SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4n18'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JIN_A_KTNA801_1
(CYTOCHROME P450
107A1)		 4n18 D-ISOMER SPECIFIC
2-HYDROXYACID
DEHYDROGENASE FAMILY
PROTEIN
(Klebsiella
pneumoniae) 		5 / 11 ALA A 246
LEU A 206
ALA A 207
ALA A 208
LEU A 243
 None
 1.04A 1jinA-4n18A:
undetectable		 1jinA-4n18A:
23.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_A_VDYA1002_1
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 4n18 D-ISOMER SPECIFIC
2-HYDROXYACID
DEHYDROGENASE FAMILY
PROTEIN
(Klebsiella
pneumoniae) 		4 / 4 ILE A 270
LEU A 262
VAL A 234
ALA A 208
 None
 1.01A 1mz9A-4n18A:
undetectable		 1mz9A-4n18A:
8.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_A_VDYA1002_3
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 4n18 D-ISOMER SPECIFIC
2-HYDROXYACID
DEHYDROGENASE FAMILY
PROTEIN
(Klebsiella
pneumoniae) 		4 / 5 ILE A 270
LEU A 262
VAL A 234
ALA A 208
 None
 0.98A 1mz9C-4n18A:
undetectable		 1mz9C-4n18A:
8.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E5D_A_NCAA1501_0
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 4n18 D-ISOMER SPECIFIC
2-HYDROXYACID
DEHYDROGENASE FAMILY
PROTEIN
(Klebsiella
pneumoniae) 		4 / 7 ARG A 225
ALA A 200
ARG A 203
ASP A  72
 None
 1.20A 2e5dA-4n18A:
undetectable
2e5dB-4n18A:
undetectable		 2e5dA-4n18A:
19.52
2e5dB-4n18A:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QBO_A_CAMA442_0
(CYTOCHROME P450-CAM)		 4n18 D-ISOMER SPECIFIC
2-HYDROXYACID
DEHYDROGENASE FAMILY
PROTEIN
(Klebsiella
pneumoniae) 		5 / 10 PHE A 251
THR A 271
VAL A 268
ILE A 270
VAL A 269
 None
 1.12A 2qboA-4n18A:
undetectable		 2qboA-4n18A:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD4_A_CHDA803_0
(FERROCHELATASE)		 4n18 D-ISOMER SPECIFIC
2-HYDROXYACID
DEHYDROGENASE FAMILY
PROTEIN
(Klebsiella
pneumoniae) 		4 / 5 LEU A  74
PRO A  75
LEU A  78
ILE A  64
 None
 0.81A 2qd4A-4n18A:
5.5		 2qd4A-4n18A:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VMY_B_GLYB502_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 4n18 D-ISOMER SPECIFIC
2-HYDROXYACID
DEHYDROGENASE FAMILY
PROTEIN
(Klebsiella
pneumoniae) 		4 / 8 TYR A 176
SER A 161
SER A 188
HIS A 136
 None
 1.07A 2vmyA-4n18A:
3.8
2vmyB-4n18A:
3.8		 2vmyA-4n18A:
21.98
2vmyB-4n18A:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VMY_B_GLYB502_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 4n18 D-ISOMER SPECIFIC
2-HYDROXYACID
DEHYDROGENASE FAMILY
PROTEIN
(Klebsiella
pneumoniae) 		4 / 8 TYR A 176
SER A 161
SER A 188
HIS A 136
 None
 1.33A 2vmyA-4n18A:
3.8
2vmyB-4n18A:
3.8		 2vmyA-4n18A:
21.98
2vmyB-4n18A:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_B_SALB3004_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 4n18 D-ISOMER SPECIFIC
2-HYDROXYACID
DEHYDROGENASE FAMILY
PROTEIN
(Klebsiella
pneumoniae) 		4 / 5 ILE A 145
PHE A  93
ASP A  92
GLU A  91
 None
 0.99A 3kp6A-4n18A:
undetectable
3kp6B-4n18A:
undetectable		 3kp6A-4n18A:
17.54
3kp6B-4n18A:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_B_06XB501_1
(CYTOCHROME P450 2B6)		 4n18 D-ISOMER SPECIFIC
2-HYDROXYACID
DEHYDROGENASE FAMILY
PROTEIN
(Klebsiella
pneumoniae) 		4 / 7 ILE A  19
ILE A   6
GLU A 289
VAL A  88
 None
 0.76A 3ua5B-4n18A:
undetectable		 3ua5B-4n18A:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VW1_B_CVIB301_0
(PUTATIVE REGULATORY
PROTEIN)		 4n18 D-ISOMER SPECIFIC
2-HYDROXYACID
DEHYDROGENASE FAMILY
PROTEIN
(Klebsiella
pneumoniae) 		5 / 12 LEU A 196
ILE A 205
LEU A 142
PHE A 185
LEU A 182
 None
