SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4n0v'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HS1_A_017A201_2
(HIV-1 PROTEASE)		 4n0v GLUTATHIONE
S-TRANSFERASE,
N-TERMINAL DOMAIN
(Marinobacter
hydrocarbonoclas
ticus) 		5 / 12 GLY A 173
ALA A 172
ILE A  17
ILE A 204
VAL A 165
 None
 0.90A 2hs1B-4n0vA:
undetectable		 2hs1B-4n0vA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHF_A_ACTA508_0
(CHORISMATE SYNTHASE)		 4n0v GLUTATHIONE
S-TRANSFERASE,
N-TERMINAL DOMAIN
(Marinobacter
hydrocarbonoclas
ticus) 		4 / 5 LEU A  19
ARG A  16
ALA A  18
ILE A   3
 None
 1.18A 2qhfA-4n0vA:
undetectable		 2qhfA-4n0vA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C6G_A_VD3A701_1
(CYTOCHROME P450 2R1)		 4n0v GLUTATHIONE
S-TRANSFERASE,
N-TERMINAL DOMAIN
(Marinobacter
hydrocarbonoclas
ticus) 		5 / 12 ALA A  18
ALA A 172
GLY A   8
ILE A   3
THR A  25
 None
 0.91A 3c6gA-4n0vA:
undetectable		 3c6gA-4n0vA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GC9_A_SAMA401_1
(DIMETHYLADENOSINE
TRANSFERASE 1,
MITOCHONDRIAL)		 4n0v GLUTATHIONE
S-TRANSFERASE,
N-TERMINAL DOMAIN
(Marinobacter
hydrocarbonoclas
ticus) 		3 / 3 GLU A  39
ASP A  34
ASP A   5
 None
 0.55A 4gc9A-4n0vA:
undetectable		 4gc9A-4n0vA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q1X_A_017A101_1
(ASPARTYL PROTEASE)		 4n0v GLUTATHIONE
S-TRANSFERASE,
N-TERMINAL DOMAIN
(Marinobacter
hydrocarbonoclas
ticus) 		5 / 11 GLY A 173
ALA A 172
ILE A  17
ILE A 204
VAL A 165
 None
 0.89A 4q1xA-4n0vA:
undetectable		 4q1xA-4n0vA:
18.87