SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4n3n'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDS_A_ESTA350_1
(17-BETA-HYDROXYSTERO
ID-DEHYDROGENASE)		 4n3n EUKARYOTIC
TRANSLATION
INITIATION FACTOR
5B-LIKE PROTEIN,
EIF5B(517-C)
(Chaetomium
thermophilum) 		5 / 12 VAL A 587
LEU A 742
TYR A 744
GLY A 589
SER A 770
 None
 1.42A 1fdsA-4n3nA:
4.3		 1fdsA-4n3nA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_F_THAF6_1
(LIVER
CARBOXYLESTERASE I)		 4n3n EUKARYOTIC
TRANSLATION
INITIATION FACTOR
5B-LIKE PROTEIN,
EIF5B(517-C)
(Chaetomium
thermophilum) 		5 / 12 GLY A 901
LEU A 859
LEU A 887
LEU A 862
LEU A 886
 None
 1.07A 1mx1F-4n3nA:
undetectable		 1mx1F-4n3nA:
23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G70_A_SAMA2001_0
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 4n3n EUKARYOTIC
TRANSLATION
INITIATION FACTOR
5B-LIKE PROTEIN,
EIF5B(517-C)
(Chaetomium
thermophilum) 		5 / 12 GLN A 960
ASP A 909
VAL A 905
ALA A 951
CYH A 928
 None
 1.43A 2g70A-4n3nA:
undetectable		 2g70A-4n3nA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G70_B_SAMB2002_0
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 4n3n EUKARYOTIC
TRANSLATION
INITIATION FACTOR
5B-LIKE PROTEIN,
EIF5B(517-C)
(Chaetomium
thermophilum) 		5 / 12 GLN A 960
ASP A 909
VAL A 905
ALA A 951
CYH A 928
 None
 1.36A 2g70B-4n3nA:
undetectable		 2g70B-4n3nA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIP_A_MTXA605_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 4n3n EUKARYOTIC
TRANSLATION
INITIATION FACTOR
5B-LIKE PROTEIN,
EIF5B(517-C)
(Chaetomium
thermophilum) 		5 / 12 VAL A 644
ALA A 646
LEU A 539
ILE A 592
LEU A 590
 None
 1.04A 2oipA-4n3nA:
undetectable		 2oipA-4n3nA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PNJ_A_CHDA501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4n3n EUKARYOTIC
TRANSLATION
INITIATION FACTOR
5B-LIKE PROTEIN,
EIF5B(517-C)
(Chaetomium
thermophilum) 		5 / 12 LEU A 859
LEU A 862
PHE A 863
ILE A 834
LEU A 927
 None
 1.08A 2pnjA-4n3nA:
2.0		 2pnjA-4n3nA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G4L_C_ROFC903_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 4n3n EUKARYOTIC
TRANSLATION
INITIATION FACTOR
5B-LIKE PROTEIN,
EIF5B(517-C)
(Chaetomium
thermophilum) 		3 / 3 SER A 861
GLN A 860
PHE A 863
 None
 0.62A 3g4lC-4n3nA:
undetectable		 3g4lC-4n3nA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MNE_A_DEXA784_1
(GLUCOCORTICOID
RECEPTOR)		 4n3n EUKARYOTIC
TRANSLATION
INITIATION FACTOR
5B-LIKE PROTEIN,
EIF5B(517-C)
(Chaetomium
thermophilum) 		5 / 12 GLN A 558
ARG A 544
LEU A 753
THR A 764
ILE A 758
 None
 1.28A 3mneA-4n3nA:
undetectable		 3mneA-4n3nA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MNO_A_DEXA784_1
(GLUCOCORTICOID
RECEPTOR)		 4n3n EUKARYOTIC
TRANSLATION
INITIATION FACTOR
5B-LIKE PROTEIN,
EIF5B(517-C)
(Chaetomium
thermophilum) 		5 / 12 GLN A 558
ARG A 544
LEU A 753
THR A 764
ILE A 758
 None
 1.27A 3mnoA-4n3nA:
undetectable		 3mnoA-4n3nA:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MNP_A_DEXA784_1
(GLUCOCORTICOID
RECEPTOR)		 4n3n EUKARYOTIC
