SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4n49'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EIZ_A_SAMA301_0
(FTSJ)
4n49 CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1

(Homo
sapiens)
7 / 12 ALA A 236
PRO A 280
GLY A 281
GLY A 282
LEU A 302
LEU A 383
LYS A 404
SAM  A 601 (-3.2A)
SAM  A 601 (-3.6A)
SAM  A 601 (-3.6A)
SAM  A 601 (-3.1A)
SAM  A 601 (-4.1A)
SAM  A 601 (-4.6A)
SAM  A 601 ( 4.1A)
0.62A 1eizA-4n49A:
17.8
1eizA-4n49A:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EJ0_A_SAMA301_0
(FTSJ)
4n49 CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1

(Homo
sapiens)
7 / 12 ALA A 236
PRO A 280
GLY A 281
GLY A 282
LEU A 302
LEU A 383
LYS A 404
SAM  A 601 (-3.2A)
SAM  A 601 (-3.6A)
SAM  A 601 (-3.6A)
SAM  A 601 (-3.1A)
SAM  A 601 (-4.1A)
SAM  A 601 (-4.6A)
SAM  A 601 ( 4.1A)
0.58A 1ej0A-4n49A:
17.9
1ej0A-4n49A:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_L_TRPL81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)
4n49 CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1

(Homo
sapiens)
5 / 9 VAL A 395
GLY A 357
ALA A 274
THR A 353
ILE A 394
None
1.28A 1gtnL-4n49A:
undetectable
1gtnM-4n49A:
undetectable
1gtnL-4n49A:
11.49
1gtnM-4n49A:
11.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HMY_A_SAMA328_0
(HAEIII
METHYLTRANSFERASE)
4n49 CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1

(Homo
sapiens)
4 / 8 ASP A 335
ILE A 336
THR A 337
LEU A 383
SAM  A 601 (-3.6A)
SAM  A 601 (-4.1A)
SAM  A 601 ( 3.9A)
SAM  A 601 (-4.6A)
0.57A 1hmyA-4n49A:
6.3
1hmyA-4n49A:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1O86_A_LPRA702_2
(ANGIOTENSIN
CONVERTING ENZYME)
4n49 CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1

(Homo
sapiens)
4 / 4 SER A 413
VAL A 481
PHE A 388
VAL A 444
None
1.19A 1o86A-4n49A:
undetectable
1o86A-4n49A:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_E_FUAE706_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)
4n49 CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1

(Homo
sapiens)
5 / 10 THR A 410
SER A 413
LEU A 429
PHE A 158
VAL A 417
None
1.30A 1q23E-4n49A:
undetectable
1q23E-4n49A:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B9E_A_SAMA1201_0
(NOL1/NOP2/SUN DOMAIN
FAMILY, MEMBER 5
ISOFORM 2)
4n49 CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1

(Homo
sapiens)
5 / 12 CYH A 277
PRO A 280
GLY A 281
LEU A 302
ASP A 335
SAM  A 601 (-3.7A)
SAM  A 601 (-3.6A)
SAM  A 601 (-3.6A)
SAM  A 601 (-4.1A)
SAM  A 601 (-3.6A)
0.91A 2b9eA-4n49A:
8.7
2b9eA-4n49A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HMY_B_SAMB328_0
(PROTEIN
(CYTOSINE-SPECIFIC
METHYLTRANSFERASE
HHAI))
4n49 CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1

(Homo
sapiens)
5 / 12 GLY A 279
GLY A 282
ASP A 335
ILE A 336
LEU A 383
SAM  A 601 (-3.5A)
SAM  A 601 (-3.1A)
SAM  A 601 (-3.6A)
SAM  A 601 (-4.1A)
SAM  A 601 (-4.6A)
0.71A 2hmyB-4n49A:
6.1
2hmyB-4n49A:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYU_B_SAMB201_0
(PUTATIVE RIBOSOMAL
RNA
METHYLTRANSFERASE 2)
4n49 CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1

(Homo
sapiens)
5 / 12 GLY A 281
LEU A 302
THR A 337
LEU A 383
LYS A 404
SAM  A 601 (-3.6A)
SAM  A 601 (-4.1A)
SAM  A 601 ( 3.9A)
SAM  A 601 (-4.6A)
SAM  A 601 ( 4.1A)
0.73A 2nyuB-4n49A:
15.1
2nyuB-4n49A:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_A_SAMA300_0
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)
4n49 CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1

(Homo
sapiens)
5 / 12 GLY A 279
GLY A 282
THR A 301
LEU A 302
ASP A 364
SAM  A 601 (-3.5A)
SAM  A 601 (-3.1A)
SAM  A 601 (-4.1A)
SAM  A 601 (-4.1A)
SAM  A 601 (-3.6A)
0.52A 2oxtA-4n49A:
16.3
2oxtA-4n49A:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_B_SAMB300_0
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)
4n49 CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1

