SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4n0g'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICT_C_T44C128_1
(TRANSTHYRETIN)		 4n0g ABSCISIC ACID
RECEPTOR PYL13
(Arabidopsis
thaliana) 		5 / 11 LEU C  28
LEU C  80
SER C 106
THR C 108
VAL C 110
 None
 1.20A 1ictA-4n0gC:
undetectable
1ictC-4n0gC:
undetectable		 1ictA-4n0gC:
20.12
1ictC-4n0gC:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PK2_A_ACAA91_1
(TISSUE-TYPE
PLASMINOGEN
ACTIVATOR)		 4n0g PROTEIN PHOSPHATASE
2C 37
(Arabidopsis
thaliana) 		4 / 8 VAL A 220
ASP A 116
HIS A 148
LEU A 212
 None
None
ZN  A 401 (-3.3A)
None
 1.22A 1pk2A-4n0gA:
undetectable		 1pk2A-4n0gA:
13.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PWY_E_AC2E290_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 4n0g PROTEIN PHOSPHATASE
2C 37
(Arabidopsis
thaliana) 		5 / 10 GLY A 221
VAL A 220
GLY A 145
THR A 223
VAL A 149
 None
 1.30A 1pwyE-4n0gA:
undetectable		 1pwyE-4n0gA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_B_SAMB301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 4n0g PROTEIN PHOSPHATASE
2C 37
(Arabidopsis
thaliana) 		5 / 12 LEU A 289
LEU A 300
GLY A 296
CYH A 153
ALA A 224
 None
 1.24A 2bm9B-4n0gA:
undetectable		 2bm9B-4n0gA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM4_A_DR7A100_2
(PROTEASE)		 4n0g PROTEIN PHOSPHATASE
2C 37
(Arabidopsis
thaliana) 		5 / 9 ASP A 185
ASP A 307
LEU A 300
VAL A 149
ILE A 295
 None
 1.17A 3em4B-4n0gA:
undetectable		 3em4B-4n0gA:
14.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HS4_A_AZMA702_1
(CARBONIC ANHYDRASE 2)		 4n0g PROTEIN PHOSPHATASE
2C 37
(Arabidopsis
thaliana) 		4 / 7 VAL A 228
LYS A 233
GLU A 232
PRO A 231
 None
 1.17A 3hs4A-4n0gA:
undetectable		 3hs4A-4n0gA:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RQW_I_ACHI323_0
(ELIC PENTAMERIC
LIGAND GATED ION
CHANNEL FROM ERWINIA
CHRYSANTHEMI)		 4n0g ABSCISIC ACID
RECEPTOR PYL13
(Arabidopsis
thaliana) 		4 / 8 TYR C 127
ILE C 141
LEU C 101
PHE C 143
 None
 0.98A 3rqwI-4n0gC:
undetectable
3rqwJ-4n0gC:
undetectable		 3rqwI-4n0gC:
19.00
3rqwJ-4n0gC:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WBO_B_ANWB601_0
(RHODOPSIN KINASE)		 4n0g ABSCISIC ACID
RECEPTOR PYL13
(Arabidopsis
thaliana) 		4 / 8 LEU C 158
ALA C  36
LEU C  28
ALA C  19
 None
 0.68A 4wboB-4n0gC:
undetectable		 4wboB-4n0gC:
15.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNV_A_QI9A602_0
(CYTOCHROME P450 2D6)		 4n0g PROTEIN PHOSPHATASE
2C 37
(Arabidopsis
thaliana) 		5 / 9 LEU A 346
THR A 370
VAL A 384
VAL A 386
LEU A 329
 None
 1.35A 4wnvA-4n0gA:
undetectable		 4wnvA-4n0gA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1I_B_LOCB502_2
(TUBULIN BETA CHAIN)		 4n0g PROTEIN PHOSPHATASE
2C 37
(Arabidopsis
thaliana) 		6 / 12 CYH A 321
LEU A 346
LYS A 104
ASN A 360
ALA A 366
ALA A 342
 None
 1.28A 4x1iB-4n0gA:
undetectable		 4x1iB-4n0gA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1I_D_LOCD502_1
