SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4n1u'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PXX_B_DIFB1701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4n1u 7,8-DIHYDRO-8-OXOGUA
NINE TRIPHOSPHATASE
(Homo
sapiens) 		5 / 9 VAL A  10
LEU A  11
TRP A 123
VAL A  67
GLY A  68
 None
None
2GE  A 201 (-4.9A)
None
None
 1.21A 1pxxB-4n1uA:
undetectable		 1pxxB-4n1uA:
14.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PXX_D_DIFD3701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4n1u 7,8-DIHYDRO-8-OXOGUA
NINE TRIPHOSPHATASE
(Homo
sapiens) 		5 / 10 VAL A  10
LEU A  11
TRP A 123
VAL A  67
GLY A  68
 None
None
2GE  A 201 (-4.9A)
None
None
 1.21A 1pxxD-4n1uA:
undetectable		 1pxxD-4n1uA:
14.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SJ0_X_DXCX75_0
(CYTOCHROME C7)		 4n1u 7,8-DIHYDRO-8-OXOGUA
NINE TRIPHOSPHATASE
(Homo
sapiens) 		4 / 7 ILE A  91
PHE A  35
MET A 101
GLY A  21
 None
None
SO4  A 202 (-3.5A)
None
 1.24A 3sj0X-4n1uA:
undetectable		 3sj0X-4n1uA:
15.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4C9W_A_VGHA1158_1
(7,8-DIHYDRO-8-OXOGUA
NINE TRIPHOSPHATASE)		 4n1u 7,8-DIHYDRO-8-OXOGUA
NINE TRIPHOSPHATASE
(Homo
sapiens) 		5 / 12 LEU A   9
PHE A 139
VAL A  83
TRP A 117
ASP A 120
 2GE  A 201 (-4.1A)
2GE  A 201 (-3.7A)
2GE  A 201 ( 4.8A)
2GE  A 201 (-3.9A)
2GE  A 201 (-2.8A)
 1.47A 4c9wA-4n1uA:
28.1		 4c9wA-4n1uA:
98.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4C9W_A_VGHA1158_1
(7,8-DIHYDRO-8-OXOGUA
NINE TRIPHOSPHATASE)		 4n1u 7,8-DIHYDRO-8-OXOGUA
NINE TRIPHOSPHATASE
(Homo
sapiens) 		12 / 12 TYR A   7
LEU A   9
ASN A  33
PHE A  72
PHE A  74
MET A  81
VAL A  83
TRP A 117
ASP A 119
ASP A 120
PHE A 139
GLN A 142
 2GE  A 201 ( 4.7A)
2GE  A 201 (-4.1A)
2GE  A 201 (-3.1A)
2GE  A 201 (-3.3A)
2GE  A 201 (-4.8A)
2GE  A 201 ( 4.3A)
2GE  A 201 ( 4.8A)
2GE  A 201 (-3.9A)
2GE  A 201 (-2.8A)
2GE  A 201 (-2.8A)
2GE  A 201 (-3.7A)
None
 0.54A 4c9wA-4n1uA:
28.1		 4c9wA-4n1uA:
98.73