(Homo
sapiens)
6 / 12 GLY A 279
GLY A 281
THR A 301
LEU A 302
ILE A 336
LYS A 404
SAM  A 601 (-3.5A)
SAM  A 601 (-3.6A)
SAM  A 601 (-4.1A)
SAM  A 601 (-4.1A)
SAM  A 601 (-4.1A)
SAM  A 601 ( 4.1A)
0.66A 2oxtB-4n49A:
16.6
2oxtB-4n49A:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_C_SAMC300_0
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)
4n49 CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1

(Homo
sapiens)
7 / 12 GLY A 279
GLY A 282
THR A 301
LEU A 302
ILE A 336
ASP A 364
LYS A 404
SAM  A 601 (-3.5A)
SAM  A 601 (-3.1A)
SAM  A 601 (-4.1A)
SAM  A 601 (-4.1A)
SAM  A 601 (-4.1A)
SAM  A 601 (-3.6A)
SAM  A 601 ( 4.1A)
0.78A 2oxtC-4n49A:
16.2
2oxtC-4n49A:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_D_SAMD300_0
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)
4n49 CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1

(Homo
sapiens)
6 / 12 ASP A 275
GLY A 279
GLY A 282
THR A 301
LEU A 302
ASP A 364
None
SAM  A 601 (-3.5A)
SAM  A 601 (-3.1A)
SAM  A 601 (-4.1A)
SAM  A 601 (-4.1A)
SAM  A 601 (-3.6A)
0.60A 2oxtD-4n49A:
14.7
2oxtD-4n49A:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PXC_A_SAMA500_0
(GENOME POLYPROTEIN
[CONTAINS: CAPSID
PROTEIN C (CORE
PROTEIN)
ENVELOPE PROTEIN M
(MATRIX PROTEIN)
MAJOR ENVELOPE
PROTEIN E
NON-STRUCTURAL
PROTEIN 1 (NS1)
NON-STRUCTURAL
PROTEIN 2A (NS2A)
FLAVIVIRIN PROTEASE
NS2B REGULATORY
SUBUNIT
FLAVIVIRIN PROTEASE
NS3 CATALYTIC
SUBUNIT
NON-STRUCTURAL
PROTEIN 4A (NS4A)
NON-STRUCTURAL
PROTEIN 4B (NS4B)
RNA-DIRECTED RNA
POLYMERASE (EC
2.7.7.48) (NS5)])
4n49 CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1

(Homo
sapiens)
5 / 12 GLY A 279
GLY A 282
THR A 301
ASP A 335
ASP A 364
SAM  A 601 (-3.5A)
SAM  A 601 (-3.1A)
SAM  A 601 (-4.1A)
SAM  A 601 (-3.6A)
SAM  A 601 (-3.6A)
0.57A 2pxcA-4n49A:
15.1
2pxcA-4n49A:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_A_P1ZA1352_1
(PROSTAGLANDIN
REDUCTASE 2)
4n49 CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1

(Homo
sapiens)
4 / 7 LEU A 479
ASN A 478
TYR A 459
LYS A 381
None
1.45A 2w98A-4n49A:
6.7
2w98B-4n49A:
2.5
2w98A-4n49A:
20.81
2w98B-4n49A:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WA2_A_SAMA1248_0
(NON-STRUCTURAL
PROTEIN 5)
4n49 CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1

(Homo
sapiens)
5 / 12 GLY A 279
THR A 301
LEU A 302
ASP A 335
THR A 337
SAM  A 601 (-3.5A)
SAM  A 601 (-4.1A)
SAM  A 601 (-4.1A)
SAM  A 601 (-3.6A)
SAM  A 601 ( 3.9A)
0.60A 2wa2A-4n49A:
16.1
2wa2A-4n49A:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WA2_B_SAMB1267_0
(NON-STRUCTURAL
PROTEIN 5)
4n49 CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1

(Homo
sapiens)
5 / 12 GLY A 279
THR A 301
LEU A 302
THR A 337
ASP A 364
SAM  A 601 (-3.5A)
SAM  A 601 (-4.1A)
SAM  A 601 (-4.1A)
SAM  A 601 ( 3.9A)
SAM  A 601 (-3.6A)
0.56A 2wa2B-4n49A:
15.7
2wa2B-4n49A:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZMB_A_PXBA692_1
(LACTOTRANSFERRIN)
4n49 CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1

(Homo
sapiens)
3 / 3 PRO A 149
GLU A 225
TYR A 224
None
0.64A 2zmbA-4n49A:
0.7
2zmbA-4n49A:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DOU_A_SAMA1_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)
4n49 CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1

(Homo
sapiens)
7 / 12 ALA A 236
PRO A 280
GLY A 281
GLY A 282
LEU A 302
ILE A 336
LYS A 404
SAM  A 601 (-3.2A)
SAM  A 601 (-3.6A)
SAM  A 601 (-3.6A)
SAM  A 601 (-3.1A)
SAM  A 601 (-4.1A)
SAM  A 601 (-4.1A)
SAM  A 601 ( 4.1A)
0.62A 3douA-4n49A:
16.0
3douA-4n49A:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELU_A_SAMA4633_0
(METHYLTRANSFERASE)
4n49 CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1

