SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4n14'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JGS_A_SALA256_1
(MULTIPLE ANTIBIOTIC
RESISTANCE PROTEIN
MARR)		 4n14 CELL DIVISION CYCLE
PROTEIN 20 HOMOLOG
(Homo
sapiens) 		4 / 7 VAL A 232
LEU A 241
LEU A 281
VAL A 271
 None
 0.98A 1jgsA-4n14A:
undetectable		 1jgsA-4n14A:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZGF_A_TRUA300_1
(CARBONIC ANHYDRASE
II)		 4n14 CELL DIVISION CYCLE
PROTEIN 20 HOMOLOG
(Homo
sapiens) 		5 / 12 HIS A 301
HIS A 267
VAL A 312
LEU A 305
THR A 304
 None
 1.24A 1zgfA-4n14A:
undetectable		 1zgfA-4n14A:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZWG_B_DAHB98_1
(TYROSINASE
MELC)		 4n14 CELL DIVISION CYCLE
PROTEIN 20 HOMOLOG
(Homo
sapiens) 		5 / 11 HIS A 267
HIS A 301
VAL A 302
SER A 266
ASP A 294
 None
 1.35A 2zwgA-4n14A:
undetectable
2zwgB-4n14A:
undetectable		 2zwgA-4n14A:
21.43
2zwgB-4n14A:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3F8W_A_ADNA300_1
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 4n14 CELL DIVISION CYCLE
PROTEIN 20 HOMOLOG
(Homo
sapiens) 		5 / 12 SER A 266
GLY A 288
VAL A 312
GLY A 284
HIS A 301
 None
 1.12A 3f8wA-4n14A:
undetectable		 3f8wA-4n14A:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB2_A_SAMA1101_0
(STRUCTURAL PROTEIN
VP3)		 4n14 CELL DIVISION CYCLE
PROTEIN 20 HOMOLOG
(Homo
sapiens) 		5 / 12 GLU A 249
GLY A 244
ARG A 270
VAL A 232
ILE A 229
 None
 1.22A 3jb2A-4n14A:
undetectable		 3jb2A-4n14A:
14.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N49_A_SAMA601_1
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 4n14 CELL DIVISION CYCLE
PROTEIN 20 HOMOLOG
(Homo
sapiens) 		4 / 4 ASN A 334
GLY A 307
ASP A 184
ASP A 330
 None
 1.26A 4n49A-4n14A:
undetectable		 4n49A-4n14A:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PWJ_B_30ZB201_1
(TRANSTHYRETIN)		 4n14 CELL DIVISION CYCLE
PROTEIN 20 HOMOLOG
(Homo
sapiens) 		4 / 7 THR A 457
ALA A 459
SER A 448
THR A 450
 None
 0.65A 4pwjB-4n14A:
undetectable		 4pwjB-4n14A:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1K_D_LOCD502_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 4n14 CELL DIVISION CYCLE
PROTEIN 20 HOMOLOG
(Homo
sapiens) 		4 / 4 ASN A 329
SER A 378
ALA A 357
VAL A 358
 None
 0.99A 4x1kC-4n14A:
undetectable		 4x1kC-4n14A:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BOJ_B_4TXB201_1
(TRANSTHYRETIN)		 4n14 CELL DIVISION CYCLE
PROTEIN 20 HOMOLOG
(Homo
sapiens) 		4 / 7 THR A 457
ALA A 459
SER A 448
THR A 450
 None
 0.72A 5bojB-4n14A:
undetectable		 5bojB-4n14A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_A_CUA604_0
(THIOCYANATE
DEHYDROGENASE)		 4n14 CELL DIVISION CYCLE
PROTEIN 20 HOMOLOG
(Homo
sapiens) 		3 / 3 HIS A 300
HIS A 301
HIS A 291
 None
 0.76A 5oexA-4n14A:
9.6		 5oexA-4n14A:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0M_B_DAHB98_0
(MELC
TYROSINASE)		 4n14 CELL DIVISION CYCLE
PROTEIN 20 HOMOLOG
(Homo
sapiens) 		5 / 11 HIS A 267
HIS A 301
VAL A 302
SER A 266
ASP A 294
 None
 1.37A 5z0mA-4n14A:
undetectable
5z0mB-4n14A:
undetectable		 5z0mA-4n14A:
13.49
5z0mB-4n14A:
13.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_A_SUEA1202_0
(NS3 PROTEASE)		 4n14 CELL DIVISION CYCLE
PROTEIN 20 HOMOLOG
(Homo
sapiens) 		5 / 12 ILE A 415
LEU A 406
GLY A 455
SER A 452
ALA A 459
 None
 1.12A 6c2mA-4n14A:
undetectable		 6c2mA-4n14A:
14.43