(TUBULIN BETA CHAIN)		 4n0g PROTEIN PHOSPHATASE
2C 37
(Arabidopsis
thaliana) 		6 / 12 CYH A 321
LEU A 346
LYS A 104
ASN A 360
ALA A 366
ALA A 342
 None
 1.29A 4x1iD-4n0gA:
undetectable		 4x1iD-4n0gA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1I_D_LOCD502_1
(TUBULIN BETA CHAIN)		 4n0g PROTEIN PHOSPHATASE
2C 37
(Arabidopsis
thaliana) 		6 / 12 CYH A 321
LEU A 389
LEU A 346
LYS A 104
ASN A 360
ALA A 342
 None
 1.49A 4x1iD-4n0gA:
undetectable		 4x1iD-4n0gA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X3U_B_SVRB102_1
(CHROMOBOX PROTEIN
HOMOLOG 7)		 4n0g ABSCISIC ACID
RECEPTOR PYL13
(Arabidopsis
thaliana) 		3 / 3 LYS C 105
ARG C  63
VAL C  62
 None
 1.05A 4x3uA-4n0gC:
undetectable
4x3uB-4n0gC:
undetectable		 4x3uA-4n0gC:
18.99
4x3uB-4n0gC:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HP1_A_PPFA602_1
(HIV-1 REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 4n0g PROTEIN PHOSPHATASE
2C 37
(Arabidopsis
thaliana) 		4 / 6 ARG A 114
ASP A 327
GLY A 328
ASP A 331
 None
MG  A 403 ( 3.0A)
None
MG  A 405 (-2.0A)
 1.24A 5hp1A-4n0gA:
undetectable		 5hp1A-4n0gA:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JGL_A_SAMA301_0
(UBIE/COQ5 FAMILY
METHYLTRANSFERASE,
PUTATIVE)		 4n0g PROTEIN PHOSPHATASE
2C 37
(Arabidopsis
thaliana) 		5 / 12 ALA A 294
LEU A 300
ALA A 224
GLY A 240
PRO A 261
 None
 1.00A 5jglA-4n0gA:
undetectable		 5jglA-4n0gA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5C_B_TA1B502_1
(TUBULIN BETA-2B
CHAIN)		 4n0g PROTEIN PHOSPHATASE
2C 37
(Arabidopsis
thaliana) 		5 / 12 VAL A 225
ALA A 244
SER A 256
GLY A 328
LEU A 329
 None
 1.16A 5m5cB-4n0gA:
undetectable		 5m5cB-4n0gA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5C_E_TA1E502_1
(TUBULIN BETA-2B
CHAIN)		 4n0g PROTEIN PHOSPHATASE
2C 37
(Arabidopsis
thaliana) 		5 / 10 VAL A 225
ALA A 244
SER A 256
GLY A 328
LEU A 329
 None
 1.17A 5m5cE-4n0gA:
undetectable		 5m5cE-4n0gA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NM5_B_LOCB502_2
(TUBULIN BETA-2B
CHAIN)		 4n0g PROTEIN PHOSPHATASE
2C 37
(Arabidopsis
thaliana) 		5 / 12 CYH A 321
LEU A 389
LEU A 346
ASN A 360
ALA A 342
 None
 1.29A 5nm5B-4n0gA:
undetectable		 5nm5B-4n0gA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_B_ZITB501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		 4n0g PROTEIN PHOSPHATASE
2C 37
(Arabidopsis
thaliana) 		5 / 12 LEU A 389
ASP A 388
VAL A 225
ALA A 252
GLY A 250
 None
 1.06A 5uxdB-4n0gA:
undetectable		 5uxdB-4n0gA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A94_B_ZOTB3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		 4n0g PROTEIN PHOSPHATASE
2C 37
(Arabidopsis
thaliana) 		5 / 12 VAL A 384
SER A 383
VAL A 387
GLY A 106
VAL A 225
 None
 1.19A 6a94B-4n0gA:
undetectable		 6a94B-4n0gA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA825_0
(GEPHYRIN)		 4n0g PROTEIN PHOSPHATASE
2C 37
(Arabidopsis
thaliana) 		3 / 3 LYS A 233
VAL A 312
ASP A 314
 None
 0.67A 6fgdA-4n0gA:
undetectable		 6fgdA-4n0gA:
21.51