(Homo
sapiens)
5 / 12 GLY A 279
GLY A 282
THR A 301
LEU A 302
ASP A 364
SAM  A 601 (-3.5A)
SAM  A 601 (-3.1A)
SAM  A 601 (-4.1A)
SAM  A 601 (-4.1A)
SAM  A 601 (-3.6A)
0.48A 3eluA-4n49A:
15.9
3eluA-4n49A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELW_A_SAMA4633_0
(METHYLTRANSFERASE)
4n49 CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1

(Homo
sapiens)
5 / 12 GLY A 279
GLY A 282
THR A 301
LEU A 302
ASP A 364
SAM  A 601 (-3.5A)
SAM  A 601 (-3.1A)
SAM  A 601 (-4.1A)
SAM  A 601 (-4.1A)
SAM  A 601 (-3.6A)
0.48A 3elwA-4n49A:
16.2
3elwA-4n49A:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EMB_A_SAMA4633_0
(METHYLTRANSFERASE)
4n49 CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1

(Homo
sapiens)
5 / 12 GLY A 279
GLY A 282
THR A 301
LEU A 302
ASP A 364
SAM  A 601 (-3.5A)
SAM  A 601 (-3.1A)
SAM  A 601 (-4.1A)
SAM  A 601 (-4.1A)
SAM  A 601 (-3.6A)
0.53A 3embA-4n49A:
16.1
3embA-4n49A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GCZ_A_SAMA4633_0
(POLYPROTEIN)
4n49 CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1

(Homo
sapiens)
6 / 12 GLY A 279
GLY A 282
THR A 301
LEU A 302
ASP A 335
ASP A 364
SAM  A 601 (-3.5A)
SAM  A 601 (-3.1A)
SAM  A 601 (-4.1A)
SAM  A 601 (-4.1A)
SAM  A 601 (-3.6A)
SAM  A 601 (-3.6A)
0.60A 3gczA-4n49A:
13.7
3gczA-4n49A:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IHT_A_SAMA200_0
(S-ADENOSYL-L-METHION
INE METHYL
TRANSFERASE)
4n49 CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1

(Homo
sapiens)
5 / 12 GLY A 279
GLY A 281
ASP A 335
ILE A 336
ASP A 364
SAM  A 601 (-3.5A)
SAM  A 601 (-3.6A)
SAM  A 601 (-3.6A)
SAM  A 601 (-4.1A)
SAM  A 601 (-3.6A)
0.76A 3ihtA-4n49A:
7.9
3ihtA-4n49A:
16.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M6V_A_SAMA465_0
(RRNA METHYLASE)
4n49 CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1

(Homo
sapiens)
5 / 12 PRO A 280
GLY A 281
GLY A 282
ASP A 364
LEU A 383
SAM  A 601 (-3.6A)
SAM  A 601 (-3.6A)
SAM  A 601 (-3.1A)
SAM  A 601 (-3.6A)
SAM  A 601 (-4.6A)
0.58A 3m6vA-4n49A:
10.2
3m6vA-4n49A:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M6V_B_SAMB465_0
(RRNA METHYLASE)
4n49 CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1

(Homo
sapiens)
5 / 12 PRO A 280
GLY A 281
GLY A 282
ASP A 364
LEU A 383
SAM  A 601 (-3.6A)
SAM  A 601 (-3.6A)
SAM  A 601 (-3.1A)
SAM  A 601 (-3.6A)
SAM  A 601 (-4.6A)
0.55A 3m6vB-4n49A:
10.1
3m6vB-4n49A:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O0M_A_ACTA146_0
(HIT FAMILY PROTEIN)
4n49 CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1

(Homo
sapiens)
4 / 4 ASP A 210
GLU A 212
GLU A 213
ARG A 216
None
0.66A 3o0mA-4n49A:
undetectable
3o0mA-4n49A:
16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P5N_A_RBFA190_1
(RIBOFLAVIN UPTAKE
PROTEIN)
4n49 CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1

(Homo
sapiens)
5 / 12 THR A 301
GLY A 365
ALA A 363
LEU A 361
LEU A 383
SAM  A 601 (-4.1A)
SAM  A 601 ( 4.0A)
None
None
SAM  A 601 (-4.6A)
1.17A 3p5nA-4n49A:
undetectable
3p5nA-4n49A:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P5N_B_RBFB190_1
(RIBOFLAVIN UPTAKE
PROTEIN)
4n49 CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1

(Homo
sapiens)
5 / 12 THR A 301
GLY A 365
ALA A 363
LEU A 361
LEU A 383
SAM  A 601 (-4.1A)
SAM  A 601 ( 4.0A)
None
None
SAM  A 601 (-4.6A)
1.17A 3p5nB-4n49A:
undetectable
3p5nB-4n49A:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P97_A_SAMA263_0
(NON-STRUCTURAL
PROTEIN 5)
4n49 CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1