TRANSLATION
INITIATION FACTOR
5B-LIKE PROTEIN,
EIF5B(517-C)
(Chaetomium
thermophilum) 		5 / 12 GLN A 558
ARG A 544
LEU A 753
THR A 764
ILE A 758
 None
 1.27A 3mnpA-4n3nA:
undetectable		 3mnpA-4n3nA:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TGV_B_BEZB1_0
(HEME-BINDING PROTEIN
HUTZ)		 4n3n EUKARYOTIC
TRANSLATION
INITIATION FACTOR
5B-LIKE PROTEIN,
EIF5B(517-C)
(Chaetomium
thermophilum) 		4 / 6 GLN A 559
PHE A 565
PRO A 566
LEU A 590
 None
 1.40A 3tgvB-4n3nA:
undetectable		 3tgvB-4n3nA:
12.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TWP_A_SALA404_1
(ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE)		 4n3n EUKARYOTIC
TRANSLATION
INITIATION FACTOR
5B-LIKE PROTEIN,
EIF5B(517-C)
(Chaetomium
thermophilum) 		4 / 7 ASN A 672
ALA A 674
TYR A 654
ARG A 682
 None
 1.13A 3twpA-4n3nA:
undetectable		 3twpA-4n3nA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_G_ACTG305_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 4n3n EUKARYOTIC
TRANSLATION
INITIATION FACTOR
5B-LIKE PROTEIN,
EIF5B(517-C)
(Chaetomium
thermophilum) 		3 / 3 ASP A 892
ARG A 865
LYS A 891
 None
 1.02A 3wipG-4n3nA:
undetectable		 3wipG-4n3nA:
15.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J5J_B_478B401_2
(PROTEASE)		 4n3n EUKARYOTIC
TRANSLATION
INITIATION FACTOR
5B-LIKE PROTEIN,
EIF5B(517-C)
(Chaetomium
thermophilum) 		5 / 10 ALA A 835
ILE A 765
GLY A 784
VAL A 763
VAL A 755
 None
 1.05A 4j5jB-4n3nA:
undetectable		 4j5jB-4n3nA:
10.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N49_A_SAMA601_0
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 4n3n EUKARYOTIC
TRANSLATION
INITIATION FACTOR
5B-LIKE PROTEIN,
EIF5B(517-C)
(Chaetomium
thermophilum) 		5 / 12 GLY A 836
LEU A 839
ILE A 789
THR A 791
LEU A 830
 None
 0.95A 4n49A-4n3nA:
undetectable		 4n49A-4n3nA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBS_A_DIFA503_1
(PENTALENIC ACID
SYNTHASE)		 4n3n EUKARYOTIC
TRANSLATION
INITIATION FACTOR
5B-LIKE PROTEIN,
EIF5B(517-C)
(Chaetomium
thermophilum) 		4 / 7 ALA A 615
LEU A 636
LEU A 633
ILE A 616
 None
 0.66A 4ubsA-4n3nA:
undetectable		 4ubsA-4n3nA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCK_B_SAMB2409_1
(RNA-DIRECTED RNA
POLYMERASE L)		 4n3n EUKARYOTIC
TRANSLATION
INITIATION FACTOR
5B-LIKE PROTEIN,
EIF5B(517-C)
(Chaetomium
thermophilum) 		4 / 6 SER A 861
GLY A 881
GLU A 884
ASP A 930
 None
 1.04A 4uckB-4n3nA:
undetectable		 4uckB-4n3nA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GWY_E_010E6_0
(N-[(5-METHYLISOXAZOL
-3-YL)CARBONYL]ALANY
L-L-VALYL-N~1~-((1R,
2Z)-4-(BENZYLOXY)-4-
OXO-1-{[(3R)-2-OXOPY
RROLIDIN-3-YL]METHYL
}BUT-2-ENYL)-L-LEUCI
NAMIDE
MAIN PROTEASE)		 4n3n EUKARYOTIC
TRANSLATION
INITIATION FACTOR
5B-LIKE PROTEIN,
EIF5B(517-C)
(Chaetomium
thermophilum) 		4 / 4 THR A 595
LEU A 529
HIS A 598
GLY A 530
 None
 1.10A 5gwyA-4n3nA:
undetectable		 5gwyA-4n3nA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW4_A_SAMA801_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE I)		 4n3n EUKARYOTIC
TRANSLATION
INITIATION FACTOR
5B-LIKE PROTEIN,
EIF5B(517-C)
(Chaetomium
