SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4n6b'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N4H_A_REAA500_1
(NUCLEAR RECEPTOR
ROR-BETA)		 4n6b SERINE
ACETYLTRANSFERASE
APOENZYME
(Glycine
max) 		5 / 11 ALA A  81
VAL A 127
ARG A 133
LEU A  69
ALA A 142
 None
 1.13A 1n4hA-4n6bA:
undetectable		 1n4hA-4n6bA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P33_A_MTXA351_1
(PTERIDINE REDUCTASE
1)		 4n6b SERINE
ACETYLTRANSFERASE
APOENZYME
(Glycine
max) 		5 / 12 SER A  83
PHE A  82
LEU A  60
LEU A 113
LEU A  96
 None
 1.30A 1p33A-4n6bA:
undetectable		 1p33A-4n6bA:
24.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P33_B_MTXB352_1
(PTERIDINE REDUCTASE
1)		 4n6b SERINE
ACETYLTRANSFERASE
APOENZYME
(Glycine
max) 		5 / 12 SER A  83
PHE A  82
LEU A  60
LEU A 113
LEU A  96
 None
 1.31A 1p33B-4n6bA:
undetectable		 1p33B-4n6bA:
24.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P33_C_MTXC353_1
(PTERIDINE REDUCTASE
1)		 4n6b SERINE
ACETYLTRANSFERASE
APOENZYME
(Glycine
max) 		5 / 12 SER A  83
PHE A  82
LEU A  60
LEU A 113
LEU A  96
 None
 1.38A 1p33C-4n6bA:
undetectable		 1p33C-4n6bA:
24.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XZ1_A_HLTA2001_1
(FERRITIN LIGHT CHAIN)		 4n6b SERINE
ACETYLTRANSFERASE
APOENZYME
(Glycine
max) 		4 / 4 LEU A 113
SER A 110
TYR A 109
LEU A  96
 None
 1.09A 1xz1A-4n6bA:
undetectable		 1xz1A-4n6bA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XZ3_A_ICFA201_1
(FERRITIN LIGHT CHAIN)		 4n6b SERINE
ACETYLTRANSFERASE
APOENZYME
(Glycine
max) 		4 / 4 LEU A 113
SER A 110
TYR A 109
LEU A  96
 None
 1.09A 1xz3A-4n6bA:
undetectable		 1xz3A-4n6bA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXM_A_IMNA2001_1
(SERUM ALBUMIN)		 4n6b SERINE
ACETYLTRANSFERASE
APOENZYME
(Glycine
max) 		4 / 8 PHE A 151
ALA A 124
ARG A 126
LEU A  60
 None
 0.91A 2bxmA-4n6bA:
2.1		 2bxmA-4n6bA:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GLU_A_SAMA301_0
(YCGJ)		 4n6b SERINE
ACETYLTRANSFERASE
APOENZYME
(Glycine
max) 		5 / 12 GLY A 221
GLY A 194
THR A 178
THR A 218
ARG A 203
 None
 1.06A 2gluA-4n6bA:
undetectable		 2gluA-4n6bA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PRG_B_BRLB2_1
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 4n6b SERINE
ACETYLTRANSFERASE
APOENZYME
(Glycine
max) 		5 / 12 SER A 110
TYR A  41
LEU A  38
HIS A  59
LEU A 120
 None
 1.42A 2prgB-4n6bA:
undetectable		 2prgB-4n6bA:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MG0_Y_BO2Y1403_1
(PROTEASOME COMPONENT
PRE2
PROTEASOME COMPONENT
C5)		 4n6b SERINE
ACETYLTRANSFERASE
APOENZYME
(Glycine
max) 		5 / 12 ALA A 247
THR A 246
ALA A 229
ALA A 233
GLY A 214
 None
COA  A 300 (-3.7A)
None
COA  A 300 (-3.7A)
COA  A 300 ( 4.0A)
 0.85A 3mg0Y-4n6bA:
undetectable
3mg0Z-4n6bA:
undetectable		 3mg0Y-4n6bA:
22.56
3mg0Z-4n6bA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U52_A_CUA515_0
(PHENOL HYDROXYLASE
COMPONENT PHL
PHENOL HYDROXYLASE
COMPONENT PHN)		 4n6b SERINE
ACETYLTRANSFERASE
APOENZYME
(Glycine
max) 		3 / 3 HIS A 129
HIS A 125
ILE A 161
 None
 0.67A 3u52A-4n6bA:
undetectable
3u52C-4n6bA:
undetectable		 3u52A-4n6bA:
19.22
3u52C-4n6bA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UYM_B_VORB590_1
(14-ALPHA STEROL
DEMETHYLASE)		 4n6b SERINE
ACETYLTRANSFERASE
APOENZYME
(Glycine
max) 		4 / 7 PHE A  82
ALA A  92
LEU A 120
PHE A 119
 None
 0.89A 4uymB-4n6bA:
undetectable		 4uymB-4n6bA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y8W_B_STRB603_1
(CYTOCHROME P450
21-HYDROXYLASE)		 4n6b SERINE
ACETYLTRANSFERASE
APOENZYME
(Glycine
max) 		5 / 12 VAL A 241
SER A 235
VAL A 211
LEU A 212
GLY A 214
 None
None
None
None
COA  A 300 ( 4.0A)
 1.11A 4y8wB-4n6bA:
undetectable		 4y8wB-4n6bA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZVC_A_BEZA301_0
(DIGUANYLATE CYCLASE
DOSC)		 4n6b SERINE
ACETYLTRANSFERASE
APOENZYME
(Glycine
max) 		4 / 8 ILE A  24
LEU A  52
ILE A  46
LEU A 114
 None
 0.81A 4zvcA-4n6bA:
undetectable
4zvcB-4n6bA:
undetectable		 4zvcA-4n6bA:
21.59
4zvcB-4n6bA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZVC_A_BEZA301_0
(DIGUANYLATE CYCLASE
DOSC)		 4n6b SERINE
ACETYLTRANSFERASE
APOENZYME
(Glycine
max) 		4 / 8 ILE A  46
LEU A 114
ILE A  24
LEU A  52
 None
 0.81A 4zvcA-4n6bA:
undetectable
4zvcB-4n6bA:
undetectable		 4zvcA-4n6bA:
21.59
4zvcB-4n6bA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E4D_B_BEZB201_0
(HYDROXYNITRILE LYASE)		 4n6b SERINE
ACETYLTRANSFERASE
APOENZYME
(Glycine
max) 		5 / 11 VAL A 191
PHE A 167
ILE A 161
ILE A 155
LEU A 193
 None
 1.13A 5e4dB-4n6bA:
undetectable		 5e4dB-4n6bA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JI0_D_BRLD501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4n6b SERINE
ACETYLTRANSFERASE
APOENZYME
(Glycine
max) 		5 / 12 SER A 110
TYR A  41
LEU A  38
HIS A  59
LEU A 120
 None
 1.44A 5ji0D-4n6bA:
undetectable		 5ji0D-4n6bA:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KVA_B_SAMB301_0
(CAFFEOYL-COA
O-METHYLTRANSFERASE)		 4n6b SERINE
ACETYLTRANSFERASE
APOENZYME
(Glycine
max) 		5 / 12 THR A 218
GLY A 176
ILE A 155
ALA A 158
ALA A 179
 None
 1.12A 5kvaB-4n6bA:
undetectable		 5kvaB-4n6bA:
20.45