SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4n74'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SG9_A_SAMA301_0
(HEMK PROTEIN)		 4n74 PREDICTED OUTER
MEMBRANE PROTEIN AND
SURFACE ANTIGEN
(Escherichia
coli) 		5 / 12 PRO A 464
ILE A 484
GLY A 495
VAL A 526
SER A 527
 None
 0.95A 1sg9A-4n74A:
undetectable		 1sg9A-4n74A:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SG9_B_SAMB302_0
(HEMK PROTEIN)		 4n74 PREDICTED OUTER
MEMBRANE PROTEIN AND
SURFACE ANTIGEN
(Escherichia
coli) 		5 / 12 PRO A 464
ILE A 484
GLY A 495
VAL A 526
SER A 527
 None
 0.94A 1sg9B-4n74A:
undetectable		 1sg9B-4n74A:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SG9_C_SAMC303_0
(HEMK PROTEIN)		 4n74 PREDICTED OUTER
MEMBRANE PROTEIN AND
SURFACE ANTIGEN
(Escherichia
coli) 		5 / 12 PRO A 464
ILE A 484
GLY A 495
VAL A 526
SER A 527
 None
 0.93A 1sg9C-4n74A:
undetectable		 1sg9C-4n74A:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_B_TACB1888_1
(ELONGATION FACTOR
EF-TU)		 4n74 PREDICTED OUTER
MEMBRANE PROTEIN AND
SURFACE ANTIGEN
(Escherichia
coli) 		4 / 5 THR A 383
SER A 422
ASP A 423
SER A 416
 None
 1.16A 2hdnA-4n74A:
undetectable
2hdnB-4n74A:
undetectable
2hdnD-4n74A:
undetectable		 2hdnA-4n74A:
9.67
2hdnB-4n74A:
22.38
2hdnD-4n74A:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_D_TACD2888_1
(ELONGATION FACTOR
EF-TU)		 4n74 PREDICTED OUTER
MEMBRANE PROTEIN AND
SURFACE ANTIGEN
(Escherichia
coli) 		4 / 5 SER A 416
THR A 383
SER A 422
ASP A 423
 None
 1.14A 2hdnB-4n74A:
undetectable
2hdnC-4n74A:
undetectable
2hdnD-4n74A:
undetectable		 2hdnB-4n74A:
22.38
2hdnC-4n74A:
9.67
2hdnD-4n74A:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VMY_A_FFOA505_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 4n74 PREDICTED OUTER
MEMBRANE PROTEIN AND
SURFACE ANTIGEN
(Escherichia
coli) 		5 / 12 GLY A 279
LEU A 339
SER A 305
GLY A 471
ARG A 281
 None
 1.18A 2vmyB-4n74A:
undetectable		 2vmyB-4n74A:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K9F_H_LFXH0_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B)		 4n74 PREDICTED OUTER
MEMBRANE PROTEIN AND
SURFACE ANTIGEN
(Escherichia
coli) 		4 / 6 ARG A 543
GLY A 574
GLU A 505
GLU A 576
 None
 1.16A 3k9fA-4n74A:
undetectable
3k9fB-4n74A:
undetectable
3k9fD-4n74A:
undetectable		 3k9fA-4n74A:
19.12
3k9fB-4n74A:
19.12
3k9fD-4n74A:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PHN_A_ACTA108_0
(PROTEIN P-30)		 4n74 PREDICTED OUTER
MEMBRANE PROTEIN AND
SURFACE ANTIGEN
(Escherichia
coli) 		3 / 3 THR A 348
SER A 370
ARG A 368
 None
 0.56A 3phnA-4n74A:
undetectable		 3phnA-4n74A:
16.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUD_C_SUEC1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 4n74 PREDICTED OUTER
MEMBRANE PROTEIN AND
SURFACE ANTIGEN
(Escherichia
coli) 		4 / 4 PHE A 429
TYR A 415
LEU A 499
LYS A 498
 None
 1.29A 3sudC-4n74A:
0.0		 3sudC-4n74A:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_C_SUEC1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 4n74 PREDICTED OUTER
MEMBRANE PROTEIN AND
SURFACE ANTIGEN
(Escherichia
coli) 		4 / 5 PHE A 429
TYR A 415
LEU A 499
LYS A 498
 None
 1.23A 3sueC-4n74A:
undetectable		 3sueC-4n74A:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDP_H_EVPH2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B)		 4n74 PREDICTED OUTER
MEMBRANE PROTEIN AND
SURFACE ANTIGEN
(Escherichia
coli) 		4 / 6 SER A 546
GLY A 541
ASP A 554
GLY A 516
 None
 0.99A 5cdpA-4n74A:
undetectable
5cdpB-4n74A:
undetectable		 5cdpA-4n74A:
23.01
5cdpB-4n74A:
22.34