SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4n5x'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4F_A_ADNA601_1
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 4n5x CALCIUM-BINDING
MITOCHONDRIAL
CARRIER PROTEIN
SCAMC-1
(Homo
sapiens) 		5 / 12 LEU A  75
LEU A  27
LEU A  31
GLY A  47
PHE A  64
 None
 1.35A 1d4fA-4n5xA:
undetectable		 1d4fA-4n5xA:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B9E_A_SAMA1201_0
(NOL1/NOP2/SUN DOMAIN
FAMILY, MEMBER 5
ISOFORM 2)		 4n5x CALCIUM-BINDING
MITOCHONDRIAL
CARRIER PROTEIN
SCAMC-1
(Homo
sapiens) 		5 / 12 GLY A  47
ASN A  50
ASP A  40
ASP A  76
PHE A  77
 None
None
None
CA  A 203 ( 4.9A)
None
 1.38A 2b9eA-4n5xA:
undetectable		 2b9eA-4n5xA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_B_CHDB153_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 4n5x CALCIUM-BINDING
MITOCHONDRIAL
CARRIER PROTEIN
SCAMC-1
(Homo
sapiens) 		4 / 6 ILE A 111
THR A 170
PHE A 165
PHE A 151
 None
 1.12A 3elzB-4n5xA:
undetectable		 3elzB-4n5xA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GQB_A_GCSA602_1
(CHITINASE)		 4n5x CALCIUM-BINDING
MITOCHONDRIAL
CARRIER PROTEIN
SCAMC-1
(Homo
sapiens) 		3 / 3 TRP A 144
GLU A  88
ASP A 149
 None
 0.87A 5gqbA-4n5xA:
undetectable		 5gqbA-4n5xA:
16.97