SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4n3s'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CQP_B_803B311_1
(ANTIGEN CD11A (P180))		 4n3s EUKARYOTIC
TRANSLATION
INITIATION FACTOR 5B
(Saccharomyces
cerevisiae) 		4 / 7 VAL A 649
LEU A 678
VAL A 699
LEU A 721
 None
 0.86A 1cqpA-4n3sA:
undetectable
1cqpB-4n3sA:
undetectable		 1cqpA-4n3sA:
18.14
1cqpB-4n3sA:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DDR_A_MTXA200_1
(DIHYDROFOLATE
REDUCTASE)		 4n3s EUKARYOTIC
TRANSLATION
INITIATION FACTOR 5B
(Saccharomyces
cerevisiae) 		6 / 12 ILE A 594
THR A 511
SER A 514
ILE A 515
ARG A 519
LEU A 577
 None
 1.39A 1ddrA-4n3sA:
undetectable		 1ddrA-4n3sA:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SQF_A_SAMA430_1
(SUN PROTEIN)		 4n3s EUKARYOTIC
TRANSLATION
INITIATION FACTOR 5B
(Saccharomyces
cerevisiae) 		3 / 3 PRO A 786
ASP A 791
ASP A 816
 None
 0.73A 1sqfA-4n3sA:
undetectable		 1sqfA-4n3sA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVD_B_SAMB601_1
(CATECHOL-O-METHYLTRA
NSFERASE)		 4n3s EUKARYOTIC
TRANSLATION
INITIATION FACTOR 5B
(Saccharomyces
cerevisiae) 		3 / 3 SER A 579
GLU A 571
ASP A 502
 None
 0.89A 2avdB-4n3sA:
undetectable		 2avdB-4n3sA:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXE_B_1FLB2003_1
(SERUM ALBUMIN)		 4n3s EUKARYOTIC
TRANSLATION
INITIATION FACTOR 5B
(Saccharomyces
cerevisiae) 		5 / 10 LEU A 472
PHE A 447
LEU A 612
LEU A 608
ILE A 425
 None
 1.13A 2bxeB-4n3sA:
undetectable		 2bxeB-4n3sA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G1U_B_ADNB438_1
(ADENOSYLHOMOCYSTEINA
SE)		 4n3s EUKARYOTIC
TRANSLATION
INITIATION FACTOR 5B
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 518
THR A 511
LEU A 572
LEU A 577
GLY A 576
 None
 1.31A 3g1uB-4n3sA:
3.0		 3g1uB-4n3sA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G1U_D_ADND438_1
(ADENOSYLHOMOCYSTEINA
SE)		 4n3s EUKARYOTIC
TRANSLATION
INITIATION FACTOR 5B
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 518
THR A 511
LEU A 572
LEU A 577
GLY A 576
 None
 1.25A 3g1uD-4n3sA:
undetectable		 3g1uD-4n3sA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IB0_A_DIFA701_1
(LACTOTRANSFERRIN)		 4n3s EUKARYOTIC
TRANSLATION
INITIATION FACTOR 5B
(Saccharomyces
cerevisiae) 		4 / 4 PRO A 778
TYR A 805
GLY A 752
THR A 751
 None
 1.47A 3ib0A-4n3sA:
undetectable		 3ib0A-4n3sA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TGV_B_BEZB1_0
(HEME-BINDING PROTEIN
HUTZ)		 4n3s EUKARYOTIC
TRANSLATION
INITIATION FACTOR 5B
(Saccharomyces
cerevisiae) 		4 / 6 GLN A 441
PHE A 447
PRO A 448
LEU A 472
 None
 1.39A 3tgvB-4n3sA:
undetectable		 3tgvB-4n3sA:
14.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V5W_A_8PRA701_2
(G-PROTEIN COUPLED
RECEPTOR KINASE 2)		 4n3s EUKARYOTIC
TRANSLATION
INITIATION FACTOR 5B
(Saccharomyces
cerevisiae) 		3 / 3 LEU A 664
MET A 734
ASP A 728
 None
 0.67A 3v5wA-4n3sA:
undetectable		 3v5wA-4n3sA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7H_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE OXYGENASE)		 4n3s EUKARYOTIC
TRANSLATION
INITIATION FACTOR 5B
(Saccharomyces
cerevisiae) 		3 / 3 ARG A 547
THR A 456
TRP A 610
 None
 1.20A 4d7hA-4n3sA:
undetectable		 4d7hA-4n3sA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DFR_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 4n3s EUKARYOTIC
TRANSLATION
INITIATION FACTOR 5B
(Saccharomyces
cerevisiae) 		6 / 12 ILE A 594
ALA A 528
THR A 511
SER A 514
ILE A 515
ARG A 519
 None
 1.50A 4dfrA-4n3sA:
undetectable		 4dfrA-4n3sA:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DFR_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 4n3s EUKARYOTIC
TRANSLATION
INITIATION FACTOR 5B
(Saccharomyces
cerevisiae) 		6 / 12 ILE A 594
THR A 511
SER A 514
ILE A 515