(Homo
sapiens)
5 / 12 GLY A 279
GLY A 282
THR A 301
ASP A 335
ASP A 364
SAM  A 601 (-3.5A)
SAM  A 601 (-3.1A)
SAM  A 601 (-4.1A)
SAM  A 601 (-3.6A)
SAM  A 601 (-3.6A)
0.57A 3p97A-4n49A:
15.5
3p97A-4n49A:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P97_C_SAMC263_0
(NON-STRUCTURAL
PROTEIN 5)
4n49 CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1

(Homo
sapiens)
5 / 12 GLY A 279
GLY A 282
THR A 301
ASP A 335
ASP A 364
SAM  A 601 (-3.5A)
SAM  A 601 (-3.1A)
SAM  A 601 (-4.1A)
SAM  A 601 (-3.6A)
SAM  A 601 (-3.6A)
0.63A 3p97C-4n49A:
15.7
3p97C-4n49A:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B17_A_SAMA1358_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE M)
4n49 CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1

(Homo
sapiens)
5 / 12 PRO A 280
GLY A 281
GLY A 282
ASP A 335
ASP A 364
SAM  A 601 (-3.6A)
SAM  A 601 (-3.6A)
SAM  A 601 (-3.1A)
SAM  A 601 (-3.6A)
SAM  A 601 (-3.6A)
0.70A 4b17A-4n49A:
10.3
4b17A-4n49A:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CTJ_A_SAMA1263_0
(NON-STRUCTURAL
PROTEIN 5)
4n49 CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1

(Homo
sapiens)
5 / 12 GLY A 279
GLY A 282
THR A 301
ASP A 335
ASP A 364
SAM  A 601 (-3.5A)
SAM  A 601 (-3.1A)
SAM  A 601 (-4.1A)
SAM  A 601 (-3.6A)
SAM  A 601 (-3.6A)
0.55A 4ctjA-4n49A:
15.7
4ctjA-4n49A:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CTK_A_SAMA1263_0
(POLYPROTEIN)
4n49 CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1

(Homo
sapiens)
5 / 12 GLY A 279
GLY A 282
THR A 301
ASP A 335
ASP A 364
SAM  A 601 (-3.5A)
SAM  A 601 (-3.1A)
SAM  A 601 (-4.1A)
SAM  A 601 (-3.6A)
SAM  A 601 (-3.6A)
0.58A 4ctkA-4n49A:
15.8
4ctkA-4n49A:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_A_SAMA401_0
(METHYLTRANSFERASE
NSUN4)
4n49 CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1

(Homo
sapiens)
7 / 12 CYH A 277
PRO A 280
GLY A 281
GLY A 282
LEU A 302
ASP A 364
LEU A 383
SAM  A 601 (-3.7A)
SAM  A 601 (-3.6A)
SAM  A 601 (-3.6A)
SAM  A 601 (-3.1A)
SAM  A 601 (-4.1A)
SAM  A 601 (-3.6A)
SAM  A 601 (-4.6A)
0.96A 4fp9A-4n49A:
8.1
4fp9A-4n49A:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_C_SAMC401_0
(METHYLTRANSFERASE
NSUN4)
4n49 CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1

(Homo
sapiens)
7 / 12 CYH A 277
PRO A 280
GLY A 281
GLY A 282
LEU A 302
ASP A 364
LEU A 383
SAM  A 601 (-3.7A)
SAM  A 601 (-3.6A)
SAM  A 601 (-3.6A)
SAM  A 601 (-3.1A)
SAM  A 601 (-4.1A)
SAM  A 601 (-3.6A)
SAM  A 601 (-4.6A)
0.97A 4fp9C-4n49A:
8.2
4fp9C-4n49A:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_D_SAMD401_0
(METHYLTRANSFERASE
NSUN4)
4n49 CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1

(Homo
sapiens)
7 / 12 CYH A 277
PRO A 280
GLY A 281
GLY A 282
LEU A 302
ASP A 335
LEU A 383
SAM  A 601 (-3.7A)
SAM  A 601 (-3.6A)
SAM  A 601 (-3.6A)
SAM  A 601 (-3.1A)
SAM  A 601 (-4.1A)
SAM  A 601 (-3.6A)
SAM  A 601 (-4.6A)
1.03A 4fp9D-4n49A:
8.4
4fp9D-4n49A:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_F_SAMF401_0
(METHYLTRANSFERASE
NSUN4)
4n49 CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1

(Homo
sapiens)
7 / 12 CYH A 277
PRO A 280
GLY A 281
GLY A 282
LEU A 302
ASP A 364
LEU A 383
SAM  A 601 (-3.7A)
SAM  A 601 (-3.6A)
SAM  A 601 (-3.6A)
SAM  A 601 (-3.1A)
SAM  A 601 (-4.1A)
SAM  A 601 (-3.6A)
SAM  A 601 (-4.6A)
0.99A 4fp9F-4n49A:
8.1
4fp9F-4n49A:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FZV_A_SAMA401_0
(PUTATIVE
METHYLTRANSFERASE
NSUN4)
4n49 CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1

