SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4n42'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1B02_A_C2FA281_0
(PROTEIN (THYMIDYLATE
SYNTHASE))		 4n42 XYLANASE AND
ALPHA-AMYLASE
INHIBITOR PROTEIN
ISOFORM III
(Scadoxus
multiflorus) 		5 / 11 ALA A 136
THR A 172
ASP A 161
LEU A 164
GLY A 165
 None
 1.14A 1b02A-4n42A:
undetectable		 1b02A-4n42A:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E9L_A_GCSA800_1
(YM1 SECRETORY
PROTEIN)		 4n42 XYLANASE AND
ALPHA-AMYLASE
INHIBITOR PROTEIN
ISOFORM III
(Scadoxus
multiflorus) 		5 / 9 TYR A   8
PHE A  34
GLY A  76
TYR A 181
TRP A 253
 None
 0.91A 1e9lA-4n42A:
19.0		 1e9lA-4n42A:
24.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_B_SAMB1293_0
(GLYCINE
N-METHYLTRANSFERASE)		 4n42 XYLANASE AND
ALPHA-AMYLASE
INHIBITOR PROTEIN
ISOFORM III
(Scadoxus
multiflorus) 		5 / 12 TRP A 177
ILE A 176
GLY A 215
ALA A 218
GLY A 249
 None
 1.23A 1kiaB-4n42A:
undetectable		 1kiaB-4n42A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMM_B_SAMB301_0
(UPF0217 PROTEIN
AF_1056)		 4n42 XYLANASE AND
ALPHA-AMYLASE
INHIBITOR PROTEIN
ISOFORM III
(Scadoxus
multiflorus) 		5 / 11 ILE A  74
GLY A  75
GLY A  76
LEU A 151
LEU A  71
 None
 0.98A 2qmmA-4n42A:
undetectable
2qmmB-4n42A:
undetectable		 2qmmA-4n42A:
23.22
2qmmB-4n42A:
23.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2UY4_A_AZMA1311_1
(ENDOCHITINASE)		 4n42 XYLANASE AND
ALPHA-AMYLASE
INHIBITOR PROTEIN
ISOFORM III
(Scadoxus
multiflorus) 		6 / 9 TYR A   8
GLY A  76
GLU A 125
GLN A 179
TYR A 181
TRP A 253
 None
 0.90A 2uy4A-4n42A:
34.3		 2uy4A-4n42A:
37.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2UY4_A_AZMA1311_1
(ENDOCHITINASE)		 4n42 XYLANASE AND
ALPHA-AMYLASE
INHIBITOR PROTEIN
ISOFORM III
(Scadoxus
multiflorus) 		6 / 9 TYR A   8
PHE A  34
GLY A  76
GLN A 179
TYR A 181
TRP A 253
 None
 0.52A 2uy4A-4n42A:
34.3		 2uy4A-4n42A:
37.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9S_D_TOPD1158_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 4n42 XYLANASE AND
ALPHA-AMYLASE
INHIBITOR PROTEIN
ISOFORM III
(Scadoxus
multiflorus) 		5 / 10 ALA A 154
ASP A 121
LEU A  71
ILE A  31
TYR A 181
 None
 1.22A 2w9sD-4n42A:
undetectable		 2w9sD-4n42A:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9S_F_TOPF1159_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 4n42 XYLANASE AND
ALPHA-AMYLASE
INHIBITOR PROTEIN
ISOFORM III
(Scadoxus
multiflorus) 		5 / 10 ALA A 154
ASP A 121
LEU A  71
ILE A  31
TYR A 181
 None
 1.23A 2w9sF-4n42A:
undetectable		 2w9sF-4n42A:
21.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2XTK_A_AZMA1339_1
(CLASS III CHITINASE
CHIA1)		 4n42 XYLANASE AND
ALPHA-AMYLASE
INHIBITOR PROTEIN
ISOFORM III
(Scadoxus
multiflorus) 		6 / 11 GLU A 125
GLN A 179
TYR A 181
ASN A 182
ALA A 223
TRP A 253
 None
 0.90A 2xtkA-4n42A:
35.0		 2xtkA-4n42A:
34.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2XTK_A_AZMA1339_1
(CLASS III CHITINASE
CHIA1)		 4n42 XYLANASE AND
ALPHA-AMYLASE
INHIBITOR PROTEIN
ISOFORM III
(Scadoxus
multiflorus) 		8 / 11 TYR A   8
PHE A  34
GLY A  76
GLN A 179
TYR A 181
ASN A 182
ALA A 223
TRP A 253
 None
 0.47A 2xtkA-4n42A:
35.0		 2xtkA-4n42A:
34.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2XTK_B_AZMB1339_1
(CLASS III CHITINASE
CHIA1)		 4n42 XYLANASE AND
ALPHA-AMYLASE
INHIBITOR PROTEIN
ISOFORM III
(Scadoxus
multiflorus) 		6 / 10 TYR A   8
GLY A  76
GLU A 125
GLN A 179
TYR A 181
TRP A 253
 None
