SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4n2z'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BTE_A_LEUA1894_0
(AMINOACYL-TRNA
SYNTHETASE)		 4n2z GH62
ARABINOFURANOSIDASE
(Podospora
anserina) 		4 / 8 SER A  64
TYR A  71
TYR A 320
HIS A 285
 TRS  A 402 ( 4.4A)
TRS  A 402 (-4.6A)
CTR  A 405 ( 3.8A)
CA  A 401 ( 3.3A)
 1.21A 2bteA-4n2zA:
undetectable		 2bteA-4n2zA:
16.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2D55_C_DVAC2_0
(ACTINOMYCIN D)		 4n2z GH62
ARABINOFURANOSIDASE
(Podospora
anserina) 		3 / 3 THR A 140
PRO A 142
PRO A  96
 None
 0.72A 2d55C-4n2zA:
undetectable		 2d55C-4n2zA:
5.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2D55_C_DVAC8_0
(ACTINOMYCIN D)		 4n2z GH62
ARABINOFURANOSIDASE
(Podospora
anserina) 		3 / 3 PRO A  96
THR A 140
PRO A 142
 None
 0.58A 2d55C-4n2zA:
undetectable		 2d55C-4n2zA:
5.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OKC_A_SAMA500_1
(TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN)		 4n2z GH62
ARABINOFURANOSIDASE
(Podospora
anserina) 		4 / 6 THR A  31
THR A  29
ASN A 304
ASP A 301
 None
 1.27A 2okcA-4n2zA:
undetectable		 2okcA-4n2zA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_A_REMA350_2
(RENIN)		 4n2z GH62
ARABINOFURANOSIDASE
(Podospora
anserina) 		4 / 5 TYR A 187
ALA A 218
ALA A 125
MET A 200
 None
 1.07A 3d91A-4n2zA:
undetectable		 3d91A-4n2zA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H0A_A_9RAA500_2
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4n2z GH62
ARABINOFURANOSIDASE
(Podospora
anserina) 		3 / 3 ILE A 289
PHE A 329
HIS A  60
 None
 0.74A 3h0aA-4n2zA:
undetectable		 3h0aA-4n2zA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HRD_E_NIOE5660_1
(NICOTINATE
DEHYDROGENASE LARGE
MOLYBDOPTERIN
SUBUNIT
NICOTINATE
DEHYDROGENASE MEDIUM
MOLYBDOPTERIN
SUBUNIT)		 4n2z GH62
ARABINOFURANOSIDASE
(Podospora
anserina) 		3 / 3 GLU A 216
GLU A 233
TRP A 325
 CTR  A 405 ( 2.8A)
None
None
 1.23A 3hrdA-4n2zA:
undetectable
3hrdE-4n2zA:
undetectable
3hrdF-4n2zA:
undetectable		 3hrdA-4n2zA:
23.33
3hrdE-4n2zA:
23.33
3hrdF-4n2zA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R6W_A_NFZA213_1
(FMN-DEPENDENT
NADH-AZOREDUCTASE 1)		 4n2z GH62
ARABINOFURANOSIDASE
(Podospora
anserina) 		5 / 10 PHE A  78
GLY A 328
PHE A 329
PHE A  89
PHE A  76
 None
 1.20A 3r6wA-4n2zA:
undetectable
3r6wB-4n2zA:
undetectable		 3r6wA-4n2zA:
21.79
3r6wB-4n2zA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E7C_A_ACTA504_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 4n2z GH62
ARABINOFURANOSIDASE
(Podospora
anserina) 		3 / 3 ARG A 188
TRP A 255
GLY A 253
 None
 0.93A 4e7cA-4n2zA:
undetectable		 4e7cA-4n2zA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NED_A_PFNA709_1
(LACTOTRANSFERRIN)		 4n2z GH62
ARABINOFURANOSIDASE
(Podospora
anserina) 		4 / 6 VAL A 164
ASP A 165
SER A  64
PHE A 243
 TRS  A 402 ( 3.8A)
TRS  A 402 (-2.7A)
TRS  A 402 ( 4.4A)
None
 1.17A 4nedA-4n2zA:
undetectable		 4nedA-4n2zA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KGJ_A_X6XA402_1
(PREDICTED
ACETYLTRANSFERASE)		 4n2z GH62
ARABINOFURANOSIDASE
(Podospora
anserina) 		4 / 5 ARG A 241
GLU A 233
ASP A  49
TRP A 325
 CTR  A 405 (-3.0A)
None
TRS  A 402 (-2.7A)
None
 1.48A 5kgjA-4n2zA:
undetectable		 5kgjA-4n2zA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M24_A_9CRA501_1
(RETINOIC ACID
RECEPTOR GAMMA)		 4n2z GH62
ARABINOFURANOSIDASE
(Podospora
anserina) 		5 / 12 PHE A  76
ALA A  63
ILE A  52
PHE A  78
ILE A  47
 None
 1.11A 5m24A-4n2zA:
undetectable		 5m24A-4n2zA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_C_PCFC607_0
(CYTOCHROME B)		 4n2z GH62
ARABINOFURANOSIDASE
(Podospora
anserina) 		5 / 10 PHE A 178
TYR A 117
TYR A 127
THR A 129
PHE A 108
 None
 1.48A 6hu9C-4n2zA:
undetectable		 6hu9C-4n2zA:
22.54