SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4n6d'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D0V_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 4n6d TRAP DICARBOXYLATE
TRANSPORTER-DCTP
SUBUNIT
(Desulfovibrio
salexigens) 		4 / 8 GLY A  86
LEU A  74
SER A  33
GLY A  91
 None
None
CL  A 403 (-4.6A)
None
 0.72A 1d0vA-4n6dA:
undetectable		 1d0vA-4n6dA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHA_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 4n6d TRAP DICARBOXYLATE
TRANSPORTER-DCTP
SUBUNIT
(Desulfovibrio
salexigens) 		4 / 8 GLY A  86
LEU A  74
SER A  33
GLY A  91
 None
None
CL  A 403 (-4.6A)
None
 0.74A 1jhaA-4n6dA:
undetectable		 1jhaA-4n6dA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJF_A_ADNA2001_1
(235AA LONG
HYPOTHETICAL
BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)		 4n6d TRAP DICARBOXYLATE
TRANSPORTER-DCTP
SUBUNIT
(Desulfovibrio
salexigens) 		4 / 7 GLU A 109
ALA A 120
PRO A 234
ALA A 146
 None
 0.89A 2ejfA-4n6dA:
2.1		 2ejfA-4n6dA:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2I91_A_ACTA601_0
(60 KDA SS-A/RO
RIBONUCLEOPROTEIN)		 4n6d TRAP DICARBOXYLATE
TRANSPORTER-DCTP
SUBUNIT
(Desulfovibrio
salexigens) 		4 / 7 SER A 117
ALA A 120
SER A 121
SER A 147
 None
 0.82A 2i91A-4n6dA:
undetectable		 2i91A-4n6dA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2I91_B_ACTB602_0
(60 KDA SS-A/RO
RIBONUCLEOPROTEIN)		 4n6d TRAP DICARBOXYLATE
TRANSPORTER-DCTP
SUBUNIT
(Desulfovibrio
salexigens) 		4 / 7 SER A 117
ALA A 120
SER A 121
SER A 147
 None
 0.81A 2i91B-4n6dA:
undetectable		 2i91B-4n6dA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NV4_B_SAMB202_0
(UPF0066 PROTEIN
AF_0241)		 4n6d TRAP DICARBOXYLATE
TRANSPORTER-DCTP
SUBUNIT
(Desulfovibrio
salexigens) 		5 / 12 ALA A 146
GLN A  47
GLY A 259
LEU A 258
LEU A 124
 None
 1.11A 2nv4B-4n6dA:
undetectable		 2nv4B-4n6dA:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WQ5_A_MIYA1120_1
(PHOSPHOLIPASE A2,
ACIDIC)		 4n6d TRAP DICARBOXYLATE
TRANSPORTER-DCTP
SUBUNIT
(Desulfovibrio
salexigens) 		4 / 7 ALA A  88
GLY A  82
PHE A 139
PHE A 136
 None
 0.86A 2wq5A-4n6dA:
undetectable		 2wq5A-4n6dA:
13.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XYT_D_TC9D1206_2
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 4n6d TRAP DICARBOXYLATE
TRANSPORTER-DCTP
SUBUNIT
(Desulfovibrio
salexigens) 		4 / 8 TYR A 285
MET A 289
ILE A 287
ASP A 283
 None
 1.11A 2xytE-4n6dA:
undetectable		 2xytE-4n6dA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XYT_H_TC9H1206_2
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 4n6d TRAP DICARBOXYLATE
TRANSPORTER-DCTP
SUBUNIT
(Desulfovibrio
salexigens) 		4 / 7 TYR A 285
MET A 289
ILE A 287
ASP A 283
 None
 1.14A 2xytI-4n6dA:
undetectable		 2xytI-4n6dA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZGW_A_ADNA1301_1
(BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)		 4n6d TRAP DICARBOXYLATE
TRANSPORTER-DCTP
SUBUNIT
(Desulfovibrio
salexigens) 		4 / 7 GLU A 109
ALA A 120
PRO A 234
ALA A 146
 None
 0.95A 2zgwA-4n6dA:
undetectable		 2zgwA-4n6dA:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZGW_B_ADNB1302_1
(BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)		 4n6d TRAP DICARBOXYLATE
TRANSPORTER-DCTP
SUBUNIT
(Desulfovibrio
salexigens) 		4 / 6 GLU A 109
ALA A 120
PRO A 234
ALA A 146
 None
 0.91A 2zgwB-4n6dA:
undetectable		 2zgwB-4n6dA:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CFL_A_5CHA693_1
(LACTOTRANSFERRIN)		 4n6d TRAP DICARBOXYLATE
TRANSPORTER-DCTP
SUBUNIT
(Desulfovibrio
salexigens) 		4 / 4 THR A 115
VAL A 274
GLY A 267
THR A 266
 None
 0.90A 3cflA-4n6dA:
undetectable		 3cflA-4n6dA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LVC_B_ADNB501_2
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(SAHASE))		 4n6d TRAP DICARBOXYLATE
TRANSPORTER-DCTP
SUBUNIT
(Desulfovibrio
salexigens) 		4 / 5 THR A 154
THR A 230
LEU A 182
LEU A 164
 None
 1.06A 4lvcB-4n6dA:
undetectable		 4lvcB-4n6dA:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOI_A_ML1A303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4n6d TRAP DICARBOXYLATE
TRANSPORTER-DCTP
SUBUNIT
(Desulfovibrio
salexigens) 		4 / 8 PHE A 102
TYR A 128
PHE A 136
GLY A  91
 None
 0.92A 4qoiA-4n6dA:
undetectable
4qoiB-4n6dA:
undetectable		 4qoiA-4n6dA:
20.39
4qoiB-4n6dA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z69_A_DIFA1008_1
(SERUM ALBUMIN)		 4n6d TRAP DICARBOXYLATE
TRANSPORTER-DCTP
SUBUNIT
(Desulfovibrio
salexigens) 		5 / 9 SER A  94
PHE A 235
PHE A 102
SER A 147
VAL A 232
 EDO  A 404 (-4.0A)
None
None
None
None
 1.47A 4z69A-4n6dA:
1.5		 4z69A-4n6dA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_C_7V7C202_1
(ENDO-1,4-BETA-XYLANA
SE A)		 4n6d TRAP DICARBOXYLATE
TRANSPORTER-DCTP
SUBUNIT
(Desulfovibrio
salexigens) 		4 / 8 THR A 118
THR A 266
ARG A  50
GLN A 262
 None
 1.36A 5tzoC-4n6dA:
undetectable		 5tzoC-4n6dA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_A_ACTA307_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 4n6d TRAP DICARBOXYLATE
TRANSPORTER-DCTP
SUBUNIT
(Desulfovibrio
salexigens) 		4 / 4 LEU A 161
LEU A 164
SER A 181
ALA A 184
 None
 0.93A 5uunA-4n6dA:
undetectable		 5uunA-4n6dA:
23.84