 0.90A 2xtkB-4n42A:
35.1		 2xtkB-4n42A:
34.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2XTK_B_AZMB1339_1
(CLASS III CHITINASE
CHIA1)		 4n42 XYLANASE AND
ALPHA-AMYLASE
INHIBITOR PROTEIN
ISOFORM III
(Scadoxus
multiflorus) 		6 / 10 TYR A   8
PHE A  34
GLY A  76
GLN A 179
TYR A 181
TRP A 253
 None
 0.42A 2xtkB-4n42A:
35.1		 2xtkB-4n42A:
34.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O5R_A_FK5A1001_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP5)		 4n42 XYLANASE AND
ALPHA-AMYLASE
INHIBITOR PROTEIN
ISOFORM III
(Scadoxus
multiflorus) 		5 / 11 ASP A 174
ARG A 143
VAL A 167
ILE A 168
LYS A 210
 None
 0.92A 3o5rA-4n42A:
undetectable		 3o5rA-4n42A:
17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_C_SUEC1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 4n42 XYLANASE AND
ALPHA-AMYLASE
INHIBITOR PROTEIN
ISOFORM III
(Scadoxus
multiflorus) 		4 / 5 TYR A 256
ILE A 267
LEU A 268
LYS A 266
 None
 1.30A 3sueC-4n42A:
undetectable		 3sueC-4n42A:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_A_RTZA2_1
(CYTOCHROME P450 2D6)		 4n42 XYLANASE AND
ALPHA-AMYLASE
INHIBITOR PROTEIN
ISOFORM III
(Scadoxus
multiflorus) 		5 / 11 LEU A  18
THR A  21
GLU A  15
LEU A  72
PHE A  34
 None
 1.35A 3tbgA-4n42A:
undetectable		 3tbgA-4n42A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JVL_A_ESTA702_1
(ESTROGEN
SULFOTRANSFERASE)		 4n42 XYLANASE AND
ALPHA-AMYLASE
INHIBITOR PROTEIN
ISOFORM III
(Scadoxus
multiflorus) 		4 / 9 TYR A 132
HIS A 126
PHE A  38
ILE A 120
 None
 1.16A 4jvlA-4n42A:
undetectable		 4jvlA-4n42A:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PD4_C_AOQC4003_1
(CYTOCHROME B)		 4n42 XYLANASE AND
ALPHA-AMYLASE
INHIBITOR PROTEIN
ISOFORM III
(Scadoxus
multiflorus) 		5 / 12 PHE A  38
GLY A  75
ILE A  74
LEU A  83
ILE A 138
 None
 1.00A 4pd4C-4n42A:
undetectable		 4pd4C-4n42A:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GQB_A_GCSA603_1
(CHITINASE)		 4n42 XYLANASE AND
ALPHA-AMYLASE
INHIBITOR PROTEIN
ISOFORM III
(Scadoxus
multiflorus) 		4 / 8 GLY A  76
GLU A 125
TYR A 181
TRP A 253
 None
 0.99A 5gqbA-4n42A:
10.1		 5gqbA-4n42A:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GQB_A_GCSA603_1
(CHITINASE)		 4n42 XYLANASE AND
ALPHA-AMYLASE
INHIBITOR PROTEIN
ISOFORM III
(Scadoxus
multiflorus) 		4 / 8 PHE A  34
GLY A  76
TYR A 181
TRP A 253
 None
 0.52A 5gqbA-4n42A:
10.1		 5gqbA-4n42A:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GWZ_D_010D6_0
(N-[(5-METHYLISOXAZOL
-3-YL)CARBONYL]ALANY
L-L-VALYL-N~1~-((1R,
2Z)-4-(BENZYLOXY)-4-
OXO-1-{[(3R)-2-OXOPY
RROLIDIN-3-YL]METHYL
}BUT-2-ENYL)-L-LEUCI
NAMIDE
PEDV MAIN PROTEASE)		 4n42 XYLANASE AND
ALPHA-AMYLASE
INHIBITOR PROTEIN
ISOFORM III
(Scadoxus
multiflorus) 		3 / 3 MET A 228
HIS A 236
GLY A 191
 None
 0.82A 5gwzB-4n42A:
undetectable		 5gwzB-4n42A:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I73_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 4n42 XYLANASE AND
ALPHA-AMYLASE
INHIBITOR PROTEIN
ISOFORM III
(Scadoxus
multiflorus) 		5 / 12 ILE A   5
ALA A   6
GLY A   1
GLY A 249
GLY A 271
 None
 0.93A 5i73A-4n42A:
undetectable		 5i73A-4n42A:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W7B_B_PA1B204_1
(ACYLOXYACYL
HYDROLASE SMALL
SUBUNIT
ACYLOXYACYL
HYDROLASE LARGE
SUBUNIT)		 4n42 XYLANASE AND
ALPHA-AMYLASE
INHIBITOR PROTEIN
ISOFORM III
(Scadoxus
multiflorus) 		3 / 3 GLY A  25
ASN A  26
ARG A  16
 None
 0.74A 5w7bD-4n42A:
undetectable		 5w7bD-4n42A:
13.47