SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4n5q'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_B_P1ZB1357_1
(PROSTAGLANDIN
REDUCTASE 2)		 4n5q TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 3
(Mus
musculus) 		4 / 6 TYR A 321
LEU A 333
ASN A 298
ASP A 293
 None
 1.46A 2w98A-4n5qA:
undetectable
2w98B-4n5qA:
undetectable		 2w98A-4n5qA:
22.53
2w98B-4n5qA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CE6_B_ADNB500_2
(ADENOSYLHOMOCYSTEINA
SE)		 4n5q TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 3
(Mus
musculus) 		4 / 5 LEU A 281
GLN A 286
THR A 287
THR A 231
 None
 1.31A 3ce6B-4n5qA:
undetectable		 3ce6B-4n5qA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NBQ_A_URFA400_1
(URIDINE
PHOSPHORYLASE 1)		 4n5q TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 3
(Mus
musculus) 		5 / 9 THR A 287
GLU A 285
LEU A 281
LEU A 280
ILE A 235
 None
 1.44A 3nbqA-4n5qA:
undetectable		 3nbqA-4n5qA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TE8_B_08JB602_1
(CYTOCHROME P450 3A4)		 4n5q TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 3
(Mus
musculus) 		4 / 8 ALA A 232
ILE A 223
ALA A 222
LEU A 219
 None
 0.79A 5te8B-4n5qA:
undetectable		 5te8B-4n5qA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GIQ_T_PCFT101_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 1,
MITOCHONDRIAL
CYTOCHROME B-C1
COMPLEX SUBUNIT 9
CYTOCHROME B-C1
COMPLEX SUBUNIT
RIESKE,
MITOCHONDRIAL)		 4n5q TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 3
(Mus
musculus) 		4 / 8 ASP A 293
SER A 294
TYR A 260
VAL A 248
 None
 1.12A 6giqL-4n5qA:
undetectable
6giqP-4n5qA:
undetectable
6giqT-4n5qA:
undetectable		 6giqL-4n5qA:
19.44
6giqP-4n5qA:
22.51
6giqT-4n5qA:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MXT_A_K5YA1401_0
(ENDOLYSIN, BETA-2
ADRENERGIC RECEPTOR
CHIMERA)		 4n5q TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 3
(Mus
musculus) 		5 / 12 ASP A 156
PHE A 157
PHE A 193
ILE A 199
ASN A 197
 None
 1.07A 6mxtA-4n5qA:
undetectable		 6mxtA-4n5qA:
20.46