SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4n0i'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A27_A_ESTA350_1
(17-BETA-HYDROXYSTERO
ID-DEHYDROGENASE)		 4n0i GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A,
MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		5 / 12 SER A 433
GLY A 443
VAL A 419
MET A 248
GLU A 246
 None
 1.18A 1a27A-4n0iA:
undetectable		 1a27A-4n0iA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GYX_A_BEZA1077_0
(HYPOTHETICAL PROTEIN
YDCE)		 4n0i GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A,
MITOCHONDRIAL
GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT B,
MITOCHONDRIAL
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		4 / 7 ARG B 105
TYR A 171
PRO B 304
SER A 185
 None
 1.48A 1gyxA-4n0iB:
undetectable
1gyxB-4n0iB:
undetectable		 1gyxA-4n0iB:
13.35
1gyxB-4n0iB:
13.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HXB_A_ROCA100_4
(HIV-1 PROTEASE)		 4n0i GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A,
MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		4 / 4 GLY A 190
ASP A 150
GLY A 428
THR A 215
 None
GLN  A 501 ( 4.7A)
None
None
 1.07A 1hxbB-4n0iA:
undetectable		 1hxbB-4n0iA:
12.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHO_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 4n0i GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A,
MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		5 / 9 GLY A 328
GLY A 101
PHE A 100
GLU A  99
GLY A 103
 None
None
None
None
GLN  A 501 (-3.8A)
 1.18A 1jhoA-4n0iA:
undetectable		 1jhoA-4n0iA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHR_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 4n0i GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A,
MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		5 / 9 GLY A 328
GLY A 101
PHE A 100
GLU A  99
GLY A 103
 None
None
None
None
GLN  A 501 (-3.8A)
 1.16A 1jhrA-4n0iA:
undetectable		 1jhrA-4n0iA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHY_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 4n0i GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A,
MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		5 / 9 GLY A 328
GLY A 101
PHE A 100
GLU A  99
GLY A 103
 None
None
None
None
GLN  A 501 (-3.8A)
 1.16A 1jhyA-4n0iA:
undetectable		 1jhyA-4n0iA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KGL_A_RTLA175_0
(CELLULAR
RETINOL-BINDING
PROTEIN TYPE I)		 4n0i GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A,
MITOCHONDRIAL
GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT B,
MITOCHONDRIAL
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		5 / 12 ALA A  78
SER A 175
PHE A 177
GLY B  73
ILE A 180
 None
 1.21A 1kglA-4n0iA:
undetectable		 1kglA-4n0iA:
12.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L4N_A_NIOA991_1
(NICOTINATE-NUCLEOTID
E--DIMETHYLBENZIMIDA
ZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 4n0i GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A,
MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		5 / 9 GLY A 328
GLY A 101
PHE A 100
GLU A  99
GLY A 103
 None
None
None
None
GLN  A 501 (-3.8A)
 1.13A 1l4nA-4n0iA:
undetectable		 1l4nA-4n0iA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5K_A_NIOA991_1
(NICOTINATE-NUCLEOTID
E--DIMETHYLBENZIMIDA
ZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 4n0i GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A,
MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		5 / 9 GLY A 328
GLY A 101
PHE A 100
GLU A  99
GLY A 103
 None
None
None
None
GLN  A 501 (-3.8A)
 1.16A 1l5kA-4n0iA:
undetectable		 1l5kA-4n0iA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5L_A_NIOA991_1
(NICOTINATE-NUCLEOTID
E--DIMETHYLBENZIMIDA
ZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 4n0i GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A,
MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		5 / 9 GLY A 328
GLY A 101
PHE A 100
GLU A  99
GLY A 103
 None
None
None
None
GLN  A 501 (-3.8A)
 1.14A 1l5lA-4n0iA:
undetectable		 1l5lA-4n0iA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5M_A_NIOA991_1
(NICOTINATE-NUCLEOTID
