SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4n4p'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_C_DVAC6_0
(GRAMICIDIN A)		 4n4p ACYLNEURAMINATE
LYASE
(Mycoplasma
synoviae) 		3 / 3 ALA A 221
VAL A 234
TRP A 226
 None
 0.88A 1c4dC-4n4pA:
undetectable
1c4dD-4n4pA:
undetectable		 1c4dC-4n4pA:
4.56
1c4dD-4n4pA:
4.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_A_CCSA47_0
(GLUTATHIONE
S-TRANSFERASE)		 4n4p ACYLNEURAMINATE
LYASE
(Mycoplasma
synoviae) 		4 / 7 LEU A  24
THR A  16
GLY A  28
LEU A  68
 None
 0.92A 1gtiA-4n4pA:
undetectable		 1gtiA-4n4pA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK1_A_T44A3004_1
(SERUM ALBUMIN)		 4n4p ACYLNEURAMINATE
LYASE
(Mycoplasma
synoviae) 		4 / 6 PHE A  59
GLU A  93
LEU A  97
MET A  66
 None
 0.90A 1hk1A-4n4pA:
undetectable		 1hk1A-4n4pA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KVL_A_CLSA371_1
(BETA-LACTAMASE)		 4n4p ACYLNEURAMINATE
LYASE
(Mycoplasma
synoviae) 		5 / 10 GLY A  52
LEU A  36
ASN A 213
THR A  48
GLY A  49
 None
None
None
None
CL  A 300 ( 4.1A)
 1.33A 1kvlA-4n4pA:
undetectable		 1kvlA-4n4pA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y7I_A_SALA501_1
(SALICYLIC
ACID-BINDING PROTEIN
2)		 4n4p ACYLNEURAMINATE
LYASE
(Mycoplasma
synoviae) 		5 / 9 GLY A 252
SER A 256
LEU A 253
TYR A 244
HIS A 286
 None
 1.46A 1y7iA-4n4pA:
undetectable		 1y7iA-4n4pA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_C_CTXC3_1
(CES1 PROTEIN)		 4n4p ACYLNEURAMINATE
LYASE
(Mycoplasma
synoviae) 		5 / 12 PHE A  18
GLY A  52
GLY A  49
MET A  66
LEU A  94
 None
None
CL  A 300 ( 4.1A)
None
None
 1.03A 1ya4C-4n4pA:
undetectable		 1ya4C-4n4pA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B17_A_DIFA701_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 4n4p ACYLNEURAMINATE
LYASE
(Mycoplasma
synoviae) 		5 / 10 LEU A 137
ALA A 191
ILE A 208
GLY A 206
PHE A 176
 None
 1.43A 2b17A-4n4pA:
undetectable		 2b17A-4n4pA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KHM_A_TPFA501_1
(STEROL 14
ALPHA-DEMETHYLASE)		 4n4p ACYLNEURAMINATE
LYASE
(Mycoplasma
synoviae) 		4 / 8 TYR A 244
TYR A 241
THR A  51
LEU A 257
 None
None
CL  A 300 (-4.0A)
None
 0.80A 3khmA-4n4pA:
undetectable		 3khmA-4n4pA:
24.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L4D_A_TPFA490_1
(STEROL 14-ALPHA
DEMETHYLASE)		 4n4p ACYLNEURAMINATE
LYASE
(Mycoplasma
synoviae) 		4 / 8 TYR A 244
TYR A 241
THR A  51
LEU A 257
 None
None
CL  A 300 (-4.0A)
None
 0.58A 3l4dA-4n4pA:
undetectable		 3l4dA-4n4pA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QX3_A_EVPA1_1
(DNA TOPOISOMERASE
2-BETA)		 4n4p ACYLNEURAMINATE
LYASE
(Mycoplasma
synoviae) 		4 / 5 GLY A  28
ASP A 267
ARG A 262
GLN A  40
 None
 1.38A 3qx3A-4n4pA:
undetectable		 3qx3A-4n4pA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RV5_B_DXCB92_0
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 4n4p ACYLNEURAMINATE
LYASE
(Mycoplasma
synoviae) 		4 / 5 VAL A  37
VAL A  77
ARG A  76
LYS A 102
 None
 1.41A 3rv5A-4n4pA:
undetectable
3rv5B-4n4pA:
undetectable		 3rv5A-4n4pA:
20.40
3rv5B-4n4pA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZS3_A_ACTA1224_0
(THAUMATIN-LIKE
PROTEIN)		 4n4p ACYLNEURAMINATE
LYASE
(Mycoplasma
synoviae) 		4 / 5 SER A 210
GLU A 194
THR A 211
TYR A 244
 None
 1.48A 3zs3A-4n4pA:
undetectable		 3zs3A-4n4pA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IIL_A_RBFA401_2
(MEMBRANE LIPOPROTEIN
TPN38(B))		 4n4p ACYLNEURAMINATE
LYASE
(Mycoplasma
synoviae) 		4 / 8 PRO A 111
ASN A  87
GLN A  82
ILE A 128
 None
 1.09A 4iilA-4n4pA:
2.6		 4iilA-4n4pA:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R20_A_AERA602_1
(CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2)		 4n4p ACYLNEURAMINATE
LYASE
(Mycoplasma
synoviae) 		4 / 8 ILE A 208
GLY A  49
THR A  16
VAL A  29
 None
CL  A 300 ( 4.1A)
None
None
 0.78A 4r20A-4n4pA:
undetectable		 4r20A-4n4pA:
17.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U14_A_0HKA2000_1
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M3,ENDOLYSIN,MUSCARI
NIC ACETYLCHOLINE
RECEPTOR M3)		 4n4p ACYLNEURAMINATE
LYASE
(Mycoplasma
synoviae) 		5 / 12 ILE A 208
THR A  91
ALA A  95
ALA A  98
TYR A 139
 None
 0.94A 4u14A-4n4pA:
undetectable		 4u14A-4n4pA:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCI_A_ADNA2414_1
(RNA-DIRECTED RNA
POLYMERASE L)		 4n4p ACYLNEURAMINATE
LYASE
(Mycoplasma
synoviae) 		4 / 6 GLU A 177
PHE A 176
PHE A 188
TYR A 183
 None
 1.24A 4uciA-4n4pA:
undetectable		 4uciA-4n4pA:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCI_B_ADNB2415_1
(RNA-DIRECTED RNA
POLYMERASE L)		 4n4p ACYLNEURAMINATE
LYASE
(Mycoplasma
synoviae) 		4 / 7 GLU A 177
PHE A 176
PHE A 188
TYR A 183
 None
 1.24A 4uciB-4n4pA:
undetectable		 4uciB-4n4pA:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE1_A_X2NA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4n4p ACYLNEURAMINATE
LYASE
(Mycoplasma
synoviae) 		4 / 5 TYR A 103
ILE A  83
PRO A  12
THR A  16
 None
 1.32A 4ze1A-4n4pA:
undetectable		 4ze1A-4n4pA:
21.73