SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4n27'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UXO_B_TACB1211_1
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR TTGR)		 4n27 BACTERIAL
TRANSFERASE
HEXAPEPTIDE REPEAT
(Brucella
abortus) 		5 / 11 VAL A 123
LEU A 134
ILE A  82
VAL A 111
ILE A 129
 None
 1.13A 2uxoB-4n27A:
undetectable		 2uxoB-4n27A:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7W_C_SALC1300_1
(LYSR-TYPE REGULATORY
PROTEIN)		 4n27 BACTERIAL
TRANSFERASE
HEXAPEPTIDE REPEAT
(Brucella
abortus) 		4 / 7 THR A  58
ILE A  54
GLY A  55
ILE A  93
 None
 0.88A 2y7wC-4n27A:
undetectable		 2y7wC-4n27A:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_A_W9TA1002_1
(HEMOLYTIC LECTIN
CEL-III)		 4n27 BACTERIAL
TRANSFERASE
HEXAPEPTIDE REPEAT
(Brucella
abortus) 		3 / 3 ASP A 131
GLU A  95
GLY A  94
 None
 0.69A 3w9tA-4n27A:
undetectable		 3w9tA-4n27A:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FZV_A_SAMA401_1
(PUTATIVE
METHYLTRANSFERASE
NSUN4)		 4n27 BACTERIAL
TRANSFERASE
HEXAPEPTIDE REPEAT
(Brucella
abortus) 		3 / 3 ASP A  48
ARG A  46
ASP A  69
 PE5  A 202 ( 4.0A)
PE5  A 202 (-4.0A)
PE5  A 202 (-3.9A)
 0.88A 4fzvA-4n27A:
undetectable		 4fzvA-4n27A:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_C_SAMC301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 4n27 BACTERIAL
TRANSFERASE
HEXAPEPTIDE REPEAT
(Brucella
abortus) 		5 / 12 ASP A  15
ALA A  14
GLN A  61
GLY A  38
SER A  18
 None
None
PE5  A 203 (-3.0A)
None
None
 1.36A 5hfjC-4n27A:
undetectable		 5hfjC-4n27A:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_A_Z80A401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 4n27 BACTERIAL
TRANSFERASE
HEXAPEPTIDE REPEAT
(Brucella
abortus) 		5 / 11 ILE A 129
VAL A 111
THR A  97
ILE A  99
ALA A 103
 None
 0.95A 5lg3A-4n27A:
undetectable		 5lg3A-4n27A:
17.61