E--DIMETHYLBENZIMIDA
ZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 4n0i GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A,
MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		5 / 9 GLY A 328
GLY A 101
PHE A 100
GLU A  99
GLY A 103
 None
None
None
None
GLN  A 501 (-3.8A)
 1.15A 1l5mA-4n0iA:
undetectable		 1l5mA-4n0iA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PK9_C_2FAC308_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 4n0i GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A,
MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		5 / 11 SER A 154
GLY A 148
VAL A 189
SER A 131
ILE A  55
 GLN  A 501 (-1.2A)
None
None
None
None
 1.13A 1pk9C-4n0iA:
undetectable		 1pk9C-4n0iA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RQP_A_SAMA500_1
(5'-FLUORO-5'-DEOXYAD
ENOSINE SYNTHASE)		 4n0i GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A,
MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		4 / 7 PHE A 365
PHE A 369
SER A 431
ARG A 156
 None
 1.16A 1rqpB-4n0iA:
1.4		 1rqpB-4n0iA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RQP_B_SAMB500_1
(5'-FLUORO-5'-DEOXYAD
ENOSINE SYNTHASE)		 4n0i GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A,
MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		4 / 8 PHE A 365
PHE A 369
SER A 431
ARG A 156
 None
 1.15A 1rqpC-4n0iA:
undetectable		 1rqpC-4n0iA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SBR_A_VIBA502_1
(YKOF)		 4n0i GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A,
MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		4 / 6 PHE A 145
ALA A 146
LEU A 147
ILE A  51
 None
 0.86A 1sbrA-4n0iA:
undetectable
1sbrB-4n0iA:
undetectable		 1sbrA-4n0iA:
18.75
1sbrB-4n0iA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZQ9_A_SAMA4000_0
(PROBABLE
DIMETHYLADENOSINE
TRANSFERASE)		 4n0i GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A,
MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		5 / 12 GLY A 166
LEU A 444
LEU A 432
ILE A 442
MET A 127
 None
 1.10A 1zq9A-4n0iA:
undetectable		 1zq9A-4n0iA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXE_A_1FLA2001_1
(SERUM ALBUMIN)		 4n0i GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A,
MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		5 / 11 LEU A  69
ILE A  68
VAL A 331
GLY A 328
LEU A 297
 None
 1.33A 2bxeA-4n0iA:
undetectable		 2bxeA-4n0iA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXK_A_IMNA2001_1
(SERUM ALBUMIN)		 4n0i GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A,
MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		4 / 8 PHE A 365
ALA A 427
LEU A 361
ASP A 150
 None
None
None
GLN  A 501 ( 4.7A)
 1.14A 2bxkA-4n0iA:
undetectable		 2bxkA-4n0iA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G72_A_SAMA2001_1
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 4n0i GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A,
MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		4 / 6 TYR A 286
GLY A 103
TYR A 285
ASP A  98
 None
GLN  A 501 (-3.8A)
GLN  A 501 (-4.3A)
None
 1.23A 2g72A-4n0iA:
undetectable		 2g72A-4n0iA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GVC_B_MMZB501_1
(MONOOXYGENASE)		 4n0i GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A,
MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		3 / 3 ASN A 341
TYR A 415
SER A 289
 None
None
GLN  A 501 ( 4.3A)
 0.41A 2gvcB-4n0iA:
undetectable		 2gvcB-4n0iA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GVC_E_MMZE501_1
(MONOOXYGENASE)		 4n0i GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A,
MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		3 / 3 ASN A 341
TYR A 415
SER A 289
 None
None
GLN  A 501 ( 4.3A)
 0.42A 2gvcE-4n0iA:
undetectable		 2gvcE-4n0iA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_B_TACB1888_1
(ELONGATION FACTOR
EF-TU)		 4n0i GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT B,
MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		4 / 5 THR B 222
SER B 217
ASP B 219
SER B 216
 None
 1.30A 2hdnA-4n0iB:
undetectable
2hdnB-4n0iB:
undetectable
2hdnD-4n0iB:
undetectable		 2hdnA-4n0iB:
13.64
2hdnB-4n0iB:
24.04
2hdnD-4n0iB:
