SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4n6q'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TLS_A_C2FA266_0
(THYMIDYLATE SYNTHASE)		 4n6q VOSA
(Aspergillus
nidulans) 		5 / 12 SER A 100
LEU A  77
GLY A  96
VAL A  44
ALA A  31
 None
 1.06A 1tlsA-4n6qA:
undetectable		 1tlsA-4n6qA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TLS_B_C2FB266_0
(THYMIDYLATE SYNTHASE)		 4n6q VOSA
(Aspergillus
nidulans) 		5 / 12 SER A 100
LEU A  77
GLY A  96
VAL A  44
ALA A  31
 None
 1.06A 1tlsB-4n6qA:
undetectable		 1tlsB-4n6qA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TSN_A_C2FA266_0
(THYMIDYLATE SYNTHASE)		 4n6q VOSA
(Aspergillus
nidulans) 		5 / 12 SER A 100
LEU A  77
GLY A  96
VAL A  44
ALA A  31
 None
 1.06A 1tsnA-4n6qA:
undetectable		 1tsnA-4n6qA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V54_C_CHDC3271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE III
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 4n6q VOSA
(Aspergillus
nidulans) 		4 / 8 LYS A 132
LEU A 131
PHE A 129
LEU A 121
 None
 0.87A 1v54C-4n6qA:
undetectable
1v54J-4n6qA:
undetectable		 1v54C-4n6qA:
22.18
1v54J-4n6qA:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V54_P_CHDP4271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE III
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 4n6q VOSA
(Aspergillus
nidulans) 		4 / 8 LYS A 132
LEU A 131
PHE A 129
LEU A 121
 None
 0.84A 1v54P-4n6qA:
undetectable
1v54W-4n6qA:
undetectable		 1v54P-4n6qA:
22.18
1v54W-4n6qA:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V55_C_CHDC3271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE III
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 4n6q VOSA
(Aspergillus
nidulans) 		4 / 7 LYS A 132
LEU A 131
PHE A 129
LEU A 121
 None
 0.86A 1v55C-4n6qA:
undetectable
1v55J-4n6qA:
undetectable		 1v55C-4n6qA:
22.18
1v55J-4n6qA:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYR_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4n6q VOSA
(Aspergillus
nidulans) 		4 / 8 LYS A 132
LEU A 131
PHE A 129
LEU A 121
 None
 0.88A 2dyrC-4n6qA:
undetectable
2dyrJ-4n6qA:
undetectable		 2dyrC-4n6qA:
22.18
2dyrJ-4n6qA:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYR_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4n6q VOSA
(Aspergillus
nidulans) 		4 / 8 LYS A 132
LEU A 131
PHE A 129
LEU A 121
 None
 0.86A 2dyrP-4n6qA:
undetectable
2dyrW-4n6qA:
undetectable		 2dyrP-4n6qA:
22.18
2dyrW-4n6qA:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYS_P_CHDP310_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4n6q VOSA
(Aspergillus
nidulans) 		4 / 7 LYS A 132
LEU A 131
PHE A 129
LEU A 121
 None
 0.76A 2dysP-4n6qA:
undetectable
2dysW-4n6qA:
undetectable		 2dysP-4n6qA:
22.18
2dysW-4n6qA:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIJ_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4n6q VOSA
(Aspergillus
nidulans) 		4 / 7 LYS A 132
LEU A 131
PHE A 129
LEU A 121
 None
 0.85A 2eijC-4n6qA:
undetectable
2eijJ-4n6qA:
undetectable		 2eijC-4n6qA:
22.18
2eijJ-4n6qA:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIK_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4n6q VOSA
(Aspergillus
nidulans) 		4 / 8 LYS A 132
LEU A 131
PHE A 129
LEU A 121
 None
 0.87A 2eikP-4n6qA:
undetectable
2eikW-4n6qA:
undetectable		 2eikP-4n6qA:
22.18
2eikW-4n6qA:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIL_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4n6q VOSA
(Aspergillus
nidulans) 		4 / 8 LYS A 132
LEU A 131
PHE A 129
LEU A 121
 None
 0.82A 2eilC-4n6qA:
undetectable
2eilJ-4n6qA:
undetectable		 2eilC-4n6qA:
22.18
2eilJ-4n6qA:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIM_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4n6q VOSA
(Aspergillus
nidulans) 		4 / 7 LYS A 132
LEU A 131
PHE A 129
LEU A 121
 None
 0.79A 2eimC-4n6qA:
undetectable
2eimJ-4n6qA:
undetectable		 2eimC-4n6qA:
22.18
