SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4n2r'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BTE_A_LEUA1894_0
(AMINOACYL-TRNA
SYNTHETASE)		 4n2r ALPHA-L-ARABINOFURAN
OSIDASE UMABF62A
(Ustilago
maydis) 		4 / 8 SER A  51
TYR A  58
TYR A 296
HIS A 261
 FUB  A 402 ( 4.4A)
FUB  A 402 ( 3.8A)
None
CA  A 401 (-3.6A)
 1.23A 2bteA-4n2rA:
undetectable		 2bteA-4n2rA:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FK8_A_SAMA302_1
(METHOXY MYCOLIC ACID
SYNTHASE 4)		 4n2r ALPHA-L-ARABINOFURAN
OSIDASE UMABF62A
(Ustilago
maydis) 		3 / 3 SER A  51
THR A 145
GLN A 198
 FUB  A 402 ( 4.4A)
None
CA  A 401 (-2.9A)
 0.79A 2fk8A-4n2rA:
undetectable		 2fk8A-4n2rA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6K_A_ADNA699_1
(CHLORINASE)		 4n2r ALPHA-L-ARABINOFURAN
OSIDASE UMABF62A
(Ustilago
maydis) 		4 / 7 ASP A  36
PHE A  37
TYR A  58
TYR A  52
 FUB  A 402 ( 2.8A)
None
FUB  A 402 ( 3.8A)
None
 1.21A 2q6kA-4n2rA:
undetectable		 2q6kA-4n2rA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZT7_A_GLYA1300_0
(GLYCYL-TRNA
SYNTHETASE)		 4n2r ALPHA-L-ARABINOFURAN
OSIDASE UMABF62A
(Ustilago
maydis) 		4 / 7 GLU A 195
GLU A 213
TYR A 296
SER A 260
 AHR  A 403 (-2.8A)
None
None
None
 1.10A 2zt7A-4n2rA:
undetectable		 2zt7A-4n2rA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A3Y_A_OBNA6000_1
(NA, K-ATPASE ALPHA
SUBUNIT)		 4n2r ALPHA-L-ARABINOFURAN
OSIDASE UMABF62A
(Ustilago
maydis) 		5 / 10 PHE A 157
ALA A  86
PHE A 109
LEU A 129
THR A  88
 None
AHR  A 403 ( 3.9A)
None
None
None
 1.25A 3a3yA-4n2rA:
undetectable		 3a3yA-4n2rA:
13.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E23_A_SAMA221_1
(UNCHARACTERIZED
PROTEIN RPA2492)		 4n2r ALPHA-L-ARABINOFURAN
OSIDASE UMABF62A
(Ustilago
maydis) 		3 / 3 TYR A 296
ASP A 258
HIS A 261
 None
None
CA  A 401 (-3.6A)
 0.88A 3e23A-4n2rA:
undetectable		 3e23A-4n2rA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IB0_A_DIFA701_1
(LACTOTRANSFERRIN)		 4n2r ALPHA-L-ARABINOFURAN
OSIDASE UMABF62A
(Ustilago
maydis) 		4 / 4 PRO A 141
TYR A 165
GLY A 132
THR A 180
 None
None
None
TRS  A 404 (-3.1A)
 1.45A 3ib0A-4n2rA:
undetectable		 3ib0A-4n2rA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RV5_A_DXCA91_0
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 4n2r ALPHA-L-ARABINOFURAN
OSIDASE UMABF62A
(Ustilago
maydis) 		3 / 3 PHE A  90
GLN A 198
PHE A 174
 None
CA  A 401 (-2.9A)
None
 0.77A 3rv5A-4n2rA:
undetectable		 3rv5A-4n2rA:
12.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T7S_C_SAMC300_0
(PUTATIVE
METHYLTRANSFERASE)		 4n2r ALPHA-L-ARABINOFURAN
OSIDASE UMABF62A
(Ustilago
maydis) 		5 / 12 GLY A 140
GLY A 138
GLU A 195
ALA A 159
TYR A 165
 None
None
AHR  A 403 (-2.8A)
None
None
 1.18A 3t7sC-4n2rA:
undetectable		 3t7sC-4n2rA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WQ5_B_ACTB404_0
(TRNA N6-ADENOSINE
THREONYLCARBAMOYLTRA
NSFERASE)		 4n2r ALPHA-L-ARABINOFURAN
OSIDASE UMABF62A
(Ustilago
maydis) 		3 / 3 TYR A 154
ARG A 151
LYS A 152
 None
 1.20A 4wq5B-4n2rA:
undetectable		 4wq5B-4n2rA:
23.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CCL_A_SAMA504_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SMYD3)		 4n2r ALPHA-L-ARABINOFURAN
OSIDASE UMABF62A
(Ustilago
maydis) 		5 / 12 ARG A 220
GLY A 216
ASN A 218
ASN A 250
PHE A 222
 None
 1.31A 5cclA-4n2rA:
undetectable		 5cclA-4n2rA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CCM_A_SAMA504_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SMYD3)		 4n2r ALPHA-L-ARABINOFURAN
OSIDASE UMABF62A
(Ustilago
maydis) 		5 / 12 ARG A 220
GLY A 216
ASN A 218
ASN A 250
PHE A 222
 None
 1.50A 5ccmA-4n2rA:
undetectable		 5ccmA-4n2rA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FSA_B_X2NB590_2
(CYP51 VARIANT1)		 4n2r ALPHA-L-ARABINOFURAN
OSIDASE UMABF62A
(Ustilago
maydis) 		3 / 3 PRO A  41
LEU A 283
SER A 267
 None
 0.81A 5fsaB-4n2rA:
undetectable		 5fsaB-4n2rA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XXG_A_SAMA502_0
(SMYD3)		 4n2r ALPHA-L-ARABINOFURAN
OSIDASE UMABF62A
(Ustilago
maydis) 		5 / 12 ARG A 220
GLY A 216
ASN A 218
ASN A 250
PHE A 222
 None
 1.49A 5xxgA-4n2rA:
undetectable		 5xxgA-4n2rA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YJO_A_SAMA505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SMYD3)		 4n2r ALPHA-L-ARABINOFURAN
OSIDASE UMABF62A
(Ustilago
maydis) 		5 / 12 ARG A 220
GLY A 216
ASN A 218
ASN A 250
PHE A 222
 None
 1.49A 5yjoA-4n2rA:
undetectable		 5yjoA-4n2rA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NKN_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4n2r ALPHA-L-ARABINOFURAN
OSIDASE UMABF62A
(Ustilago
maydis) 		3 / 3 ARG A 266
PHE A 156
PHE A  90
 None
 1.07A 6nknC-4n2rA:
undetectable
6nknJ-4n2rA:
undetectable		 6nknC-4n2rA:
20.23
6nknJ-4n2rA:
10.24