ARG A 519
LEU A 577
 None
 1.34A 4dfrA-4n3sA:
undetectable		 4dfrA-4n3sA:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYT_A_OBNA1104_2
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 4n3s EUKARYOTIC
TRANSLATION
INITIATION FACTOR 5B
(Saccharomyces
cerevisiae) 		4 / 5 ASP A 502
ASN A 530
ILE A 532
VAL A 600
 None
 1.42A 4hytA-4n3sA:
2.8		 4hytA-4n3sA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NC3_A_ERMA1202_2
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 2B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 4n3s EUKARYOTIC
TRANSLATION
INITIATION FACTOR 5B
(Saccharomyces
cerevisiae) 		4 / 6 THR A 633
ASN A 495
GLN A 617
LEU A 624
 None
 1.21A 4nc3A-4n3sA:
undetectable		 4nc3A-4n3sA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UG5_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE OXYGENASE)		 4n3s EUKARYOTIC
TRANSLATION
INITIATION FACTOR 5B
(Saccharomyces
cerevisiae) 		3 / 3 ARG A 547
THR A 456
TRP A 610
 None
 1.25A 4ug5A-4n3sA:
undetectable		 4ug5A-4n3sA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UGL_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE)		 4n3s EUKARYOTIC
TRANSLATION
INITIATION FACTOR 5B
(Saccharomyces
cerevisiae) 		3 / 3 ARG A 547
THR A 456
TRP A 610
 None
 1.25A 4uglA-4n3sA:
undetectable		 4uglA-4n3sA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XJ7_D_ADND303_1
(5'/3'-NUCLEOTIDASE
SURE)		 4n3s EUKARYOTIC
TRANSLATION
INITIATION FACTOR 5B
(Saccharomyces
cerevisiae) 		5 / 10 LEU A 664
LEU A 721
SER A 717
ALA A 709
ILE A 662
 None
None
EDO  A 903 (-2.9A)
None
None
 1.07A 4xj7C-4n3sA:
2.4
4xj7D-4n3sA:
undetectable		 4xj7C-4n3sA:
23.78
4xj7D-4n3sA:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EML_A_SAMA701_1
(PROTEIN ARGININE
N-METHYLTRANSFERASE
5)		 4n3s EUKARYOTIC
TRANSLATION
INITIATION FACTOR 5B
(Saccharomyces
cerevisiae) 		4 / 6 LYS A 420
GLY A 479
GLU A 481
ASP A 812
 None
 1.31A 5emlA-4n3sA:
2.2		 5emlA-4n3sA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G6C_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE OXYGENASE)		 4n3s EUKARYOTIC
TRANSLATION
INITIATION FACTOR 5B
(Saccharomyces
cerevisiae) 		3 / 3 ARG A 547
THR A 456
TRP A 610
 None
 1.24A 5g6cA-4n3sA:
undetectable		 5g6cA-4n3sA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NUN_A_Z80A201_1
(BETA-LACTOGLOBULIN)		 4n3s EUKARYOTIC
TRANSLATION
INITIATION FACTOR 5B
(Saccharomyces
cerevisiae) 		5 / 9 VAL A 699
ILE A 707
LEU A 678
ILE A 675
ILE A 662
 None
 0.99A 5nunA-4n3sA:
undetectable		 5nunA-4n3sA:
13.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y80_A_IREA402_0
(CYCLIN-G-ASSOCIATED
KINASE)		 4n3s EUKARYOTIC
TRANSLATION
INITIATION FACTOR 5B
(Saccharomyces
cerevisiae) 		5 / 11 ALA A 701
ILE A 496
ASN A 495
THR A 616
ILE A 498
 None
 1.31A 5y80A-4n3sA:
undetectable		 5y80A-4n3sA:
8.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B58_A_ACTA607_0
(FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT)		 4n3s EUKARYOTIC
TRANSLATION
INITIATION FACTOR 5B
(Saccharomyces
cerevisiae) 		4 / 4 GLY A 718
ARG A 521
ASN A 485
LEU A 762
 None
 1.03A 6b58A-4n3sA:
undetectable		 6b58A-4n3sA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ESM_A_PZEA307_1
(MATRIX
METALLOPROTEINASE-9,
MATRIX
METALLOPROTEINASE-9)		 4n3s EUKARYOTIC
TRANSLATION
INITIATION FACTOR 5B
(Saccharomyces
cerevisiae) 		3 / 3 TYR A 693
HIS A 695
PHE A 643
 None
 1.03A 6esmA-4n3sA:
undetectable		 6esmA-4n3sA:
12.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QGB_A_BEZA701_0
(MONO(2-HYDROXYETHYL)
TEREPHTHALATE
HYDROLASE)		 4n3s EUKARYOTIC
TRANSLATION
INITIATION FACTOR 5B
(Saccharomyces
cerevisiae) 		5 / 11 GLY A 412
SER A 514
LEU A 499
ALA A 497
HIS A 480
 None
 1.49A 6qgbA-4n3sA:
undetectable		 6qgbA-4n3sA:
21.10