(Homo
sapiens)
7 / 12 CYH A 277
PRO A 280
GLY A 281
GLY A 282
LEU A 302
ASP A 335
LEU A 383
SAM  A 601 (-3.7A)
SAM  A 601 (-3.6A)
SAM  A 601 (-3.6A)
SAM  A 601 (-3.1A)
SAM  A 601 (-4.1A)
SAM  A 601 (-3.6A)
SAM  A 601 (-4.6A)
1.02A 4fzvA-4n49A:
7.9
4fzvA-4n49A:
22.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4N48_A_SAMA601_0
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)
4n49 CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1

(Homo
sapiens)
12 / 12 CYH A 277
GLY A 279
PRO A 280
GLY A 281
PHE A 283
THR A 301
LEU A 302
ASN A 306
ILE A 336
THR A 337
GLY A 365
LEU A 383
SAM  A 601 (-3.7A)
SAM  A 601 (-3.5A)
SAM  A 601 (-3.6A)
SAM  A 601 (-3.6A)
SAM  A 601 (-3.5A)
SAM  A 601 (-4.1A)
SAM  A 601 (-4.1A)
None
SAM  A 601 (-4.1A)
SAM  A 601 ( 3.9A)
SAM  A 601 ( 4.0A)
SAM  A 601 (-4.6A)
0.23A 4n48A-4n49A:
68.2
4n48A-4n49A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4N48_A_SAMA601_0
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)
4n49 CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1

(Homo
sapiens)
5 / 12 PRO A 280
LEU A 302
THR A 337
GLY A 366
LEU A 383
SAM  A 601 (-3.6A)
SAM  A 601 (-4.1A)
SAM  A 601 ( 3.9A)
SAM  A 601 (-4.6A)
SAM  A 601 (-4.6A)
1.10A 4n48A-4n49A:
68.2
4n48A-4n49A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4N48_A_SAMA601_1
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)
4n49 CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1

(Homo
sapiens)
5 / 5 ASN A 234
ALA A 236
GLY A 282
ASP A 335
ASP A 364
SAM  A 601 (-3.3A)
SAM  A 601 (-3.2A)
SAM  A 601 (-3.1A)
SAM  A 601 (-3.6A)
SAM  A 601 (-3.6A)
0.19A 4n48A-4n49A:
68.2
4n48A-4n49A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4N48_B_SAMB601_0
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)
4n49 CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1

(Homo
sapiens)
12 / 12 ALA A 236
CYH A 277
GLY A 279
GLY A 281
PHE A 283
THR A 301
LEU A 302
ASN A 306
ILE A 336
THR A 337
GLY A 365
LEU A 383
SAM  A 601 (-3.2A)
SAM  A 601 (-3.7A)
SAM  A 601 (-3.5A)
SAM  A 601 (-3.6A)
SAM  A 601 (-3.5A)
SAM  A 601 (-4.1A)
SAM  A 601 (-4.1A)
None
SAM  A 601 (-4.1A)
SAM  A 601 ( 3.9A)
SAM  A 601 ( 4.0A)
SAM  A 601 (-4.6A)
0.23A 4n48B-4n49A:
67.5
4n48B-4n49A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4N48_B_SAMB601_1
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)
4n49 CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1

(Homo
sapiens)
4 / 5 ASN A 234
PRO A 280
GLY A 282
ASP A 333
SAM  A 601 (-3.3A)
SAM  A 601 (-3.6A)
SAM  A 601 (-3.1A)
None
0.97A 4n48B-4n49A:
67.5
4n48B-4n49A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4N48_B_SAMB601_1
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)
4n49 CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1

(Homo
sapiens)
5 / 5 ASN A 234
PRO A 280
GLY A 282
ASP A 335
ASP A 364
SAM  A 601 (-3.3A)
SAM  A 601 (-3.6A)
SAM  A 601 (-3.1A)
SAM  A 601 (-3.6A)
SAM  A 601 (-3.6A)
0.32A 4n48B-4n49A:
67.5
4n48B-4n49A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4N49_A_SAMA601_0
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)
4n49 CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1

(Homo
sapiens)
12 / 12 ALA A 236
CYH A 277
GLY A 279
PRO A 280
GLY A 281
PHE A 283
THR A 301
LEU A 302
ASN A 306
ILE A 336
THR A 337
LEU A 383
SAM  A 601 (-3.2A)
SAM  A 601 (-3.7A)
SAM  A 601 (-3.5A)
SAM  A 601 (-3.6A)
SAM  A 601 (-3.6A)
SAM  A 601 (-3.5A)
SAM  A 601 (-4.1A)
SAM  A 601 (-4.1A)
None
SAM  A 601 (-4.1A)
SAM  A 601 ( 3.9A)
SAM  A 601 (-4.6A)
0.00A 4n49A-4n49A:
73.4
4n49A-4n49A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4N49_A_SAMA601_1
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)
4n49 CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1

