SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4n2p'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L2I_A_CCSA417_0
(ESTROGEN RECEPTOR)		 4n2p PROTEIN ARCHEASE
(Pyrococcus
horikoshii) 		3 / 3 GLU A  28
LYS A  87
VAL A  86
 None
 0.89A 1l2iA-4n2pA:
undetectable		 1l2iA-4n2pA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOF_C_FRDC305_1
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 4n2p PROTEIN ARCHEASE
(Pyrococcus
horikoshii) 		4 / 5 ASP A  83
GLY A  20
ALA A  31
ILE A  32
 None
 0.96A 2aofA-4n2pA:
undetectable		 2aofA-4n2pA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYS_P_CHDP310_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4n2p PROTEIN ARCHEASE
(Pyrococcus
horikoshii) 		4 / 7 LEU A 139
GLN A 138
LEU A  67
PHE A  66
 None
 1.07A 2dysP-4n2pA:
undetectable
2dysW-4n2pA:
undetectable		 2dysP-4n2pA:
17.11
2dysW-4n2pA:
13.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLD_A_GW6A1_2
(GLUCOCORTICOID
RECEPTOR)		 4n2p PROTEIN ARCHEASE
(Pyrococcus
horikoshii) 		5 / 9 LEU A  67
LEU A  70
ALA A  29
MET A 125
GLN A 138
 None
 1.25A 3cldA-4n2pA:
undetectable		 3cldA-4n2pA:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O02_B_JN3B1_1
(CELL INVASION
PROTEIN SIPD)		 4n2p PROTEIN ARCHEASE
(Pyrococcus
horikoshii) 		5 / 10 ARG A  17
ILE A  16
ALA A 137
LEU A  67
LEU A  63
 None
 1.03A 3o02A-4n2pA:
undetectable
3o02B-4n2pA:
undetectable		 3o02A-4n2pA:
17.83
3o02B-4n2pA:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_B_SAMB401_1
(MNMC2)		 4n2p PROTEIN ARCHEASE
(Pyrococcus
horikoshii) 		4 / 4 GLU A 112
ASP A 107
ASP A  36
GLU A 104
 None
 1.49A 3vywB-4n2pA:
undetectable		 3vywB-4n2pA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_B_2FAB401_2
(ADENOSINE KINASE)		 4n2p PROTEIN ARCHEASE
(Pyrococcus
horikoshii) 		4 / 5 LEU A  67
ILE A 127
MET A 125
PHE A  27
 None
 0.95A 4dc3B-4n2pA:
undetectable		 4dc3B-4n2pA:
14.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R87_J_SPMJ202_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 4n2p PROTEIN ARCHEASE
(Pyrococcus
horikoshii) 		4 / 7 GLU A  55
TYR A  95
GLU A  57
ARG A  90
 None
 1.31A 4r87J-4n2pA:
undetectable
4r87L-4n2pA:
undetectable		 4r87J-4n2pA:
24.04
4r87L-4n2pA:
24.04