRN
LARGE SUBUNIT P51
(Homo
sapiens) 		4 / 8 GLU A 151
LEU A  68
PHE A 154
PHE A  24
 None
 1.10A 3rqwF-4n0fA:
3.1
3rqwJ-4n0fA:
2.1		 3rqwF-4n0fA:
19.58
3rqwJ-4n0fA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CEV_F_GAIF411_0
(PROTEIN (ARGINASE))		 4n0f IGG RECEPTOR FCRN
LARGE SUBUNIT P51
(Homo
sapiens) 		4 / 6 HIS A 248
GLU A 247
LEU A 196
ASP A 246
 None
 1.37A 4cevE-4n0fA:
undetectable
4cevF-4n0fA:
undetectable		 4cevE-4n0fA:
21.70
4cevF-4n0fA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_E_IPHE101_0
(INSULIN)		 4n0f IGG RECEPTOR FCRN
LARGE SUBUNIT P51
(Homo
sapiens) 		5 / 11 LEU A  68
HIS A  10
LEU A  11
LEU A   8
LEU A  36
 None
 1.06A 4p65E-4n0fA:
undetectable
4p65F-4n0fA:
undetectable
4p65J-4n0fA:
undetectable
4p65L-4n0fA:
undetectable		 4p65E-4n0fA:
6.67
4p65F-4n0fA:
11.62
4p65J-4n0fA:
11.62
4p65L-4n0fA:
11.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E43_D_BEZD502_0
(INDOLEAMINE
2,3-DIOXYGENASE 1)		 4n0f IGG RECEPTOR FCRN
LARGE SUBUNIT P51
(Homo
sapiens) 		4 / 6 PHE A 154
VAL A  26
LEU A  93
LEU A  94
 None
 1.04A 6e43D-4n0fA:
undetectable		 6e43D-4n0fA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JI6_A_ACTA305_0
(GLUTATHIONE
S-TRANSFERASE
CLASS-MU 26 KDA
ISOZYME)		 4n0f IGG RECEPTOR FCRN
LARGE SUBUNIT P51
(Homo
sapiens) 		4 / 5 GLY A  31
LEU A   5
TYR A 204
GLN A  33
 None
 1.14A 6ji6A-4n0fA:
undetectable		 6ji6A-4n0fA:
20.42