(Homo
sapiens)
4 / 4 ASN A 234
GLY A 282
ASP A 335
ASP A 364
SAM  A 601 (-3.3A)
SAM  A 601 (-3.1A)
SAM  A 601 (-3.6A)
SAM  A 601 (-3.6A)
0.01A 4n49A-4n49A:
73.4
4n49A-4n49A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NTX_A_AMRA509_1
(ACID-SENSING ION
CHANNEL 1
BASIC PHOSPHOLIPASE
A2 HOMOLOG TX-BETA)
4n49 CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1

(Homo
sapiens)
4 / 6 ASP A 333
GLU A 340
ASN A 468
ARG A 471
None
1.06A 4ntxA-4n49A:
undetectable
4ntxC-4n49A:
undetectable
4ntxA-4n49A:
21.49
4ntxC-4n49A:
14.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCK_B_SAMB2409_0
(RNA-DIRECTED RNA
POLYMERASE L)
4n49 CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1

(Homo
sapiens)
5 / 12 GLY A 279
GLY A 281
LEU A 302
THR A 337
LYS A 404
SAM  A 601 (-3.5A)
SAM  A 601 (-3.6A)
SAM  A 601 (-4.1A)
SAM  A 601 ( 3.9A)
SAM  A 601 ( 4.1A)
0.79A 4uckB-4n49A:
12.2
4uckB-4n49A:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E9Q_A_SAMA301_0
(GENOME POLYPROTEIN)
4n49 CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1

(Homo
sapiens)
5 / 12 GLY A 279
GLY A 282
THR A 301
ASP A 335
ASP A 364
SAM  A 601 (-3.5A)
SAM  A 601 (-3.1A)
SAM  A 601 (-4.1A)
SAM  A 601 (-3.6A)
SAM  A 601 (-3.6A)
0.57A 5e9qA-4n49A:
16.0
5e9qA-4n49A:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E9Q_C_SAMC4000_0
(GENOME POLYPROTEIN)
4n49 CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1

(Homo
sapiens)
5 / 12 GLY A 279
GLY A 282
THR A 301
ASP A 335
ASP A 364
SAM  A 601 (-3.5A)
SAM  A 601 (-3.1A)
SAM  A 601 (-4.1A)
SAM  A 601 (-3.6A)
SAM  A 601 (-3.6A)
0.65A 5e9qC-4n49A:
15.2
5e9qC-4n49A:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EC8_C_SAMC4000_0
(GENOME POLYPROTEIN)
4n49 CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1

(Homo
sapiens)
5 / 12 GLY A 279
GLY A 282
THR A 301
ASP A 335
ASP A 364
SAM  A 601 (-3.5A)
SAM  A 601 (-3.1A)
SAM  A 601 (-4.1A)
SAM  A 601 (-3.6A)
SAM  A 601 (-3.6A)
0.59A 5ec8C-4n49A:
15.7
5ec8C-4n49A:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_O_TRPO101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
4n49 CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1

(Homo
sapiens)
5 / 10 GLY A 357
HIS A 359
ALA A 274
THR A 353
ILE A 394
None
1.46A 5eeuN-4n49A:
undetectable
5eeuO-4n49A:
undetectable
5eeuN-4n49A:
11.49
5eeuO-4n49A:
11.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_O_TRPO101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
4n49 CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1

(Homo
sapiens)
5 / 10 GLY A 357
HIS A 359
ALA A 274
THR A 353
ILE A 394
None
1.46A 5eevN-4n49A:
undetectable
5eevO-4n49A:
undetectable
5eevN-4n49A:
11.49
5eevO-4n49A:
11.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_O_TRPO101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
4n49 CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1

(Homo
sapiens)
5 / 10 GLY A 357
HIS A 359
ALA A 274
THR A 353
ILE A 394
None
1.46A 5eewN-4n49A:
undetectable
5eewO-4n49A:
undetectable
5eewN-4n49A:
11.49
5eewO-4n49A:
11.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_O_TRPO101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
4n49 CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1

(Homo
sapiens)
5 / 10 GLY A 357
HIS A 359
ALA A 274
THR A 353
ILE A 394
None
1.46A 5eexN-4n49A:
undetectable
5eexO-4n49A:
undetectable
5eexN-4n49A:
11.49
5eexO-4n49A:
11.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_O_TRPO101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
4n49 CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1

(Homo
sapiens)
5 / 10 GLY A 357
HIS A 359
ALA A 274
THR A 353
ILE A 394
None
1.46A 5eeyN-4n49A:
undetectable
5eeyO-4n49A:
undetectable
5eeyN-4n49A:
11.49
5eeyO-4n49A:
11.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_O_TRPO101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
4n49 CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1

(Homo
sapiens)
5 / 10 GLY A 357
HIS A 359
ALA A 274
THR A 353
ILE A 394
None
1.46A 5eezN-4n49A:
undetectable
5eezO-4n49A:
undetectable
5eezN-4n49A:
11.49
5eezO-4n49A:
11.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_O_TRPO101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
4n49 CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1

(Homo
sapiens)
5 / 10 GLY A 357
HIS A 359
ALA A 274
THR A 353
ILE A 394
None
1.46A 5ef0N-4n49A:
undetectable
5ef0O-4n49A:
undetectable
5ef0N-4n49A:
11.49
5ef0O-4n49A:
11.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_O_TRPO101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
4n49 CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1

