SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4n6k'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_A_2FAA500_2
(ADENOSYLHOMOCYSTEINA
SE)		 4n6k TRAP DICARBOXYLATE
TRANSPORTER-DCTP
SUBUNIT
(Desulfovibrio
salexigens) 		4 / 5 THR A 229
THR A 235
HIS A 237
LEU A 185
 None
 0.96A 2zj0A-4n6kA:
undetectable		 2zj0A-4n6kA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CE6_A_ADNA500_2
(ADENOSYLHOMOCYSTEINA
SE)		 4n6k TRAP DICARBOXYLATE
TRANSPORTER-DCTP
SUBUNIT
(Desulfovibrio
salexigens) 		4 / 5 THR A 229
THR A 235
HIS A 237
LEU A 185
 None
 1.04A 3ce6A-4n6kA:
undetectable		 3ce6A-4n6kA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CE6_C_ADNC500_2
(ADENOSYLHOMOCYSTEINA
SE)		 4n6k TRAP DICARBOXYLATE
TRANSPORTER-DCTP
SUBUNIT
(Desulfovibrio
salexigens) 		4 / 5 THR A 229
THR A 235
HIS A 237
LEU A 185
 None
 1.02A 3ce6C-4n6kA:
undetectable		 3ce6C-4n6kA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G1U_A_ADNA438_2
(ADENOSYLHOMOCYSTEINA
SE)		 4n6k TRAP DICARBOXYLATE
TRANSPORTER-DCTP
SUBUNIT
(Desulfovibrio
salexigens) 		4 / 4 GLN A 159
THR A 229
THR A 235
HIS A 237
 None
 1.41A 3g1uA-4n6kA:
undetectable		 3g1uA-4n6kA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GLQ_A_RABA602_2
(ADENOSYLHOMOCYSTEINA
SE)		 4n6k TRAP DICARBOXYLATE
TRANSPORTER-DCTP
SUBUNIT
(Desulfovibrio
salexigens) 		4 / 5 GLN A 159
THR A 229
THR A 235
HIS A 237
 None
 1.44A 3glqA-4n6kA:
undetectable		 3glqA-4n6kA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GLQ_B_RABB602_2
(ADENOSYLHOMOCYSTEINA
SE)		 4n6k TRAP DICARBOXYLATE
TRANSPORTER-DCTP
SUBUNIT
(Desulfovibrio
salexigens) 		4 / 5 GLN A 159
THR A 229
THR A 235
HIS A 237
 None
 1.41A 3glqB-4n6kA:
undetectable		 3glqB-4n6kA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HGX_A_SALA102_1
(SALICYLATE
BIOSYNTHESIS PROTEIN
PCHB)		 4n6k TRAP DICARBOXYLATE
TRANSPORTER-DCTP
SUBUNIT
(Desulfovibrio
salexigens) 		4 / 7 ILE A  64
TYR A  57
ILE A  66
GLN A  67
 None
 0.94A 3hgxA-4n6kA:
undetectable		 3hgxA-4n6kA:
16.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N58_A_ADNA500_2
(ADENOSYLHOMOCYSTEINA
SE)		 4n6k TRAP DICARBOXYLATE
TRANSPORTER-DCTP
SUBUNIT
(Desulfovibrio
salexigens) 		4 / 5 GLN A 159
THR A 229
THR A 235
HIS A 237
 None
 1.37A 3n58A-4n6kA:
undetectable		 3n58A-4n6kA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P4W_C_DSFC320_1
(GLR4197 PROTEIN)		 4n6k TRAP DICARBOXYLATE
TRANSPORTER-DCTP
SUBUNIT
(Desulfovibrio
salexigens) 		4 / 8 TYR A 258
ILE A 261
ILE A 262
ILE A  66
 None
 0.67A 3p4wC-4n6kA:
undetectable		 3p4wC-4n6kA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RC0_A_SAMA484_0
(N-LYSINE
METHYLTRANSFERASE
SETD6)		 4n6k TRAP DICARBOXYLATE
TRANSPORTER-DCTP
SUBUNIT
(Desulfovibrio
salexigens) 		5 / 11 GLY A 243
TYR A 149
ALA A  76
TYR A  77
PHE A  98
 None
None
None
X3X  A 401 (-4.5A)
X3X  A 401 (-4.5A)
 1.23A 3rc0A-4n6kA:
0.1		 3rc0A-4n6kA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LVC_A_ADNA501_2
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(SAHASE))		 4n6k TRAP DICARBOXYLATE
TRANSPORTER-DCTP
SUBUNIT
(Desulfovibrio
salexigens) 		4 / 5 GLN A 159
THR A 229
THR A 235
HIS A 237
 None
 1.36A 4lvcA-4n6kA:
undetectable		 4lvcA-4n6kA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LVC_A_ADNA501_2
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(SAHASE))		 4n6k TRAP DICARBOXYLATE
TRANSPORTER-DCTP
