SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4n6f'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSF_C_EAAC223_1
(GLUTATHIONE
TRANSFERASE A1-1)		 4n6f PUTATIVE THIOSUGAR
SYNTHASE
(Amycolatopsis
orientalis) 		4 / 8 GLY A  29
LEU A 215
VAL A 168
PHE A  86
 F6R  A 304 ( 3.7A)
None
F6R  A 304 (-3.6A)
None
 0.96A 1gsfC-4n6fA:
undetectable		 1gsfC-4n6fA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_A_SAMA293_0
(GLYCINE
N-METHYLTRANSFERASE)		 4n6f PUTATIVE THIOSUGAR
SYNTHASE
(Amycolatopsis
orientalis) 		5 / 12 ILE A 180
GLY A 195
VAL A 193
ALA A 169
SER A 170
 None
F6R  A 304 (-3.5A)
None
F6R  A 304 (-4.7A)
None
 1.23A 1nbhA-4n6fA:
undetectable		 1nbhA-4n6fA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_C_SAMC2293_0
(GLYCINE
N-METHYLTRANSFERASE)		 4n6f PUTATIVE THIOSUGAR
SYNTHASE
(Amycolatopsis
orientalis) 		5 / 12 ILE A 180
GLY A 195
VAL A 193
ALA A 169
SER A 170
 None
F6R  A 304 (-3.5A)
None
F6R  A 304 (-4.7A)
None
 1.23A 1nbhC-4n6fA:
undetectable		 1nbhC-4n6fA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_D_SAMD3293_0
(GLYCINE
N-METHYLTRANSFERASE)		 4n6f PUTATIVE THIOSUGAR
SYNTHASE
(Amycolatopsis
orientalis) 		5 / 12 ILE A 180
GLY A 195
VAL A 193
ALA A 169
SER A 170
 None
F6R  A 304 (-3.5A)
None
F6R  A 304 (-4.7A)
None
 1.23A 1nbhD-4n6fA:
undetectable		 1nbhD-4n6fA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9Q_B_CHDB500_0
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 4n6f PUTATIVE THIOSUGAR
SYNTHASE
(Amycolatopsis
orientalis) 		4 / 4 LEU A  27
VAL A  28
ILE A  26
TRP A  14
 None
 1.39A 1s9qB-4n6fA:
undetectable		 1s9qB-4n6fA:
26.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA502_1
(CYTOCHROME P450 2B4)		 4n6f PUTATIVE THIOSUGAR
SYNTHASE
(Amycolatopsis
orientalis) 		5 / 12 LEU A  43
ILE A  30
ILE A  52
LEU A 215
THR A 214
 None
 0.96A 2bdmA-4n6fA:
undetectable		 2bdmA-4n6fA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FXD_A_DR7A102_2
(POL PROTEIN)		 4n6f PUTATIVE THIOSUGAR
SYNTHASE
(Amycolatopsis
orientalis) 		4 / 7 ARG A  61
ASP A 112
GLY A  29
ILE A  30
 None
F6R  A 304 (-3.4A)
F6R  A 304 ( 3.7A)
None
 0.86A 2fxdB-4n6fA:
undetectable		 2fxdB-4n6fA:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCT_A_ASDA1223_1
(GLUTATHIONE
S-TRANSFERASE A2)		 4n6f PUTATIVE THIOSUGAR
SYNTHASE
(Amycolatopsis
orientalis) 		4 / 8 ILE A  52
GLY A  82
LEU A 109
LEU A 111
 None
 0.87A 2vctA-4n6fA:
undetectable		 2vctA-4n6fA:
24.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCT_B_ASDB1223_1
(GLUTATHIONE
S-TRANSFERASE A2)		 4n6f PUTATIVE THIOSUGAR
SYNTHASE
(Amycolatopsis
orientalis) 		4 / 8 ILE A  52
GLY A  82
LEU A 109
LEU A 111
 None
 0.90A 2vctB-4n6fA:
undetectable		 2vctB-4n6fA:
24.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP2_B_PNNB5002_0
(TRANSCRIPTIONAL