24.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_D_TACD2888_1
(ELONGATION FACTOR
EF-TU)		 4n0i GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT B,
MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		4 / 5 SER B 216
THR B 222
SER B 217
ASP B 219
 None
 1.33A 2hdnB-4n0iB:
undetectable
2hdnC-4n0iB:
undetectable
2hdnD-4n0iB:
undetectable		 2hdnB-4n0iB:
24.04
2hdnC-4n0iB:
13.64
2hdnD-4n0iB:
24.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IJ7_A_TPFA2472_1
(CYTOCHROME P450 121)		 4n0i GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A,
MITOCHONDRIAL
GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT B,
MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		5 / 11 ASN A 341
ALA A 294
SER A 298
PHE B 109
ARG A 324
 None
 1.47A 2ij7A-4n0iA:
undetectable		 2ij7A-4n0iA:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IJ7_D_TPFD2473_1
(CYTOCHROME P450 121)		 4n0i GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A,
MITOCHONDRIAL
GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT B,
MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		5 / 10 ASN A 341
ALA A 294
SER A 298
PHE B 109
ARG A 324
 None
 1.49A 2ij7D-4n0iA:
undetectable		 2ij7D-4n0iA:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NV4_A_SAMA201_0
(UPF0066 PROTEIN
AF_0241)		 4n0i GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A,
MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		5 / 12 TYR A 171
ASP A 187
PRO A 214
GLY A 172
LEU A 217
 None
 1.25A 2nv4A-4n0iA:
undetectable		 2nv4A-4n0iA:
15.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W8Y_A_486A1000_1
(PROGESTERONE
RECEPTOR)		 4n0i GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A,
MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 457
GLY A 448
GLN A 449
PHE A 203
VAL A 390
 None
 1.36A 2w8yA-4n0iA:
undetectable		 2w8yA-4n0iA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGP_A_PCFA1213_0
(WNT INHIBITORY
FACTOR 1)		 4n0i GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT B,
MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		5 / 12 ILE B 185
LEU B 153
ILE B 215
VAL B 319
PRO B 324
 None
 0.86A 2ygpA-4n0iB:
undetectable		 2ygpA-4n0iB:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZW9_A_SAMA801_0
(LEUCINE CARBOXYL
METHYLTRANSFERASE 2)		 4n0i GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A,
MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		5 / 12 SER A 154
GLY A 101
ASP A  98
ASN A 341
TYR A 285
 GLN  A 501 (-1.2A)
None
None
None
GLN  A 501 (-4.3A)
 1.18A 2zw9A-4n0iA:
undetectable		 2zw9A-4n0iA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3APW_B_DP0B190_1
(ALPHA-1-ACID
GLYCOPROTEIN 2)		 4n0i GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT B,
MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		5 / 12 PHE B  46
PHE B 103
LEU B  78
GLN B  48
ALA B  86
 None
 1.43A 3apwB-4n0iB:
undetectable		 3apwB-4n0iB:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CFL_A_5CHA693_1
(LACTOTRANSFERRIN)		 4n0i GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A,
MITOCHONDRIAL
GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT B,
MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		4 / 4 THR A 149
VAL A  80
GLY B  73
THR B  74
 None
 1.04A 3cflA-4n0iA:
2.3		 3cflA-4n0iA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL9_A_DR7A100_1
(PROTEASE)		 4n0i GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A,
MITOCHONDRIAL
GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT B,
MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		4 / 8 ASP A 187
GLY B  73
PRO A 214
THR A 215
 None
 0.74A 3el9A-4n0iA:
undetectable		 3el9A-4n0iA:
12.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_A_CHDA151_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 4n0i GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A,
MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		4 / 7 TYR A 285
GLY A 152
TYR A 171
ARG A 358
 GLN  A 501 (-4.3A)
GLN  A 501 (-3.6A)
None
None
 0.84A 3elzA-4n0iA:
undetectable		 3elzA-4n0iA:
14.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JZJ_A_ACRA405_1
(ACARBOSE/MALTOSE
