SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4n75'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QKN_A_RALA600_1
(ESTROGEN RECEPTOR
BETA)		 4n75 OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTOR BAMA
(Escherichia
coli) 		5 / 12 THR A 617
GLU A 717
ARG A 661
GLY A 584
LEU A 581
 None
 0.99A 1qknA-4n75A:
undetectable		 1qknA-4n75A:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WG8_B_SAMB3141_0
(PREDICTED
S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 4n75 OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTOR BAMA
(Escherichia
coli) 		5 / 12 GLY A 655
GLY A 656
GLY A 662
ASP A 740
SER A 658
 None
 1.20A 1wg8B-4n75A:
undetectable		 1wg8B-4n75A:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1H_A_GBNA502_1
(BRANCHED CHAIN
AMINOTRANSFERASE)		 4n75 OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTOR BAMA
(Escherichia
coli) 		4 / 8 THR A 571
GLY A 528
THR A 514
VAL A 532
 None
 0.87A 2a1hA-4n75A:
undetectable
2a1hB-4n75A:
undetectable		 2a1hA-4n75A:
21.96
2a1hB-4n75A:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_B_SAMB1002_1
(SAM DEPENDENT
METHYLTRANSFERASE)		 4n75 OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTOR BAMA
(Escherichia
coli) 		3 / 3 ASP A 500
ASP A 503
ASP A 464
 None
 0.73A 2igtB-4n75A:
undetectable		 2igtB-4n75A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QWX_A_ML1A233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4n75 OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTOR BAMA
(Escherichia
coli) 		4 / 8 TRP A 776
PHE A 785
GLY A 807
ILE A 430
 None
 0.97A 2qwxA-4n75A:
undetectable
2qwxB-4n75A:
undetectable		 2qwxA-4n75A:
20.10
2qwxB-4n75A:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XF3_A_J01A500_1
(ORF12)		 4n75 OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTOR BAMA
(Escherichia
coli) 		5 / 10 VAL A 660
LEU A 501
GLY A 707
ALA A 705
LYS A 671
 None
 1.24A 2xf3A-4n75A:
undetectable		 2xf3A-4n75A:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XF3_B_J01B500_1
(ORF12)		 4n75 OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTOR BAMA
(Escherichia
coli) 		5 / 9 VAL A 660
LEU A 501
GLY A 707
ALA A 705
LYS A 671
 None
 1.23A 2xf3B-4n75A:
0.6		 2xf3B-4n75A:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XFS_A_J01A500_1
(ORF12)		 4n75 OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTOR BAMA
(Escherichia
coli) 		5 / 8 VAL A 660
LEU A 501
GLY A 707
ALA A 705
LYS A 671
 None
 1.30A 2xfsA-4n75A:
undetectable		 2xfsA-4n75A:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XFS_B_J01B500_1
(ORF12)		 4n75 OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTOR BAMA
(Escherichia
coli) 		5 / 9 VAL A 660
LEU A 501
GLY A 707
ALA A 705
LYS A 671
 None
 1.25A 2xfsB-4n75A:
0.7		 2xfsB-4n75A:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XH9_A_J01A1436_1
(ORF12)		 4n75 OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTOR BAMA
(Escherichia
coli) 		5 / 8 VAL A 660
LEU A 501
GLY A 707
ALA A 705
LYS A 671
 None
 1.26A 2xh9A-4n75A:
undetectable		 2xh9A-4n75A:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XH9_B_J01B1436_1
(ORF12)		 4n75 OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTOR BAMA
(Escherichia
coli) 		5 / 9 VAL A 660
LEU A 501
GLY A 707
ALA A 705
LYS A 671
 None
 1.26A 2xh9B-4n75A:
0.6		 2xh9B-4n75A:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A35_A_RBFA191_1
(LUMAZINE PROTEIN)		 4n75 OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTOR BAMA
(Escherichia
coli) 		5 / 12 SER A 472
THR A 474
ASP A 447
ASN A 459
ILE A 458
 None
 1.21A 3a35A-4n75A:
undetectable		 3a35A-4n75A:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A3B_A_RBFA191_1
(LUMAZINE PROTEIN)		 4n75 OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTOR BAMA
(Escherichia
coli) 		5 / 12 SER A 472
THR A 474
ASP A 447
ASN A 459
ILE A 458
 None
 1.16A 3a3bA-4n75A:
undetectable		 3a3bA-4n75A:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HII_A_PNTA901_0
(AMILORIDE-SENSITIVE
AMINE OXIDASE)		 4n75 OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTOR BAMA
(Escherichia
coli) 		5 / 12 ASP A 746
GLY A 707
VAL A 744
TYR A 653
TYR A 637
 None
 1.46A 3hiiA-4n75A:
1.5		 3hiiA-4n75A:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HII_B_PNTB901_0
(AMILORIDE-SENSITIVE
AMINE OXIDASE)		 4n75 OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTOR BAMA
(Escherichia
coli) 		5 / 12 ASP A 746
GLY A 707
VAL A 744
TYR A 653
TYR A 637
 None
 1.45A 3hiiB-4n75A:
2.0		 3hiiB-4n75A:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZT_A_SAMA1472_1
(METHYLTRANSFERASE
WBDD)		 4n75 OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTOR BAMA
(Escherichia
coli) 		3 / 3 GLN A 561
ASP A 497
GLN A 495
 None
 0.54A 4aztA-4n75A:
undetectable		 4aztA-4n75A:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B3Q_A_NVPA999_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 4n75 OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTOR BAMA
(Escherichia
coli) 		4 / 7 VAL A 532
TYR A 491
TYR A 509
