SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4n5a'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KT6_A_RTLA184_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 4n5a PROTEIN EFR3
(Saccharomyces
cerevisiae) 		5 / 11 LEU A  50
LEU A  57
ALA A  74
VAL A  53
LEU A  39
 None
 1.37A 1kt6A-4n5aA:
undetectable		 1kt6A-4n5aA:
14.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KT7_A_RTLA184_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 4n5a PROTEIN EFR3
(Saccharomyces
cerevisiae) 		5 / 11 LEU A  50
LEU A  57
ALA A  74
VAL A  53
LEU A  39
 None
 1.41A 1kt7A-4n5aA:
undetectable		 1kt7A-4n5aA:
14.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VM1_A_TAZA504_1
(BETA-LACTAMASE SHV-1)		 4n5a PROTEIN EFR3
(Saccharomyces
cerevisiae) 		3 / 3 ASP A  97
TYR A 100
GLU A 142
 None
 0.82A 1vm1A-4n5aA:
undetectable		 1vm1A-4n5aA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GVC_B_MMZB501_1
(MONOOXYGENASE)		 4n5a PROTEIN EFR3
(Saccharomyces
cerevisiae) 		3 / 3 ASN A  72
TYR A  56
SER A  63
 None
 0.86A 2gvcB-4n5aA:
undetectable		 2gvcB-4n5aA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GVC_E_MMZE501_1
(MONOOXYGENASE)		 4n5a PROTEIN EFR3
(Saccharomyces
cerevisiae) 		3 / 3 ASN A  72
TYR A  56
SER A  63
 None
 0.85A 2gvcE-4n5aA:
undetectable		 2gvcE-4n5aA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OPX_A_DXCA1001_0
(ALDEHYDE
DEHYDROGENASE A)		 4n5a PROTEIN EFR3
(Saccharomyces
cerevisiae) 		4 / 7 LEU A 106
PHE A 155
PHE A 150
ILE A 121
 None
 0.95A 2opxA-4n5aA:
undetectable		 2opxA-4n5aA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_C_TFPC202_1
(PROTEIN S100-A4)		 4n5a PROTEIN EFR3
(Saccharomyces
cerevisiae) 		5 / 11 ASP A 174
LEU A 251
SER A 253
PHE A 255
PHE A 190
 None
 1.33A 3ko0A-4n5aA:
undetectable
3ko0B-4n5aA:
1.5
3ko0C-4n5aA:
undetectable
3ko0D-4n5aA:
1.5		 3ko0A-4n5aA:
11.95
3ko0B-4n5aA:
11.95
3ko0C-4n5aA:
11.95
3ko0D-4n5aA:
11.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_E_TFPE202_1
(PROTEIN S100-A4)		 4n5a PROTEIN EFR3
(Saccharomyces
cerevisiae) 		5 / 11 SER A 182
LEU A 270
SER A 266
ILE A 199
PHE A 155
 None
 1.46A 3ko0C-4n5aA:
undetectable
3ko0D-4n5aA:
undetectable
3ko0E-4n5aA:
1.6
3ko0F-4n5aA:
undetectable		 3ko0C-4n5aA:
11.95
3ko0D-4n5aA:
11.95
3ko0E-4n5aA:
11.95
3ko0F-4n5aA:
11.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_N_TFPN202_1
(PROTEIN S100-A4)		 4n5a PROTEIN EFR3
(Saccharomyces
cerevisiae) 		5 / 11 SER A 182
LEU A 270
SER A 266
ILE A 199
PHE A 155
 None
 1.48A 3ko0K-4n5aA:
1.6
3ko0L-4n5aA:
undetectable
3ko0M-4n5aA:
undetectable
3ko0N-4n5aA:
undetectable		 3ko0K-4n5aA:
11.95
3ko0L-4n5aA:
11.95
3ko0M-4n5aA:
11.95
3ko0N-4n5aA:
11.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_O_TFPO202_1
(PROTEIN S100-A4)		 4n5a PROTEIN EFR3
(Saccharomyces
cerevisiae) 		5 / 11 LEU A 251
SER A 253
PHE A 255
PHE A 190
ASP A 174
 None
 1.33A 3ko0O-4n5aA:
1.6
3ko0P-4n5aA:
1.6
3ko0Q-4n5aA:
1.7
3ko0R-4n5aA:
1.6		 3ko0O-4n5aA:
11.95
3ko0P-4n5aA:
11.95
3ko0Q-4n5aA:
11.95
3ko0R-4n5aA:
11.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_T_TFPT202_1
(PROTEIN S100-A4)		 4n5a PROTEIN EFR3
(Saccharomyces
cerevisiae) 		5 / 11 SER A 182
LEU A 270
SER A 266
ILE A 199
PHE A 155
 None
 1.49A 3ko0Q-4n5aA:
undetectable
3ko0R-4n5aA:
1.6
3ko0S-4n5aA:
1.6
3ko0T-4n5aA:
undetectable		 3ko0Q-4n5aA:
11.95
3ko0R-4n5aA:
11.95
3ko0S-4n5aA:
11.95
3ko0T-4n5aA:
11.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUG_A_SUEA1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 4n5a PROTEIN EFR3
(Saccharomyces
cerevisiae) 		5 / 12 ASP A 242
ARG A 205
GLY A 235
ALA A 239
ASP A 245
 None
 1.04A 3sugA-4n5aA:
undetectable		 3sugA-4n5aA:
17.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WXO_A_NIZA803_1
(CATALASE-PEROXIDASE)		 4n5a PROTEIN EFR3
(Saccharomyces
cerevisiae) 		4 / 4 ASP A 174
THR A 178
VAL A 151
SER A 176
 None
 1.22A 3wxoA-4n5aA:
1.5		 3wxoA-4n5aA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F4D_B_CHDB504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4n5a PROTEIN EFR3
(Saccharomyces
cerevisiae) 		4 / 4 LEU A 450
PRO A 446
LEU A 420
ILE A 424
 None
 0.97A 4f4dB-4n5aA:
undetectable		 4f4dB-4n5aA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KLR_A_CHDA505_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4n5a PROTEIN EFR3