BINDING PROTEIN GACH)		 4n0i GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A,
MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		5 / 12 GLU A 292
GLY A 172
ARG A 358
GLY A 152
ARG A 156
 None
None
None
GLN  A 501 (-3.6A)
None
 1.44A 3jzjA-4n0iA:
1.8		 3jzjA-4n0iA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_D_ROCD201_2
(HIV-1 PROTEASE)		 4n0i GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A,
MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		4 / 4 GLY A 190
ASP A 150
GLY A 428
THR A 215
 None
GLN  A 501 ( 4.7A)
None
None
 1.02A 3k4vC-4n0iA:
undetectable		 3k4vC-4n0iA:
11.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVV_C_URFC254_1
(URIDINE
PHOSPHORYLASE)		 4n0i GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT B,
MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		4 / 6 GLY B 318
MET B 323
ILE B 316
VAL B 315
 None
 1.15A 3kvvC-4n0iB:
undetectable		 3kvvC-4n0iB:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDR_A_GJZA506_1
(CHOLESTEROL
24-HYDROXYLASE)		 4n0i GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A,
MITOCHONDRIAL
GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT B,
MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		4 / 6 LEU A 319
PHE A 320
ILE A 303
THR B 173
 None
 1.08A 3mdrA-4n0iA:
undetectable		 3mdrA-4n0iA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OND_A_ADNA506_2
(ADENOSYLHOMOCYSTEINA
SE)		 4n0i GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT B,
MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		3 / 3 GLN B 121
THR B 120
LEU B 151
 None
 0.65A 3ondA-4n0iB:
undetectable		 3ondA-4n0iB:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OND_B_ADNB507_2
(ADENOSYLHOMOCYSTEINA
SE)		 4n0i GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT B,
MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		3 / 3 GLN B 121
THR B 120
LEU B 151
 None
 0.65A 3ondB-4n0iB:
undetectable		 3ondB-4n0iB:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_A_SAMA6735_0
(16S RRNA METHYLASE)		 4n0i GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A,
MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		5 / 12 GLY A 105
PRO A 158
ALA A 135
ALA A 136
THR A  95
 None
 1.06A 3p2kA-4n0iA:
undetectable		 3p2kA-4n0iA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_B_SUEB1201_3
(NS3 PROTEASE, NS4A
PROTEIN)		 4n0i GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A,
MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		4 / 5 SER A 425
PRO A 430
TYR A 450
VAL A 447
 None
 1.41A 3sufC-4n0iA:
undetectable		 3sufC-4n0iA:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_G_ACHG301_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 4n0i GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A,
MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		4 / 8 THR A 392
ARG A 156
LEU A 432
MET A 434
 None
 1.18A 3wipG-4n0iA:
undetectable
3wipH-4n0iA:
undetectable		 3wipG-4n0iA:
20.00
3wipH-4n0iA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_G_ACHG301_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 4n0i GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A,
MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		4 / 8 TYR A 256
THR A 392
LEU A 432
MET A 434
 None
 1.23A 3wipG-4n0iA:
undetectable
3wipH-4n0iA:
undetectable		 3wipG-4n0iA:
20.00
3wipH-4n0iA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_I_ACHI301_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 4n0i GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A,
MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		5 / 9 TYR A 256
THR A 392
ARG A 156
LEU A 432
MET A 434
 None
 1.25A 3wipI-4n0iA:
0.0
3wipJ-4n0iA:
0.0		 3wipI-4n0iA:
20.00
3wipJ-4n0iA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_J_ACHJ301_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 4n0i GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A,
MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		4 / 8 ARG A 156
LEU A 432
MET A 434
THR A 392
 None
 1.27A 3wipF-4n0iA:
undetectable
3wipJ-4n0iA:
undetectable		 3wipF-4n0iA:
20.00
