SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4n0l'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3B_B_CFFB2434_1
(CHITINASE)		 4n0l PREDICTED COMPONENT
OF A
THERMOPHILE-SPECIFIC
DNA REPAIR SYSTEM,
CONTAINS A RAMP
DOMAIN
(Methanopyrus
kandleri) 		4 / 6 GLU A 295
ASP A 297
PHE A 292
ARG A 321
 None
 1.37A 2a3bB-4n0lA:
undetectable		 2a3bB-4n0lA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NMZ_B_ROCB401_2
(PROTEASE)		 4n0l PREDICTED COMPONENT
OF A
THERMOPHILE-SPECIFIC
DNA REPAIR SYSTEM,
CONTAINS A RAMP
DOMAIN
(Methanopyrus
kandleri) 		3 / 3 ARG A  15
VAL A  38
THR A  20
 None
 0.79A 2nmzA-4n0lA:
undetectable		 2nmzA-4n0lA:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YFB_B_ACTB501_0
(METHYL-ACCEPTING
CHEMOTAXIS
TRANSDUCER)		 4n0l PREDICTED COMPONENT
OF A
THERMOPHILE-SPECIFIC
DNA REPAIR SYSTEM,
CONTAINS A RAMP
DOMAIN
(Methanopyrus
kandleri) 		4 / 6 ARG A 150
VAL A  76
ILE A  72
TYR A 151
 None
 1.17A 2yfbB-4n0lA:
undetectable		 2yfbB-4n0lA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_D_ROCD201_4
(HIV-1 PROTEASE)		 4n0l PREDICTED COMPONENT
OF A
THERMOPHILE-SPECIFIC
DNA REPAIR SYSTEM,
CONTAINS A RAMP
DOMAIN
(Methanopyrus
kandleri) 		3 / 3 ARG A  15
VAL A  38
THR A  20
 None
 0.84A 3k4vD-4n0lA:
undetectable		 3k4vD-4n0lA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDT_A_ROCA101_2
(PROTEASE)		 4n0l PREDICTED COMPONENT
OF A
THERMOPHILE-SPECIFIC
DNA REPAIR SYSTEM,
CONTAINS A RAMP
DOMAIN
(Methanopyrus
kandleri) 		3 / 3 ARG A  15
VAL A  38
THR A  20
 None
 0.66A 3ndtA-4n0lA:
undetectable		 3ndtA-4n0lA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NMU_J_SAMJ228_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE
NOP5/NOP56 RELATED
PROTEIN)		 4n0l PREDICTED COMPONENT
OF A
THERMOPHILE-SPECIFIC
DNA REPAIR SYSTEM,
CONTAINS A RAMP
DOMAIN
(Methanopyrus
kandleri) 		5 / 11 GLY A 127
ALA A 124
ILE A 128
GLU A  87
ALA A  80
 None
 1.12A 3nmuB-4n0lA:
0.9
3nmuJ-4n0lA:
undetectable		 3nmuB-4n0lA:
22.08
3nmuJ-4n0lA:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3R_A_9PLA501_1
(CYTOCHROME P450 2A6)		 4n0l PREDICTED COMPONENT
OF A
THERMOPHILE-SPECIFIC
DNA REPAIR SYSTEM,
CONTAINS A RAMP
DOMAIN
(Methanopyrus
kandleri) 		5 / 11 PHE A 224
VAL A  49
GLY A 266
LEU A  54
PHE A 270
 None
 1.11A 3t3rA-4n0lA:
undetectable		 3t3rA-4n0lA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3R_B_9PLB501_1
(CYTOCHROME P450 2A6)		 4n0l PREDICTED COMPONENT
OF A
THERMOPHILE-SPECIFIC
DNA REPAIR SYSTEM,
CONTAINS A RAMP
DOMAIN
(Methanopyrus
kandleri) 		5 / 9 PHE A 270
ILE A 257
GLY A 266
THR A  20
PHE A 224
 None
 1.26A 3t3rB-4n0lA:
undetectable		 3t3rB-4n0lA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_A_ACTA503_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 4n0l PREDICTED COMPONENT
OF A
THERMOPHILE-SPECIFIC
DNA REPAIR SYSTEM,
CONTAINS A RAMP
DOMAIN
(Methanopyrus
kandleri) 		3 / 3 ARG A  40
GLU A 196
THR A 195
 None
 0.93A 3v4tA-4n0lA:
undetectable		 3v4tA-4n0lA:
24.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_B_CLQB303_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4n0l PREDICTED COMPONENT
OF A
THERMOPHILE-SPECIFIC
DNA REPAIR SYSTEM,
CONTAINS A RAMP
DOMAIN
(Methanopyrus
kandleri) 		5 / 11 PHE A 224
ILE A  14
GLY A 266
TYR A 265
ASN A  36
 None
 1.36A 4fglA-4n0lA:
undetectable
4fglB-4n0lA:
undetectable		 4fglA-4n0lA:
20.56
4fglB-4n0lA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G1B_C_ECNC403_1
(FLAVOHEMOGLOBIN)		 4n0l PREDICTED COMPONENT
OF A
THERMOPHILE-SPECIFIC
DNA REPAIR SYSTEM,
CONTAINS A RAMP
DOMAIN
(Methanopyrus
kandleri) 		5 / 9 ILE A 272
LEU A 226