thermophilum) 		5 / 12 ILE A1038
GLY A1037
THR A1036
PHE A 992
VAL A1002
 None
 1.14A 5hw4A-4n3nA:
3.0		 5hw4A-4n3nA:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW4_C_SAMC801_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE I)		 4n3n EUKARYOTIC
TRANSLATION
INITIATION FACTOR
5B-LIKE PROTEIN,
EIF5B(517-C)
(Chaetomium
thermophilum) 		5 / 12 ILE A1038
GLY A1037
THR A1036
PHE A 992
VAL A1002
 None
 1.11A 5hw4C-4n3nA:
3.0		 5hw4C-4n3nA:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J2T_C_VLBC503_1
(TUBULIN BETA-2B
CHAIN
TUBULIN ALPHA-1B
CHAIN)		 4n3n EUKARYOTIC
TRANSLATION
INITIATION FACTOR
5B-LIKE PROTEIN,
EIF5B(517-C)
(Chaetomium
thermophilum) 		5 / 9 VAL A 875
ASP A 909
PHE A 929
THR A 879
LEU A 887
 None
 1.31A 5j2tB-4n3nA:
2.0		 5j2tB-4n3nA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NKN_A_LOCA201_2
(NEUTROPHIL
GELATINASE-ASSOCIATE
D LIPOCALIN)		 4n3n EUKARYOTIC
TRANSLATION
INITIATION FACTOR
5B-LIKE PROTEIN,
EIF5B(517-C)
(Chaetomium
thermophilum) 		3 / 3 VAL A 587
LYS A 728
MET A 726
 None
 1.03A 5nknA-4n3nA:
undetectable		 5nknA-4n3nA:
9.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NUN_A_Z80A201_1
(BETA-LACTOGLOBULIN)		 4n3n EUKARYOTIC
TRANSLATION
INITIATION FACTOR
5B-LIKE PROTEIN,
EIF5B(517-C)
(Chaetomium
thermophilum) 		5 / 9 VAL A 817
ILE A 825
LEU A 796
ILE A 793
ILE A 780
 None
 0.99A 5nunA-4n3nA:
undetectable		 5nunA-4n3nA:
10.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_B_C2FB702_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 4n3n EUKARYOTIC
TRANSLATION
INITIATION FACTOR
5B-LIKE PROTEIN,
EIF5B(517-C)
(Chaetomium
thermophilum) 		5 / 12 ARG A 779
ASP A 778
VAL A 817
LEU A 769
ILE A 793
 None
 1.13A 5vooB-4n3nA:
undetectable		 5vooB-4n3nA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_C_C2FC702_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 4n3n EUKARYOTIC
TRANSLATION
INITIATION FACTOR
5B-LIKE PROTEIN,
EIF5B(517-C)
(Chaetomium
thermophilum) 		5 / 12 ARG A 779
ASP A 778
VAL A 817
LEU A 769
ILE A 793
 None
 1.17A 5vooC-4n3nA:
2.5		 5vooC-4n3nA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B58_A_ACTA607_0
(FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT)		 4n3n EUKARYOTIC
TRANSLATION
INITIATION FACTOR
5B-LIKE PROTEIN,
EIF5B(517-C)
(Chaetomium
thermophilum) 		4 / 4 GLY A 836
ARG A 639
ASN A 603
LEU A 880
 None
 1.09A 6b58A-4n3nA:
undetectable		 6b58A-4n3nA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QGB_A_BEZA701_0
(MONO(2-HYDROXYETHYL)
TEREPHTHALATE
HYDROLASE)		 4n3n EUKARYOTIC
TRANSLATION
INITIATION FACTOR
5B-LIKE PROTEIN,
EIF5B(517-C)
(Chaetomium
thermophilum) 		5 / 11 GLY A 530
SER A 632
LEU A 617
ALA A 615
HIS A 598
 None
 1.46A 6qgbA-4n3nA:
undetectable		 6qgbA-4n3nA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QGB_F_BEZF701_0
(MONO(2-HYDROXYETHYL)
TEREPHTHALATE
HYDROLASE)		 4n3n EUKARYOTIC
TRANSLATION
INITIATION FACTOR
5B-LIKE PROTEIN,
EIF5B(517-C)
(Chaetomium
thermophilum) 		5 / 10 GLY A 530
SER A 632
LEU A 617
ALA A 615
HIS A 598
 None
 1.49A 6qgbF-4n3nA:
undetectable		 6qgbF-4n3nA:
21.61