3wipJ-4n0iA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_J_ACHJ301_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 4n0i GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A,
MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		4 / 8 LEU A 432
MET A 434
TYR A 256
THR A 392
 None
 1.31A 3wipF-4n0iA:
undetectable
3wipJ-4n0iA:
undetectable		 3wipF-4n0iA:
20.00
3wipJ-4n0iA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJ1_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 4n0i GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A,
MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		4 / 4 GLU A 292
ASP A 187
ARG A 299
THR A 151
 None
None
None
GLN  A 501 (-4.4A)
 1.31A 4ej1A-4n0iA:
undetectable		 4ej1A-4n0iA:
15.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EOH_A_TEPA402_1
(PYRIDOXAL KINASE)		 4n0i GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A,
MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		4 / 5 SER A 216
GLY A 172
THR A  79
VAL A 189
 None
 0.89A 4eohA-4n0iA:
undetectable		 4eohA-4n0iA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KQI_A_NIOA403_1
(NICOTINATE-NUCLEOTID
E--DIMETHYLBENZIMIDA
ZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 4n0i GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A,
MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		5 / 9 GLY A 328
GLY A 101
PHE A 100
GLU A  99
GLY A 103
 None
None
None
None
GLN  A 501 (-3.8A)
 1.14A 4kqiA-4n0iA:
undetectable		 4kqiA-4n0iA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LB0_A_ACTA401_0
(UNCHARACTERIZED
PROTEIN)		 4n0i GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A,
MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		5 / 9 SER A 154
GLY A 153
TYR A 182
GLY A 152
THR A 151
 GLN  A 501 (-1.2A)
GLN  A 501 (-4.1A)
GLN  A 501 (-4.5A)
GLN  A 501 (-3.6A)
GLN  A 501 (-4.4A)
 1.47A 4lb0A-4n0iA:
undetectable		 4lb0A-4n0iA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PD5_A_GEOA501_1
(NUPC FAMILY PROTEIN)		 4n0i GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT B,
MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		5 / 12 GLY B 218
GLN B 207
ALA B 224
ASN B 246
ILE B 203
 None
 1.17A 4pd5A-4n0iB:
undetectable		 4pd5A-4n0iB:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RKU_A_PQNA5001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 4n0i GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A,
MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		4 / 8 MET A 248
PHE A 252
LEU A 436
PHE A 369
 None
 0.91A 4rkuA-4n0iA:
0.8
4rkuJ-4n0iA:
undetectable		 4rkuA-4n0iA:
21.88
4rkuJ-4n0iA:
6.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RYA_A_MTLA501_0
(ABC TRANSPORTER
SUBSTRATE BINDING
PROTEIN (SORBITOL))		 4n0i GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A,
MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		5 / 12 GLY A 148
ALA A 134
PHE A 145
ALA A  49
VAL A  89
 None
 1.23A 4ryaA-4n0iA:
1.5		 4ryaA-4n0iA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FHZ_A_REAA602_1
(ALDEHYDE
DEHYDROGENASE FAMILY
1 MEMBER A3)		 4n0i GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A,
MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 180
ARG A 176
THR A 151
PHE A 100
MET A 102
 None
None
GLN  A 501 (-4.4A)
None
None
 1.22A 5fhzA-4n0iA:
undetectable		 5fhzA-4n0iA:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G48_B_1FLB1375_1
(DNA POLYMERASE III
SUBUNIT BETA)		 4n0i GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A,
MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		5 / 9 LEU A  44
LEU A 206
ILE A 191
PRO A 169
LEU A 174
 None
 1.49A 5g48B-4n0iA:
undetectable		 5g48B-4n0iA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3C_C_AC2C301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 4n0i GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A,
MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		5 / 11 SER A 154
GLY A 148
VAL A 189
SER A 131
ILE A  55
 GLN  A 501 (-1.2A)
None
None
None
None
 1.17A 5i3cC-4n0iA:
undetectable		 5i3cC-4n0iA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I71_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 4n0i GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A,
MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		5 / 12 ASP A 187
PHE A 100
GLY A 101
GLY A 148
LEU A 147
 None
 1.01A 5i71A-4n0iA:
undetectable		 5i71A-4n0iA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MM4_B_TA1B501_1
(TUBULIN BETA CHAIN)		 4n0i GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A,
MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		5 / 10 VAL A 138
LEU A 206
ALA A 134
THR A 188
PRO A 158
 None
 1.34A 5mm4B-4n0iA:
undetectable		 5mm4B-4n0iA:
11.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MWY_A_YNUA1101_1
(MINERALOCORTICOID
RECEPTOR)		 4n0i GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A,
MITOCHONDRIAL
GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT B,
MITOCHONDRIAL
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		4 / 6 GLN A 184
ARG B 105
CYH A  64
THR A  62
 None
 1.37A 5mwyA-4n0iA:
undetectable		 5mwyA-4n0iA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0S_B_SAMB501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 4n0i GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A,
MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		5 / 12 HIS A 204
GLN A  86
ILE A  91
ALA A  49
VAL A  81
 None
 1.12A 5n0sB-4n0iA:
undetectable		 5n0sB-4n0iA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O4Y_A_CCSA14_0
(PHE-MAA-ASN-PRO-HIS-
LEU-SER-TRP-SER-TRP-
9KK-9KK-ARG-CCS-GLY-
NH2)		 4n0i GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A,
MITOCHONDRIAL
GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT B,
MITOCHONDRIAL
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		4 / 6 PHE A 347
ASN A 350
ARG B 299
GLY A 338
 None
 0.75A 5o4yA-4n0iA:
undetectable		 5o4yA-4n0iA:
3.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BPL_B_PA1B605_1
(LIPID A EXPORT
ATP-BINDING/PERMEASE
PROTEIN MSBA)		 4n0i GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A,
MITOCHONDRIAL
GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT B,
MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		3 / 3 ARG B 105
ARG A 176
ARG A 299
 None
 0.95A 6bplA-4n0iB:
undetectable
6bplB-4n0iB:
undetectable		 6bplA-4n0iB:
11.76
6bplB-4n0iB:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BXM_A_SAMA402_0
(DIPHTHAMIDE
BIOSYNTHESIS ENZYME
DPH2)		 4n0i GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A,
MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		5 / 12 LEU A  92
GLY A  93
VAL A 189
ILE A  55
ASP A  53
 None
 1.13A 6bxmA-4n0iA:
undetectable		 6bxmA-4n0iA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGC_A_ACTA813_0
(GEPHYRIN)		 4n0i GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A,
MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		3 / 3 THR A 287
ALA A 354
LYS A 356
 None
 0.51A 6fgcA-4n0iA:
undetectable		 6fgcA-4n0iA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA817_0
(GEPHYRIN)		 4n0i GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A,
MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		3 / 3 THR A 287
ALA A 354
LYS A 356
 None
 0.49A 6fgdA-4n0iA:
undetectable		 6fgdA-4n0iA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HLP_A_GAWA1501_0
(SUBSTANCE-P
RECEPTOR,SUBSTANCE-P
RECEPTOR)		 4n0i GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT B,
MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		5 / 12 ILE B 250
ILE B 254
ILE B 251
PHE B 193
PHE B 202
 None
 1.15A 6hlpA-4n0iB:
undetectable		 6hlpA-4n0iB:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JMJ_A_ASCA201_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 4n0i GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT B,
MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		4 / 5 GLY B 223
THR B 222
SER B  52
SER B  55
 None
 1.01A 6jmjA-4n0iB:
undetectable		 6jmjA-4n0iB:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JOG_A_ASCA201_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 4n0i GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT B,
MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		4 / 6 GLY B 223
THR B 222
SER B  52
SER B  55
 None
 1.02A 6jogA-4n0iB:
undetectable		 6jogA-4n0iB:
17.85