(Homo
sapiens)
5 / 10 GLY A 357
HIS A 359
ALA A 274
THR A 353
ILE A 394
None
1.46A 5ef1N-4n49A:
undetectable
5ef1O-4n49A:
undetectable
5ef1N-4n49A:
11.49
5ef1O-4n49A:
11.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_O_TRPO101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
4n49 CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1

(Homo
sapiens)
5 / 10 GLY A 357
HIS A 359
ALA A 274
THR A 353
ILE A 394
None
1.46A 5ef2N-4n49A:
undetectable
5ef2O-4n49A:
undetectable
5ef2N-4n49A:
11.49
5ef2O-4n49A:
11.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_O_TRPO101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
4n49 CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1

(Homo
sapiens)
5 / 10 GLY A 357
HIS A 359
ALA A 274
THR A 353
ILE A 394
None
1.46A 5ef3N-4n49A:
undetectable
5ef3O-4n49A:
undetectable
5ef3N-4n49A:
11.49
5ef3O-4n49A:
11.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EHG_A_SAMA301_0
(RNA-DIRECTED RNA
POLYMERASE NS5)
4n49 CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1

(Homo
sapiens)
5 / 12 GLY A 279
GLY A 282
THR A 301
ASP A 335
ASP A 364
SAM  A 601 (-3.5A)
SAM  A 601 (-3.1A)
SAM  A 601 (-4.1A)
SAM  A 601 (-3.6A)
SAM  A 601 (-3.6A)
0.54A 5ehgA-4n49A:
13.5
5ehgA-4n49A:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EHI_A_SAMA4001_0
(NS5
METHYLTRANSFERASE
DENGUE VIRUS)
4n49 CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1

(Homo
sapiens)
5 / 12 GLY A 279
GLY A 282
THR A 301
ASP A 335
ASP A 364
SAM  A 601 (-3.5A)
SAM  A 601 (-3.1A)
SAM  A 601 (-4.1A)
SAM  A 601 (-3.6A)
SAM  A 601 (-3.6A)
0.57A 5ehiA-4n49A:
15.8
5ehiA-4n49A:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EHI_C_SAMC4000_0
(NS5
METHYLTRANSFERASE
DENGUE VIRUS)
4n49 CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1

(Homo
sapiens)
5 / 12 GLY A 279
GLY A 282
THR A 301
ASP A 335
ASP A 364
SAM  A 601 (-3.5A)
SAM  A 601 (-3.1A)
SAM  A 601 (-4.1A)
SAM  A 601 (-3.6A)
SAM  A 601 (-3.6A)
0.60A 5ehiC-4n49A:
15.3
5ehiC-4n49A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EIF_A_SAMA301_0
(GENOME POLYPROTEIN)
4n49 CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1

(Homo
sapiens)
5 / 12 GLY A 279
GLY A 282
THR A 301
ASP A 335
ASP A 364
SAM  A 601 (-3.5A)
SAM  A 601 (-3.1A)
SAM  A 601 (-4.1A)
SAM  A 601 (-3.6A)
SAM  A 601 (-3.6A)
0.56A 5eifA-4n49A:
15.7
5eifA-4n49A:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EIF_C_SAMC4000_0
(GENOME POLYPROTEIN)
4n49 CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1

(Homo
sapiens)
5 / 12 GLY A 279
GLY A 282
THR A 301
ASP A 335
ASP A 364
SAM  A 601 (-3.5A)
SAM  A 601 (-3.1A)
SAM  A 601 (-4.1A)
SAM  A 601 (-3.6A)
SAM  A 601 (-3.6A)
0.61A 5eifC-4n49A:
15.9
5eifC-4n49A:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EIW_A_SAMA301_0
(NS5
METHYLTRANSFERASE)
4n49 CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1

(Homo
sapiens)
5 / 12 GLY A 279
GLY A 282
THR A 301
ASP A 335
ASP A 364
SAM  A 601 (-3.5A)
SAM  A 601 (-3.1A)
SAM  A 601 (-4.1A)
SAM  A 601 (-3.6A)
SAM  A 601 (-3.6A)
0.58A 5eiwA-4n49A:
15.3
5eiwA-4n49A:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EIW_C_SAMC4000_0
(NS5
METHYLTRANSFERASE)
4n49 CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1

(Homo
sapiens)
5 / 12 GLY A 279
GLY A 282
THR A 301
ASP A 335
ASP A 364
SAM  A 601 (-3.5A)
SAM  A 601 (-3.1A)
SAM  A 601 (-4.1A)
SAM  A 601 (-3.6A)
SAM  A 601 (-3.6A)
0.56A 5eiwC-4n49A:
15.5
5eiwC-4n49A:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EKX_A_SAMA301_0
(NS5
METHYLTRANSFERASE)
4n49 CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1

