SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4n0q'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7C_A_HLTA4002_1
(SERUM ALBUMIN)		 4n0q LEU/ILE/VAL-BINDING
PROTEIN HOMOLOG 3
(Brucella
melitensis) 		4 / 5 ALA A  31
ALA A  48
LYS A  46
GLU A  49
 None
 1.24A 1e7cA-4n0qA:
undetectable		 1e7cA-4n0qA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MF1_A_ACTA458_0
(ADENYLOSUCCINATE
SYNTHETASE)		 4n0q LEU/ILE/VAL-BINDING
PROTEIN HOMOLOG 3
(Brucella
melitensis) 		4 / 4 GLY A 175
LYS A 174
GLY A 173
HIS A 167
 None
 0.95A 1mf1A-4n0qA:
1.8		 1mf1A-4n0qA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NV8_B_SAMB301_0
(HEMK PROTEIN)		 4n0q LEU/ILE/VAL-BINDING
PROTEIN HOMOLOG 3
(Brucella
melitensis) 		5 / 12 THR A 318
ILE A  55
GLY A  60
GLY A  63
ILE A  25
 None
 1.03A 1nv8B-4n0qA:
4.9		 1nv8B-4n0qA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PKV_A_RBFA100_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 4n0q LEU/ILE/VAL-BINDING
PROTEIN HOMOLOG 3
(Brucella
melitensis) 		5 / 11 SER A 350
LEU A 341
THR A 342
ILE A 308
VAL A 119
 None
 1.24A 1pkvA-4n0qA:
undetectable
1pkvB-4n0qA:
undetectable		 1pkvA-4n0qA:
15.54
1pkvB-4n0qA:
15.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SG9_B_SAMB302_0
(HEMK PROTEIN)		 4n0q LEU/ILE/VAL-BINDING
PROTEIN HOMOLOG 3
(Brucella
melitensis) 		5 / 12 THR A 318
ILE A  55
GLY A  60
GLY A  63
ILE A  25
 None
 1.03A 1sg9B-4n0qA:
2.8		 1sg9B-4n0qA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VQ1_B_SAMB301_0
(N5-GLUTAMINE
METHYLTRANSFERASE,
HEMK)		 4n0q LEU/ILE/VAL-BINDING
PROTEIN HOMOLOG 3
(Brucella
melitensis) 		5 / 12 THR A 318
ILE A  55
GLY A  60
GLY A  63
ILE A  25
 None
 0.96A 1vq1B-4n0qA:
4.6		 1vq1B-4n0qA:
24.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOF_C_FRDC305_1
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 4n0q LEU/ILE/VAL-BINDING
PROTEIN HOMOLOG 3
(Brucella
melitensis) 		4 / 5 GLY A 102
PRO A  32
ALA A  31
ILE A  30
 None
 0.95A 2aofA-4n0qA:
undetectable		 2aofA-4n0qA:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_E_SAME301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 4n0q LEU/ILE/VAL-BINDING
PROTEIN HOMOLOG 3
(Brucella
melitensis) 		5 / 12 LEU A 111
LEU A  98
GLY A  80
ASP A  73
ALA A  83
 None
 1.16A 2br4E-4n0qA:
2.7		 2br4E-4n0qA:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJ3_B_GBNB914_1
(BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE)		 4n0q LEU/ILE/VAL-BINDING
PROTEIN HOMOLOG 3
(Brucella
melitensis) 		5 / 10 TYR A 220
TYR A 224
GLY A 170
GLY A 175
ALA A 177
 None
LEU  A 500 (-4.8A)
None
None
None
 1.09A 2ej3B-4n0qA:
undetectable		 2ej3B-4n0qA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UXO_B_TACB1211_1
