SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4n2c'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CQP_B_803B311_1
(ANTIGEN CD11A (P180))		 4n2c PROTEIN-ARGININE
DEIMINASE TYPE-2
(Homo
sapiens) 		4 / 7 VAL A 417
LEU A 430
VAL A 460
LEU A 561
 None
 0.86A 1cqpA-4n2cA:
undetectable
1cqpB-4n2cA:
undetectable		 1cqpA-4n2cA:
14.22
1cqpB-4n2cA:
14.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N5X_A_TEIA3006_1
(XANTHINE
DEHYDROGENASE)		 4n2c PROTEIN-ARGININE
DEIMINASE TYPE-2
(Homo
sapiens) 		5 / 12 LEU A 555
LEU A 430
SER A 414
VAL A 417
ALA A 458
 None
 1.21A 1n5xA-4n2cA:
undetectable		 1n5xA-4n2cA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N5X_B_TEIB4006_1
(XANTHINE
DEHYDROGENASE)		 4n2c PROTEIN-ARGININE
DEIMINASE TYPE-2
(Homo
sapiens) 		5 / 12 LEU A 555
LEU A 430
SER A 414
VAL A 417
ALA A 458
 None
 1.21A 1n5xB-4n2cA:
undetectable		 1n5xB-4n2cA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TUF_B_AZ1B503_1
(DIAMINOPIMELATE
DECARBOXYLASE)		 4n2c PROTEIN-ARGININE
DEIMINASE TYPE-2
(Homo
sapiens) 		4 / 6 GLU A 474
SER A 404
ARG A 441
ARG A 580
 None
 1.29A 1tufA-4n2cA:
undetectable
1tufB-4n2cA:
undetectable		 1tufA-4n2cA:
19.23
1tufB-4n2cA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B17_A_DIFA701_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 4n2c PROTEIN-ARGININE
DEIMINASE TYPE-2
(Homo
sapiens) 		5 / 10 ALA A 295
ILE A 150
CYH A 155
ASP A 156
PHE A 257
 None
None
None
CA  A 702 ( 2.8A)
None
 1.21A 2b17A-4n2cA:
undetectable		 2b17A-4n2cA:
9.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		 4n2c PROTEIN-ARGININE
DEIMINASE TYPE-2
(Homo
sapiens) 		5 / 12 PHE A 478
ILE A 303
LEU A 304
LEU A 559
PHE A 656
 None
 1.15A 2jn3A-4n2cA:
undetectable		 2jn3A-4n2cA:
11.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IK3_A_0LIA1_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4n2c PROTEIN-ARGININE
DEIMINASE TYPE-2
(Homo
sapiens) 		4 / 7 LEU A 304
VAL A 447
ILE A 429
ARG A 373
 None
 1.19A 3ik3A-4n2cA:
undetectable		 3ik3A-4n2cA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IK3_B_0LIB2_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4n2c PROTEIN-ARGININE
DEIMINASE TYPE-2
(Homo
sapiens) 		4 / 7 LEU A 304
VAL A 447
ILE A 429
ARG A 373
 None
 1.17A 3ik3B-4n2cA:
undetectable		 3ik3B-4n2cA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RF4_A_FUNA201_1
(MACROPHAGE MIGRATION
INHIBITORY FACTOR)		 4n2c PROTEIN-ARGININE
DEIMINASE TYPE-2
(Homo
sapiens) 		5 / 11 SER A 267
ILE A 268
VAL A 212
VAL A 252
ILE A 294
 None
 1.27A 3rf4A-4n2cA:
undetectable
3rf4C-4n2cA:
undetectable		 3rf4A-4n2cA:
10.87
3rf4C-4n2cA:
10.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RF4_B_FUNB202_1
(MACROPHAGE MIGRATION
INHIBITORY FACTOR)		 4n2c PROTEIN-ARGININE
DEIMINASE TYPE-2
(Homo
sapiens) 		5 / 11 ILE A 294
SER A 267
ILE A 268
VAL A 212
VAL A 252
 None
 1.28A 3rf4A-4n2cA:
undetectable
3rf4B-4n2cA:
undetectable		 3rf4A-4n2cA:
10.87
3rf4B-4n2cA:
10.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RF4_C_FUNC203_1
(MACROPHAGE MIGRATION
INHIBITORY FACTOR)		 4n2c PROTEIN-ARGININE
DEIMINASE TYPE-2
(Homo
sapiens) 		5 / 11 ILE A 294
SER A 267
ILE A 268
VAL A 212
VAL A 252
 None
 1.27A 3rf4B-4n2cA:
undetectable
3rf4C-4n2cA:
undetectable		 3rf4B-4n2cA:
10.87
3rf4C-4n2cA:
10.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_A_CHDA1502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4n2c PROTEIN-ARGININE
DEIMINASE TYPE-2
(Homo
sapiens) 		5 / 12 MET A 476
LEU A 462
LEU A 430
SER A 414
VAL A 417
 None
 1.30A 3w1wA-4n2cA:
undetectable		 3w1wA-4n2cA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9P_B_CAMB423_0
(CYTOCHROME P450)		 4n2c PROTEIN-ARGININE
DEIMINASE TYPE-2
(Homo
sapiens) 		5 / 10 THR A  27
LEU A   9
GLY A 110
VAL A  50
VAL A  79
 None
 1.12A 4c9pB-4n2cA:
undetectable		 4c9pB-4n2cA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F4D_A_CHDA504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4n2c PROTEIN-ARGININE
DEIMINASE TYPE-2
(Homo
sapiens) 		5 / 12 LEU A 451
LEU A 411
ARG A 395
THR A 300
VAL A 393
 None
 1.28A 4f4dA-4n2cA:
undetectable		 4f4dA-4n2cA:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G24_A_ACAA1004_1
(PENTATRICOPEPTIDE
REPEAT-CONTAINING
PROTEIN AT2G32230,
MITOCHONDRIAL)		 4n2c PROTEIN-ARGININE
DEIMINASE TYPE-2
(Homo
sapiens) 		4 / 6 LEU A 152
VAL A 153
ASP A 166
GLU A 165
 None
None
CA  A 702 ( 3.2A)
None
 1.06A 4g24A-4n2cA:
undetectable		 4g24A-4n2cA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ACL_A_SASA1111_1
(MCG)		 4n2c PROTEIN-ARGININE
DEIMINASE TYPE-2
(Homo
sapiens) 		4 / 7 TYR A 392
GLU A 165
PRO A 381
PHE A 365
 None
 1.15A 5aclA-4n2cA:
3.9		 5aclA-4n2cA:
10.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GWY_E_010E6_0
(N-[(5-METHYLISOXAZOL
-3-YL)CARBONYL]ALANY
L-L-VALYL-N~1~-((1R,
2Z)-4-(BENZYLOXY)-4-
OXO-1-{[(3R)-2-OXOPY
RROLIDIN-3-YL]METHYL
}BUT-2-ENYL)-L-LEUCI
NAMIDE
MAIN PROTEASE)		 4n2c PROTEIN-ARGININE
DEIMINASE TYPE-2
(Homo
sapiens) 		4 / 4 THR A  94
LEU A  42
HIS A  44
GLY A  65
 None
 1.25A 5gwyA-4n2cA:
undetectable		 5gwyA-4n2cA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KI6_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 4n2c PROTEIN-ARGININE
DEIMINASE TYPE-2
(Homo
sapiens) 		4 / 5 CYH A 613
GLN A 607
PRO A 606
ILE A 528
 None
 1.45A 5ki6A-4n2cA:
undetectable		 5ki6A-4n2cA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L66_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA
TYPE-8,PROTEASOME
SUBUNIT BETA TYPE-5
PROTEASOME SUBUNIT
BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA TYPE-6)		 4n2c PROTEIN-ARGININE
DEIMINASE TYPE-2
(Homo
sapiens) 		5 / 10 THR A  23
THR A  80
ALA A 115
ASP A  91
SER A  85
 None
 1.31A 5l66K-4n2cA:
undetectable
5l66L-4n2cA:
undetectable		 5l66K-4n2cA:
15.72
5l66L-4n2cA:
14.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L66_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA
TYPE-8,PROTEASOME
SUBUNIT BETA TYPE-5
PROTEASOME SUBUNIT
BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA TYPE-6)		 4n2c PROTEIN-ARGININE
DEIMINASE TYPE-2
(Homo
sapiens) 		5 / 10 THR A  23
THR A  80
ALA A 115
ASP A  91
SER A  85
 None
 1.31A 5l66Y-4n2cA:
undetectable
5l66Z-4n2cA:
undetectable		 5l66Y-4n2cA:
15.72
5l66Z-4n2cA:
14.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X80_A_SALA201_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		 4n2c PROTEIN-ARGININE
DEIMINASE TYPE-2
(Homo
sapiens) 		4 / 5 VAL A 456
PRO A 425
GLY A 427
TYR A 424
 None
 1.20A 5x80A-4n2cA:
undetectable
5x80B-4n2cA:
undetectable		 5x80A-4n2cA:
13.50
5x80B-4n2cA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X80_D_SALD201_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		 4n2c PROTEIN-ARGININE
DEIMINASE TYPE-2
(Homo
sapiens) 		4 / 5 PRO A 425
GLY A 427
TYR A 424
VAL A 456
 None
 1.17A 5x80C-4n2cA:
undetectable
5x80D-4n2cA:
undetectable		 5x80C-4n2cA:
13.50
5x80D-4n2cA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YN6_A_SAMA401_0
(NSP16 PROTEIN)		 4n2c PROTEIN-ARGININE
DEIMINASE TYPE-2
(Homo
sapiens) 		5 / 12 GLY A 254
GLY A 231
ASN A 154
LEU A 152
CYH A 155
 None
None
CA  A 702 (-3.1A)
None
None
 1.22A 5yn6A-4n2cA:
undetectable		 5yn6A-4n2cA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YNI_A_SAMA401_0
(NSP16 PROTEIN)		 4n2c PROTEIN-ARGININE
DEIMINASE TYPE-2
(Homo
sapiens) 		5 / 12 GLY A 254
GLY A 231
ASN A 154
LEU A 152
CYH A 155
 None
None
CA  A 702 (-3.1A)
None
None
 1.22A 5yniA-4n2cA:
undetectable		 5yniA-4n2cA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YNM_A_SAMA401_0
(NSP16 PROTEIN)		 4n2c PROTEIN-ARGININE
DEIMINASE TYPE-2
(Homo
sapiens) 		5 / 12 GLY A 254
GLY A 231
ASN A 154
LEU A 152
CYH A 155
 None
None
CA  A 702 (-3.1A)
None
None
 1.23A 5ynmA-4n2cA:
undetectable		 5ynmA-4n2cA:
18.47