(Homo
sapiens)
5 / 12 GLY A 279
GLY A 282
THR A 301
ASP A 335
ASP A 364
SAM  A 601 (-3.5A)
SAM  A 601 (-3.1A)
SAM  A 601 (-4.1A)
SAM  A 601 (-3.6A)
SAM  A 601 (-3.6A)
0.56A 5ekxA-4n49A:
15.8
5ekxA-4n49A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKM_A_SAMA311_0
(NS5 METHYL
TRANSFERASE)
4n49 CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1

(Homo
sapiens)
5 / 12 GLY A 279
GLY A 282
THR A 301
ASP A 335
ASP A 364
SAM  A 601 (-3.5A)
SAM  A 601 (-3.1A)
SAM  A 601 (-4.1A)
SAM  A 601 (-3.6A)
SAM  A 601 (-3.6A)
0.56A 5ikmA-4n49A:
16.0
5ikmA-4n49A:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KQS_A_SAMA307_0
(GENOME POLYPROTEIN)
4n49 CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1

(Homo
sapiens)
5 / 12 GLY A 279
GLY A 282
THR A 301
ASP A 335
ASP A 364
SAM  A 601 (-3.5A)
SAM  A 601 (-3.1A)
SAM  A 601 (-4.1A)
SAM  A 601 (-3.6A)
SAM  A 601 (-3.6A)
0.56A 5kqsA-4n49A:
15.8
5kqsA-4n49A:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NJV_A_SAMA301_0
(NS5)
4n49 CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1

(Homo
sapiens)
5 / 12 GLY A 279
GLY A 282
THR A 301
ASP A 335
ASP A 364
SAM  A 601 (-3.5A)
SAM  A 601 (-3.1A)
SAM  A 601 (-4.1A)
SAM  A 601 (-3.6A)
SAM  A 601 (-3.6A)
0.56A 5njvA-4n49A:
15.6
5njvA-4n49A:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NJV_B_SAMB301_0
(NS5)
4n49 CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1

(Homo
sapiens)
5 / 12 GLY A 279
GLY A 282
THR A 301
ASP A 335
ASP A 364
SAM  A 601 (-3.5A)
SAM  A 601 (-3.1A)
SAM  A 601 (-4.1A)
SAM  A 601 (-3.6A)
SAM  A 601 (-3.6A)
0.55A 5njvB-4n49A:
14.9
5njvB-4n49A:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WWS_A_SAMA501_0
(PUTATIVE
METHYLTRANSFERASE
NSUN6)
4n49 CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1

(Homo
sapiens)
6 / 12 CYH A 277
PRO A 280
GLY A 282
ASP A 335
ASP A 364
LEU A 383
SAM  A 601 (-3.7A)
SAM  A 601 (-3.6A)
SAM  A 601 (-3.1A)
SAM  A 601 (-3.6A)
SAM  A 601 (-3.6A)
SAM  A 601 (-4.6A)
1.03A 5wwsA-4n49A:
8.5
5wwsA-4n49A:
24.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WWS_B_SAMB501_0
(PUTATIVE
METHYLTRANSFERASE
NSUN6)
4n49 CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1

(Homo
sapiens)
5 / 12 CYH A 277
PRO A 280
GLY A 282
ASP A 335
ASP A 364
SAM  A 601 (-3.7A)
SAM  A 601 (-3.6A)
SAM  A 601 (-3.1A)
SAM  A 601 (-3.6A)
SAM  A 601 (-3.6A)
0.64A 5wwsB-4n49A:
9.8
5wwsB-4n49A:
24.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ2_A_SAMA601_0
(NS5 MTASE)
4n49 CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1

(Homo
sapiens)
5 / 12 GLY A 279
GLY A 282
THR A 301
ASP A 335
ASP A 364
SAM  A 601 (-3.5A)
SAM  A 601 (-3.1A)
SAM  A 601 (-4.1A)
SAM  A 601 (-3.6A)
SAM  A 601 (-3.6A)
0.63A 5wz2A-4n49A:
15.2
5wz2A-4n49A:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ2_B_SAMB601_0
(NS5 MTASE)
4n49 CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1

(Homo
sapiens)
5 / 12 GLY A 279
GLY A 282
THR A 301
ASP A 335
ASP A 364
SAM  A 601 (-3.5A)
SAM  A 601 (-3.1A)
SAM  A 601 (-4.1A)
SAM  A 601 (-3.6A)
SAM  A 601 (-3.6A)
0.61A 5wz2B-4n49A:
15.7
5wz2B-4n49A:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZW2_A_ACTA511_0
(L-PROLYL-[PEPTIDYL-C
ARRIER PROTEIN]
DEHYDROGENASE)
4n49 CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1

(Homo
sapiens)
3 / 3 ARG A 346
ILE A 394
SER A 393
None
0.87A 5zw2A-4n49A:
undetectable
5zw2A-4n49A:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_A_AQ4A602_1
(CYTOCHROME P450 1A1)
4n49 CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1

(Homo
sapiens)
4 / 5 ILE A 342
SER A 343
ALA A 462
LEU A 385
None
0.93A 6dwnA-4n49A:
undetectable
6dwnA-4n49A:
15.18