SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4n17'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JJ8_C_AZZC1211_1
(DEOXYNUCLEOSIDE
KINASE)		 4n17 TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT
(Burkholderia
ambifaria) 		5 / 12 GLU A 252
MET A  87
PHE A 240
ALA A 255
MET A  48
 None
 1.28A 2jj8C-4n17A:
undetectable		 2jj8C-4n17A:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEU_A_ACTA141_0
(PUTATIVE
CARBOXYMUCONOLACTONE
DECARBOXYLASE)		 4n17 TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT
(Burkholderia
ambifaria) 		3 / 3 VAL A  34
ASP A  33
GLU A  73
 None
None
GTR  A 401 ( 2.9A)
 0.74A 2qeuA-4n17A:
undetectable		 2qeuA-4n17A:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEU_A_ACTA141_0
(PUTATIVE
CARBOXYMUCONOLACTONE
DECARBOXYLASE)		 4n17 TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT
(Burkholderia
ambifaria) 		3 / 3 VAL A 321
ASP A 322
GLU A 312
 None
CA  A 403 (-2.5A)
CA  A 403 ( 4.9A)
 0.49A 2qeuA-4n17A:
undetectable		 2qeuA-4n17A:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEU_C_ACTC141_0
(PUTATIVE
CARBOXYMUCONOLACTONE
DECARBOXYLASE)		 4n17 TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT
(Burkholderia
ambifaria) 		3 / 3 VAL A  34
ASP A  33
GLU A  73
 None
None
GTR  A 401 ( 2.9A)
 0.72A 2qeuC-4n17A:
undetectable		 2qeuC-4n17A:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEU_C_ACTC141_0
(PUTATIVE
CARBOXYMUCONOLACTONE
DECARBOXYLASE)		 4n17 TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT
(Burkholderia
ambifaria) 		3 / 3 VAL A 321
ASP A 322
GLU A 312
 None
CA  A 403 (-2.5A)
CA  A 403 ( 4.9A)
 0.49A 2qeuC-4n17A:
undetectable		 2qeuC-4n17A:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XFF_A_QPSA600_1
(BETA-AMYLASE)		 4n17 TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT
(Burkholderia
ambifaria) 		5 / 12 GLU A 236
ARG A  89
GLY A  92
THR A 234
MET A 176
 GTR  A 401 (-2.9A)
GTR  A 401 (-2.7A)
None
None
None
 1.39A 2xffA-4n17A:
undetectable		 2xffA-4n17A:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7W_C_SALC1300_1
(LYSR-TYPE REGULATORY
PROTEIN)		 4n17 TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT
(Burkholderia
ambifaria) 		4 / 7 ILE A 129
GLY A 126
PHE A 111
ILE A 324
 None
 0.80A 2y7wC-4n17A:
5.1		 2y7wC-4n17A:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_S_TFPS202_1
(PROTEIN S100-A4)		 4n17 TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT
(Burkholderia
ambifaria) 		4 / 6 LEU A 110
PHE A 107
ILE A 104
PHE A  95
 None
 1.02A 3ko0S-4n17A:
undetectable		 3ko0S-4n17A:
14.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5I_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 4n17 TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT
(Burkholderia
ambifaria) 		3 / 3 ASP A  33
ARG A 169
ARG A 149
 None
GTR  A 401 (-3.0A)
GTR  A 401 (-3.1A)
 0.96A 4x5iA-4n17A:
undetectable		 4x5iA-4n17A:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZO1_X_T3X500_1
(THYROID HORMONE
RECEPTOR BETA)		 4n17 TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT
(Burkholderia
ambifaria) 		5 / 12 ILE A 256
ALA A 260
MET A  48
LEU A  55
PHE A 240
 None
 1.46A 4zo1X-4n17A:
undetectable		 4zo1X-4n17A:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HNZ_B_TA1B902_1
(TUBULIN BETA-2B
CHAIN)		 4n17 TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT
(Burkholderia
ambifaria) 		5 / 12 GLU A 323
ASP A 113
HIS A 116
ALA A 120
THR A 234
 None
 1.21A 5hnzB-4n17A:
undetectable		 5hnzB-4n17A:
23.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H3D_A_DHIA601_0
(DUF2338
DOMAIN-CONTAINING
PROTEIN)		 4n17 TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT
(Burkholderia
ambifaria) 		4 / 5 TYR A 267
ASN A  91
ARG A  89
PHE A  39
 None
GTR  A 401 (-4.1A)
GTR  A 401 (-2.7A)
None
 1.31A 6h3dA-4n17A:
undetectable		 6h3dA-4n17A:
21.49