SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4n40'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YDA_A_AZMA264_1
(CARBONIC ANHYDRASE
II)		 4n40 PROTEIN ECT2
(Homo
sapiens) 		6 / 10 HIS A 279
VAL A 281
PHE A 250
VAL A 301
THR A 262
TRP A 305
 None
 1.43A 1ydaA-4n40A:
undetectable		 1ydaA-4n40A:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YDB_A_AZMA264_1
(CARBONIC ANHYDRASE
II)		 4n40 PROTEIN ECT2
(Homo
sapiens) 		6 / 11 HIS A 279
VAL A 281
PHE A 250
VAL A 301
THR A 262
TRP A 305
 None
 1.40A 1ydbA-4n40A:
undetectable		 1ydbA-4n40A:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YDD_A_AZMA264_1
(CARBONIC ANHYDRASE
II)		 4n40 PROTEIN ECT2
(Homo
sapiens) 		5 / 10 HIS A 279
VAL A 281
PHE A 250
VAL A 301
THR A 262
 None
 1.38A 1yddA-4n40A:
undetectable		 1yddA-4n40A:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H4N_A_AZMA264_1
(CARBONIC ANHYDRASE
II)		 4n40 PROTEIN ECT2
(Homo
sapiens) 		5 / 9 HIS A 279
VAL A 281
PHE A 250
THR A 262
TRP A 305
 None
 1.43A 2h4nA-4n40A:
undetectable		 2h4nA-4n40A:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DAZ_A_MZMA263_1
(CARBONIC ANHYDRASE 2)		 4n40 PROTEIN ECT2
(Homo
sapiens) 		5 / 10 HIS A 279
VAL A 281
PHE A 250
THR A 262
TRP A 305
 None
 1.43A 3dazA-4n40A:
undetectable		 3dazA-4n40A:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DC3_A_AZMA263_1
(CARBONIC ANHYDRASE 2)		 4n40 PROTEIN ECT2
(Homo
sapiens) 		6 / 12 HIS A 279
VAL A 281
PHE A 250
VAL A 301
THR A 262
TRP A 305
 None
 1.41A 3dc3A-4n40A:
undetectable		 3dc3A-4n40A:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DCS_A_MZMA263_1
(CARBONIC ANHYDRASE 2)		 4n40 PROTEIN ECT2
(Homo
sapiens) 		5 / 10 HIS A 279
VAL A 281
PHE A 250
THR A 262
TRP A 305
 None
 1.44A 3dcsA-4n40A:
undetectable		 3dcsA-4n40A:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E22_B_LOCB700_2
(TUBULIN BETA-2B
CHAIN)		 4n40 PROTEIN ECT2
(Homo
sapiens) 		5 / 11 LEU A 124
LEU A  69
ALA A  68
ALA A  59
VAL A  98
 None
 1.30A 3e22B-4n40A:
undetectable		 3e22B-4n40A:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP3_B_AICB2002_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 4n40 PROTEIN ECT2
(Homo
sapiens) 		3 / 3 ALA A 227
ARG A 232
LYS A 236
 None
 1.03A 3kp3B-4n40A:
undetectable		 3kp3B-4n40A:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KWA_A_SPMA300_1
(CARBONIC ANHYDRASE 2)		 4n40 PROTEIN ECT2
(Homo
sapiens) 		5 / 11 HIS A 279
VAL A 281
PHE A 250
VAL A 301
THR A 262
 None
 1.34A 3kwaA-4n40A:
undetectable		 3kwaA-4n40A:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KWA_A_SPMA300_1
(CARBONIC ANHYDRASE 2)		 4n40 PROTEIN ECT2
(Homo
sapiens) 		5 / 11 HIS A 279
VAL A 281
PHE A 250
VAL A 301
TRP A 305
 None
 1.36A 3kwaA-4n40A:
undetectable		 3kwaA-4n40A:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LK0_D_Z80D92_1
(PROTEIN S100-B)		 4n40 PROTEIN ECT2
(Homo
sapiens) 		3 / 3 HIS A 169
PHE A 102
PHE A 107
 None
 0.71A 3lk0D-4n40A:
undetectable		 3lk0D-4n40A:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ML5_A_AZMA264_1
(CARBONIC ANHYDRASE 7)		 4n40 PROTEIN ECT2
(Homo
sapiens) 		5 / 11 HIS A 279
VAL A 281
PHE A 250
VAL A 301
TRP A 305
 None
 1.34A 3ml5A-4n40A:
undetectable		 3ml5A-4n40A:
24.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V2J_A_AZMA302_1
(CARBONIC ANHYDRASE 2)		 4n40 PROTEIN ECT2
(Homo
sapiens) 		6 / 11 HIS A 279
VAL A 281
PHE A 250
VAL A 301
THR A 262
TRP A 305
 None
 1.43A 3v2jA-4n40A:
undetectable		 3v2jA-4n40A:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JQ1_B_NPSB401_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 4n40 PROTEIN ECT2