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR TTGR)		 4n0q LEU/ILE/VAL-BINDING
PROTEIN HOMOLOG 3
(Brucella
melitensis) 		5 / 11 VAL A 119
LEU A  68
ILE A 338
VAL A 307
ILE A 308
 None
 0.95A 2uxoB-4n0qA:
undetectable		 2uxoB-4n0qA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D41_A_FCNA4001_1
(FOMA PROTEIN)		 4n0q LEU/ILE/VAL-BINDING
PROTEIN HOMOLOG 3
(Brucella
melitensis) 		4 / 8 GLY A 228
GLY A 229
GLY A 259
THR A 266
 None
 0.66A 3d41A-4n0qA:
undetectable		 3d41A-4n0qA:
24.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_A_CHDA150_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 4n0q LEU/ILE/VAL-BINDING
PROTEIN HOMOLOG 3
(Brucella
melitensis) 		5 / 12 GLN A 146
ASN A 270
THR A 122
PHE A 297
TYR A 224
 None
None
LEU  A 500 (-4.0A)
LEU  A 500 (-4.1A)
LEU  A 500 (-4.8A)
 1.44A 3em0A-4n0qA:
undetectable		 3em0A-4n0qA:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_C_H3PC552_1
(GLUTAMATE
DEHYDROGENASE)		 4n0q LEU/ILE/VAL-BINDING
PROTEIN HOMOLOG 3
(Brucella
melitensis) 		3 / 3 TYR A 220
TYR A 172
GLY A 246
 None
LEU  A 500 (-3.6A)
None
 0.70A 3eteB-4n0qA:
5.6
3eteD-4n0qA:
5.1
3eteF-4n0qA:
5.7		 3eteB-4n0qA:
22.54
3eteD-4n0qA:
22.54
3eteF-4n0qA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G4L_C_ROFC903_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 4n0q LEU/ILE/VAL-BINDING
PROTEIN HOMOLOG 3
(Brucella
melitensis) 		3 / 3 SER A 205
GLN A 234
PHE A 204
 None
 0.42A 3g4lC-4n0qA:
undetectable		 3g4lC-4n0qA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_B_SALB3008_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 4n0q LEU/ILE/VAL-BINDING
PROTEIN HOMOLOG 3
(Brucella
melitensis) 		4 / 7 HIS A 329
VAL A 307
ALA A 310
ARG A 314
 None
 0.92A 3kp6B-4n0qA:
undetectable		 3kp6B-4n0qA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P97_A_SAMA263_0
(NON-STRUCTURAL
PROTEIN 5)		 4n0q LEU/ILE/VAL-BINDING
PROTEIN HOMOLOG 3
(Brucella
melitensis) 		6 / 12 GLY A 173
GLY A 247
GLY A 222
THR A 269
ASP A 355
ASP A 143
 None
 1.45A 3p97A-4n0qA:
2.4		 3p97A-4n0qA:
24.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_D_SUED1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 4n0q LEU/ILE/VAL-BINDING
PROTEIN HOMOLOG 3
(Brucella
melitensis) 		5 / 12 GLY A 173
ASP A 178
GLY A 246
PHE A 180
LYS A 181
 None
 1.23A 3sueD-4n0qA:
undetectable		 3sueD-4n0qA:
23.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SXJ_A_SAMA258_0
(PUTATIVE
METHYLTRANSFERASE)		 4n0q LEU/ILE/VAL-BINDING
PROTEIN HOMOLOG 3
(Brucella
melitensis) 		5 / 12 GLN A 146
GLY A 222
GLY A 247
LEU A 245
ALA A 177
 None
 1.10A 3sxjA-4n0qA:
2.3		 3sxjA-4n0qA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SXJ_B_SAMB258_0
(PUTATIVE