 1.49A 3vw1B-4n18A:
undetectable		 3vw1B-4n18A:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F4D_B_CHDB504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4n18 D-ISOMER SPECIFIC
2-HYDROXYACID
DEHYDROGENASE FAMILY
PROTEIN
(Klebsiella
pneumoniae) 		4 / 4 LEU A  74
PRO A  75
LEU A  78
ILE A  64
 None
 0.90A 4f4dB-4n18A:
3.9		 4f4dB-4n18A:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GC9_A_SAMA401_0
(DIMETHYLADENOSINE
TRANSFERASE 1,
MITOCHONDRIAL)		 4n18 D-ISOMER SPECIFIC
2-HYDROXYACID
DEHYDROGENASE FAMILY
PROTEIN
(Klebsiella
pneumoniae) 		5 / 12 GLY A 141
GLY A 146
ILE A 193
LEU A 196
PRO A 197
 CIT  A 402 ( 3.7A)
None
None
None
CIT  A 402 ( 4.8A)
 0.92A 4gc9A-4n18A:
5.5		 4gc9A-4n18A:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OT2_A_NPSA601_1
(SERUM ALBUMIN)		 4n18 D-ISOMER SPECIFIC
2-HYDROXYACID
DEHYDROGENASE FAMILY
PROTEIN
(Klebsiella
pneumoniae) 		5 / 12 PHE A 108
TYR A 100
VAL A 268
GLY A 245
LEU A 248
 None
 1.39A 4ot2A-4n18A:
undetectable		 4ot2A-4n18A:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FHZ_C_REAC602_1
(ALDEHYDE
DEHYDROGENASE FAMILY
1 MEMBER A3)		 4n18 D-ISOMER SPECIFIC
2-HYDROXYACID
DEHYDROGENASE FAMILY
PROTEIN
(Klebsiella
pneumoniae) 		5 / 10 ILE A 193
GLY A 191
ASN A 222
LEU A 220
LEU A 243
 None
 1.19A 5fhzC-4n18A:
3.6		 5fhzC-4n18A:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FSA_A_X2NA590_1
(CYP51 VARIANT1)		 4n18 D-ISOMER SPECIFIC
2-HYDROXYACID
DEHYDROGENASE FAMILY
PROTEIN
(Klebsiella
pneumoniae) 		5 / 12 TYR A 158
LEU A 153
PHE A  98
LEU A 106
PHE A 135
 None
 0.97A 5fsaA-4n18A:
undetectable		 5fsaA-4n18A:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I73_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 4n18 D-ISOMER SPECIFIC
2-HYDROXYACID
DEHYDROGENASE FAMILY
PROTEIN
(Klebsiella
pneumoniae) 		5 / 12 ILE A 149
ALA A 150
GLY A 224
GLY A 141
LEU A 142
 None
None
None
CIT  A 402 ( 3.7A)
None
 0.95A 5i73A-4n18A:
undetectable		 5i73A-4n18A:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJB_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 1)		 4n18 D-ISOMER SPECIFIC
2-HYDROXYACID
DEHYDROGENASE FAMILY
PROTEIN
(Klebsiella
pneumoniae) 		5 / 12 ALA A 284
SER A  46
TYR A  44
ILE A   4
LEU A 300
 None
 1.25A 5ljbA-4n18A:
undetectable		 5ljbA-4n18A:
16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJC_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 1)		 4n18 D-ISOMER SPECIFIC
2-HYDROXYACID
DEHYDROGENASE FAMILY
PROTEIN
(Klebsiella
pneumoniae) 		5 / 12 ALA A 284
SER A  46
TYR A  44
ILE A   4
LEU A 300
 None
 1.25A 5ljcA-4n18A:
undetectable		 5ljcA-4n18A:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_A_CVIA301_0
(REGULATORY PROTEIN
TETR)		 4n18 D-ISOMER SPECIFIC
2-HYDROXYACID
DEHYDROGENASE FAMILY
PROTEIN
(Klebsiella
pneumoniae) 		5 / 12 ALA A  39
SER A  58
LEU A  61
ILE A  64
CYH A  10
 None
 1.34A 5vlmA-4n18A:
undetectable		 5vlmA-4n18A:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_B_NOVB403_1
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		 4n18 D-ISOMER SPECIFIC
2-HYDROXYACID
DEHYDROGENASE FAMILY
PROTEIN
(Klebsiella
pneumoniae) 		4 / 7 PHE A  15
ARG A  17
ALA A  67
GLN A  65
 None
 1.16A 6b89A-4n18A:
undetectable		 6b89A-4n18A:
13.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CI6_A_NBOA606_1
(SERUM ALBUMIN)		 4n18 D-ISOMER SPECIFIC
2-HYDROXYACID
DEHYDROGENASE FAMILY
PROTEIN
(Klebsiella
pneumoniae) 		5 / 12 PHE A 108
TYR A 100
VAL A 268
GLY A 245
LEU A 248
 None
 1.45A 6ci6A-4n18A:
undetectable		 6ci6A-4n18A:
11.45