SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4n0t'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_A_SAMA293_1
(GLYCINE
N-METHYLTRANSFERASE)		 4n0t U4/U6
SNRNA-ASSOCIATED-SPL
ICING FACTOR PRP24
(Saccharomyces
cerevisiae) 		3 / 3 ARG A  38
ASP A 321
ASN A 353
 G  B  50 ( 3.6A)
A  B  51 ( 3.4A)
None
 0.91A 1nbhA-4n0tA:
undetectable		 1nbhA-4n0tA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_D_SAMD3293_1
(GLYCINE
N-METHYLTRANSFERASE)		 4n0t U4/U6
SNRNA-ASSOCIATED-SPL
ICING FACTOR PRP24
(Saccharomyces
cerevisiae) 		3 / 3 ARG A  38
ASP A 321
ASN A 353
 G  B  50 ( 3.6A)
A  B  51 ( 3.4A)
None
 0.92A 1nbhD-4n0tA:
undetectable		 1nbhD-4n0tA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SKX_A_RFPA1_2
(ORPHAN NUCLEAR
RECEPTOR PXR)		 4n0t U4/U6
SNRNA-ASSOCIATED-SPL
ICING FACTOR PRP24
(Saccharomyces
cerevisiae) 		4 / 5 PHE A 234
LEU A 286
MET A 258
LEU A 226
 None
 1.47A 1skxA-4n0tA:
undetectable		 1skxA-4n0tA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA3_A_STRA1001_2
(MINERALOCORTICOID
RECEPTOR)		 4n0t U4/U6
SNRNA-ASSOCIATED-SPL
ICING FACTOR PRP24
(Saccharomyces
cerevisiae) 		4 / 4 LEU A 313
LEU A 316
SER A 384
LEU A 369
 None
 1.17A 1ya3A-4n0tA:
undetectable		 1ya3A-4n0tA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC0_A_MIYA1204_1
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS B FROM
TRANSPOSON TN1 0)		 4n0t U4/U6
SNRNA-ASSOCIATED-SPL
ICING FACTOR PRP24
(Saccharomyces
cerevisiae) 		5 / 12 PHE A 331
GLN A 330
LEU A 327
GLN A 378
LEU A 149
 None
 1.34A 4ac0A-4n0tA:
undetectable		 4ac0A-4n0tA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GC9_A_SAMA401_0
(DIMETHYLADENOSINE
TRANSFERASE 1,
MITOCHONDRIAL)		 4n0t U4/U6
SNRNA-ASSOCIATED-SPL
ICING FACTOR PRP24
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 110
VAL A  57
ASN A  47
LEU A  48
PRO A  49
 None
 0.94A 4gc9A-4n0tA:
undetectable		 4gc9A-4n0tA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J7W_C_MTXC402_1
(THYMIDYLATE SYNTHASE)		 4n0t U4/U6
SNRNA-ASSOCIATED-SPL
ICING FACTOR PRP24
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 301
ILE A 356
LEU A 372
GLY A 354
ILE A 346
 None
 1.21A 5j7wC-4n0tA:
undetectable		 5j7wC-4n0tA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0S_B_SAMB501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 4n0t U4/U6
SNRNA-ASSOCIATED-SPL
ICING FACTOR PRP24
(Saccharomyces
cerevisiae) 		5 / 12 HIS A  69
VAL A  72
ILE A  97
ALA A  93
VAL A 111
 None
 1.17A 5n0sB-4n0tA:
undetectable		 5n0sB-4n0tA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XV7_A_EMHA705_2
(SERINE-ARGININE (SR)
PROTEIN KINASE 1)		 4n0t U4/U6
SNRNA-ASSOCIATED-SPL
ICING FACTOR PRP24
(Saccharomyces
cerevisiae) 		4 / 4 VAL A  45
LEU A  44
LEU A 114
ASP A 164
 None
 1.02A 5xv7A-4n0tA:
undetectable		 5xv7A-4n0tA:
10.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BEO_A_DHIA4_0
((DPR)PY(DHI)PKDL(DGN
))		 4n0t U4/U6
SNRNA-ASSOCIATED-SPL
ICING FACTOR PRP24
(Saccharomyces
cerevisiae) 		3 / 3 TYR A 162
PRO A 150
LEU A 149
 G  B  50 ( 3.5A)
A  B  51 ( 4.8A)
None
 0.70A 6beoA-4n0tA:
undetectable		 6beoA-4n0tA:
3.83