METHYLTRANSFERASE)		 4n0q LEU/ILE/VAL-BINDING
PROTEIN HOMOLOG 3
(Brucella
melitensis) 		5 / 12 GLN A 146
GLY A 222
GLY A 247
LEU A 245
ALA A 177
 None
 1.11A 3sxjB-4n0qA:
2.2		 3sxjB-4n0qA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_F_W9TF512_1
(HEMOLYTIC LECTIN
CEL-III)		 4n0q LEU/ILE/VAL-BINDING
PROTEIN HOMOLOG 3
(Brucella
melitensis) 		4 / 6 THR A  34
GLY A  75
ASP A  73
ILE A  30
 None
 0.94A 3w9tF-4n0qA:
undetectable		 3w9tF-4n0qA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CTJ_A_SAMA1263_0
(NON-STRUCTURAL
PROTEIN 5)		 4n0q LEU/ILE/VAL-BINDING
PROTEIN HOMOLOG 3
(Brucella
melitensis) 		6 / 12 GLY A 173
GLY A 247
GLY A 222
THR A 269
ASP A 355
ASP A 143
 None
 1.42A 4ctjA-4n0qA:
undetectable		 4ctjA-4n0qA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CTK_A_SAMA1263_0
(POLYPROTEIN)		 4n0q LEU/ILE/VAL-BINDING
PROTEIN HOMOLOG 3
(Brucella
melitensis) 		6 / 12 GLY A 173
GLY A 247
GLY A 222
THR A 269
ASP A 355
ASP A 143
 None
 1.43A 4ctkA-4n0qA:
2.5		 4ctkA-4n0qA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FVQ_A_ACTA904_0
(TYROSINE-PROTEIN
KINASE JAK2)		 4n0q LEU/ILE/VAL-BINDING
PROTEIN HOMOLOG 3
(Brucella
melitensis) 		3 / 3 PHE A 180
VAL A 165
GLU A 191
 None
 0.77A 4fvqA-4n0qA:
undetectable		 4fvqA-4n0qA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_A_ACTA506_0
(RNA POLYMERASE
3D-POL)		 4n0q LEU/ILE/VAL-BINDING
PROTEIN HOMOLOG 3
(Brucella
melitensis) 		3 / 3 VAL A  88
GLY A  91
LYS A  93
 None
 0.50A 4k50A-4n0qA:
undetectable		 4k50A-4n0qA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_E_ACTE504_0
(RNA POLYMERASE
3D-POL)		 4n0q LEU/ILE/VAL-BINDING
PROTEIN HOMOLOG 3
(Brucella
melitensis) 		3 / 3 VAL A  88
GLY A  91
LYS A  93
 None
 0.41A 4k50E-4n0qA:
undetectable		 4k50E-4n0qA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_I_ACTI504_0
(RNA POLYMERASE
3D-POL)		 4n0q LEU/ILE/VAL-BINDING
PROTEIN HOMOLOG 3
(Brucella
melitensis) 		3 / 3 VAL A  88
GLY A  91
LYS A  93
 None
 0.50A 4k50I-4n0qA:
undetectable		 4k50I-4n0qA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNX_A_T44A501_1
(THYROID HORMONE
RECEPTOR ALPHA)		 4n0q LEU/ILE/VAL-BINDING
PROTEIN HOMOLOG 3
(Brucella
melitensis) 		4 / 6 GLU A 295
GLN A  43
VAL A  99
THR A 100
 None
None
None
LEU  A 500 (-4.6A)
 1.29A 4lnxA-4n0qA:
undetectable		 4lnxA-4n0qA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNX_A_T44A501_1
(THYROID HORMONE
RECEPTOR ALPHA)		 4n0q LEU/ILE/VAL-BINDING
PROTEIN HOMOLOG 3
(Brucella
melitensis) 		4 / 6 SER A 205
GLN A 234
VAL A 197
THR A 198
 None
 1.18A 4lnxA-4n0qA:
undetectable		 4lnxA-4n0qA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R1Z_B_AERB601_1
(CYP17A1 PROTEIN)		 4n0q LEU/ILE/VAL-BINDING