VAL A 228
VAL A 252
LEU A 249
 None
 1.10A 4g1bC-4n0lA:
undetectable		 4g1bC-4n0lA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L9Q_A_9TPA601_1
(SERUM ALBUMIN)		 4n0l PREDICTED COMPONENT
OF A
THERMOPHILE-SPECIFIC
DNA REPAIR SYSTEM,
CONTAINS A RAMP
DOMAIN
(Methanopyrus
kandleri) 		5 / 12 LEU A 136
PRO A 154
ILE A 128
LEU A 160
GLY A 125
 None
 1.33A 4l9qA-4n0lA:
undetectable		 4l9qA-4n0lA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O7G_A_ASCA303_0
(PROBABLE
TRANSMEMBRANE
ASCORBATE
FERRIREDUCTASE 2)		 4n0l PREDICTED COMPONENT
OF A
THERMOPHILE-SPECIFIC
DNA REPAIR SYSTEM,
CONTAINS A RAMP
DOMAIN
(Methanopyrus
kandleri) 		4 / 7 PHE A  62
ILE A 120
TYR A 230
ARG A 171
 None
 1.36A 4o7gA-4n0lA:
undetectable
4o7gB-4n0lA:
undetectable		 4o7gA-4n0lA:
20.87
4o7gB-4n0lA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_B_29SB601_1
(ESTROGEN RECEPTOR)		 4n0l PREDICTED COMPONENT
OF A
THERMOPHILE-SPECIFIC
DNA REPAIR SYSTEM,
CONTAINS A RAMP
DOMAIN
(Methanopyrus
kandleri) 		5 / 12 THR A   7
ALA A 277
LEU A 275
LEU A 347
GLY A 235
 None
 1.03A 4xi3B-4n0lA:
undetectable		 4xi3B-4n0lA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_C_29SC601_1
(ESTROGEN RECEPTOR)		 4n0l PREDICTED COMPONENT
OF A
THERMOPHILE-SPECIFIC
DNA REPAIR SYSTEM,
CONTAINS A RAMP
DOMAIN
(Methanopyrus
kandleri) 		5 / 12 THR A   7
ALA A 277
LEU A 275
LEU A 347
GLY A 235
 None
 1.00A 4xi3C-4n0lA:
undetectable		 4xi3C-4n0lA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUM_A_IMNA502_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4n0l PREDICTED COMPONENT
OF A
THERMOPHILE-SPECIFIC
DNA REPAIR SYSTEM,
CONTAINS A RAMP
DOMAIN
(Methanopyrus
kandleri) 		4 / 7 GLU A 335
ILE A 272
LEU A  54
MET A 246
 None
 0.98A 4xumA-4n0lA:
undetectable		 4xumA-4n0lA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTA_G_MFXG101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 4n0l PREDICTED COMPONENT
OF A
THERMOPHILE-SPECIFIC
DNA REPAIR SYSTEM,
CONTAINS A RAMP
DOMAIN
(Methanopyrus
kandleri) 		4 / 7 SER A  44
ASP A 310
GLY A 225
GLU A  13
 None
 0.87A 5btaA-4n0lA:
undetectable
5btaC-4n0lA:
1.2
5btaD-4n0lA:
undetectable		 5btaA-4n0lA:
23.17
5btaC-4n0lA:
23.17
5btaD-4n0lA:
26.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTF_F_GFNF101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 4n0l PREDICTED COMPONENT
OF A
THERMOPHILE-SPECIFIC
DNA REPAIR SYSTEM,
CONTAINS A RAMP
DOMAIN
(Methanopyrus
kandleri) 		4 / 7 SER A  44
ASP A 310
GLY A 225
GLU A  13
 None
 0.94A 5btfA-4n0lA:
undetectable
5btfB-4n0lA:
undetectable
5btfC-4n0lA:
undetectable		 5btfA-4n0lA:
23.17
5btfB-4n0lA:
26.36
5btfC-4n0lA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F9Z_A_HFGA702_0
(AMINOACYL-TRNA
SYNTHETASE)		 4n0l PREDICTED COMPONENT
OF A
THERMOPHILE-SPECIFIC
DNA REPAIR SYSTEM,
CONTAINS A RAMP
DOMAIN
(Methanopyrus
kandleri) 		5 / 12 LEU A  54
GLY A 225
GLU A 227
ARG A 175
SER A  44
 None
 1.18A 5f9zA-4n0lA:
undetectable		 5f9zA-4n0lA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O4Y_A_CCSA14_0
(PHE-MAA-ASN-PRO-HIS-
LEU-SER-TRP-SER-TRP-
9KK-9KK-ARG-CCS-GLY-
NH2)		 4n0l PREDICTED COMPONENT
OF A
THERMOPHILE-SPECIFIC
DNA REPAIR SYSTEM,
CONTAINS A RAMP
DOMAIN
(Methanopyrus
kandleri) 		4 / 6 PHE A 270
LEU A  10
ARG A 271
GLY A  12
 None
 0.97A 5o4yA-4n0lA:
undetectable		 5o4yA-4n0lA:
3.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TRQ_B_ACTB306_0
(WELO5)		 4n0l PREDICTED COMPONENT
OF A
THERMOPHILE-SPECIFIC
DNA REPAIR SYSTEM,
CONTAINS A RAMP
DOMAIN
(Methanopyrus
kandleri) 		3 / 3 GLU A 105
ARG A 150
TYR A 151
 None
 0.66A 5trqB-4n0lA:
undetectable		 5trqB-4n0lA:
20.91