TYR A 649
 None
 1.15A 4b3qA-4n75A:
undetectable		 4b3qA-4n75A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K8C_A_ADNA401_2
(SUGAR KINASE)		 4n75 OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTOR BAMA
(Escherichia
coli) 		3 / 3 SER A 591
TYR A 578
PRO A 587
 None
 0.92A 4k8cA-4n75A:
undetectable		 4k8cA-4n75A:
24.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAH_A_ADNA401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 4n75 OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTOR BAMA
(Escherichia
coli) 		3 / 3 SER A 591
TYR A 578
PRO A 587
 None
 0.91A 4kahA-4n75A:
undetectable		 4kahA-4n75A:
24.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAH_B_ADNB502_2
(PROBABLE SUGAR
KINASE PROTEIN)		 4n75 OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTOR BAMA
(Escherichia
coli) 		3 / 3 SER A 591
TYR A 578
PRO A 587
 None
 0.91A 4kahB-4n75A:
undetectable		 4kahB-4n75A:
24.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAN_A_ADNA401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 4n75 OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTOR BAMA
(Escherichia
coli) 		3 / 3 SER A 591
TYR A 578
PRO A 587
 None
 0.93A 4kanA-4n75A:
undetectable		 4kanA-4n75A:
24.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAN_B_ADNB401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 4n75 OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTOR BAMA
(Escherichia
coli) 		3 / 3 SER A 591
TYR A 578
PRO A 587
 None
 0.91A 4kanB-4n75A:
undetectable		 4kanB-4n75A:
24.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KBE_A_ADNA401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 4n75 OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTOR BAMA
(Escherichia
coli) 		3 / 3 SER A 591
TYR A 578
PRO A 587
 None
 0.92A 4kbeA-4n75A:
undetectable		 4kbeA-4n75A:
24.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KBE_B_ADNB401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 4n75 OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTOR BAMA
(Escherichia
coli) 		3 / 3 SER A 591
TYR A 578
PRO A 587
 None
 0.93A 4kbeB-4n75A:
undetectable		 4kbeB-4n75A:
24.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBG_A_ADNA401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 4n75 OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTOR BAMA
(Escherichia
coli) 		3 / 3 SER A 591
TYR A 578
PRO A 587
 None
 0.89A 4lbgA-4n75A:
undetectable		 4lbgA-4n75A:
24.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBG_B_ADNB401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 4n75 OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTOR BAMA
(Escherichia
coli) 		3 / 3 SER A 591
TYR A 578
PRO A 587
 None
 0.90A 4lbgB-4n75A:
undetectable		 4lbgB-4n75A:
24.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_B_SAMB601_0
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 4n75 OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTOR BAMA
(Escherichia
coli) 		5 / 12 ALA A 654
GLY A 655
GLY A 656
ASP A 740
GLY A 707
 None
 0.99A 4obwB-4n75A:
undetectable		 4obwB-4n75A:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOG_A_ML1A302_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4n75 OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTOR BAMA
(Escherichia
coli) 		4 / 8 TRP A 776
PHE A 785
GLY A 807
ILE A 430
 None
 0.93A 4qogA-4n75A:
undetectable
4qogB-4n75A:
undetectable		 4qogA-4n75A:
20.10
4qogB-4n75A:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KPC_B_SAMB401_0
(PAVINE
N-METHYLTRANSFERASE)		 4n75 OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTOR BAMA
(Escherichia
coli) 		5 / 12 PHE A 652
GLY A 669
GLY A 707
ASP A 762
ALA A 654
 None
 1.15A 5kpcB-4n75A:
undetectable		 5kpcB-4n75A:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X80_A_SALA201_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		 4n75 OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTOR BAMA
(Escherichia
coli) 		4 / 5 VAL A 456
PRO A 476
GLY A 453
TYR A 454
 None
 1.37A 5x80A-4n75A:
undetectable
5x80B-4n75A:
undetectable		 5x80A-4n75A:
18.67
5x80B-4n75A:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X80_D_SALD201_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		 4n75 OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTOR BAMA
(Escherichia
coli) 		4 / 5 PRO A 476
GLY A 453
TYR A 454
VAL A 456
 None
 1.31A 5x80C-4n75A:
undetectable
5x80D-4n75A:
undetectable		 5x80C-4n75A:
18.67
5x80D-4n75A:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWD_A_GLYA717_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		 4n75 OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTOR BAMA
(Escherichia
coli) 		4 / 5 SER A 715
ARG A 632
ASP A 740
ARG A 661
 None
 1.50A 6dwdA-4n75A:
undetectable		 6dwdA-4n75A:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNE_B_ACRB602_1
(-)		 4n75 OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTOR BAMA
(Escherichia
coli) 		5 / 12 GLU A 435
GLY A 656
GLY A 655
VAL A 744
GLY A 742
 None
 1.08A 6gneB-4n75A:
undetectable		 6gneB-4n75A:
20.90