SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4n77'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_B_RALB600_1
(ESTROGEN RECEPTOR)		 4n77 UNCHARACTERIZED
PROTEIN
(Thermus
thermophilus) 		5 / 12 ALA A 178
LEU A   5
LEU A 170
LEU A 196
LEU A 229
 None
 1.17A 1errB-4n77A:
undetectable		 1errB-4n77A:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_A_SNLA1001_2
(MINERALOCORTICOID
RECEPTOR)		 4n77 UNCHARACTERIZED
PROTEIN
(Thermus
thermophilus) 		4 / 5 LEU A 140
ALA A  42
LEU A  38
MET A  59
 None
 1.23A 2oaxA-4n77A:
undetectable		 2oaxA-4n77A:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RIW_A_T44A1395_1
(THYROXINE-BINDING
GLOBULIN)		 4n77 UNCHARACTERIZED
PROTEIN
(Thermus
thermophilus) 		5 / 10 ALA A  40
LEU A 137
LEU A 136
LEU A  54
LEU A 140
 None
 1.12A 2riwA-4n77A:
undetectable
2riwB-4n77A:
undetectable		 2riwA-4n77A:
19.94
2riwB-4n77A:
10.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_D_SAMD300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 4n77 UNCHARACTERIZED
PROTEIN
(Thermus
thermophilus) 		5 / 12 LEU A 130
GLU A 180
ALA A 178
GLY A 129
LEU A   5
 None
 1.42A 3ou6D-4n77A:
undetectable		 3ou6D-4n77A:
24.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TOP_B_ACRB1_2
(MALTASE-GLUCOAMYLASE
, INTESTINAL)		 4n77 UNCHARACTERIZED
PROTEIN
(Thermus
thermophilus) 		4 / 5 PRO A 210
ILE A   6
TRP A  15
PHE A 214
 None
 1.32A 3topB-4n77A:
undetectable		 3topB-4n77A:
13.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WW7_A_ACTA303_0
(EKC/KEOPS COMPLEX
SUBUNIT BUD32)		 4n77 UNCHARACTERIZED
PROTEIN
(Thermus
thermophilus) 		4 / 4 LEU A 198
VAL A 224
GLU A 199
ARG A 222
 None
 0.84A 4ww7A-4n77A:
undetectable		 4ww7A-4n77A:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J2T_C_VLBC503_2
(TUBULIN ALPHA-1B
CHAIN)		 4n77 UNCHARACTERIZED
PROTEIN
(Thermus
thermophilus) 		5 / 12 LEU A   4
VAL A  35
PHE A 126
VAL A 128
GLY A 129
 None
 0.57A 5j2tC-4n77A:
undetectable		 5j2tC-4n77A:
20.93