SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4n0n'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P9G_A_ACTA42_0
(EAFP 2)		 4n0n REPLICASE
POLYPROTEIN 1AB
(Equine
arteritis
virus) 		3 / 3 CYH A  53
ARG A  49
CYH A  56
 ZN  A 502 (-2.2A)
None
ZN  A 502 (-2.4A)
 1.50A 1p9gA-4n0nA:
undetectable		 1p9gA-4n0nA:
9.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TKQ_B_DVAB8_0
(GRAMICIDIN A)		 4n0n REPLICASE
POLYPROTEIN 1AB
(Equine
arteritis
virus) 		4 / 5 VAL A 141
GLY A 140
VAL A 142
TRP A  20
 None
 1.36A 1tkqB-4n0nA:
undetectable		 1tkqB-4n0nA:
4.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOJ_C_FRDC305_1
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 4n0n REPLICASE
POLYPROTEIN 1AB
(Equine
arteritis
virus) 		4 / 5 LEU A 181
GLY A 263
PRO A 184
VAL A 183
 None
 0.90A 2aojA-4n0nA:
undetectable		 2aojA-4n0nA:
13.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA2_B_SCKB951_1
(ACETYLCHOLINESTERASE)		 4n0n REPLICASE
POLYPROTEIN 1AB
(Equine
arteritis
virus) 		4 / 8 TYR A 309
ASP A 264
TYR A 312
HIS A 167
 None
 1.49A 2ha2B-4n0nA:
undetectable		 2ha2B-4n0nA:
24.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_A_SAMA1001_1
(SAM DEPENDENT
METHYLTRANSFERASE)		 4n0n REPLICASE
POLYPROTEIN 1AB
(Equine
arteritis
virus) 		3 / 3 ASP A  80
ASP A 136
ASP A  73
 None
MG  A 509 (-2.8A)
None
 0.49A 2igtA-4n0nA:
2.7		 2igtA-4n0nA:
23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_B_SAMB1002_1
(SAM DEPENDENT
METHYLTRANSFERASE)		 4n0n REPLICASE
POLYPROTEIN 1AB
(Equine
arteritis
virus) 		3 / 3 ASP A  80
ASP A 136
ASP A  73
 None
MG  A 509 (-2.8A)
None
 0.51A 2igtB-4n0nA:
2.4		 2igtB-4n0nA:
23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WA2_B_SAMB1267_0
(NON-STRUCTURAL
PROTEIN 5)		 4n0n REPLICASE
POLYPROTEIN 1AB
(Equine
arteritis
virus) 		6 / 12 SER A 162
GLY A 163
GLY A 261
GLY A 263
GLU A 157
VAL A 259
 SO4  A 508 (-4.0A)
SO4  A 508 (-3.6A)
None
None
None
None
 1.44A 2wa2B-4n0nA:
undetectable		 2wa2B-4n0nA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B6R_B_CRNB603_1
(CREATINE KINASE
B-TYPE)		 4n0n REPLICASE
POLYPROTEIN 1AB
(Equine
arteritis
virus) 		4 / 6 VAL A 183
LEU A 168
CYH A 192
SER A 188
 None
 1.18A 3b6rB-4n0nA:
undetectable		 3b6rB-4n0nA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_B_SVRB512_1
(PHOSPHOLIPASE A2)		 4n0n REPLICASE
POLYPROTEIN 1AB
(Equine
arteritis
virus) 		4 / 5 VAL A 182
THR A 165
THR A 224
ARG A 226
 None
 1.19A 3bjwA-4n0nA:
undetectable		 3bjwA-4n0nA:
14.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DOU_A_SAMA1_1
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)		 4n0n REPLICASE
POLYPROTEIN 1AB
(Equine
arteritis
virus) 		3 / 3 ASP A  80
ASP A 136
ASP A  73
 None
MG  A 509 (-2.8A)
None
 0.76A 3douA-4n0nA:
undetectable		 3douA-4n0nA:
15.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_B_CHDB500_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 4n0n REPLICASE
POLYPROTEIN 1AB
(Equine
arteritis
virus) 		4 / 7 THR A 180
VAL A 239
THR A 237
VAL A 259
 None
 0.67A 3em0B-4n0nA:
undetectable		 3em0B-4n0nA:
15.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G1B_C_ECNC403_1
(FLAVOHEMOGLOBIN)		 4n0n REPLICASE
POLYPROTEIN 1AB
(Equine
arteritis
virus) 		5 / 9 ILE A 223
LEU A 196
VAL A 169
VAL A 183
LEU A 181
 SO4  A 504 (-3.8A)
None
None
None
None
 1.24A 4g1bC-4n0nA:
undetectable		 4g1bC-4n0nA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_H_CVIH301_0
(REGULATORY PROTEIN
TETR)		 4n0n REPLICASE
POLYPROTEIN 1AB
(Equine
arteritis
virus) 		5 / 12 ALA A 187
LEU A 227
ARG A 102
VAL A 113
TYR A 210
 None
 1.40A 5vlmH-4n0nA:
undetectable		 5vlmH-4n0nA:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YNI_A_SAMA401_0
(NSP16 PROTEIN)		 4n0n REPLICASE
POLYPROTEIN 1AB
(Equine
arteritis
virus) 		5 / 12 GLY A 263
GLY A 163
ASP A 264
LEU A 265
ASN A 266
 None
SO4  A 508 (-3.6A)
None
None
None
 1.01A 5yniA-4n0nA:
undetectable		 5yniA-4n0nA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YNM_A_SAMA401_0
(NSP16 PROTEIN)		 4n0n REPLICASE
POLYPROTEIN 1AB
(Equine
arteritis
virus) 		5 / 12 GLY A 263
GLY A 163
ASP A 264
LEU A 265
ASN A 266
 None
SO4  A 508 (-3.6A)
None
None
None
 1.02A 5ynmA-4n0nA:
undetectable		 5ynmA-4n0nA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YOD_D_BEZD201_0
(NS3 PROTEASE)		 4n0n REPLICASE
POLYPROTEIN 1AB
(Equine
arteritis
virus) 		4 / 5 HIS A  29
ALA A  16
SER A  15
GLY A  19
 ZN  A 501 (-3.3A)
None
ZN  A 501 ( 3.8A)
None
 1.09A 5yodD-4n0nA:
undetectable		 5yodD-4n0nA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6N91_A_DCFA401_0
(ADENOSINE DEAMINASE)		 4n0n REPLICASE
POLYPROTEIN 1AB
(Equine
arteritis
virus) 		5 / 12 LEU A 304
LEU A 399
ILE A 349
ALA A 378
ASP A 390
 None
 1.22A 6n91A-4n0nA:
undetectable		 6n91A-4n0nA:
11.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6N91_B_DCFB401_0
(ADENOSINE DEAMINASE)		 4n0n REPLICASE
POLYPROTEIN 1AB
(Equine
arteritis
virus) 		5 / 12 LEU A 304
LEU A 399
ILE A 349
ALA A 378
ASP A 390
 None
 1.19A 6n91B-4n0nA:
undetectable		 6n91B-4n0nA:
11.53