SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4n1j'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A52_A_ESTA1_1
(ESTROGEN RECEPTOR)		 4n1j NACHT, LRR AND PYD
DOMAINS-CONTAINING
PROTEIN 14
(Homo
sapiens) 		5 / 10 ALA A  53
GLU A  49
LEU A  61
ILE A  78
LEU A  19
 None
 1.42A 1a52A-4n1jA:
undetectable		 1a52A-4n1jA:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A52_A_ESTA1_1
(ESTROGEN RECEPTOR)		 4n1j NACHT, LRR AND PYD
DOMAINS-CONTAINING
PROTEIN 14
(Homo
sapiens) 		6 / 10 ALA A  53
GLU A  49
LEU A  61
MET A  62
ILE A  78
LEU A  27
 None
 1.39A 1a52A-4n1jA:
undetectable		 1a52A-4n1jA:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A52_B_ESTB2_1
(ESTROGEN RECEPTOR)		 4n1j NACHT, LRR AND PYD
DOMAINS-CONTAINING
PROTEIN 14
(Homo
sapiens) 		5 / 10 ALA A  53
GLU A  49
LEU A  61
ILE A  78
LEU A  19
 None
 1.46A 1a52B-4n1jA:
undetectable		 1a52B-4n1jA:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A52_B_ESTB2_1
(ESTROGEN RECEPTOR)		 4n1j NACHT, LRR AND PYD
DOMAINS-CONTAINING
PROTEIN 14
(Homo
sapiens) 		6 / 10 ALA A  53
GLU A  49
LEU A  61
MET A  62
ILE A  78
LEU A  27
 None
 1.38A 1a52B-4n1jA:
undetectable		 1a52B-4n1jA:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PCG_A_ESTA1_1
(ESTROGEN RECEPTOR)		 4n1j NACHT, LRR AND PYD
DOMAINS-CONTAINING
PROTEIN 14
(Homo
sapiens) 		5 / 10 ALA A  53
GLU A  49
MET A  62
ILE A  78
LEU A  27
 None
 1.30A 1pcgA-4n1jA:
undetectable		 1pcgA-4n1jA:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QKU_A_ESTA600_1
(ESTRADIOL RECEPTOR)		 4n1j NACHT, LRR AND PYD
DOMAINS-CONTAINING
PROTEIN 14
(Homo
sapiens) 		5 / 10 ALA A  53
GLU A  49
LEU A  61
MET A  62
ILE A  78
 None
 1.43A 1qkuA-4n1jA:
undetectable		 1qkuA-4n1jA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QKU_A_ESTA600_1
(ESTRADIOL RECEPTOR)		 4n1j NACHT, LRR AND PYD
DOMAINS-CONTAINING
PROTEIN 14
(Homo
sapiens) 		5 / 10 ALA A  53
GLU A  49
MET A  62
ILE A  78
LEU A  27
 None
 1.39A 1qkuA-4n1jA:
undetectable		 1qkuA-4n1jA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QKU_B_ESTB600_1
(ESTRADIOL RECEPTOR)		 4n1j NACHT, LRR AND PYD
DOMAINS-CONTAINING
PROTEIN 14
(Homo
sapiens) 		5 / 10 ALA A  53
GLU A  49
LEU A  61
MET A  62
ILE A  78
 None
 1.44A 1qkuB-4n1jA:
undetectable		 1qkuB-4n1jA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QKU_B_ESTB600_1
(ESTRADIOL RECEPTOR)		 4n1j NACHT, LRR AND PYD
DOMAINS-CONTAINING
PROTEIN 14
(Homo
sapiens) 		5 / 10 ALA A  53
GLU A  49
MET A  62
ILE A  78
LEU A  27
 None
 1.40A 1qkuB-4n1jA:
undetectable		 1qkuB-4n1jA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QKU_C_ESTC600_1
(ESTRADIOL RECEPTOR)		 4n1j NACHT, LRR AND PYD
DOMAINS-CONTAINING
PROTEIN 14
(Homo
sapiens) 		5 / 10 ALA A  53
GLU A  49
LEU A  61
MET A  62
ILE A  78
 None
 1.44A 1qkuC-4n1jA:
undetectable		 1qkuC-4n1jA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QKU_C_ESTC600_1
(ESTRADIOL RECEPTOR)		 4n1j NACHT, LRR AND PYD
DOMAINS-CONTAINING
PROTEIN 14
(Homo
sapiens) 		5 / 10 ALA A  53
GLU A  49
MET A  62
ILE A  78
LEU A  27
 None
 1.40A 1qkuC-4n1jA:
undetectable		 1qkuC-4n1jA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DX3_A_ESTA601_1
(ESTROGEN RECEPTOR)		 4n1j NACHT, LRR AND PYD
DOMAINS-CONTAINING
PROTEIN 14
(Homo
sapiens) 		5 / 10 ALA A  53
GLU A  49
LEU A  61
MET A  62
LEU A  27
 None
 1.40A 5dx3A-4n1jA:
undetectable		 5dx3A-4n1jA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CBZ_B_ESTB602_1
(ESTROGEN RECEPTOR)		 4n1j NACHT, LRR AND PYD
DOMAINS-CONTAINING
PROTEIN 14
(Homo
sapiens) 		5 / 10 ALA A  53
GLU A  49
LEU A  61
ILE A  78
LEU A  19
 None
 1.46A 6cbzB-4n1jA:
undetectable		 6cbzB-4n1jA:
26.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CBZ_B_ESTB602_1
(ESTROGEN RECEPTOR)		 4n1j NACHT, LRR AND PYD
DOMAINS-CONTAINING
PROTEIN 14
(Homo
sapiens) 		5 / 10 ALA A  53
GLU A  49
LEU A  61
MET A  62
ILE A  78
 None
 1.32A 6cbzB-4n1jA:
undetectable		 6cbzB-4n1jA:
26.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CBZ_B_ESTB602_1
(ESTROGEN RECEPTOR)		 4n1j NACHT, LRR AND PYD
DOMAINS-CONTAINING
PROTEIN 14
(Homo
sapiens) 		5 / 10 ALA A  53
GLU A  49
MET A  62
ILE A  78
LEU A  27
 None
 1.29A 6cbzB-4n1jA:
undetectable		 6cbzB-4n1jA:
26.55