(Saccharomyces
cerevisiae) 		4 / 5 LEU A 450
PRO A 446
LEU A 420
ILE A 424
 None
 0.92A 4klrA-4n5aA:
undetectable		 4klrA-4n5aA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKX_A_198A1002_2
(ANDROGEN RECEPTOR)		 4n5a PROTEIN EFR3
(Saccharomyces
cerevisiae) 		4 / 6 LEU A 457
MET A 470
LEU A 420
ILE A 449
 None
 1.11A 4okxA-4n5aA:
undetectable		 4okxA-4n5aA:
16.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRW_D_LURD705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4n5a PROTEIN EFR3
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 536
LEU A 484
GLY A 552
ALA A 553
LEU A 557
 None
 1.03A 4rrwD-4n5aA:
2.2		 4rrwD-4n5aA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRZ_D_LURD705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4n5a PROTEIN EFR3
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 536
LEU A 484
GLY A 552
ALA A 553
LEU A 557
 None
 1.03A 4rrzD-4n5aA:
2.2		 4rrzD-4n5aA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBS_A_DIFA502_1
(PENTALENIC ACID
SYNTHASE)		 4n5a PROTEIN EFR3
(Saccharomyces
cerevisiae) 		5 / 9 LEU A 344
LEU A 301
ARG A 304
SER A 307
LEU A 306
 None
 1.35A 4ubsA-4n5aA:
2.6		 4ubsA-4n5aA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IAO_C_URFC301_1
(BIFUNCTIONAL PROTEIN
PYRR)		 4n5a PROTEIN EFR3
(Saccharomyces
cerevisiae) 		3 / 3 ARG A  25
HIS A  67
ARG A  69
 None
 0.84A 5iaoC-4n5aA:
undetectable		 5iaoC-4n5aA:
14.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IAO_F_URFF301_1
(BIFUNCTIONAL PROTEIN
PYRR)		 4n5a PROTEIN EFR3
(Saccharomyces
cerevisiae) 		3 / 3 ARG A  25
HIS A  67
ARG A  69
 None
 0.90A 5iaoF-4n5aA:
undetectable		 5iaoF-4n5aA:
14.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JMN_A_FUAA1101_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 4n5a PROTEIN EFR3
(Saccharomyces
cerevisiae) 		4 / 5 ILE A 418
ILE A 406
HIS A 433
VAL A 410
 None
 0.91A 5jmnA-4n5aA:
undetectable		 5jmnA-4n5aA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JMN_B_FUAB1101_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 4n5a PROTEIN EFR3
(Saccharomyces
cerevisiae) 		4 / 5 ILE A 363
LEU A 214
LYS A 280
VAL A 327
 None
 1.15A 5jmnB-4n5aA:
2.3		 5jmnB-4n5aA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_B_ACTB309_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 4n5a PROTEIN EFR3
(Saccharomyces
cerevisiae) 		3 / 3 TYR A 540
ALA A 509
TYR A 517
 None
 0.78A 5uunB-4n5aA:
undetectable		 5uunB-4n5aA:
18.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AZ3_1_PAR11803_1
(RRNA ALPHA
RIBOSOMAL PROTEIN
EL18)		 4n5a PROTEIN EFR3
(Saccharomyces
cerevisiae) 		3 / 3 SER A 452
LYS A 453
SER A 456
 None
 0.70A 6az3P-4n5aA:
undetectable		 6az3P-4n5aA:
10.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H7U_A_FVTA501_0
(PEPTIDE ABC
TRANSPORTER PERMEASE)		 4n5a PROTEIN EFR3
(Saccharomyces
cerevisiae) 		4 / 6 ASN A 314
PRO A 315
ILE A 316
GLU A 356
 None
 1.03A 6h7uA-4n5aA:
undetectable		 6h7uA-4n5aA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HZP_A_FVTA501_0
(PEPTIDE ABC
TRANSPORTER PERMEASE)		 4n5a PROTEIN EFR3
(Saccharomyces
cerevisiae) 		4 / 8 ASN A 314
PRO A 315
ILE A 316
GLU A 356
 None
 1.12A 6hzpA-4n5aA:
undetectable		 6hzpA-4n5aA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_A_AM2A301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 4n5a PROTEIN EFR3
(Saccharomyces
cerevisiae) 		4 / 8 HIS A 412
GLU A 411
ASP A 407
GLU A 404
 None
 1.04A 6mn4A-4n5aA:
undetectable		 6mn4A-4n5aA:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_B_AM2B301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 4n5a PROTEIN EFR3
(Saccharomyces
cerevisiae) 		4 / 8 HIS A 412
GLU A 411
ASP A 407
GLU A 404
 None
 1.15A 6mn4B-4n5aA:
undetectable		 6mn4B-4n5aA:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_F_AM2F301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 4n5a PROTEIN EFR3
(Saccharomyces
cerevisiae) 		4 / 7 HIS A 412
GLU A 411
ASP A 407
GLU A 404
 None
 1.23A 6mn4F-4n5aA:
undetectable		 6mn4F-4n5aA:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_E_LLLE301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 4n5a PROTEIN EFR3
(Saccharomyces
cerevisiae) 		4 / 7 GLU A 411
ASP A 407
CYH A 362
GLU A 404
 None
 1.07A 6mn5E-4n5aA:
undetectable		 6mn5E-4n5aA:
9.19