SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4n3w'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CDQ_B_SAMB1500_0
(ASPARTOKINASE)		 4n3w CREB-BINDING PROTEIN
(Homo
sapiens) 		4 / 7 SER A1136
ASP A1134
SER A1108
LEU A1098
 None
 1.01A 2cdqB-4n3wA:
undetectable		 2cdqB-4n3wA:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XF3_A_J01A500_1
(ORF12)		 4n3w CREB-BINDING PROTEIN
(Homo
sapiens) 		5 / 10 VAL A1157
ILE A1138
LEU A1196
LEU A1142
ALA A1093
 None
 1.20A 2xf3A-4n3wA:
undetectable		 2xf3A-4n3wA:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IK3_A_0LIA1_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4n3w CREB-BINDING PROTEIN
(Homo
sapiens) 		4 / 7 LEU A1275
TYR A1204
VAL A1295
ARG A1288
 None
 1.25A 3ik3A-4n3wA:
undetectable		 3ik3A-4n3wA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IK3_B_0LIB2_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4n3w CREB-BINDING PROTEIN
(Homo
sapiens) 		4 / 7 LEU A1275
TYR A1204
VAL A1295
ARG A1288
 None
 1.22A 3ik3B-4n3wA:
undetectable		 3ik3B-4n3wA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U5K_B_08JB2_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 4n3w CREB-BINDING PROTEIN
(Homo
sapiens) 		4 / 7 PRO A1110
VAL A1115
LEU A1120
ASN A1168
 None
 0.51A 3u5kB-4n3wA:
13.5		 3u5kB-4n3wA:
20.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4A9K_A_TYLA2200_1
(CREB-BINDING PROTEIN)		 4n3w CREB-BINDING PROTEIN
(Homo
sapiens) 		6 / 6 VAL A1115
LEU A1120
ILE A1122
TYR A1167
ASN A1168
VAL A1174
 None
 0.78A 4a9kA-4n3wA:
17.7		 4a9kA-4n3wA:
98.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4A9K_B_TYLB2198_1
(CREB-BINDING PROTEIN)		 4n3w CREB-BINDING PROTEIN
(Homo
sapiens) 		5 / 5 VAL A1115
LEU A1120
ILE A1122
ASN A1168
VAL A1174
 None
 0.54A 4a9kB-4n3wA:
18.0		 4a9kB-4n3wA:
98.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C66_A_H4CA1168_0
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 4n3w CREB-BINDING PROTEIN
(Homo
sapiens) 		5 / 9 PRO A1110
GLN A1113
VAL A1115
LEU A1120
ASN A1168
 None
 0.66A 4c66A-4n3wA:
13.7		 4c66A-4n3wA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y03_A_SALA801_1
(PROTEIN POLYBROMO-1)		 4n3w CREB-BINDING PROTEIN
(Homo
sapiens) 		4 / 7 TYR A1125
MET A1160
ALA A1164
ASN A1168
 None
 0.58A 4y03A-4n3wA:
12.3		 4y03A-4n3wA:
24.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HRQ_K_IPHK101_0
(INSULIN A-CHAIN
INSULIN B-CHAIN)		 4n3w CREB-BINDING PROTEIN
(Homo
sapiens) 		4 / 6 VAL A1295
CYH A1308
CYH A1283
HIS A1291
 None
ZN  A1402 (-2.3A)
ZN  A1402 (-2.2A)
ZN  A1401 (-3.0A)
 1.34A 5hrqH-4n3wA:
undetectable
5hrqK-4n3wA:
undetectable
5hrqL-4n3wA:
undetectable		 5hrqH-4n3wA:
7.79
5hrqK-4n3wA:
8.42
5hrqL-4n3wA:
7.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5PBE_A_TYLA2001_1
(BROMODOMAIN ADJACENT
TO ZINC FINGER
DOMAIN PROTEIN 2B)		 4n3w CREB-BINDING PROTEIN
(Homo
sapiens) 		4 / 6 PRO A1110
VAL A1115
TYR A1125
ASN A1168
 None
 0.49A 5pbeA-4n3wA:
13.3		 5pbeA-4n3wA:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y1Y_A_HNQA201_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 4n3w CREB-BINDING PROTEIN
(Homo
sapiens) 		4 / 8 PRO A1110
VAL A1115
LEU A1120
TYR A1167
 None
 0.42A 5y1yA-4n3wA:
13.4		 5y1yA-4n3wA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y1Y_A_HNQA201_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 4n3w CREB-BINDING PROTEIN
(Homo
sapiens) 		4 / 8 VAL A1115
LEU A1120
TYR A1167
ASN A1168
 None
 0.46A 5y1yA-4n3wA:
13.4		 5y1yA-4n3wA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JNH_A_ASCA202_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 4n3w CREB-BINDING PROTEIN
(Homo
sapiens) 		3 / 3 ASN A1163
PRO A1258
GLN A1259
 None
 0.78A 6jnhA-4n3wA:
undetectable		 6jnhA-4n3wA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JOG_A_ASCA202_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 4n3w CREB-BINDING PROTEIN
(Homo
sapiens) 		3 / 3 ASN A1163
PRO A1258
GLN A1259
 None
 0.76A 6jogA-4n3wA:
undetectable		 6jogA-4n3wA:
21.29