PROTEIN HOMOLOG 3
(Brucella
melitensis) 		4 / 7 ALA A  83
GLY A  75
ALA A  74
THR A  34
 None
 0.61A 4r1zB-4n0qA:
undetectable		 4r1zB-4n0qA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XJ7_A_ADNA303_1
(5'/3'-NUCLEOTIDASE
SURE)		 4n0q LEU/ILE/VAL-BINDING
PROTEIN HOMOLOG 3
(Brucella
melitensis) 		5 / 10 GLY A 228
ASP A 168
ALA A 177
LEU A 250
TYR A 220
 None
 1.12A 4xj7A-4n0qA:
3.2
4xj7B-4n0qA:
3.2		 4xj7A-4n0qA:
24.12
4xj7B-4n0qA:
24.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XV2_A_P06A801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 4n0q LEU/ILE/VAL-BINDING
PROTEIN HOMOLOG 3
(Brucella
melitensis) 		4 / 4 GLY A 215
LEU A 231
PHE A 221
ILE A 166
 None
 0.94A 4xv2A-4n0qA:
undetectable		 4xv2A-4n0qA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E9Q_A_SAMA301_0
(GENOME POLYPROTEIN)		 4n0q LEU/ILE/VAL-BINDING
PROTEIN HOMOLOG 3
(Brucella
melitensis) 		6 / 12 GLY A 173
GLY A 247
GLY A 222
THR A 269
ASP A 355
ASP A 143
 None
 1.44A 5e9qA-4n0qA:
undetectable		 5e9qA-4n0qA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EHG_A_SAMA301_0
(RNA-DIRECTED RNA
POLYMERASE NS5)		 4n0q LEU/ILE/VAL-BINDING
PROTEIN HOMOLOG 3
(Brucella
melitensis) 		6 / 12 GLY A 173
GLY A 247
GLY A 222
THR A 269
ASP A 355
ASP A 143
 None
 1.41A 5ehgA-4n0qA:
undetectable		 5ehgA-4n0qA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EIF_A_SAMA301_0
(GENOME POLYPROTEIN)		 4n0q LEU/ILE/VAL-BINDING
PROTEIN HOMOLOG 3
(Brucella
melitensis) 		6 / 12 GLY A 173
GLY A 247
GLY A 222
THR A 269
ASP A 355
ASP A 143
 None
 1.43A 5eifA-4n0qA:
2.3		 5eifA-4n0qA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EIW_C_SAMC4000_0
(NS5
METHYLTRANSFERASE)		 4n0q LEU/ILE/VAL-BINDING
PROTEIN HOMOLOG 3
(Brucella
melitensis) 		6 / 12 GLY A 173
GLY A 247
GLY A 222
THR A 269
ASP A 355
ASP A 143
 None
 1.42A 5eiwC-4n0qA:
undetectable		 5eiwC-4n0qA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HQA_A_ACRA705_2
(ALPHA-GLUCOSIDASE)		 4n0q LEU/ILE/VAL-BINDING
PROTEIN HOMOLOG 3
(Brucella
melitensis) 		4 / 8 ASN A 300
TRP A 359
PHE A 354
THR A 275
 None
 1.26A 5hqaA-4n0qA:
undetectable		 5hqaA-4n0qA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKM_A_SAMA311_0
(NS5 METHYL
TRANSFERASE)		 4n0q LEU/ILE/VAL-BINDING
PROTEIN HOMOLOG 3
(Brucella
melitensis) 		6 / 12 GLY A 173
GLY A 247
GLY A 222
THR A 269
ASP A 355
ASP A 143
 None
 1.46A 5ikmA-4n0qA:
3.0		 5ikmA-4n0qA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UVM_B_ADNB207_1
(HISTIDINE TRIAD
(HIT) PROTEIN)		 4n0q LEU/ILE/VAL-BINDING
PROTEIN HOMOLOG 3
(Brucella
melitensis) 		6 / 12 VAL A 307
ILE A 334
ILE A 338
LEU A 349
THR A 120
VAL A 119
 None
 1.43A 5uvmB-4n0qA:
undetectable		 5uvmB-4n0qA:
18.77