REGULATOR TCAR)		 4n6f PUTATIVE THIOSUGAR
SYNTHASE
(Amycolatopsis
orientalis) 		4 / 5 ASN A 176
ALA A 179
ALA A 178
ARG A 181
 None
 1.21A 3kp2B-4n6fA:
undetectable		 3kp2B-4n6fA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_C_IPHC101_0
(INSULIN)		 4n6f PUTATIVE THIOSUGAR
SYNTHASE
(Amycolatopsis
orientalis) 		5 / 11 LEU A 132
LEU A  94
ALA A  97
LEU A 109
VAL A 113
 None
 1.09A 4p65C-4n6fA:
undetectable
4p65D-4n6fA:
undetectable
4p65J-4n6fA:
undetectable
4p65L-4n6fA:
undetectable		 4p65C-4n6fA:
4.58
4p65D-4n6fA:
7.03
4p65J-4n6fA:
7.03
4p65L-4n6fA:
7.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_G_IPHG101_0
(INSULIN)		 4n6f PUTATIVE THIOSUGAR
SYNTHASE
(Amycolatopsis
orientalis) 		5 / 11 LEU A 109
VAL A 113
LEU A 132
LEU A  94
ALA A  97
 None
 1.12A 4p65B-4n6fA:
undetectable
4p65D-4n6fA:
undetectable
4p65G-4n6fA:
undetectable
4p65H-4n6fA:
undetectable		 4p65B-4n6fA:
7.03
4p65D-4n6fA:
7.03
4p65G-4n6fA:
4.58
4p65H-4n6fA:
7.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_F_377F402_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 4n6f PUTATIVE THIOSUGAR
SYNTHASE
(Amycolatopsis
orientalis) 		4 / 8 ALA A 200
ALA A 204
ALA A 239
ALA A 232
 None
 0.76A 4twdF-4n6fA:
undetectable
4twdG-4n6fA:
undetectable
4twdH-4n6fA:
undetectable
4twdI-4n6fA:
undetectable
4twdJ-4n6fA:
undetectable		 4twdF-4n6fA:
23.93
4twdG-4n6fA:
23.93
4twdH-4n6fA:
23.93
4twdI-4n6fA:
23.93
4twdJ-4n6fA:
23.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_A_C2FA3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 4n6f PUTATIVE THIOSUGAR
SYNTHASE
(Amycolatopsis
orientalis) 		6 / 12 GLU A 194
GLY A 196
VAL A  42
LEU A  38
GLY A  29
ARG A 114
 F6R  A 304 (-3.6A)
F6R  A 304 (-3.5A)
None
None
F6R  A 304 ( 3.7A)
F6R  A 304 (-2.8A)
 1.37A 5vooA-4n6fA:
6.9		 5vooA-4n6fA:
26.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_C_C2FC702_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 4n6f PUTATIVE THIOSUGAR
SYNTHASE
(Amycolatopsis
orientalis) 		6 / 12 GLU A 194
GLY A 196
VAL A  42
LEU A  38
GLY A  29
ARG A 114
 F6R  A 304 (-3.6A)
F6R  A 304 (-3.5A)
None
None
F6R  A 304 ( 3.7A)
F6R  A 304 (-2.8A)
 1.37A 5vooC-4n6fA:
3.5		 5vooC-4n6fA:
26.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOP_A_C2FA3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 4n6f PUTATIVE THIOSUGAR
SYNTHASE
(Amycolatopsis
orientalis) 		6 / 12 GLU A 194
GLY A 196
VAL A  42
LEU A  38
GLY A  29
ARG A 114
 F6R  A 304 (-3.6A)
F6R  A 304 (-3.5A)
None
None
F6R  A 304 ( 3.7A)
F6R  A 304 (-2.8A)
 1.35A 5vopA-4n6fA:
7.2		 5vopA-4n6fA:
26.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_E_CHDE401_0
(BILE SALT HYDROLASE)		 4n6f PUTATIVE THIOSUGAR
SYNTHASE
(Amycolatopsis
orientalis) 		4 / 8 ILE A 143
LEU A 183
LEU A 209
ALA A 211
 None
 0.79A 5y7pE-4n6fA:
undetectable		 5y7pE-4n6fA:
22.26