2eimJ-4n6qA:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIM_W_CHDW1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4n6q VOSA
(Aspergillus
nidulans) 		4 / 7 LYS A 132
LEU A 131
PHE A 129
LEU A 121
 None
 0.77A 2eimP-4n6qA:
undetectable
2eimW-4n6qA:
undetectable		 2eimP-4n6qA:
22.18
2eimW-4n6qA:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIN_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4n6q VOSA
(Aspergillus
nidulans) 		4 / 7 LYS A 132
LEU A 131
PHE A 129
LEU A 121
 None
 0.79A 2einC-4n6qA:
undetectable
2einJ-4n6qA:
undetectable		 2einC-4n6qA:
22.18
2einJ-4n6qA:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2I30_A_SALA1100_1
(SERUM ALBUMIN)		 4n6q VOSA
(Aspergillus
nidulans) 		4 / 6 PHE A 116
TYR A  65
ARG A  53
GLY A 114
 None
 1.46A 2i30A-4n6qA:
undetectable		 2i30A-4n6qA:
15.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KCE_A_D16A566_1
(THYMIDYLATE SYNTHASE)		 4n6q VOSA
(Aspergillus
nidulans) 		5 / 12 SER A 100
LEU A  77
GLY A  96
VAL A  44
ALA A  31
 None
 1.00A 2kceA-4n6qA:
undetectable		 2kceA-4n6qA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KCE_B_D16B568_1
(THYMIDYLATE SYNTHASE)		 4n6q VOSA
(Aspergillus
nidulans) 		5 / 12 SER A 100
LEU A  77
GLY A  96
VAL A  44
ALA A  31
 None
 1.01A 2kceB-4n6qA:
undetectable		 2kceB-4n6qA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASN_P_CHDP1271_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1)		 4n6q VOSA
(Aspergillus
nidulans) 		4 / 7 LYS A 132
LEU A 131
PHE A 129
LEU A 121
 None
 0.87A 3asnP-4n6qA:
undetectable
3asnW-4n6qA:
undetectable		 3asnP-4n6qA:
22.18
3asnW-4n6qA:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASO_P_CHDP1271_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1)		 4n6q VOSA
(Aspergillus
nidulans) 		4 / 7 LYS A 132
LEU A 131
PHE A 129
LEU A 121
 None
 0.89A 3asoP-4n6qA:
undetectable
3asoW-4n6qA:
undetectable		 3asoP-4n6qA:
22.18
3asoW-4n6qA:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OM3_B_DXTB501_1
(ALPHA-1-ANTICHYMOTRY
PSIN)		 4n6q VOSA
(Aspergillus
nidulans) 		4 / 6 LEU A 171
SER A 172
PHE A 175
HIS A 103
 None
 0.61A 5om3A-4n6qA:
undetectable
5om3B-4n6qA:
undetectable		 5om3A-4n6qA:
18.18
5om3B-4n6qA:
13.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W97_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4n6q VOSA
(Aspergillus
nidulans) 		4 / 6 LYS A 132
LEU A 131
PHE A 129
LEU A 121
 None
 0.84A 5w97C-4n6qA:
undetectable
5w97J-4n6qA:
undetectable		 5w97C-4n6qA:
22.18
5w97J-4n6qA:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X19_P_CHDP305_0
(CYTOCHROME C OXIDASE
SUBUNIT 3)		 4n6q VOSA
(Aspergillus
nidulans) 		4 / 6 LYS A 132
LEU A 131
PHE A 129
LEU A 121
 None
 0.85A 5x19P-4n6qA:
undetectable		 5x19P-4n6qA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1F_P_CHDP304_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4n6q VOSA
(Aspergillus
nidulans) 		4 / 7 LYS A 132
LEU A 131
PHE A 129
LEU A 121
 None
 0.82A 5x1fP-4n6qA:
undetectable
5x1fW-4n6qA:
undetectable		 5x1fP-4n6qA:
22.18
5x1fW-4n6qA:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H7J_A_5FWA401_0
(BETA-1 ADRENERGIC
RECEPTOR)		 4n6q VOSA
(Aspergillus
nidulans) 		5 / 12 ASP A 109
VAL A 108
SER A 174
PHE A 115
PHE A 175
 None
 1.26A 6h7jA-4n6qA:
undetectable		 6h7jA-4n6qA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H7J_B_5FWB402_0
(BETA-1 ADRENERGIC
RECEPTOR)		 4n6q VOSA
(Aspergillus
nidulans) 		5 / 12 ASP A 109
VAL A 108
SER A 174
PHE A 115
PHE A 175
 None
 1.27A 6h7jB-4n6qA:
undetectable		 6h7jB-4n6qA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H7M_A_68HA504_0
(BETA-1 ADRENERGIC
RECEPTOR)		 4n6q VOSA
(Aspergillus
nidulans) 		5 / 12 ASP A 109
VAL A 108
SER A 174
PHE A 115
PHE A 175
 None
 1.25A 6h7mA-4n6qA:
undetectable		 6h7mA-4n6qA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H7M_B_68HB405_0
(BETA-1 ADRENERGIC
RECEPTOR)		 4n6q VOSA
(Aspergillus
nidulans) 		5 / 12 ASP A 109
VAL A 108
SER A 174
PHE A 115
PHE A 175
 None
 1.25A 6h7mB-4n6qA:
undetectable		 6h7mB-4n6qA:
19.47