SUBUNIT
(Desulfovibrio
salexigens) 		4 / 5 GLN A 159
THR A 229
THR A 235
LEU A 168
 None
 1.34A 4lvcA-4n6kA:
undetectable		 4lvcA-4n6kA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LVC_A_ADNA501_2
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(SAHASE))		 4n6k TRAP DICARBOXYLATE
TRANSPORTER-DCTP
SUBUNIT
(Desulfovibrio
salexigens) 		4 / 5 THR A 229
THR A 235
HIS A 237
LEU A 185
 None
 0.97A 4lvcA-4n6kA:
undetectable		 4lvcA-4n6kA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LVC_C_ADNC501_2
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(SAHASE))		 4n6k TRAP DICARBOXYLATE
TRANSPORTER-DCTP
SUBUNIT
(Desulfovibrio
salexigens) 		4 / 5 GLN A 159
THR A 229
THR A 235
HIS A 237
 None
 1.33A 4lvcC-4n6kA:
undetectable		 4lvcC-4n6kA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LVC_C_ADNC501_2
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(SAHASE))		 4n6k TRAP DICARBOXYLATE
TRANSPORTER-DCTP
SUBUNIT
(Desulfovibrio
salexigens) 		4 / 5 GLN A 159
THR A 229
THR A 235
LEU A 168
 None
 1.35A 4lvcC-4n6kA:
undetectable		 4lvcC-4n6kA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LVC_C_ADNC501_2
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(SAHASE))		 4n6k TRAP DICARBOXYLATE
TRANSPORTER-DCTP
SUBUNIT
(Desulfovibrio
salexigens) 		4 / 5 THR A 229
THR A 235
HIS A 237
LEU A 185
 None
 0.97A 4lvcC-4n6kA:
undetectable		 4lvcC-4n6kA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M11_C_MXMC606_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4n6k TRAP DICARBOXYLATE
TRANSPORTER-DCTP
SUBUNIT
(Desulfovibrio
salexigens) 		3 / 3 LEU A 337
ARG A 333
MET A 113
 None
 0.84A 4m11C-4n6kA:
undetectable		 4m11C-4n6kA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PFJ_A_ADNA502_2
(ADENOSYLHOMOCYSTEINA
SE)		 4n6k TRAP DICARBOXYLATE
TRANSPORTER-DCTP
SUBUNIT
(Desulfovibrio
salexigens) 		4 / 7 THR A 229
THR A 235
HIS A 237
LEU A 185
 None
 1.04A 4pfjA-4n6kA:
undetectable		 4pfjA-4n6kA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RFQ_A_SAMA401_1
(HISTIDINE PROTEIN
METHYLTRANSFERASE 1
HOMOLOG)		 4n6k TRAP DICARBOXYLATE
TRANSPORTER-DCTP
SUBUNIT
(Desulfovibrio
salexigens) 		4 / 4 THR A 218
GLY A 240
ASP A  95
SER A 215
 X3X  A 401 (-2.7A)
None
X3X  A 401 (-3.6A)
None
 1.27A 4rfqA-4n6kA:
undetectable		 4rfqA-4n6kA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5K_A_ADNA502_2
(ADENOSYLHOMOCYSTEINA
SE)		 4n6k TRAP DICARBOXYLATE
TRANSPORTER-DCTP
SUBUNIT
(Desulfovibrio
salexigens) 		4 / 4 GLN A 159
THR A 229
THR A 235
LEU A 168
 None
 1.42A 5m5kA-4n6kA:
undetectable		 5m5kA-4n6kA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5K_C_ADNC502_2
(ADENOSYLHOMOCYSTEINA
SE)		 4n6k TRAP DICARBOXYLATE
TRANSPORTER-DCTP
SUBUNIT
(Desulfovibrio
salexigens) 		4 / 4 GLN A 159
THR A 229
THR A 235
LEU A 168
 None
 1.40A 5m5kC-4n6kA:
undetectable		 5m5kC-4n6kA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M66_B_ADNB502_2
(ADENOSYLHOMOCYSTEINA
SE)		 4n6k TRAP DICARBOXYLATE
TRANSPORTER-DCTP
SUBUNIT
(Desulfovibrio
salexigens) 		4 / 4 GLN A 159
THR A 229
THR A 235
LEU A 168
 None
 1.43A 5m66B-4n6kA:
undetectable		 5m66B-4n6kA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUR_B_PFLB407_1
(PROTON-GATED ION
CHANNEL)		 4n6k TRAP DICARBOXYLATE
TRANSPORTER-DCTP
SUBUNIT
(Desulfovibrio
salexigens) 		4 / 7 TYR A 258
ILE A 261
ILE A 262
ILE A  66
 None
 0.71A 5murB-4n6kA:
undetectable		 5murB-4n6kA:
15.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6APH_A_ADNA501_2
(ADENOSYLHOMOCYSTEINA
SE)		 4n6k TRAP DICARBOXYLATE
TRANSPORTER-DCTP
SUBUNIT
(Desulfovibrio
salexigens) 		4 / 5 GLN A 159
THR A 229
THR A 235
HIS A 237
 None
 1.36A 6aphA-4n6kA:
undetectable		 6aphA-4n6kA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F3M_B_ADNB502_2
(-)		 4n6k TRAP DICARBOXYLATE
TRANSPORTER-DCTP
SUBUNIT
(Desulfovibrio
salexigens) 		4 / 4 GLN A 159
THR A 229
THR A 235
LEU A 168
 None
 1.43A 6f3mB-4n6kA:
undetectable		 6f3mB-4n6kA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F3M_D_ADND502_2
(-)		 4n6k TRAP DICARBOXYLATE
TRANSPORTER-DCTP
SUBUNIT
(Desulfovibrio
salexigens) 		5 / 5 ILE A 157
GLN A 159
THR A 229
THR A 235
LEU A 168
 None
 1.49A 6f3mD-4n6kA:
undetectable		 6f3mD-4n6kA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F3N_A_ADNA505_2
(-)		 4n6k TRAP DICARBOXYLATE
TRANSPORTER-DCTP
SUBUNIT
(Desulfovibrio
salexigens) 		4 / 4 GLN A 159
THR A 229
THR A 235
HIS A 237
 None
 1.45A 6f3nA-4n6kA:
undetectable		 6f3nA-4n6kA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F3N_C_ADNC505_2
(-)		 4n6k TRAP DICARBOXYLATE
TRANSPORTER-DCTP
SUBUNIT
(Desulfovibrio
salexigens) 		4 / 4 GLN A 159
THR A 229
THR A 235
HIS A 237
 None
 1.45A 6f3nC-4n6kA:
undetectable		 6f3nC-4n6kA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F3N_D_ADND506_2
(-)		 4n6k TRAP DICARBOXYLATE
TRANSPORTER-DCTP
SUBUNIT
(Desulfovibrio
salexigens) 		4 / 4 GLN A 159
THR A 229
THR A 235
HIS A 237
 None
 1.44A 6f3nD-4n6kA:
undetectable		 6f3nD-4n6kA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GBN_A_ADNA501_2
(-)		 4n6k TRAP DICARBOXYLATE
TRANSPORTER-DCTP
SUBUNIT
(Desulfovibrio
salexigens) 		4 / 5 GLN A 159
THR A 229
THR A 235
HIS A 237
 None
 1.36A 6gbnA-4n6kA:
undetectable		 6gbnA-4n6kA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GBN_A_ADNA501_2
(-)		 4n6k TRAP DICARBOXYLATE
TRANSPORTER-DCTP
SUBUNIT
(Desulfovibrio
salexigens) 		4 / 5 GLN A 159
THR A 229
THR A 235
LEU A 168
 None
 1.37A 6gbnA-4n6kA:
undetectable		 6gbnA-4n6kA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GBN_A_ADNA501_2
(-)		 4n6k TRAP DICARBOXYLATE
TRANSPORTER-DCTP
SUBUNIT
(Desulfovibrio
salexigens) 		4 / 5 THR A 229
THR A 235
HIS A 237
LEU A 185
 None
 0.96A 6gbnA-4n6kA:
undetectable		 6gbnA-4n6kA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GBN_B_ADNB501_2
(-)		 4n6k TRAP DICARBOXYLATE
TRANSPORTER-DCTP
SUBUNIT
(Desulfovibrio
salexigens) 		4 / 5 GLN A 159
THR A 229
THR A 235
HIS A 237
 None
 1.37A 6gbnB-4n6kA:
undetectable		 6gbnB-4n6kA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GBN_D_ADND501_2
(-)		 4n6k TRAP DICARBOXYLATE
TRANSPORTER-DCTP
SUBUNIT
(Desulfovibrio
salexigens) 		4 / 5 GLN A 159
THR A 229
THR A 235
HIS A 237
 None
 1.39A 6gbnD-4n6kA:
undetectable		 6gbnD-4n6kA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GBN_D_ADND501_2
(-)		 4n6k TRAP DICARBOXYLATE
TRANSPORTER-DCTP
SUBUNIT
(Desulfovibrio
salexigens) 		4 / 5 GLN A 159
THR A 229
THR A 235
LEU A 168
 None
 1.37A 6gbnD-4n6kA:
undetectable		 6gbnD-4n6kA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GBN_D_ADND501_2
(-)		 4n6k TRAP DICARBOXYLATE
TRANSPORTER-DCTP
SUBUNIT
(Desulfovibrio
salexigens) 		4 / 5 THR A 229
THR A 235
HIS A 237
LEU A 185
 None
 0.96A 6gbnD-4n6kA:
undetectable		 6gbnD-4n6kA:
21.81