(Homo
sapiens) 		4 / 8 VAL A  53
VAL A  74
ILE A  72
LEU A 124
 None
 0.93A 4jq1B-4n40A:
undetectable		 4jq1B-4n40A:
23.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_B_AERB601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4n40 PROTEIN ECT2
(Homo
sapiens) 		5 / 12 LEU A  55
ILE A  66
LEU A  65
GLY A  75
VAL A 123
 None
 0.84A 4nkvB-4n40A:
undetectable		 4nkvB-4n40A:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_C_STRC601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4n40 PROTEIN ECT2
(Homo
sapiens) 		5 / 12 LEU A  55
ILE A  66
GLY A  75
ILE A 118
VAL A 123
 None
 0.96A 4nkxC-4n40A:
undetectable		 4nkxC-4n40A:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_D_STRD601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4n40 PROTEIN ECT2
(Homo
sapiens) 		5 / 12 LEU A  55
ILE A  66
GLY A  75
ILE A 118
VAL A 123
 None
 0.97A 4nkxD-4n40A:
undetectable		 4nkxD-4n40A:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZBQ_A_DIFA601_1
(SERUM ALBUMIN)		 4n40 PROTEIN ECT2
(Homo
sapiens) 		5 / 11 LEU A 150
VAL A 187
PHE A 155
LEU A 161
GLY A 154
 None
 1.33A 4zbqA-4n40A:
undetectable		 4zbqA-4n40A:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HGC_A_HCYA501_1
(SERPIN)		 4n40 PROTEIN ECT2
(Homo
sapiens) 		5 / 12 VAL A 123
ALA A  68
ILE A  66
GLN A  62
PHE A  76
 None
 1.07A 5hgcA-4n40A:
undetectable		 5hgcA-4n40A:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JN8_A_AZMA701_1
(CARBONIC ANHYDRASE 4)		 4n40 PROTEIN ECT2
(Homo
sapiens) 		5 / 10 HIS A 279
VAL A 281
VAL A 301
THR A 262
TRP A 305
 None
 1.30A 5jn8A-4n40A:
undetectable		 5jn8A-4n40A:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JN9_B_EZLB302_1
(CARBONIC ANHYDRASE 4)		 4n40 PROTEIN ECT2
(Homo
sapiens) 		5 / 10 HIS A 279
VAL A 281
VAL A 301
THR A 262
TRP A 305
 None
 1.31A 5jn9B-4n40A:
undetectable		 5jn9B-4n40A:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JN9_D_EZLD302_1
(CARBONIC ANHYDRASE 4)		 4n40 PROTEIN ECT2
(Homo
sapiens) 		5 / 10 HIS A 279
VAL A 281
VAL A 301
THR A 262
TRP A 305
 None
 1.32A 5jn9D-4n40A:
undetectable		 5jn9D-4n40A:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JNA_B_TORB302_1
(CARBONIC ANHYDRASE 4)		 4n40 PROTEIN ECT2
(Homo
sapiens) 		5 / 12 HIS A 279
VAL A 281
VAL A 301
THR A 262
TRP A 305
 None
 1.31A 5jnaB-4n40A:
undetectable		 5jnaB-4n40A:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JNA_D_TORD302_1
(CARBONIC ANHYDRASE 4)		 4n40 PROTEIN ECT2
(Homo
sapiens) 		5 / 12 HIS A 279
VAL A 281
VAL A 301
THR A 262
TRP A 305
 None
 1.32A 5jnaD-4n40A:
undetectable		 5jnaD-4n40A:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JNC_B_6LHB302_0
(CARBONIC ANHYDRASE 4)		 4n40 PROTEIN ECT2
(Homo
sapiens) 		5 / 10 HIS A 279
VAL A 281
VAL A 301
THR A 262
TRP A 305
 None
 1.32A 5jncB-4n40A:
undetectable		 5jncB-4n40A:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KU6_A_MZMA301_1
(CARBONIC ANHYDRASE 4)		 4n40 PROTEIN ECT2
(Homo
sapiens) 		5 / 10 HIS A 279
VAL A 281
VAL A 301
THR A 262
TRP A 305
 None
 1.31A 5ku6A-4n40A:
undetectable		 5ku6A-4n40A:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KU6_B_MZMB302_1
(CARBONIC ANHYDRASE 4)		 4n40 PROTEIN ECT2
(Homo
sapiens) 		5 / 10 HIS A 279
VAL A 281
VAL A 301
THR A 262
TRP A 305
 None
 1.29A 5ku6B-4n40A:
undetectable		 5ku6B-4n40A:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8R_D_MMSD509_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		 4n40 PROTEIN ECT2
(Homo
sapiens) 		4 / 8 SER A 136
HIS A 170
LEU A 140
VAL A 168
 None
 0.95A 5m8rD-4n40A:
undetectable		 5m8rD-4n40A:
19.26